Article
Chemistry, Multidisciplinary
Razie Amraei, Wenqing Yin, Marc A. Napoleon, Ellen L. Suder, Jacob Berrigan, Qing Zhao, Judith Olejnik, Kevin Brown Chandler, Chaoshuang Xia, Jared Feldman, Blake M. Hauser, Timothy M. Caradonna, Aaron G. Schmidt, Suryaram Gummuluru, Elke Muehlberger, Vipul Chitalia, Catherine E. Costello, Nader Rahimi
Summary: The study identified CD209L and CD209 as receptors for SARS-CoV-2 entry into human cells. CD209L is prominently expressed in lung and kidney tissues and interacts with ACE2, potentially playing a role in SARS-CoV-2 infection. This finding may have implications for antiviral drug development in tissues where ACE2 expression is low or absent.
ACS CENTRAL SCIENCE
(2021)
Article
Immunology
Ying Xue, Qiao Li, Chae Gyu Park, John D. Klena, Andrey P. Anisimov, Ziyong Sun, Xiang Wei, Tie Chen
Summary: The study found that Proteus mirabilis interacts with atherosclerotic plaques via CD209s/CD207, potentially slowing down atherosclerosis progression by blocking the interaction between CD209s/CD207 and certain bacteria related to atherosclerosis with ligand-mimic oligosaccharides. This interaction was demonstrated to mediate adherence and phagocytosis by macrophages in the plaques, highlighting a potential target for therapeutic intervention in atherosclerosis. Furthermore, the presence of P. mirabilis was observed to be higher in atherosclerotic mouse hearts compared to control mice during infection challenges, underscoring the relevance of these findings in understanding the pathogenesis of atherosclerosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biology
Nader Rahimi
Summary: The interaction between the S protein of SARS-CoV-2 and CD209 family proteins plays a crucial role in the virus's transmission and infection process, potentially leading to dysregulation of the host immune response and affecting various organs, including the cardiovascular system. Understanding the mechanisms behind this interaction could provide insights for therapies and vaccine development.
Article
Cell Biology
Xiukun Hou, Xianle Shi, Wei Zhang, Dapeng Li, Linfei Hu, Jihong Yang, Jingzhu Zhao, Songfeng Wei, Xi Wei, Xianhui Ruan, Xiangqian Zheng, Ming Gao
Summary: High expression levels of LDHA in papillary thyroid carcinoma are associated with aggressive clinicopathological features and poor prognosis. LDHA promotes cancer cell migration, invasion, and proliferation, making it a potential therapeutic target.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Manyun Mao, Yating Dian, Yuming Sun, Wangqing Chen, Wu Zhu, Guangtong Deng
Summary: This study analyzed the data of 351 hospitalized COVID-19 patients treated with Azvudine and found that high levels of LDH were associated with disease progression.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Cell Biology
Changhao Wu, Chenglong Zheng, Shiyu Chen, Zhiwei He, Hao Hua, Chengyi Sun, Chao Yu
Summary: Pancreatic cancer (PC) is a gastrointestinal tract malignant tumor with a poor prognosis. FOXQ1 has been found to be overexpressed in PC tissues and associated with poor prognosis. FOXQ1 overexpression promotes PC cell proliferation, tumor stemness, invasion, and metastasis, while FOXQ1 silencing shows the reverse effect. Mechanistic studies reveal that FOXQ1 promotes LDHA transcription to enhance aerobic glycolysis, contributing to the progression of PC.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Gerine Nijman, Maike Wientjes, Jordache Ramjith, Nico Janssen, Jacobien Hoogerwerf, Evertine Abbink, Marc Blaauw, Ton Dofferhoff, Marjan van Apeldoorn, Karin Veerman, Quirijn de Mast, Jaap ten Oever, Wouter Hoefsloot, Monique H. Reijers, Reinout van Crevel, Josephine S. van de Maat
Summary: This observational multicenter cohort study conducted in the Netherlands identified specific risk factors for COVID-19 mortality, including age, immunocompromised state, use of anticoagulants or antiplatelet medication, modified early warning score (MEWS), and blood LDH levels. These findings can be used for prediction research, more intense in-hospital monitoring, or prioritizing patients for new treatments or vaccination.
Article
Biochemistry & Molecular Biology
Anastasya Boyarski, Noam Shlush, Shiraz Paz, Jerry Eichler, Lital Alfonta
Summary: In this study, four different enzymatic constructs of L-lactate dehydrogenase were compared and the fusion enzyme containing two cytochromes showed superior catalytic and electrochemical properties. This fusion enzyme exhibited higher activity, lower redox potential, wider dynamic range, and higher product inhibition concentration than the native enzyme. Additionally, it displayed measurable lactate-dependent oxygen reduction.
BIOELECTROCHEMISTRY
(2023)
Article
Medicine, General & Internal
Hala Shokr, Mandeep Kaur Marwah, Hisam Siddiqi, Farooq Wandroo, Lissette Sanchez-Aranguren, Shakil Ahmad, Keqing Wang, Sukhjinder Marwah
Summary: Investigated lactate dehydrogenase/Albumin to-urea (LAU) ratio as a potential predictor for COVID-19-induced fatal clinical complications in hospitalized patients. The results showed that LAU ratio was positively correlated with infection prognostic parameters and patients with a high LAU ratio are at increased risk of mortality due to COVID-19 infection. Early assessment of this parameter, intensive intervention and close monitoring could improve the prognosis of patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Maitham A. Khajah, Sarah Khushaish, Yunus A. Luqmani
Summary: This study revealed that the expression, activity, and lactate production of LDH-A and B were significantly enhanced in endocrine-resistant breast cancer cells. Targeting LDH might be an effective strategy to inhibit cancer cell motility.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Jun Li, Qian Zhang, Yupeng Guan, Dingzhun Liao, Donggen Jiang, Haiyun Xiong, Hengji Zhan, Jun Pang
Summary: The study reveals a novel molecular mechanism by which circVAMP3 promotes glycolysis and proliferation in RCC by regulating the enzymatic activity of LDHA, suggesting circVAMP3 as a biomarker and treatment target for RCC.
CELL DEATH & DISEASE
(2022)
Review
Medicine, Research & Experimental
John M. Macharia, Zsolt Kaposztas, Timea Varjas, Ferenc Budan, Afshin Zand, Imre Bodnar, Raposa L. Bence
Summary: Although the pathophysiology of colorectal cancer (CRC) is complex and not well understood, interactions between risk factors play a crucial role in the development and progression of the disease. The use of lactic acid bacteria (LAB) prebiotics and probiotics to modulate the tumor microenvironment (TME) has become increasingly popular in CRC management. This study aims to investigate the negative effects of LAB-derived lactic acid in the colonic mucosa in colorectal cancer management. More research is needed to ensure that LAB and their lactic acid by-products do not have unintended adverse effects in CRC management.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Panasa Mahesh, Parameswari Akshinthala, Naresh Kumar Katari, Lavleen Kumar Gupta, Dikshita Panwar, Manoj Kumar Sharma, Sreekantha Babu Jonnalagadda, Rambabu Gundla
Summary: In this study, two new series of 3,5-dimethyl-1H-pyrazole-4-sulfonamide and 1,3,5-trimethyl-1H-pyrazole-4-sulfonamide derivatives were designed and synthesized. These derivatives were characterized by various analytical techniques and their biological evaluation data were presented, paving the way for the development of new pyrazole-4-sulfonamide derivatives.
Article
Biochemistry & Molecular Biology
Michele Mannelli, Tania Gamberi, Francesca Magherini, Tania Fiaschi
Summary: This study demonstrates that cachexia induction in myotubes is associated with a metabolic shift towards fermentation, and inhibiting lactate formation can prevent cachexia. The findings suggest lactate dehydrogenase as a possible new tool for counteracting the onset of this pathology.
Article
Medicine, General & Internal
Murat Yilmaz, Beliz Oztok Tekten
Summary: This study aimed to determine the potential role of postictal serum LDH activities in differentiating epileptic seizures from non-epileptic seizures. The results showed significantly higher LDH activities in patients with epileptic seizures compared to those with non-epileptic seizures, suggesting the potential use of LDH activities as a diagnostic tool in distinguishing between seizure types.
Review
Virology
Malik Peiris, Stanley Perlman
Summary: The Middle East Respiratory Syndrome-coronavirus (MERS-CoV) primarily spreads to humans through dromedary camels in Africa, the Middle East, and Central or South Asia, with limited human-to-human transmission. Only cases in humans from the Arabian Peninsula have been reported so far, and no zoonotic MERS cases have been found in Africa or Asia, despite the high density of infected camels. Further investigation into this disparity is crucial due to the pandemic potential of MERS-CoV.
CURRENT OPINION IN VIROLOGY
(2022)
Review
Respiratory System
Nicole Ngai Yung Tsang, Hau Chi So, Benjamin J. Cowling, Gabriel M. Leung, Dennis Kai Ming Ip
Summary: This study systematically assessed the performance of saline and water gargling for SARS-CoV-2 RT-PCR testing and found that it has a high sensitivity and specificity, making it suitable for diagnosis and monitoring viral shedding.
EUROPEAN RESPIRATORY REVIEW
(2022)
Article
Biochemistry & Molecular Biology
Kathy Leung, Eric H. Y. Lau, Carlos K. H. Wong, Gabriel M. Leung, Joseph T. Wu
Summary: We tracked the effective reproduction number (R-t) of the Omicron BF.7 variant of SARS-CoV-2 in Beijing from November to December 2022. After China's shift from the zero-COVID policy, R-t increased to 3.44, and the infection incidence peaked on December 11. The cumulative infection attack rate in Beijing was estimated to be 75.7% on December 22, 2022, and 92.3% on January 31, 2023.
Editorial Material
Microbiology
Stanley Perlman, Malik Peiris
Summary: Decades of research on coronaviruses and studying SARS-CoV-2 during the COVID-19 pandemic have provided a great deal of knowledge, but there are still many unanswered questions and areas that need further research.
NATURE REVIEWS MICROBIOLOGY
(2023)
Correction
Multidisciplinary Sciences
Tim K. Tsang, Ranawaka A. P. M. Perera, Vicky J. Fang, Jessica Y. Wong, Eunice Y. Shiu, Hau Chi So, Dennis K. M. Ip, J. S. Malik Peiris, Gabriel M. Leung, Benjamin J. Cowling, Simon Cauchemez
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Haogao Gu, Ahmed Abdul Quadeer, Pavithra Krishnan, Daisy Y. M. Ng, Lydia D. J. Chang, Gigi Y. Z. Liu, Samuel M. S. Cheng, Tommy T. Y. Lam, Malik Peiris, Matthew R. McKay, Leo L. M. Poon
Summary: Limited data is available on the genetic diversity of SARS-CoV-2 within hosts and its relationship with vaccination. The authors found that variant of Concern (VOC) samples have more sequence variations than non-VOC samples, and breakthrough infections in vaccinated individuals do not increase non-silent mutations. The study highlights the importance of understanding within-host diversity and the impact of vaccination on viral evolution.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Michael Kwan Leung Yu, Sophelia Hoi Shan Chan, Samuel Cheng, Daniel Leung, Sau Man Chan, Amy Suen Ka Yan, Wilfred Hing Sang Wong, Malik Peiris, Yu Lung Lau, Jaime S. Rosa Duque
Summary: Hesitancy toward COVID-19 vaccination is common for patients with neuromuscular diseases due to the lack of safety and efficacy data in this high-risk population. This study examined the factors associated with vaccine hesitancy and evaluated the reactogenicity and immunogenicity of BNT162b2 and CoronaVac vaccines in patients with neuromuscular diseases. The results showed that both vaccines were safe and effective for these patients.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Letter
Immunology
Ihab El Masry, Salim Al Makhladi, Mohsin Al Abdwany, Afrah Al Subhi, Hatim Eltahir, Samuel Cheng, Malik Peiris, Emma Gardner, Sophie Von Dobschuetz, Baba Soumare, Madhur Dhingra, Keith Sumption, Markos Tibbo
Summary: SARS-CoV-2 infection in livestock species in Oman was investigated, and serological evidence of infection in cattle, sheep, goats, and dromedary camel was provided. Integrated data analysis of epidemiologically linked human and animal cases should be conducted to understand the extent of SARS-CoV-2 infection in animals and associated risks.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Oncology
Ho Tsoi, Nicholas Nok-Ching Fung, Ellen P. S. Man, Man-Hong Leung, Chan-Ping You, Wing-Lok Chan, Sum-Yin Chan, Ui-Soon Khoo
Summary: Overexpressing BQ can confer tamoxifen resistance in ER +ve breast cancer. BQ is an alternative splice variant of NCOR2 generated through the exclusion of exon 11. SRSF5 is involved in the regulation of NCOR2 splicing. Low expression of SRSF5 increases the production of BQ mRNA by excluding exon 11. Thus, targeting the upstream pathway of BQ may reverse tamoxifen resistance.
Article
Oncology
Shakeel Ahmad Khan, Kelvin Yuen Kwong Chan, Terence Kin Wah Lee
Summary: This scientometric study provides a comprehensive overview of the global research landscape of Metronomic Chemotherapy from 2000 to 2022. It identifies key trends, collaborations, and potential opportunities using a data-driven approach. The United States, Italy, and China are the major contributors to MC research, while there is a lack of collaborative efforts between countries and organizations. The study highlights emerging interdisciplinary research areas and influential authors, institutions, and journals.
Article
Oncology
Ho Tsoi, Johann Lok, Ellen P. S. Man, Cheuk-Nam Cheng, Man-Hong Leung, Chan-Ping You, Sum-Yin Chan, Wing-Lok Chan, Ui-Soon Khoo
Summary: This study revealed that overexpression of a novel splice variant BQ323636.1 is associated with resistance to the non-steroidal aromatase inhibitor anastrozole in ER+ post-menopausal breast cancer. Mechanistic studies showed that BQ overexpression enhances androgen receptor (AR) activity, leading to hyper-activation of AR signaling and increased cell proliferation. Targeting AR can overcome anastrozole resistance in breast cancer with BQ overexpression. Clinical study also demonstrated that high nuclear expression of both BQ and AR is significantly associated with poor survival in non-steroidal aromatase inhibitor-treated ER+ breast cancer patients.
JOURNAL OF PATHOLOGY
(2023)
Article
Gastroenterology & Hepatology
Carlos King Ho Wong, Lung Yi Mak, Ivan Chi Ho Au, Wing Yiu Cheng, Ching Hei So, Kristy Tsz Kwan Lau, Eric Ho Yin Lau, Benjamin J. Cowling, Gabriel M. Leung, Man Fung Yuen
Summary: A self-controlled case-series study was conducted to evaluate the risk and severity of acute liver injury (ALI) associated with nirmatrelvir/ritonavir treatment for COVID-19. The study found that the risk of ALI was elevated before treatment initiation but not during the five-day treatment period. ALI cases in nirmatrelvir/ritonavir users were generally less severe than those in non-users and had a lower risk of all-cause death.
LIVER INTERNATIONAL
(2023)
Article
Health Care Sciences & Services
Theodora Hei Tung Lai, Leung Kuen Sandy Au, Yuen Ting Eunice Lau, Hei Man Lo, Kelvin Yuen Kwong Chan, Ka Wang Cheung, Teresa Wei Ling Ma, Wing Cheong Leung, Choi Wah Kong, Wendy Shu, Po Lam So, Anna Ka Yee Kwong, Christopher Chun Yu Mak, Mianne Lee, Martin Man Chun Chui, Brian Hon Yin Chung, Anita Sik Yau Kan
Summary: The study demonstrates the utility of whole-exome sequencing (WES) in prenatal diagnosis of fetal structural congenital abnormalities (SCAs) in Hong Kong. The highest diagnostic rate was found in fetuses with multiple SCAs, particularly involving the cardiac and musculoskeletal systems. The use of WES should be recommended in addition to conventional genetic workup.
Article
Medicine, General & Internal
B. H. Y. Chung, A. S. Y. Kan, K. Y. K. Chan, W. Yang, M. H. Y. Tang, C. C. Y. Mak, G. K. C. Leung
HONG KONG MEDICAL JOURNAL
(2022)
