Evidence of non-pancreatic beta cell-dependent roles of Tcf7l2 in the regulation of glucose metabolism in mice

TCF7L2 is a master regulator of insulin production and processing

(2014) Yuedan Zhou et al.   HUMAN MOLECULAR GENETICS

Zinc transport and diabetes risk

(2014) Ewan Pearson   NATURE GENETICS

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes

(2014) Jason Flannick et al.   NATURE GENETICS

Genetic Susceptibility to Type 2 Diabetes and Obesity: Follow-Up of Findings from Genome-Wide Association Studies

(2014) Kevin J. Basile et al.   International Journal of Endocrinology

TCF7L2 and Glucose Metabolism: Time to Look Beyond the Pancreas

(2013) M. A. Nobrega   DIABETES

Animal Models of GWAS-Identified Type 2 Diabetes Genes

(2013) Gabriela da Silva Xavier et al.   Journal of Diabetes Research

Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci

(2012) Richa Saxena et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Diabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic Demand

(2012) Sylvia F. Boj et al.   CELL

Reduced Insulin Exocytosis in Human Pancreatic  -Cells With Gene Variants Linked to Type 2 Diabetes

(2012) A. H. Rosengren et al.   DIABETES

TCF7L2 promotes beta cell regeneration in human and mouse pancreas

(2012) L. Shu et al.   DIABETOLOGIA

TCF7L2 rs7903146 impairs islet function and morphology in non-diabetic individuals

(2012) O. Le Bacquer et al.   DIABETOLOGIA

In vitro scan for enhancers at the TCF7L2 locus

(2012) D. Savic et al.   DIABETOLOGIA

Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice

(2012) G. da Silva Xavier et al.   DIABETOLOGIA

Reduction in Tcf7l2 Expression Decreases Diabetic Susceptibility in Mice

(2012) Hyekyung Yang et al.   International Journal of Biological Sciences

An in vivo cis-Regulatory Screen at the Type 2 Diabetes Associated TCF7L2 Locus Identifies Multiple Tissue-Specific Enhancers

(2012) Daniel Savic et al.   PLoS One

Quantification of islet size and architecture

(2012) German Kilimnik et al.   Islets

Transcriptional enhancers in development and disease

(2012) Noboru Sakabe et al.   GENOME BIOLOGY

Coating Human Pancreatic Islets With CD4+CD25highCD127− Regulatory T Cells as a Novel Approach for the Local Immunoprotection

(2011) Natalia Marek et al.   ANNALS OF SURGERY

Alterations in TCF7L2 expression define its role as a key regulator of glucose metabolism

(2011) D. Savic et al.   GENOME RESEARCH

Altered Islet Composition and Disproportionate Loss of Large Islets in Patients with Type 2 Diabetes

(2011) German Kilimnik et al.   PLoS One

Global Epigenomic Analysis of Primary Human Pancreatic Islets Provides Insights into Type 2 Diabetes Susceptibility Loci

(2010) Michael L. Stitzel et al.   Cell Metabolism

Conditional Gene Targeting in Mouse Pancreatic  -Cells: Analysis of Ectopic Cre Transgene Expression in the Brain

(2010) B. Wicksteed et al.   DIABETES

A map of open chromatin in human pancreatic islets

(2010) Kyle J Gaulton et al.   NATURE GENETICS

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Encapsulation of Pancreatic Islets Within Nano-Thin Functional Polyethylene Glycol Coatings for Enhanced Insulin Secretion

(2010) Seda Kizilel et al.   TISSUE ENGINEERING PART A

Genome-wide maps of transcription regulatory elements

(2010) Noboru J. Sakabe et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

TCF7L2 Regulates Late Events in Insulin Secretion From Pancreatic Islet  -Cells

(2009) G. da Silva Xavier et al.   DIABETES

Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

(2009) Luan Shu et al.   HUMAN MOLECULAR GENETICS

TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic β-cells

(2008) Merewyn K. Loder et al.   BIOCHEMICAL SOCIETY TRANSACTIONS