Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders

The New Genetics in Child Psychiatry

(2011) James J. Hudziak et al.   JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY

The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc

(2010) Paul L. Greer et al.   CELL

Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice

(2010) Shau-Kwaun Chen et al.   CELL

Neuroligin-1 Deletion Results in Impaired Spatial Memory and Increased Repetitive Behavior

(2010) J. Blundell et al.   JOURNAL OF NEUROSCIENCE

Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive–like behaviors in mice

(2010) Sergey V Shmelkov et al.   NATURE MEDICINE

Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures

(2010) Feng Zhang et al.   Nature Protocols

Directed molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs

(2010) Shuyun Dong et al.   Nature Protocols

Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2

(2010) Jessica A Cardin et al.   Nature Protocols

Forebrain overexpression of CK1  leads to down-regulation of dopamine receptors and altered locomotor activity reminiscent of ADHD

(2010) M. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Promoting social behavior with oxytocin in high-functioning autism spectrum disorders

(2010) E. Andari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optogenetic deconstruction of sleep-wake circuitry in the brain

(2010) Antoine Adamantidis   Frontiers in Molecular Neuroscience

Antidepressants in the treatment of adult attention-deficit hyperactivity disorder: a systematic review

(2009) Wim Verbeeck et al.   ADVANCES IN THERAPY

Lack of Efficacy of Citalopram in Children With Autism Spectrum Disorders and High Levels of Repetitive Behavior

(2009) Bryan H. King et al.   ARCHIVES OF GENERAL PSYCHIATRY

Refining psychiatric genetics: from ‘mouse psychiatry’ to understanding complex human disorders

(2009) Justin L. LaPorte et al.   BEHAVIOURAL PHARMACOLOGY

Genomic and epigenetic evidence for oxytocin receptor deficiency in autism

(2009) Simon G Gregory et al.   BMC Medicine

Anti-depressant and anxiolytic like behaviors in PKCI/HINT1 knockout mice associated with elevated plasma corticosterone level

(2009) Elisabeth Barbier et al.   BMC NEUROSCIENCE

Association study of promoter polymorphisms at the dopamine transporter gene in Attention Deficit Hyperactivity Disorder

(2009) Xiaohui Xu et al.   BMC Psychiatry

Abnormal Behavior in a Chromosome- Engineered Mouse Model for Human 15q11-13 Duplication Seen in Autism

(2009) Jin Nakatani et al.   CELL

Copy number variation and association analysis of SHANK3 as a candidate gene for autism in the IMGSAC collection

(2009) Nuala H Sykes et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Overexpression of 5-HT2Creceptors in forebrain leads to elevated anxiety and hypoactivity

(2009) Atsuko Kimura et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Oxytocin and the oxytocin receptor underlie intrastrain, but not interstrain, social recognition

(2009) A. H. Macbeth et al.   GENES BRAIN AND BEHAVIOR

Neuroligin-3-deficient mice: model of a monogenic heritable form of autism with an olfactory deficit

(2009) K. Radyushkin et al.   GENES BRAIN AND BEHAVIOR

Genetics of psychosis; insights from views across the genome

(2009) Michael C. O’Donovan et al.   HUMAN GENETICS

Observation of fetal brain in a rat valproate-induced autism model: a developmental neurotoxicity study

(2009) Makiko Kuwagata et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Review of the Evidence for Treatment of Children with Autism with Selective Serotonin Reuptake Inhibitors

(2009) Lis West et al.   Journal for Specialists in Pediatric Nursing

Improvement with Duloxetine in an Adult ADHD Patient

(2009) Smadar Valérie Tourjman et al.   Journal of Attention Disorders

Childhood developmental disorders: an academic and clinical convergence point for psychiatry, neurology, psychology and pediatrics

(2009) Allan L. Reiss   JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY

Children with obsessive-compulsive disorder: are they just “little adults”?

(2009) Simran K. Kalra et al.   JOURNAL OF CLINICAL INVESTIGATION

Widespread changes in dendritic and axonal morphology inMecp2-mutant mouse models of rett syndrome: Evidence for disruption of neuronal networks

(2009) Pavel V. Belichenko et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Modeling rare gene variation to gain insight into the oldest biomarker in autism: construction of the serotonin transporter Gly56Ala knock-in mouse

(2009) Jeremy Veenstra-VanderWeele et al.   Journal of Neurodevelopmental Disorders

Prenatal exposure to antibodies from mothers of children with autism produces neurobehavioral alterations: A pregnant dam mouse model

(2009) Harvey S. Singer et al.   JOURNAL OF NEUROIMMUNOLOGY

Altered Hippocampal Synaptic Plasticity in the Fmr1 Gene Family Knockout Mouse Models

(2009) Jing Zhang et al.   JOURNAL OF NEUROPHYSIOLOGY

A Psychological and Neuroanatomical Model of Obsessive-Compulsive Disorder

(2009) E. D. Huey et al.   JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES

Intact Long-Term Potentiation but Reduced Connectivity between Neocortical Layer 5 Pyramidal Neurons in a Mouse Model of Rett Syndrome

(2009) V. S. Dani et al.   JOURNAL OF NEUROSCIENCE

Control of the Postsynaptic Membrane Viscosity

(2009) M. Renner et al.   JOURNAL OF NEUROSCIENCE

New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function

(2009) M. E. Greenberg et al.   JOURNAL OF NEUROSCIENCE

Pharmacological Inhibition of mTORC1 Suppresses Anatomical, Cellular, and Behavioral Abnormalities in Neural-Specific Pten Knock-Out Mice

(2009) J. Zhou et al.   JOURNAL OF NEUROSCIENCE

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Temporally precise in vivo control of intracellular signalling

(2009) Raag D. Airan et al.   NATURE

Driving fast-spiking cells induces gamma rhythm and controls sensory responses

(2009) Jessica A. Cardin et al.   NATURE

Ube3a is required for experience-dependent maturation of the neocortex

(2009) Koji Yashiro et al.   NATURE NEUROSCIENCE

Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes

(2009) Juan E Belforte et al.   NATURE NEUROSCIENCE

D2 dopamine receptor subtype-mediated hyperactivity and amphetamine responses in a model of ADHD

(2009) Xueliang Fan et al.   NEUROBIOLOGY OF DISEASE

Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors

(2009) Georgia M. Alexander et al.   NEURON

Genetics of attention-deficit hyperactivity disorder (ADHD)

(2009) Sally I. Sharp et al.   NEUROPHARMACOLOGY

Dissecting the neural circuitry of addiction and psychiatric disease with optogenetics

(2009) Garret D Stuber   NEUROPSYCHOPHARMACOLOGY

Cocaine-conditioned locomotion in dopamine transporter, norepinephrine transporter and 5-HT transporter knockout mice

(2009) F.S. Hall et al.   NEUROSCIENCE

The genetics of bipolar disorder

(2009) J.H. Barnett et al.   NEUROSCIENCE

Relation between increased anxiety and reduced expression of alpha1 and alpha2 subunits of GABAA receptors in Wfs1-deficient mice

(2009) Sirli Raud et al.   NEUROSCIENCE LETTERS

Dissociation of social and nonsocial anxiety in a mouse model of fragile X syndrome

(2009) Zhong-Hua Liu et al.   NEUROSCIENCE LETTERS

Developing translational animal models for symptoms of schizophrenia or bipolar mania

(2009) Mark A. Geyer   NEUROTOXICITY RESEARCH

Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells

(2009) Omar Nyabi et al.   NUCLEIC ACIDS RESEARCH

Valproate, a Mood Stabilizer, Induces WFS1 Expression and Modulates Its Interaction with ER Stress Protein GRP94

(2009) Chihiro Kakiuchi et al.   PLoS One

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

(2009) Daniela Tropea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mouse neurexin-1  deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments

(2009) M. R. Etherton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overview of genetics and obsessive–compulsive disorder

(2009) Humberto Nicolini et al.   PSYCHIATRY RESEARCH

Replicable differences in preferred circadian phase between bipolar disorder patients and control individuals

(2009) Joel Wood et al.   PSYCHIATRY RESEARCH

The emerging role of synaptic cell-adhesion pathways in the pathogenesis of autism spectrum disorders

(2009) Catalina Betancur et al.   TRENDS IN NEUROSCIENCES

Engineered G-protein coupled receptors are powerful tools to investigate biological processes and behaviors

(2009) Charles D. Nichols   Frontiers in Molecular Neuroscience

The use of lentiviral vectors combined with Cre/loxP to investigate the function of genes in complex behaviors

(2009) Scott Heldt   Frontiers in Molecular Neuroscience

Neurotrophic effects of Cerebrolysin in the Mecp2308/Y transgenic model of Rett syndrome

(2008) Edith Doppler et al.   ACTA NEUROPATHOLOGICA

Structural Variation of Chromosomes in Autism Spectrum Disorder

(2008) Christian R. Marshall et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Phenomic, Convergent Functional Genomic, and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism

(2008) H. Le-Niculescu et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Autism and serotonin transporter gene polymorphisms: A systematic review and meta-analysis

(2008) Christine H. Huang et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Autism genetics: strategies, challenges, and opportunities

(2008) Brian J. O'Roak et al.   Autism Research

Minimal aberrant behavioral phenotypes of neuroligin-3 R451C knockin mice

(2008) Kathryn K. Chadman et al.   Autism Research

Social behavior phenotypes in fragile X syndrome, autism, and the Fmr1 knockout mouse: Theoretical comment on McNaughton et al. (2008).

(2008) Edward S. Brodkin   BEHAVIORAL NEUROSCIENCE

Evidence for social anxiety and impaired social cognition in a mouse model of fragile X syndrome.

(2008) Caitlyn H. McNaughton et al.   BEHAVIORAL NEUROSCIENCE

Exaggerated responses to stress in the BTBR T+tf/J mouse: An unusual behavioral phenotype

(2008) Robert Benno et al.   BEHAVIOURAL BRAIN RESEARCH

Immune involvement in schizophrenia and autism: Etiology, pathology and animal models

(2008) Paul H. Patterson   BEHAVIOURAL BRAIN RESEARCH

Limbic Epileptogenesis in a Mouse Model of Fragile X Syndrome

(2008) L.-F. Qiu et al.   CEREBRAL CORTEX

Serotoninergic mechanisms in the treatment of obsessive–compulsive disorder

(2008) Andrew W. Goddard et al.   DRUG DISCOVERY TODAY

Temporal lobe epilepsy and social behavior: An animal model for autism?

(2008) Joao Carlos M. Marin et al.   EPILEPSY & BEHAVIOR

Fragile X syndrome

(2008) Kathryn B Garber et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Targeted delivery of an Mecp2 transgene to forebrain neurons improves the behavior of female Mecp2-deficient mice

(2008) D. G.M. Jugloff et al.   HUMAN MOLECULAR GENETICS

Phosphatase and tensin homologue deleted on chromosome 10: Extending its PTENtacles

(2008) Bangyan L. Stiles   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

A FLEX Switch Targets Channelrhodopsin-2 to Multiple Cell Types for Imaging and Long-Range Circuit Mapping

(2008) D. Atasoy et al.   JOURNAL OF NEUROSCIENCE

Smaller Dendritic Spines, Weaker Synaptic Transmission, but Enhanced Spatial Learning in Mice Lacking Shank1

(2008) A. Y. Hung et al.   JOURNAL OF NEUROSCIENCE

Schizophrenia-Related Neural and Behavioral Phenotypes in Transgenic Mice Expressing Truncated Disc1

(2008) S. Shen et al.   JOURNAL OF NEUROSCIENCE

Slitrk1-deficient mice display elevated anxiety-like behavior and noradrenergic abnormalities

(2008) K Katayama et al.   MOLECULAR PSYCHIATRY

Multiple rare SAPAP3 missense variants in trichotillomania and OCD

(2008) S Züchner et al.   MOLECULAR PSYCHIATRY

Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model

(2008) Kimberly L Stark et al.   NATURE GENETICS

Engineering GPCR signaling pathways with RASSLs

(2008) Bruce R Conklin et al.   NATURE METHODS

Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion

(2008) Jun Mukai et al.   NATURE NEUROSCIENCE

Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri

(2008) Feng Zhang et al.   NATURE NEUROSCIENCE

Advances in autism genetics: on the threshold of a new neurobiology

(2008) Brett S. Abrahams et al.   NATURE REVIEWS GENETICS

Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice

(2008) Femke M.S. de Vrij et al.   NEUROBIOLOGY OF DISEASE

Distribution and Expression of Protein Kinase C Interactive Protein (PKCI/HINT1) in Mouse Central Nervous System (CNS)

(2008) Qing Liu et al.   NEUROCHEMICAL RESEARCH

Neurexin 1α structural variants associated with autism

(2008) Jin Yan et al.   NEUROSCIENCE LETTERS

Behavioral and gene expression analyses of Wfs1 knockout mice as a possible animal model of mood disorder

(2008) Tadafumi Kato et al.   NEUROSCIENCE RESEARCH

Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism

(2008) S. Jamain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired hypothalamic-pituitary-adrenal axis and its feedback regulation in serotonin transporter knockout mice

(2008) Xue Jiang et al.   PSYCHONEUROENDOCRINOLOGY

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

(2008) M. Chahrour et al.   SCIENCE

Altered excitatory-inhibitory balance in the NMDA-hypofunction model of schizophrenia

(2008) Colin Kehrer   Frontiers in Molecular Neuroscience

Gabrb3 gene deficient mice exhibit impaired social and exploratory behaviors, deficits in non-selective attention and hypoplasia of cerebellar vermal lobules: A potential model of autism spectrum disorder

(2007) T DELOREY et al.   BEHAVIOURAL BRAIN RESEARCH

Reduced ultrasonic vocalizations in vasopressin 1b knockout mice

(2007) M SCATTONI et al.   BEHAVIOURAL BRAIN RESEARCH

Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: The orbitofronto-striatal model revisited

(2007) Lara Menzies et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The Mood-Stabilizing Agent Valproate Inhibits the Activity of Glycogen Synthase Kinase-3

(2003) Guang Chen et al.   JOURNAL OF NEUROCHEMISTRY