Using drug response data to identify molecular effectors, and molecular “omic” data to identify candidate drugs in cancer

The mutational spectrum of squamous-cell carcinoma of the head and neck: targetable genetic events and clinical impact

(2014) G. Mountzios et al.   ANNALS OF ONCOLOGY

Prediction of individualized therapeutic vulnerabilities in cancer from genomic profiles

(2014) Bülent Arman Aksoy et al.   BIOINFORMATICS

NCI-60 Whole Exome Sequencing and Pharmacological CellMiner Analyses

(2014) William C. Reinhold et al.   PLoS One

Temozolomide resistance in glioblastoma cells occurs partly through epidermal growth factor receptor-mediated induction of connexin 43

(2014) J L Munoz et al.   Cell Death & Disease

Collections of Simultaneously Altered Genes as Biomarkers of Cancer Cell Drug Response

(2013) D. L. Masica et al.   CANCER RESEARCH

The Exomes of the NCI-60 Panel: A Genomic Resource for Cancer Biology and Systems Pharmacology

(2013) O. D. Abaan et al.   CANCER RESEARCH

Clinical Implementation of Germ Line Cancer Pharmacogenetic Variants During the Next-Generation Sequencing Era

(2013) N K Gillis et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Comparison and validation of genomic predictors for anticancer drug sensitivity

(2013) Simon Papillon-Cavanagh et al.   JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION

Discrepancies in drug sensitivity

(2013) John N. Weinstein et al.   NATURE

Inconsistency in large pharmacogenomic studies

(2013) Benjamin Haibe-Kains et al.   NATURE

Germline pharmacogenetics of paclitaxel for cancer treatment

(2013) Daniel L Hertz   PHARMACOGENOMICS

Global Proteome Analysis of the NCI-60 Cell Line Panel

(2013) Amin Moghaddas Gholami et al.   Cell Reports

Secondary Variants in Individuals Undergoing Exome Sequencing: Screening of 572 Individuals Identifies High-Penetrance Mutations in Cancer-Susceptibility Genes

(2012) Jennifer J. Johnston et al.   AMERICAN JOURNAL OF HUMAN GENETICS

CellMiner: A Web-Based Suite of Genomic and Pharmacologic Tools to Explore Transcript and Drug Patterns in the NCI-60 Cell Line Set

(2012) W. C. Reinhold et al.   CANCER RESEARCH

Exome sequencing is an efficient tool for genetic screening of Charcot-Marie-Tooth Disease

(2012) Byung-Ok Choi et al.   HUMAN MUTATION

Identification of Somatic Mutations in Parathyroid Tumors Using Whole-Exome Sequencing

(2012) M. Kyle Cromer et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Systematic identification of genomic markers of drug sensitivity in cancer cells

(2012) Mathew J. Garnett et al.   NATURE

Sequence analysis of mutations and translocations across breast cancer subtypes

(2012) Shantanu Banerji et al.   NATURE

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

Cell lines battle cancer

(2012) John N. Weinstein   NATURE

Exome sequencing to find rare variants causing neurologic diseases

(2012) D. Doherty et al.   NEUROLOGY

Mass Homozygotes Accumulation in the NCI-60 Cancer Cell Lines As Compared to HapMap Trios, and Relation to Fragile Site Location

(2012) Xiaoyang Ruan et al.   PLoS One

Modulators of Sensitivity and Resistance to Inhibition of PI3K Identified in a Pharmacogenomic Screen of the NCI-60 Human Tumor Cell Line Collection

(2012) Kevin A. Kwei et al.   PLoS One

Integrating Constitutive Gene Expression and Chemoactivity: Mining the NCI60 Anticancer Screen

(2012) David G. Covell   PLoS One

Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents

(2012) G. Zoppoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBF  interaction

(2012) L. Cunningham et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

Comprehensive next-generation cancer genome sequencing in the era of targeted therapy and personalized oncology

(2011) Maureen Cronin et al.   Biomarkers in Medicine

Recombination phenotypes of the NCI-60 collection of human cancer cells

(2011) Dawn M Stults et al.   BMC MOLECULAR BIOLOGY

Predicting selective drug targets in cancer through metabolic networks

(2011) O. Folger et al.   Molecular Systems Biology

Deriving chemosensitivity from cell lines: Forensic bioinformatics and reproducible research in high-throughput biology

(2010) Keith A. Baggerly et al.   Annals of Applied Statistics

Exon Array Analyses across the NCI-60 Reveal Potential Regulation of TOP1 by Transcription Pausing at Guanosine Quartets in the First Intron

(2010) W. C. Reinhold et al.   CANCER RESEARCH

mRNA and microRNA Expression Profiles of the NCI-60 Integrated with Drug Activities

(2010) H. Liu et al.   MOLECULAR CANCER THERAPEUTICS

Genome-Wide mRNA and microRNA Profiling of the NCI 60 Cell-Line Screen and Comparison of FdUMP[10] with Fluorouracil, Floxuridine, and Topoisomerase 1 Poisons

(2010) W. H. Gmeiner et al.   MOLECULAR CANCER THERAPEUTICS

Analysis of Food and Drug Administration-Approved Anticancer Agents in the NCI60 Panel of Human Tumor Cell Lines

(2010) S. L. Holbeck et al.   MOLECULAR CANCER THERAPEUTICS

Expression Profiling of Nuclear Receptors in the NCI60 Cancer Cell Panel Reveals Receptor-Drug and Receptor-Gene Interactions

(2010) Susan Holbeck et al.   MOLECULAR ENDOCRINOLOGY

Point: Hypotheses first

(2010) Robert Weinberg   NATURE

Pathway Commons, a web resource for biological pathway data

(2010) E. G. Cerami et al.   NUCLEIC ACIDS RESEARCH

Reactome: a database of reactions, pathways and biological processes

(2010) D. Croft et al.   NUCLEIC ACIDS RESEARCH

Complex Display of Putative Tumor Stem Cell Markers in the NCI60 Tumor Cell Line Panel

(2010) Christina H. Stuelten et al.   STEM CELLS

CellMiner: a relational database and query tool for the NCI-60 cancer cell lines

(2009) Uma T Shankavaram et al.   BMC GENOMICS

Personalized Cancer Therapy With Selective Kinase Inhibitors: An Emerging Paradigm in Medical Oncology

(2009) Ultan McDermott et al.   JOURNAL OF CLINICAL ONCOLOGY

DNA fingerprinting of the NCI-60 cell line panel

(2009) P. L. Lorenzi et al.   MOLECULAR CANCER THERAPEUTICS

Network-constrained regularization and variable selection for analysis of genomic data

(2008) C. Li et al.   BIOINFORMATICS

Integrating Global Gene Expression and Radiation Survival Parameters across the 60 Cell Lines of the National Cancer Institute Anticancer Drug Screen

(2008) S. A. Amundson et al.   CANCER RESEARCH

Connecting chemosensitivity, gene expression and disease

(2007) David G. Covell   TRENDS IN PHARMACOLOGICAL SCIENCES