Article
Biochemical Research Methods
Aseer Intisar, Seung Joon Lee, Yu-Gyeong Kim, Woon-Hae Kim, Hyun Young Shin, Min Young Kim, Jong Man Kim, Jungmin Lee, Yun Jeoung Mo, Yu Seon Kim, Seung-Hoon Kim, Yun-Il Lee, Minseok S. Kim
Summary: This study introduces a rapid method for enriching neurons from the mouse embryonic dorsal root ganglion using fully-automated continuous centrifugal microfluidics, achieving effective isolation within 13 minutes. The purified neurons showed improved viability and purity compared to conventional chemical purification methods, highlighting the potential of this automated system to advance neurological research.
Article
Multidisciplinary Sciences
Thomas Grueter, Nuwin Mohamad, Niklas Rilke, Alina Blusch, Melissa Sgodzai, Seray Demir, Xiomara Pedreiturria, Katharina Lemhoefer, Barbara Gisevius, Aiden Haghikia, Anna Lena Fisse, Jeremias Motte, Ralf Gold, Kalliopi Pitarokoili
Summary: In inflammatory neuropathies, treatment with propionate showed immunoregulatory and neuroprotective effects. Activation of FFAR3 and histone acetylation resulted in increased resistance to oxidative stress and enhanced neuroregeneration. This pathway provides potential neuroprotection and neuroregeneration for patients with immune-mediated neuropathies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Cell Biology
Hilary R. Katz, Anthony A. Arcese, Ona Bloom, Jennifer R. Morgan
Summary: The regenerative capacity of vertebrate nervous system varies greatly among species and neuronal populations. Activating transcription factor 3 (ATF3) has been identified as a conserved pro-regenerative factor that promotes neuronal axon regrowth and regeneration in various species. It is induced in neurons shortly after injury and its expression is found to be critical for axon regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Zain Alhashem, Karen Camargo-Sosa, Robert N. Kelsh, Claudia Linker
Summary: The coordinated migration and differentiation of distant cells are essential for the generation of complex structures during embryogenesis. A study found that in the trunk, neural crest cells migrate collectively and form chains with distinctive migratory identities. The leader cells, which direct the migration, give rise to distal derivatives, while the followers give rise to Schwann cells. The asymmetric division of leader cells separates migratory identity and fate.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Neurosciences
Kristine S. Ojala, Emily J. Reedich, Christine J. DiDonato, Stephen D. Meriney
Summary: Spinal muscular atrophy (SMA) was previously considered a devastating neuromuscular disease with poor prognosis, but recent advancements in genetically targeted therapies have transformed it into a prototype for monogenic disease treatment, significantly improving quality of life and survival rates for affected individuals.
Article
Engineering, Biomedical
Scott Stratton, Shuo Wang, Sharareh Hashemi, Yelena Pressman, James Nanchanatt, Martin Oudega, Treena Livingston Arinzeh
Summary: In this study, a zinc oxide (ZnO) containing fibrous scaffold was developed, which promoted and guided axon growth through its bifunctional properties.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Benjamin M. Zemel, Lianteng Zhi, Eric V. Brown, Stephen R. Tymanskyj, Qiansheng Liang, Manuel Covarrubias
Summary: The study suggests that a physical interaction between Kv3.4 channel and functional PKC epsilon primarily determines its stability and localization in DRG neurons, without significantly affecting its gating.
Article
Neurosciences
Ruirui Zhang, Sailing Chen, Xinghui Wang, Xiaosong Gu, Sheng Yi
Summary: The study used high-coverage single-cell sequencing to reveal the cell diversity and heterogeneity of Schwann cells in the peripheral nerves of neonatal rats. A total of 10 cell types were identified in SN and DRG with distinct cell-cell communication patterns.
Article
Multidisciplinary Sciences
Sara Caxaria, Sabah Bharde, Alice M. Fuller, Romy Evans, Bethan Thomas, Petek Celik, Francesco Dell'Accio, Simon Yona, Derek Gilroy, Mathieu-Benoit Voisin, John N. Wood, Shafaq Sikandar
Summary: We demonstrated the role of neutrophils in fibromyalgia by using a back-translational approach in mice. Adoptive transfer of neutrophils from mice with chronic widespread pain or patients with fibromyalgia can induce mechanical pain in recipient mice, sensitize spinal cord neurons, and cause changes in the expression of neutrophil proteins that lead to neutrophil infiltration into dorsal root ganglia. These findings suggest an immunological basis for chronic widespread pain in fibromyalgia mediated by neutrophils.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Cristina Fraquelli, Jasmine Hauzinger, Christian Humpel, Maria Nolano, Vincenzo Provitera, Vinay Kumar Sharma, Peng Loh, Zenon Pidsudko, Georgios Blatsios, Josef Troger
Summary: This study investigated the presence and source of serpinins in the skin, and found that serpinin was present in the dorsal root ganglia and sensory nerves of rats, with colocalization with substance P. Although predominantly found in its free form in the skin, the serpinins may have functional significance in the sensory innervation of the skin.
Article
Biochemistry & Molecular Biology
Ruirui Lu, Katharina Metzner, Fangyuan Zhou, Cathrin Flauaus, Annika Balzulat, Patrick Engel, Jonas Petersen, Rebekka Ehinger, Anne Bausch, Peter Ruth, Robert Lukowski, Achim Schmidtko
Summary: The sodium-activated potassium channel Slack plays a role in sensory neurons and is involved in mediating sodium-activated potassium current (I-KNa) and modulating neuronal activity. Studies found that Slack activity is reduced in sensory neurons after peripheral nerve injury, contributing to neuropathic pain hypersensitivity, and that it is associated with ATP-sensitive P2X3 receptors. Experiments showed that Slack-mediated I-KNa can be bidirectionally modulated in response to P2X3 activation, suggesting a potential novel strategy for treating neuropathic pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Ying Zhao, Qiang Wang, Chen Xie, Yuling Cai, Xue Chen, Yuhui Hou, Liu He, Jianping Li, Min Yao, Shuangxi Chen, Wutian Wu, Xiaojia Chen, An Hong
Summary: This study developed a novel low-molecular-weight peptide agonist CH02 targeting FGFR, which effectively promoted nerve regeneration, enhanced axon growth of sensory neurons, and robustly improved nerve regeneration and sensory-motor behavioral recovery in a rat spinal dorsal root injury model.
Article
Cell & Tissue Engineering
Junhou Lu, Dongyan Wang, Jianwei Xu, Huanxiang Zhang, Wenfeng Yu
Summary: Satellite glial cells (SGCs) surrounding sensory neurons in the peripheral nervous system ganglia originate from neural crest cells. Recent studies suggest that SGCs may have stem cell characteristics and can differentiate into functional sensory neurons. Additionally, SGCs express markers associated with Schwann cell precursors and Schwann cells, indicating a potential relationship between SGCs and Schwann cell precursors.
STEM CELL REVIEWS AND REPORTS
(2023)
Article
Cell Biology
Fangyuan Zhou, Katharina Metzner, Patrick Engel, Annika Balzulat, Marco Sisignano, Peter Ruth, Robert Lukowski, Achim Schmidtko, Ruirui Lu
Summary: The study reveals that Slack serves as a modulator of TRPA1-mediated activation of sensory neurons, but not TRPV1-mediated activation.
Article
Clinical Neurology
Ricardo H. Roda, David Bargiela, Weiran Chen, Ken Perry, Ronald J. Ellis, David B. Clifford, Ajay Bharti, Asha R. Kallianpur, Michelli F. Oliveira, Monica M. Diaz, Leah H. Rubin, Christina Gavegnano, Justin C. McArthur, Ahmet Hoke, Michael Polydefkis
Summary: The study aimed to evaluate the correlation of large mtDNA deletions in skin samples of people with HIV with measures of neuropathy and prior exposure to therapy. Results showed a correlation between the total mtDNA deletion and intraepidermal nerve fiber density (IENFD) and sural nerve amplitude in PWH with HIV-associated sensory neuropathy.
Letter
Clinical Neurology
Yousef Salimpour, Zhikui Wei, Phan Q. Duy, William S. Anderson
Letter
Clinical Neurology
Yousef Salimpour, Kelly A. Mills, Zhikui Wei, Phan Q. Duy, William S. Anderson
Letter
Biology
Phan Q. Duy, Samer Hattar
JOURNAL OF BIOLOGICAL RHYTHMS
(2017)
Article
Neurosciences
Thi Hao Le, Phan Q. Duy, Min An, Jared Talbot, Chitra C. Iyer, Marc Wolman, Christine E. Beattie
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Phan Q. Duy, Michael A. Berberoglu, Christine E. Beattie, Charles W. Hall
Article
Neurosciences
Dejan B. Budimirovic, Smiljana Cvjetkovic, Zoran Bukumiric, Phan Q. Duy, Dragana Protic
FRONTIERS IN NEUROSCIENCE
(2018)
Article
Clinical Neurology
Serban Negoita, Phan Q. Duy, Uma V. Mahajan, William S. Anderson
JOURNAL OF CLINICAL NEUROSCIENCE
(2019)
Article
Developmental Biology
Jared C. Talbot, Emily M. Teets, Dhanushika Ratnayake, Phan Q. Duy, Peter D. Currie, Sharon L. Amacher
Editorial Material
Biochemistry & Molecular Biology
Phan Q Duy, Charuta G. Furey, Kristopher T. Kahle
TRENDS IN MOLECULAR MEDICINE
(2019)
Article
Neurosciences
August A. Allocco, Sheng Chih Jin, Phan Q. Duy, Charuta G. Furey, Xue Zeng, Weilai Dong, Carol Nelson-Williams, Jason K. Karimy, Tyrone DeSpenza, Le T. Hao, Benjamin Reeves, Shozeb Haider, Murat Gunel, Richard P. Lifton, Kristopher T. Kahle
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Neurosciences
Phan Q. Duy, Serban Negoita, Uma V. Mahajan, Nicholas S. Diab, Ank Agarwal, Trisha Gupte, Manish D. Paranjpe, William S. Anderson
TRANSLATIONAL NEUROSCIENCE
(2019)
Article
Neurosciences
Phan Q. Duy, Anirudh Sreekrishnan, Wyatt David, Manish D. Paranjpe, Ishan Paranjpe, Amar Sheth, Batur Gultekin, Kevin N. Sheth
TRANSLATIONAL NEUROSCIENCE
(2019)
Article
Medicine, Research & Experimental
Min Liu, Manish D. Paranjpe, Xin Zhou, Phan Q. Duy, Manu S. Goyal, Tammie L. S. Benzinger, Jie Lu, Rongfu Wang, Yun Zhou
Review
Biology
Phan Q. Duy, William S. Anderson
YALE JOURNAL OF BIOLOGY AND MEDICINE
(2018)
Article
Neurosciences
Phan Q. Duy, Dejan B. Budimirovic
TRANSLATIONAL NEUROSCIENCE
(2017)