Hexokinase activity is required for recruitment of parkin to depolarized mitochondria

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

Loss of PINK1 Increases the Heart's Vulnerability to Ischemia-Reperfusion Injury

(2013) Hilary K. Siddall et al.   PLoS One

Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation

(2013) J.-F. Trempe et al.   SCIENCE

Mitochondrial hexokinase HKI is a novel substrate of the Parkin ubiquitin ligase

(2012) Kei Okatsu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Spatial Parkin Translocation and Degradation of Damaged Mitochondria via Mitophagy in Live Cortical Neurons

(2012) Qian Cai et al.   CURRENT BIOLOGY

ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons

(2012) Alvin P. Joselin et al.   HUMAN MOLECULAR GENETICS

Cell metabolism affects selective vulnerability in PINK1-associated Parkinson's disease

(2012) Zhi Yao et al.   JOURNAL OF CELL SCIENCE

Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

(2012) E. C. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease

(2012) O. Cooper et al.   Science Translational Medicine

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PINK1 enhances insulin-like growth factor-1-dependent Akt signaling and protection against apoptosis

(2011) Ravi S. Akundi et al.   NEUROBIOLOGY OF DISEASE

Autosomal recessive parkinsonism

(2011) Vincenzo Bonifati   PARKINSONISM & RELATED DISORDERS

The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations

(2010) Sven Geisler et al.   Autophagy

Post-translational modifications of mitochondrial outer membrane proteins

(2010) Janos Kerner et al.   FREE RADICAL RESEARCH

Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization

(2010) Victor S. Van Laar et al.   HUMAN MOLECULAR GENETICS

Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

(2010) Matthew E. Gegg et al.   HUMAN MOLECULAR GENETICS

PINK1 cleavage at position A103 by the mitochondrial protease PARL

(2010) Emma Deas et al.   HUMAN MOLECULAR GENETICS

Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL

(2010) Seok Min Jin et al.   JOURNAL OF CELL BIOLOGY

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

(2010) Noriyuki Matsuda et al.   JOURNAL OF CELL BIOLOGY

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation

(2010) Cory M. Johannessen et al.   NATURE

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

The Parkinson's Disease Associated LRRK2 Exhibits Weaker In Vitro Phosphorylation of 4E-BP Compared to Autophosphorylation

(2010) Azad Kumar et al.   PLoS One

Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

(2010) E. Ziviani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

(2010) Derek P. Narendra et al.   PLOS BIOLOGY

Mitochondrial matters of the heart: a plethora of regulatory modes to maintain function for a long lifetime

(2009) Peter L. Pedersen   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation

(2009) C. Malagelada et al.   JOURNAL OF NEUROSCIENCE

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

(2009) Luke S Tain et al.   NATURE NEUROSCIENCE

Akt signal transduction dysfunction in Parkinson's disease

(2009) Suzanne Timmons et al.   NEUROSCIENCE LETTERS

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Hexokinase II Promotes Neuronal Survival and Acts Downstream of Glycogen Synthase Kinase-3

(2008) Alfredo Gimenez-Cassina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Characterization of PINK1 processing, stability, and subcellular localization

(2008) William Lin et al.   JOURNAL OF NEUROCHEMISTRY

Cytoplasmic localization and proteasomal degradation of N-terminally cleaved form of PINK1

(2007) Sho Takatori et al.   NEUROSCIENCE LETTERS