Article
Biochemistry & Molecular Biology
Anousheh Shasttiri, Misagh Moridi, Abbas Safari, Sayed Haidar Abbas Raza, Mostafa Ghaderi-Zefrehei, Massoud Houshmand, Ahmad Oryan, Mohammad Hossein Sanati, Jacqueline Smith, Motahareh Amjadi
Summary: The Iranian gene pool exhibits high haplogroup diversities and admixture of exotic groups, with the Arab subpopulation being independent from the others. Thalassemia patients showed some significant differences in their HVS2 sequence.
BIOCHEMICAL GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Julia Leme Pablos, Ana Kristina Silva, Noemy Seraphim, Luiza de Moraes Magaldi, Anete Pereira de Souza, Andre Victor Lucci Freitas, Karina Lucas Silva-Brandao
Summary: The study on Atlantic Forest White Morpho butterflies shows that there is no clear species diversification and population structure among the populations, suggesting that the current distinction between the two species is unreasonable. Northern samples exhibit more intragroup structure, and clustering tests indicate the existence of three genetic clusters, with turnover between the states of Paran ' a and Sa similar to o Paulo.
MOLECULAR PHYLOGENETICS AND EVOLUTION
(2021)
Article
Ecology
Russell S. Pfau, Ashley N. Kozora, Ana B. Gatica-Colima, Philip S. Sudman
Summary: This study examined the genetic diversity of the desert pocket gopher, Geomys arenarius, using multilocus nuclear and mitochondrial DNA sequence data. The research found two subspecies of this endemic species, each with distinct genetic differences. Mapping of potentially habitable soils revealed barriers to dispersal. Populations of the southern subspecies had higher genetic diversity, possibly due to greater availability of suitable soils or higher food density.
ECOLOGY AND EVOLUTION
(2023)
Article
Genetics & Heredity
Corey Kirkland, Marta Farre
Summary: Through analyzing mitochondrial genomes, we constructed a phylogenetic tree of Arvicolinae species, revealing significant genetic diversity in captive water voles in Britain and confirming the classification of British water voles into two clades. This study provides valuable insights for future conservation genetics research in this species.
Article
Entomology
Marija Tanaskovic, Pavle Eric, Aleksandra Patenkovic, Katarina Eric, Milica Mihajlovic, Vanja Tanasic, Ljubisa Stanisavljevic, Slobodan Davidovic
Summary: The research found that local honey bee populations in Serbia are rapidly changing due to modern beekeeping practices, such as the introduction of nonnative queens, selection, and migratory beekeeping. Through sequencing the mitochondrial DNA of 241 worker bees, 9 haplotypes were identified, with C2d being the most common. Comparisons with sequences from neighboring countries and the NCBI GenBank revealed that all 32 haplotypes belonged to the Southeast Europe lineage C, with two newly described haplotypes from the sample.
Article
Biochemistry & Molecular Biology
Mingyue Cheng, Xueling Ge, Chaofang Zhong, Ruiqing Fu, Kang Ning, Shuhua Xu
Summary: The study found that differences in gut microbiome were greater between genetically distinct ethnic groups than those genetically closely related ones. There were considerable correlations between host genetic variants and the abundance of a subset of gut microbial species, which might have coordinated effects on specific human phenotypes. Bacteroides ovatus was significantly correlated with a host genetic variant that regulates the expression of a tumor suppressor gene in the colon.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Article
Marine & Freshwater Biology
Iraj Hashemzadeh Segherloo, Fariborz Ghojoghi, Seyedeh Narjes Tabatabaei, Eric Normandeau, Cecilia Hernandez, Eric Hallerman, Brian Boyle, Louis Bernatchez
Summary: Based on genetic analysis of Rutilus populations from the southeast and southwest Caspian Sea and the Aras River, it was found that populations in different areas are closely related but highly differentiated. The Bayes factor delimitation test supported the existence of three populations of Rutilus in the studied area, and three hybrid individuals were detected.
Article
Psychiatry
Carla Burkhard, Saba Cicek, Ran Barzilay, Rajiv Radhakrishnan, Sinan Guloksuz
Summary: This article highlights the lack of diversity in psychosis research, pointing out the Western bias and the failure to recognize differences in ethnic and cultural backgrounds. It calls for increasing diversity in research and emphasizes the uncertainty of environmental factors in influencing psychosis research.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Phillip A. Morin, Brenna R. Forester, Karin A. Forney, Carla A. Crossman, Brittany L. Hancock-Hanser, Kelly M. Robertson, Lance G. Barrett-Lennard, Robin W. Baird, John Calambokidis, Pat Gearin, M. Bradley Hanson, Cassie Schumacher, Timothy Harkins, Michael C. Fontaine, Barbara L. Taylor, Kim M. Parsons
Summary: The study revealed a strong isolation-by-distance genetic structure among harbor porpoise populations in the North Pacific, indicating restricted dispersal among individuals. A unique genetic population was found in southern California, while the Strait of Georgia was identified as a potential biogeographical boundary. The association of microhaplotypes with environmental variables suggests potential local adaptation.
Article
Zoology
Marta Farre, Cameron Johnstone, Jane Hopper, Andrew C. Kitchener, Christian Roos, Tony King
Summary: Assessing genetic diversity of captive populations is crucial for conservation-breeding programs. In this study, we sequenced a portion of the mitochondrial DNA of endangered Francois' langur individuals and found that the European captive population has good genetic diversity, which could contribute to increasing genetic diversity of wild populations. However, the small size of the captive population poses a risk of rapid genetic diversity loss. Further research and conservation efforts are recommended.
INTERNATIONAL JOURNAL OF PRIMATOLOGY
(2022)
Article
Evolutionary Biology
Andrew J. Maynard, Luke Ambrose, Michael J. Bangs, Rohani Ahmad, Charles Butafa, Nigel W. Beebe
Summary: This study analyzes the population genetics of the dengue mosquito species Ae. aegypti in Southeast Asia, the Indo-Pacific, and Australasia. The results reveal additional spatial genetic structure and differentiation in these regions compared to previous studies. It also identifies genetic breaks within Australia, Indonesia, and Malaysia. This characterization of previously unexplored populations enhances understanding of Ae. aegypti population structure and can inform control strategies and risk assessments for new invasion pathways.
EVOLUTIONARY APPLICATIONS
(2023)
Article
Evolutionary Biology
William R. Shoemaker, Daisy Chen, Nandita R. Garud
Summary: Genetic variation in the human gut microbiome plays a crucial role in various phenotypes. However, our understanding of its origins and maintenance is limited. By comparing evolutionary processes across different species, we can identify universal trends and deviations. The human gut microbiome offers unparalleled potential for comparative population genomics studies.
GENOME BIOLOGY AND EVOLUTION
(2022)
Article
Multidisciplinary Sciences
Ming Zhao, Wei Cui, Hui Xu, Yunying Zhang, Bofeng Zhu
Summary: This study evaluated the forensic efficiency of a self-developed multiplex amplification system in high-altitude adaptive ethnic groups in China. The results showed that the set of 43 deletion/insertion polymorphism loci exhibited remarkable forensic efficacy and the two Tibetan groups had closer genetic affinities to East Asian populations.
Article
Multidisciplinary Sciences
Kirsten N. Morehouse, Keith Maddox, Mahzarin R. Banaji
Summary: Although all human groups are considered equal, there is a dissociation between implicit and explicit measures regarding racial/ethnic bias. White participants, despite affirming the equality of all racial/ethnic groups, consistently associated "Human" more with White than other groups. On the other hand, non-White participants showed no bias in associating "Human" with their own group. However, when faced with multiple outgroups, non-White participants displayed biases towards associating "Human" with White. This implicit bias was largely invariant across demographic variations but varied by political ideology and gender, with conservatives and men exhibiting stronger associations between "Human" and White.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Genetics & Heredity
Maria-Anna Kyrgiafini, Themistoklis Giannoulis, Katerina A. Moutou, Zissis Mamuris
Summary: Mitochondria play important roles in cellular processes beyond energy production, and maternal inheritance of mtDNA leads to the Mother's Curse phenomenon, causing harmful mutations to accumulate more easily in males and resulting in various diseases and reproductive effects. Mito-nuclear incompatibility may impact evolution and speciation.
Review
Immunology
Mohammad Reza Haghshenas, Hamid Ghaderi, Hossein Daneste, Abbas Ghaderi
Summary: Salivary glands play a crucial role in oral immunity. Immune components and responses in the tumor microenvironment of salivary gland tumors are being investigated. Immune checkpoint molecules and chemokines are potential targets for cancer immunotherapy.
INTERNATIONAL REVIEWS OF IMMUNOLOGY
(2023)
Article
Allergy
Najmeh Sepahi, Soheila Alyasin, Zahra Kanannejad, Hossein Esmaeilzadeh, Farzaneh Mohammadalizadeh Shirazi, Maryam Babaei, Shirin Farjadian
Summary: This study aimed to identify the IgE-reactive components of A. velutinum pollen extract in patients with maple allergy. A protein band with a molecular weight of around 70 kDa was identified as the most IgE-reactive allergen, which could be considered as a potential target for diagnostic kits or immunotherapy.
IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Claudia Ojeda-Granados, Paolo Abondio, Alice Setti, Stefania Sarno, Guido Alberto Gnecchi-Ruscone, Eduardo Gonzalez-Orozco, Sara De Fanti, Andres Jimenez-Kaufmann, Hector Rangel-Villalobos, Andres Moreno-Estrada, Marco Sazzini
Summary: The genetic ancestry of Native Americans is linked to increased risk of health issues in Mexican populations due to recent environmental, dietary, and cultural changes. Indigenous Mexican groups may have retained the highest proportions of genetic components shaped by ancient environments, impacting biological traits and disease risk patterns. Adaptive variants evolved in response to local conditions may play a role in modulating susceptibility to certain diseases in present-day Native and Mestizo Mexican populations.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Immunology
Faezeh Maghsood, Mohammad-Reza Shokri, Mahmood Jeddi-Tehrani, Monireh Torabi Rahvar, Abbas Ghaderi, Vahid Salimi, Gholam Ali Kardar, Amir-Hassan Zarnani, Mohammad Mehdi Amiri, Fazel Shokri
Summary: IgG responses to RBD and NP in COVID-19 patients were found to be dominated by conformational and linear epitopes, respectively. The reactivity of patients' sera with reduced recombinant RBD protein was significantly lower than the native form, while no significant differences were observed for NP protein. The identification of immunodominant epitopes in NP and RBD could be valuable for the development of immunotherapy and diagnostic tools for COVID-19.
PATHOGENS AND DISEASE
(2022)
Review
Endocrinology & Metabolism
Mohammad Javad Fattahi, Mohammad Reza Haghshenas, Abbas Ghaderi
Summary: The initiation and progression of bladder cancer rely on its tumor microenvironment, which is influenced by immune cells. Immunometabolism plays a crucial role in immune cell function and immune response in bladder cancer. Understanding the metabolic reprogramming of bladder cancer cells and immune cells in the tumor microenvironment can provide new opportunities for targeted therapies.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2022)
Article
Immunology
Atri Ghods, Fereshteh Mehdipour, Reza Rasolmali, Abdol-Rasoul Talei, Abbas Ghaderi
Summary: This study focused on the expression of membranous and intracellular forms of TNF-alpha in lymphocytes derived from breast cancer-draining lymph nodes. The results showed that CD4+T cells primarily express the membranous form, while CD8+T cells primarily express the intracellular form. The intensity of membranous TNF-alpha expression in CD19+ cells was correlated with poor prognosticators, and the frequency of membranous TNF-alpha+CD19+ cells showed an inverse correlation with the number of involved lymph nodes.
CLINICAL IMMUNOLOGY
(2022)
Editorial Material
Environmental Sciences
Zahra Mojtahedi, Shirin Farjadian
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Marjan Hematian Larki, Elham Ashouri, Shaghik Barani, Seiyed Mohammad Ali Ghayumi, Abbas Ghaderi, Raja Rajalingam
Summary: The study reveals the association between KIR and HLA class I ligands with genetic predisposition to lung cancer in the native population of southern Iran. Specific KIR genes and HLA-C1 ligands show significant increase in patients with lung cancer, certain genotypes are positively correlated with disease risk, and iKIRs > aKIRs genotypes are more frequently presented in lung cancer patients.
SCIENTIFIC REPORTS
(2022)
Article
Otorhinolaryngology
Yousef Mohammadi, Simin Ahmadvand, Maryam Mirtalebi, Mohammad Javad Ashraf, Bijan Khademi, Abbas Ghaderi
Summary: The expression of TILs in larynx squamous cell carcinoma is associated with clinicopathological features and patient outcomes. CD45RO+ TILs, in particular, serve as independent prognostic markers and can predict risk and outcomes in patients with larynx SCC.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2022)
Article
Biochemical Research Methods
Samira Tabaei, Mohammad Reza Haghshenas, Thomas J. Webster, Abbas Ghaderi
Summary: Urothelial bladder cancer (UBC) is a complex malignancy with a high recurrence rate. Current diagnostic procedures lack sensitivity and specificity, thus biomarkers have potential value for early diagnosis, prognosis, and immunotherapy. Proteomics methods have rapidly advanced in identifying UBC biomarkers, and a panel of biomarkers may achieve higher diagnostic accuracy. This review evaluates recent literature on UBC proteomics, classifies tumor biomarkers based on their sources, and discusses the limitations and advantages of each source.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Cell Biology
Amin Ramezani, Mohammadrasul Zareinejad, Elham Mahmoudi Maymand, Elina Kaviani, Abbas Ghaderi
Summary: This study aimed to produce a biosimilar version of aflibercept (AFL) and evaluate its effect when used in combination with other vascular endothelial growth factor (VEGF) blocker drugs. The biosimilar-AFL showed significant inhibition potential on HUVEC cells in a dose-dependent manner. Furthermore, co-treatment with Everolimus (EVR), Lenvatinib (LEN), and Sorafenib (SOR) enhanced the cytotoxicity of biosimilar-AFL on HUVEC cells, with LEN and SOR showing a 10-fold increase in cytotoxicity. The combination of biosimilar-AFL with LEN showed the most efficient result, while the combination with EVR showed the least efficient result. Overall, biosimilar-AFL may improve the efficacy of LEN, EVR, and SOR in reducing the VEGF effect on endothelial cells.
Article
Biochemical Research Methods
Samira Tabaei, Mohammad Reza Haghshenas, Ali Ariafar, Kambiz Gilany, Allan Stensballe, Shirin Farjadian, Abbas Ghaderi
Summary: The aim of this study is to recognize tumor-associated proteins, which are differentially expressed in different stages of UBC patients compared to non-cancerous tissues. The study found significant changes in protein expression related to oxidative stress and antioxidant activity in UBC patients. These findings may contribute to the development of promising biomarkers for early detection, monitoring, and prognosis of UBC.
CLINICAL PROTEOMICS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Mohammad Amin Amiri, Delara Amiri, Mohammad Javad Mokhtari, Fatemeh Lavaee, Mohammad Javad Fattahi, Abbas Ghaderi, Bijan Khademi
Summary: This study found that there is no direct correlation between the SNP of lncRNA ANRIL rs4977574 and the presence of oral squamous cell carcinoma (OSCC). However, it was observed that the SNP is associated with smaller tumor size and higher level of cancer cell differentiation.
INTERNATIONAL JOURNAL OF DENTISTRY
(2023)
Article
Oncology
Hamid Ghaderi, Estie Kruger, Simin Ahmadvand, Yousef Mohammadi, Bijan Khademi, Abbas Ghaderi
Summary: This study conducted a comprehensive epidemiological analysis of salivary gland tumors in the south of Iran and found that benign tumors were the most prevalent type, with the parotid gland being the most common site. It also revealed that malignant tumors were more common among older patients.
JOURNAL OF CANCER EPIDEMIOLOGY
(2023)
Article
Immunology
Zeinab Amirkhani, Mehrosadat Alavi, Mehdi Kalani, Ali Alavianmehr, Shirin Farjadian
Summary: In patients with DTC, levels of IL-4, IL-6, IL-21, and IL-22 were higher than in healthy controls. Although IL-6 showed an increasing trend after RAI ablation, IL-4, IL-22, and IL-17A remained at considerably higher levels than in healthy controls. The study concluded that omega-3 had better anti-inflammatory effects when used therapeutically after RAI ablation in patients with DTC.
IRANIAN JOURNAL OF IMMUNOLOGY
(2022)
