Smooth muscle hyperplasia due to loss of smooth muscle α-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-β

Rare, Nonsynonymous Variant in the Smooth Muscle-Specific Isoform of Myosin Heavy Chain, MYH11 , R247C, Alters Force Generation in the Aorta and Phenotype of Smooth Muscle Cells

(2012) Shao-Qing Kuang et al.   CIRCULATION RESEARCH

PAR-2 Inhibition Reverses Experimental Pulmonary Hypertension

(2012) Grazyna Kwapiszewska et al.   CIRCULATION RESEARCH

Aortic Aneurysm Generation in Mice With Targeted Deletion of Integrin-Linked Kinase in Vascular Smooth Muscle Cells

(2011) Dongxiao Shen et al.   CIRCULATION RESEARCH

Imatinib mesylate for the treatment of pulmonary arterial hypertension

(2011) Henrik ten Freyhaus et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Airways in smooth muscle α-actin null mice experience a compensatory mechanism that modulates their contractile response

(2011) Felix R. Shardonofsky et al.   JOURNAL OF APPLIED PHYSIOLOGY

Imatinib for Chronic Myeloid Leukemia: The Impact of Its Effectiveness and Long-term Side Effects

(2011) B. D. Smith   JNCI-Journal of the National Cancer Institute

Imatinib mesylate at therapeutic doses has no impact on folliculogenesis or spermatogenesis in a leukaemic mouse model

(2011) Beate Schultheis et al.   LEUKEMIA RESEARCH

De novo ACTA2 mutation causes a novel syndrome of multisystemic smooth muscle dysfunction

(2010) Dianna M. Milewicz et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A

(2010) Rafał Pawłowski et al.   EMBO JOURNAL

Extracellular matrix effect on RhoA signaling modulation in vascular smooth muscle cells

(2010) Soon-Mi Lim et al.   EXPERIMENTAL CELL RESEARCH

Thoracic aortic disease in tuberous sclerosis complex: molecular pathogenesis and potential therapies in Tsc2+/− mice

(2010) Jiumei Cao et al.   HUMAN MOLECULAR GENETICS

Rapamycin Inhibits Cytoskeleton Reorganization and Cell Motility by Suppressing RhoA Expression and Activity

(2010) Lei Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice

(2010) Axel Visel et al.   NATURE

Mutations in Smooth Muscle Alpha-Actin (ACTA2) Cause Coronary Artery Disease, Stroke, and Moyamoya Disease, Along with Thoracic Aortic Disease

(2009) Dong-Chuan Guo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Integrated microscopy for real-time imaging of mechanotransduction studies in live cells

(2009) Andreea Trache et al.   JOURNAL OF BIOMEDICAL OPTICS

The use of flat punch indentation to determine the viscoelastic properties in the time and frequency domains of a soft layer bonded to a rigid substrate

(2008) Y CAO et al.   Acta Biomaterialia

Cytoskeletal remodeling in differentiated vascular smooth muscle is actin isoform dependent and stimulus dependent

(2008) Hak Rim Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning

(2008) Vita M. Golubovskaya et al.   BIOCHEMICAL JOURNAL

Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271

(2008) W. G. Roberts et al.   CANCER RESEARCH

Conditional Deletion of Krüppel-Like Factor 4 Delays Downregulation of Smooth Muscle Cell Differentiation Markers but Accelerates Neointimal Formation Following Vascular Injury

(2008) Tadashi Yoshida et al.   CIRCULATION RESEARCH

Kinetics of repression by modified p53 on the PDGF β-receptor promoter

(2008) Weiwen Yang et al.   INTERNATIONAL JOURNAL OF CANCER

Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner

(2008) Colin K. Choi et al.   NATURE CELL BIOLOGY

Imatinib Mesilate Inhibits Neointimal Hyperplasia via Growth Inhibition of Vascular Smooth Muscle Cells in a Rat Model of Balloon Injury

(2008) Yashiro Makiyama et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE