The amyotrophic lateral sclerosis 8 protein, VAP, is required for ER protein quality control

The ALS8 protein VAPB interacts with the ER–Golgi recycling protein YIF1A and regulates membrane delivery into dendrites

(2013) Marijn Kuijpers et al.   EMBO JOURNAL

Increased levels of phosphoinositides cause neurodegeneration in a Drosophila model of amyotrophic lateral sclerosis

(2013) Stuart Forrest et al.   HUMAN MOLECULAR GENETICS

Investigating the contribution of VAPB/ALS8 loss of function in amyotrophic lateral sclerosis

(2013) Edor Kabashi et al.   HUMAN MOLECULAR GENETICS

Amyotrophic lateral sclerosis-related VAPB P56S mutation differentially affects the function and survival of corticospinal and spinal motor neurons

(2013) Leonardo Aliaga et al.   HUMAN MOLECULAR GENETICS

The genetics and neuropathology of amyotrophic lateral sclerosis

(2012) Ammar Al-Chalabi et al.   ACTA NEUROPATHOLOGICA

Secreted VAPB/ALS8 Major Sperm Protein Domains Modulate Mitochondrial Localization and Morphology via Growth Cone Guidance Receptors

(2012) Sung Min Han et al.   DEVELOPMENTAL CELL

Reduced Calreticulin Levels Link Endoplasmic Reticulum Stress and Fas-Triggered Cell Death in Motoneurons Vulnerable to ALS

(2012) N. Bernard-Marissal et al.   JOURNAL OF NEUROSCIENCE

Multisite phosphorylation of oxysterol-binding protein regulates sterol binding and activation of sphingomyelin synthesis

(2012) Asako Goto et al.   MOLECULAR BIOLOGY OF THE CELL

Analysis of the Key Elements of FFAT-Like Motifs Identifies New Proteins That Potentially Bind VAP on the ER, Including Two AKAPs and FAPP2

(2012) Veronika Mikitova et al.   PLoS One

Protein Folding and Modification in the Mammalian Endoplasmic Reticulum

(2011) Ineke Braakman et al.   Annual Review of Biochemistry

The ER stress factor XBP1s prevents amyloid-β neurotoxicity

(2011) Sergio Casas-Tinto et al.   HUMAN MOLECULAR GENETICS

Amyotrophic lateral sclerosis

(2011) Matthew C Kiernan et al.   LANCET

Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation

(2011) Fumiko Matsuzaki et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

(2011) Laura Ferraiuolo et al.   Nature Reviews Neurology

Genetic Manipulation of Genes and Cells in the Nervous System of the Fruit Fly

(2011) Koen J.T. Venken et al.   NEURON

Protein Folding and Quality Control in the ER

(2011) K. Araki et al.   Cold Spring Harbor Perspectives in Biology

The Diverse Functions of Oxysterol-Binding Proteins

(2010) Sumana Raychaudhuri et al.   Annual Review of Cell and Developmental Biology

OSBP- and FAN-mediated sterol requirement for spermatogenesis in Drosophila

(2010) Z. Ma et al.   DEVELOPMENT

Oxysterol Binding Protein-dependent Activation of Sphingomyelin Synthesis in the Golgi Apparatus Requires Phosphatidylinositol 4-Kinase IIα

(2010) Sangeeta Banerji et al.   MOLECULAR BIOLOGY OF THE CELL

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

(2010) Janel O. Johnson et al.   NEURON

Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response

(2009) Sebastian Schuck et al.   JOURNAL OF CELL BIOLOGY

Oxysterol Binding Protein–related Protein 9 (ORP9) Is a Cholesterol Transfer Protein That Regulates Golgi Structure and Function

(2009) Mike Ngo et al.   MOLECULAR BIOLOGY OF THE CELL

A role for motoneuron subtype–selective ER stress in disease manifestations of FALS mice

(2009) Smita Saxena et al.   NATURE NEUROSCIENCE

Suppression of retinal degeneration in Drosophila by stimulation of ER-associated degradation

(2009) M.-J. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Amyotrophic Lateral Sclerosis 8 Protein VAPB Is Cleaved, Secreted, and Acts as a Ligand for Eph Receptors

(2008) Hiroshi Tsuda et al.   CELL

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1

(2008) H. Nishitoh et al.   GENES & DEVELOPMENT

The R-Ras interaction partner ORP3 regulates cell adhesion

(2008) M. Lehto et al.   JOURNAL OF CELL SCIENCE

Coordinated Lipid Transfer between the Endoplasmic Reticulum and the Golgi Complex Requires the VAP Proteins and Is Essential for Golgi-mediated Transport

(2008) Diego Peretti et al.   MOLECULAR BIOLOGY OF THE CELL

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Vesicle associated membrane protein B (VAPB) is decreased in ALS spinal cord

(2008) Georgia Anagnostou et al.   NEUROBIOLOGY OF AGING

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

(2008) Julie D. Atkin et al.   NEUROBIOLOGY OF DISEASE

A Drosophila Model of ALS: Human ALS-Associated Mutation in VAP33A Suggests a Dominant Negative Mechanism

(2008) Anuradha Ratnaparkhi et al.   PLoS One

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

The VAP protein family: from cellular functions to motor neuron disease

(2008) Sima Lev et al.   TRENDS IN CELL BIOLOGY