Article
Biotechnology & Applied Microbiology
Ying-Hua Luo, Cheng Wang, Wan-Ting Xu, Yu Zhang, Tong Zhang, Hui Xue, Yan-Nan Li, Zhong-Ren Fu, Ying Wang, Cheng-Hao Jin
Summary: The study demonstrated that 18 beta-glycyrrhetinic acid induces apoptosis and G2/M cell cycle arrest, as well as inhibits migration in A549 lung cancer cells through the activation of the ROS/MAPK/STAT3/NF-kappa B signaling pathways.
ONCOTARGETS AND THERAPY
(2021)
Article
Chemistry, Multidisciplinary
Edgar Uhl, Friederike Wolff, Sriyash Mangal, Henry Dube, Esther Zanin
Summary: The research reveals that the versatile proteasome inhibitor MG132, inactivated with a photolabile protection group, can be restored with blue light irradiation, causing cancer cells to arrest during metaphase of the cell cycle or undergo apoptosis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Han-Lin Hsu, Bo-Jyun Lin, Yu-Chen Lin, Chih-Chieh Tu, Nham-Linh Nguyen, Ching-Chiung Wang, Mei-Chuan Chen, Chun-Han Chen
Summary: This study demonstrates that Cucurbitacin E has potential as a promising drug candidate for NSCLC by inhibiting cell viability and proliferation in EGFR and KRAS mutated NSCLC cells through modulation of cell cycle progression and protein phosphorylation levels.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Food Science & Technology
Wenjin Ma, Yanbing Zhou, Wenjin Lou, Bo Wang, Bing Li, Xiaofen Liu, Jiajun Yang, Bo Yang, Jianfei Liu, Duolong Di
Summary: A water-soluble polysaccharide LBP-1 was isolated from Lycium barbarum L. and found to inhibit the growth of cancer cells through cell cycle arrest and apoptosis.
Article
Biochemistry & Molecular Biology
Omar Noman, Fahd A. Nasr, Mohammad Z. Ahmed, Md Tabish Rehman, Wajhul Qamar, Ali S. Alqahtani, Sebastian Guenther
Summary: The aim of this study was to evaluate the anticancer efficacy of chlorojanerin against different cancer cells. The effects of chlorojanerin on cell cytotoxicity, cell cycle arrest, and cell apoptosis were investigated using various assays. RT-PCR was used to analyze the expression levels of apoptosis-related genes. Docking simulations were employed to study the binding preferences of chlorojanerin with Bcl-2. The results showed that chlorojanerin inhibited cell proliferation dose-dependently and had a promising effect against A549 lung cancer cells. The inhibition of cell growth was associated with G2/M phase cell cycle arrest and apoptosis induction. We also found that chlorojanerin altered the expression of genes involved in apoptosis initiation and could fit into the active site of Bcl-2 according to docking simulations. These findings suggest that chlorojanerin has potential as a therapeutic agent in lung cancer treatment.
Article
Pharmacology & Pharmacy
Su Bo, Jing Lai, Honyu Lin, Xue Luo, Yiqiong Zeng, Tianying Du
Summary: This study demonstrated that purpurin effectively inhibits the growth of lung cancer cells by modulating PI3K/AKT signaling pathway, leading to increased cytotoxicity, ROS generation, lipid peroxidation, and apoptosis. Furthermore, purpurin treatment resulted in decreased expression of antiapoptotic proteins and increased expression of proapoptotic mediators in A549 lung cancer cells, highlighting its potential as a therapeutic agent for lung cancer.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Ali Mohammadi, Behzad Mansoori, Elham Safarzadeh, Sahar Gholizadeh, Behzad Baradaran
Summary: This study investigated the potential anti-tumoral activity and mechanisms of Anacyclus pyrethrum plant extract on A549 lung cancer cells. The extract significantly inhibited cell proliferation, induced apoptosis, and regulated gene expression involved in apoptosis and cell cycle arrest.
JOURNAL OF HERBAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Eul-Bee Ko, Yin-Gi Jang, Cho-Won Kim, Ryeo-Eun Go, Hong Kyu Lee, Kyung-Chul Choi
Summary: This study demonstrates the anti-cancer potential of gallic acid in lung cancer by regulating the PI3K/Akt pathway. Various experimental methods were used to confirm this, including cell assays and mouse models. The results showed that gallic acid inhibits lung cancer progression by inducing cell cycle arrest and apoptosis.
BIOMOLECULES & THERAPEUTICS
(2022)
Article
Engineering, Chemical
El-Sayed Khafagy, Ahmed Al Saqr, Hadil Faris Alotaibi, Amr Selim Abu Lila
Summary: Rubus chingii ethanolic leaf extract (RcL-EtOH) exhibits significant anticancer potential against non-small cell lung cancer A549 cells by inducing cell apoptosis, regulating apoptotic gene expression, and showing minimal toxicity to normal cells. RcL-EtOH may serve as a promising therapeutic option for lung cancer management.
Article
Oncology
Musiliyu A. Musa, Qudus Kolawole
Summary: This study investigates the in-vitro cytotoxic activity of 3,4-Diarylcoumarins in A549 and PC-3 cancer cell lines. Compound 4f exhibited the highest cytotoxicity in A549 cells, resulting in cell cycle arrest, loss of mitochondrial membrane potential, increased reactive oxygen species production, and induction of apoptotic cell death. The presence of 3-4-methylsulfonyl and 7,8-diacetoxy groups on 3,4-Diarylcoumarin is crucial for its cytotoxic activity and may serve as a valuable template for the development of novel anticancer agents for lung cancer treatment.
ANTICANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Yang Yang, Yu Chong, Mengyuan Chen, Wumin Dai, Xia Zhou, Yongling Ji, Guoqin Qiu, Xianghui Du
Summary: The study found that LDHA is overexpressed in NSCLC tissues and high LDHA expression is associated with poor prognosis and radioresistance in NSCLC patients. Inhibition of LDHA by oxamate increased radiosensitivity in NSCLC cell lines, induced apoptosis and autophagy, and altered cell cycle distribution. LDHA inhibition also led to ROS accumulation and ATP depletion, which may contribute to increased DNA damage and hinder DNA repair activity. The findings suggest that targeting LDHA may be a potential strategy to enhance radiotherapy efficacy in NSCLC patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Nabil A. Alhakamy, Solomon Z. Okbazghi, Mohamed A. Alfaleh, Wesam H. Abdulaal, Rana B. Bakhaidar, Mohammed O. Alselami, Majed Al Zahrani, Hani M. Alqarni, Adel F. Alghaith, Sultan Alshehri, Shaimaa M. Badr-Eldin, Hibah M. Aldawsari, Omar D. Al-hejaili, Bander M. Aldhabi, Wael A. Mahdi
Summary: In this study, Alendronate sodium (ALS)-mastoparan peptide (MP) nanoconjugates were successfully formulated and optimized using the Box-Behnken response surface design. The results showed that the optimized ALS-MP nanoconjugates exhibited significantly improved cytotoxic activity towards A549 cells. These findings may provide a new solution for the treatment of lung cancer.
Article
Multidisciplinary Sciences
Young Yun Jung, In Jin Ha, Jae-Young Um, Gautam Sethi, Kwang Seok Ahn
Summary: The study demonstrates that fangchinoline (FCN) can attenuate tumor growth and survival by modulating the STAT3 signaling pathway and inducing apoptosis in malignant cells. FCN abrogated protein expression levels of STAT3 and upstream signals, inhibited STAT3 DNA binding ability and translocation, increased SHP-1 levels, induced ROS production, and effectively suppressed tumor progression and STAT3 activation in a preclinical myeloma model.
JOURNAL OF ADVANCED RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Ting Liu, Li Sun, Yubin Zhang, Yonglin Wang, Jiang Zheng
Summary: This article reviews the impact of imbalance between ROS and GSH on cells, indicating that imbalance may lead to cell death. In addition, different factors leading to the disruption of cellular ROS and GSH balance are introduced.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Narissara Namwan, Gulsiri Senawong, Chanokbhorn Phaosiri, Pakit Kumboonma, La-Or Somsakeesit, Arunta Samankul, Chadaporn Leerat, Thanaset Senawong
Summary: The curcumin derivative CU17 shows potential in inhibiting the growth of lung cancer cells, while exhibiting less toxicity to non-cancer cells. CU17 inhibits HDAC activity, induces cell cycle arrest and apoptosis, and down-regulates expression of certain proteins associated with cancer growth in lung cancer cells.