Article
Biochemistry & Molecular Biology
Chao Ji, Yongming Pan, Songtao Xu, Chen Yu, Jian Ji, Minli Chen, Fuliang Hu
Summary: Propolis has a protective effect on carotid restenosis in hypercholesterolemia rabbits by inhibiting neointima hyperplasia, improving lipid profiles, enhancing anti-oxidative activities, and reducing inflammation. The anti-inflammatory activity of propolis may be related to the inhibition of the TLR4-mediated NF-kappa B signaling pathway, providing a potential mechanism for its therapeutic effects on vascular restenosis.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ha-Hyeon Shin, Eun-Seok Jeon, Byung-Kwan Lim
Summary: In this study, the function of coxsackievirus and adenovirus receptor (CAR) in mouse macrophages during CVB3 infection was investigated. CAR expression was found to increase after infection and its deletion in macrophages led to increased inflammation and myocarditis. Furthermore, the expression of chemokine CXCL-11 was increased, leading to stimulation of CD4 and CD8 T cell activity. These findings highlight the importance of macrophage CAR in regulating inflammation during CVB3 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yang Zhang, Wing-Yee Lui
Summary: Canonical coxsackievirus and adenovirus receptor (CXADR) is a transmembrane component crucial for cardiac and testicular functions. It is involved in cell junctions and plays a role in spermatogenesis. Knocking out CXADR in mouse Sertoli cells impairs male reproductive functions and leads to compromised blood-testis barrier, germ cell apoptosis, and premature loss of spermatids. This review summarizes the regulation and role of CXADR in spermatogenesis and pathological conditions, providing future directions for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Decai Zhu, Dawei Wang, Zhen Zhao, Qingqing Liu, Rongyuan Yang, Qing Liu
Summary: Meta-analysis showed that nanoliposome alprostadil could effectively reduce the occurrence of in-stent restenosis (ISR) after percutaneous coronary intervention (PCI) in patients with coronary atherosclerotic heart disease (CHD).
JOURNAL OF INTERVENTIONAL CARDIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Tamara Melnik, Olivier Jordan, Jean-Marc Corpataux, Florence Delie, Francois Saucy
Summary: This article reviews the development pathways of intimal hyperplasia (IH) and discusses different drugs and drug combinations that interfere with these pathways. Local application of drugs and drug combinations may provide an effective and safe approach for preventing IH.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Utsab Subedi, Shrivats Manikandan, Susmita Bhattarai, Papori Sharma, Sudha Sharma, Hong Sun, Sumitra Miriyala, Manikandan Panchatcharam
Summary: Neointimal hyperplasia is characterized by a loss of the contractile phenotype of vascular smooth muscle cells (VSMCs). Our study found that autotaxin (ATX) and lysophosphatidic acid (LPA) play a role in VSMC proliferation and migration during restenosis. Inhibition of the ATX-LPA axis could potentially be used as a therapeutic target to minimize VSMC phenotypic modulation and inflammation after vascular injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Diane Macabrey, Alban Longchamp, Sebastien Deglise, Florent Allagnat
Summary: Arterial occlusive disease is a serious condition caused by narrowing of the arteries, primarily due to atherosclerosis. It is a leading cause of death in Western countries and can lead to peripheral arterial disease, stroke, and heart disease. Current treatment options are limited, but hydrogen sulfide shows potential in preventing arterial occlusive disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Microbiology
Poornima Kotha Lakshmi Narayan, James M. Readler, Mahmoud S. Alghamri, Trisha L. Brockman, Ran Yan, Priyanka Sharma, Vladislav Snitsarev, Katherine J. D. A. Excoffon, Abimbola O. Kolawole
Summary: The coxsackievirus and adenovirus receptor (CAR) is an essential cellular protein involved in cell adhesion, cell signaling, and viral infection. The short half-life of apical CAR(Ex8) correlates well with adenovirus transduction, suggesting potential efficacy of antiviral strategies targeting degradation of the primary receptor for apical adenovirus infection.
Review
Physiology
Sebastien Deglise, Clemence Bechelli, Florent Allagnat
Summary: Arterial occlusive disease is the leading cause of death in Western countries. Core contemporary therapies suffer from high failure rates due to re-occlusive vascular wall adaptations and restenosis. Restenosis following vascular surgery is largely due to intimal hyperplasia.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qinxue Li, Yayun Liu, Xin Xia, Haichen Sun, Jinhuan Gao, Quanxin Ren, Tian Zhou, Chang Ma, Jinggang Xia, Chunlin Yin
Summary: The study suggests that hyperglycemia may exacerbate the complexity of coronary atherosclerosis through activation of TBK1-HIF-1 alpha-mediated IL-17/IL-10 signaling. Therefore, TBK1 could be a novel drug therapy target for coronary heart disease complicated with diabetes mellitus.
Article
Medicine, Research & Experimental
Shangfu Xu, Anling Hu, Jiameng Chen, Zhiqin Shuai, Taotao Liu, Jiang Deng, Lisheng Li, Qihai Gong, Zhixu He, Limei Yu
Summary: The calcium-sensing receptor (CaSR) is a G protein-coupled receptor that is widely distributed in various tissues and plays a crucial role in the migration and proliferation of stem/progenitor cells. Our study found that ginsenoside Rg1 (GS-Rg1) can inhibit restenosis after balloon injury and promote endothelial progenitor cell (EPC) mobilization, thus reducing intimal hyperplasia. These effects were significantly reduced after administration of the CaSR antagonist NPS 2143, indicating that CaSR plays a key role in the beneficial effects of GS-Rg1 on reendothelialization and intimal hyperplasia after balloon injury.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Microbiology
Yuxuan Fu, Sidong Xiong
Summary: This study found that exosomes can serve as vehicles for CVB3 virus, delivering the virus into cells and infecting receptor-negative cells. Exosomes carrying CVB3 virus have higher infection efficiency compared to free virus, and can overcome restrictions to viral tropism by accessing different routes.
Article
Cardiac & Cardiovascular Systems
Martino Pepe, Gianluigi Napoli, Eugenio Carulli, Marco Moscarelli, Cinzia Forleo, Palma Luisa Nestola, Giuseppe Biondi-Zoccai, Arturo Giordano, Stefano Favale
Summary: There is a link between autoimmune diseases and in-stent restenosis (ISR) after percutaneous coronary intervention (PCI). Patients with insulin-dependent diabetes mellitus, rheumatoid arthritis, systemic lupus erythematosus, and other autoimmune diseases face higher rates of ISR. Endothelial dysfunction appears to be the principal common pathogenic pathway for ISR, influenced by immune system disorders and systemic inflammation.
Article
Pharmacology & Pharmacy
Jiqiang Guo, Ying Gao, Mohammad Ahmed, Pengfei Dong, Yuping Gao, Zhihua Gong, Jinwen Liu, Yajie Mao, Zhijie Yue, Qingli Zheng, Jiansheng Li, Jianrong Rong, Yongnian Zhou, Meiwen An, Linxia Gu, Jin Zhang
Summary: This study found a positive correlation between serum homocysteine levels and the severity of restenosis after stent implantation. Compared to coronary angiography, homocysteine levels were shown to provide a more accurate detection of ISR severity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biophysics
Andrea Corti, Annalisa De Paolis, John Tarbell, Luis Cardoso
Summary: This study evaluates the impact of stent overexpansion on Vasa Vasorum compression, particularly in the Intima and Media layers, which may result in a significant reduction in blood flow and oxygen delivery. The observed increase in flow resistance suggests a potential risk of intimal hyperplasia and restenosis as a consequence of stent-induced VV compression.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2021)