Article
Endocrinology & Metabolism
Zixin Cai, Jiaxin Zhong, Yingling Jiang, Jingjing Zhang
Summary: This study summarizes the correlation between sex hormone levels and COVID-19. The findings suggest that COVID-19 patients have lower levels of T/LH, FSH/LH, and SHBG, and higher levels of LH and E-2/T. These findings may be helpful in evaluating the severity of COVID-19.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Zorimar Rivera-Nunez, Carolyn W. Kinkade, Leena Khoury, Jessica Brunner, Hannah Murphy, Christina Wang, Kurunthachalam Kannan, Richard K. Miller, Thomas G. O'Connor, Emily S. Barrett
Summary: The study found that maternal serum levels of poly- and perfluoroalkyl substances (PFAS) are associated with sex steroid hormone levels during pregnancy. Specifically, PFHxS is associated with increased testosterone levels in male fetuses, while PFNA and PFDA are associated with increased free testosterone levels in male fetuses. For female fetuses, PFHxS is associated with increased levels of estradiol and estriol. No associations were found for PFOS and PFOA.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Sandra India-Aldana, Andrew G. Rundle, Tess V. Clendenen, James W. Quinn, Alan A. Arslan, Yelena Afanasyeva, Karen L. Koenig, Mengling Liu, Kathryn M. Neckerman, Lorna E. Thorpe, Anne Zeleniuch-Jacquotte, Yu Chen
Summary: The study found that neighborhood walkability is associated with lower levels of androgens and estrone, and increased SHBG in postmenopausal women, as well as lower levels of DHEAS in premenopausal women. It is important to note that the associations were more pronounced in postmenopausal women.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Zorimar Rivera-Nunez, Megan Hansel, Camila Capurro, Danielle Kozlosky, Christina Wang, Cathleen L. Doherty, Brian Buckley, Pamela Ohman-Strickland, Richard K. Miller, Thomas G. O'Connor, Lauren M. Aleksunes, Emily S. Barrett
Summary: This study found that cadmium exposure during pregnancy may lead to lower testosterone levels in pregnant women, while estrogen levels remain unchanged. This effect may be stronger in pregnancies carrying female fetuses. Further research is needed to understand how alterations in gestational testosterone activity may impact pregnancy and child health.
Article
Oncology
Lei Zhang, JinFeng Wu, QiuMei Wu, XiangJuan Zhang, ShuaiCai Lin, WanLi Ran, Li Zhu, ChengYan Tang, Xing Wang
Summary: Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death. The mechanisms behind male propensity in HCC incidence, prognosis, and treatment responses are complex and inconclusive. This review integrates current knowledge on how hormones regulate HCC development in a sexually dimorphic manner. Understanding the role of sex hormones in HCC may lead to personalized therapeutic strategies in high-risk populations.
Review
Biochemistry & Molecular Biology
Donghui Zhu, Axel Montagne, Zhen Zhao
Summary: AD is a neurodegenerative disease, with studies showing gender differences in risk and progression. The higher risk and progression of AD in women are largely attributed to distinct biological mechanisms, such as deviations in brain structure and biomarkers, psychosocial stress responses, genetic background, and more.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Endocrinology & Metabolism
Hannah Collden, Maria E. Nilsson, Anna-Karin Norlen, Andreas Landin, Sara H. Windahl, Jianyao Wu, Karin L. Gustafsson, Matti Poutanen, Henrik Ryberg, Liesbeth Vandenput, Claes Ohlsson
Summary: This study established a comprehensive atlas of sex hormone concentrations in tissues and serum of male mice, revealing the distribution characteristics of sex hormones. Brain sex hormone levels are well correlated with serum levels, and white adipose tissue serves as a major reservoir of sex hormones in mice. Progesterone is the most abundant sex hormone in castrated mice.
Review
Endocrinology & Metabolism
Jose Cipolla-Neto, Fernanda Gaspar Amaral, Jose Maria Soares-Jr, Camila Congentino Gallo, Andre Furtado, Jose Eduardo Cavaco, Isabel Goncalves, Cecilia Reis Alves Santos, Telma Quintela
Summary: This study reviews the various effects of melatonin on biological functions, discusses the interactions between melatonin and sex hormones, and highlights the impact of melatonin on female gonadal steroidogenesis and hormonal control. It suggests that there is ambiguity in the influence of sex differences on the circadian rhythms of melatonin, and the debate surrounding the reciprocal relationship between melatonin and reproductive hormones remains inconclusive.
NEUROENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Lee T. Gettler, Stacy Rosenbaum, Patty X. Kuo, Mallika S. Sarma, Sonny Agustin Bechayda, Thomas W. McDade, Christopher W. Kuzawa
Summary: Testosterone plays an important role in reproductive trade-offs and can be influenced by developmental experiences and family environments. A study in the Philippines found that sons who had fathers involved in childcare during adolescence had lower testosterone levels as parents. Adolescent father-son relationships also played a contributing role, with sons having lower waking testosterone if they credited their fathers with their upbringing. These findings suggest a potential pathway for the intergenerational transmission of reproductive strategies.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Daniela Peruzzu, Maria Luisa Dupuis, Marina Pierdominici, Katia Fecchi, Maria Cristina Gagliardi, Elena Ortona, Maria Teresa Pagano
Summary: This study investigated the different effects of calcitriol in modulating T cell immunity of age-matched male and female healthy donors. The results showed that calcitriol increased vitamin D receptor expression levels and reduced pro-inflammatory cytokine expression levels in T lymphocytes of both sexes. Furthermore, calcitriol only increased the expression level of the anti-inflammatory cytokine IL-10 in T lymphocytes from female healthy donors. These findings provide new insights into the sex-specific anti-inflammatory role of calcitriol in T cell immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Sara P. Dias, Matthijs C. Brouwer, Anita Boelen, Diederik van de Beek
Summary: This study investigated the association between cerebrospinal fluid (CSF) sex steroid hormone levels and inflammatory parameters, disease severity, and outcome in pneumococcal meningitis. The results showed that higher levels of estradiol and lower levels of sex hormone-binding globulin (SHBG) were associated with unfavorable outcome in patients with pneumococcal meningitis. Estradiol was also positively correlated with inflammatory markers.
Review
Medicine, General & Internal
Le-Tian Huang, Jia-He Wang
Summary: Sarcopenia is characterized by excessive loss of skeletal muscle mass, strength, and function, associated with overall poor muscle performance status in the elderly and chronic disease patients. Its causes are multifactorial, involving molecular mechanisms such as mitochondrial function, inflammatory pathways, and circulating hormones. Age-related changes in sex steroid hormone concentrations play a significant role in the pathogenesis of sarcopenia, suggesting therapeutic interventions targeting these hormones may be beneficial in combination with specific exercise and nutrition regimens.
FRONTIERS IN MEDICINE
(2021)
Article
Biology
Rodolfo Soares Mendes Nunes, Ana Flavia Lopes Freitas, Elaine Vieira
Summary: This study found that time-of-day, chronotype, and sex differences influence the swimming performance of adolescent swimmers. It was also discovered that sleep quality is positively correlated with anxiety and depression levels among adolescent swimmers.
CHRONOBIOLOGY INTERNATIONAL
(2021)
Review
Gastroenterology & Hepatology
Leiqi Xu, Gang Huang, Yingzi Cong, Yanbo Yu, Yanqing Li
Summary: Inflammatory bowel disease (IBD) is a global health care problem characterized by chronic inflammation of the gastrointestinal tract. There are sex differences in the prevalence, pathophysiology, clinical presentation, and treatment outcome of IBD. Sex hormones, including estrogen, progesterone, and androgen, play a role in the pathogenesis of sexual dimorphism in IBD.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Obstetrics & Gynecology
Megan C. Hansel, Hannah R. Murphy, Jessica Brunner, Christina Wang, Richard K. Miller, Thomas G. O'Connor, Emily S. Barrett, Zorimar Rivera-Nunez
Summary: The study found that neighborhood stressors were associated with higher levels of maternal testosterone, which may have implications for maternal and child health.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Multidisciplinary Sciences
Elyse L. Aurbach, Edny Gula Inui, Cortney A. Turner, Megan H. Hagenauer, Katherine E. Prater, Jun Z. Li, Devin Absher, Najmul Shah, Peter Blandino, William E. Bunney, Richard M. Myers, Jack D. Barchas, Alan F. Schatzberg, Stanley J. Watson, Huda Akil
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2015)
Article
Genetics & Heredity
Ryne C. Ramaker, Kevin M. Bowling, Brittany N. Lasseigne, Megan H. Hagenauer, Andrew A. Hardigan, Nicholas S. Davis, Jason Gertz, Preston M. Cartagena, David M. Walsh, Marquis P. Vawter, Edward G. Jones, Alan F. Schatzberg, Jack D. Barchas, Stanley J. Watson, Blynn G. Bunney, Huda Akil, William E. Bunney, Jun Z. Li, Sara J. Cooper, Richard M. Myers
Article
Endocrinology & Metabolism
Alex G. Lee, Megan Hagenauer, Devin Absher, Kathleen E. Morrison, Tracy L. Bale, Richard M. Myers, Stanley J. Watson, Huda Akil, Alan F. Schatzberg, David M. Lyons
BIOLOGY OF SEX DIFFERENCES
(2017)
Article
Neurosciences
Cortney A. Turner, Vikram Sharma, Megan H. Hagenauer, Sraboni Chaudhury, Angela M. O'Connor, Elaine K. Hebda-Bauer, Robert C. Thompson, Richard M. Myers, William E. Bunney, Jack D. Barchas, Francis S. Lee, Alan F. Schatzberg, Stanley J. Watson, Huda Akil
BIOLOGICAL PSYCHIATRY
(2018)
Article
Multidisciplinary Sciences
Megan Hastings Hagenauer, Anton Schulmann, Jun Z. Li, Marquis P. Vawter, David M. Walsh, Robert C. Thompson, Cortney A. Turner, William E. Bunney, Richard M. Myers, Jack D. Barchas, Alan F. Schatzberg, Stanley J. Watson, Huda Akil
Article
Neurosciences
Cortney A. Turner, Megan H. Hagenauer, Elyse L. Aurbach, Pamela M. Maras, Chelsea L. Fournier, Peter Blandino, Rikav B. Chauhan, Jaak Panksepp, Stanley J. Watson, Huda Akil
Article
Biochemical Research Methods
Jennifer Crodelle, Sofia H. Piltz, Megan Hastings Hagenauer, Victoria Booth
PLOS COMPUTATIONAL BIOLOGY
(2019)
Article
Neurosciences
Isabelle A. Birt, Megan H. Hagenauer, Sarah M. Clinton, Cigdem Aydin, Peter Blandino, John D. H. Stead, Kathryn L. Hilde, Fan Meng, Robert C. Thompson, Huzefa Khalil, Alex Stefanov, Pamela Maras, Zhifeng Zhou, Elaine K. Hebda-Bauer, David Goldman, Stanley J. Watson, Huda Akil
Summary: By studying gene expression in the hippocampus of rats with high and low exploratory activity, candidate genes associated with metabolism, mood, and neurodevelopment were identified, suggesting divergent developmental trajectories and different reactions to the environment in bHR and bLR rats.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychiatry
Pamela M. Maras, Peter Blandino, Elaine K. Hebda-Bauer, Stanley J. Watson, Huda Akil
Summary: The study found differences in the morphological features of microglia between selectively bred rat lines bLRs and bHRs, despite similar numbers of microglia in the two lines. Specifically, microglia from bLRs exhibited more complex morphology, suggesting a possible activation stage.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychiatry
Adriana M. Medina, Megan Hastings Hagenauer, David M. Krolewski, Evan Hughes, Liam Cannon Thew Forrester, David M. Walsh, Maria Waselus, Evelyn Richardson, Cortney A. Turner, P. Adolfo Sequeira, Preston M. Cartagena, Robert C. Thompson, Marquis P. Vawter, Blynn G. Bunney, Richard M. Myers, Jack D. Barchas, Francis S. Lee, Alan F. Schatzberg, William E. Bunney, Huda Akil, Stanley J. Watson
Summary: This study investigated the expression of neurotransmission-related genes in the frontal pole region of the brain in bipolar disorder and schizophrenia. Through qPCR and microarray analysis, 20 genes were found to be differentially expressed in these disorders, including genes related to therapeutic targets and dopamine, GABA, and astrocytic function. It was also observed that treatment methods may have effects opposite to the diagnosis, while substance abuse may amplify diagnosis-related dysregulation.
TRANSLATIONAL PSYCHIATRY
(2023)
Meeting Abstract
Neurosciences
Pamela Maras, Megan Hagenauer, Kathryn Hilde, Elaine Hebda-Bauer, William Bunney, Stanley Watson, Huda Akil
BIOLOGICAL PSYCHIATRY
(2022)
Proceedings Paper
Mathematical & Computational Biology
Jennifer A. Crodelle, Sofia H. Piltz, Victoria Booth, Megan Hastings Hagenauer
WOMEN IN MATHEMATICAL BIOLOGY
(2017)
Meeting Abstract
Neurosciences
Huda Akil, Pamela Maras, Megan Hagenauer, Cigdem Aydin, Isabelle Brit, Cortney Turner, Stanley Watson
BIOLOGICAL PSYCHIATRY
(2017)
Proceedings Paper
Mathematical & Computational Biology
Megan Hastings Hagenauer, Jennifer A. Crodelle, Sofia H. Piltz, Natalia Toporikova, Paige Ferguson, Victoria Booth
WOMEN IN MATHEMATICAL BIOLOGY
(2017)
Meeting Abstract
Neurosciences
Cortney Turner, Megan Hagenauer, Shweta Ramdas, Stefanie Mayer, Jun Li, Elizabeth Young, Stanley Watson, James Abelson, Huda Akil
NEUROPSYCHOPHARMACOLOGY
(2015)
Article
Behavioral Sciences
Farrah N. Madison, Verner P. Bingman, Tom Smulders, Christine R. Lattin
Summary: Although research on the avian hippocampus has been limited, it is crucial for understanding its evolution and changes over time. The avian hippocampus plays important roles in spatial cognition as well as regulating anxiety, approach-avoidance behavior, and stress responses. Future research should focus on elucidating the cellular and molecular mechanisms, including endocrinology, to resolve outstanding questions about avian hippocampal function and organization.
HORMONES AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Judith A. H. Smit, Riet Vooijs, Peter Lindenburg, Alexander T. Baugh, Wouter Halfwerk
Summary: This study investigates the effects of urbanization on hormone levels in tungara frogs and found that urban frogs and forest frogs have different endocrine phenotypes. Exposure to urban noise and light pollution led to an increase in testosterone and a decrease in corticosterone in urban frogs, while forest frogs showed no endocrine response to sensory pollutants. These results suggest that urbanization can modulate hormone levels and influence behavior in frogs.
HORMONES AND BEHAVIOR
(2024)
Article
Behavioral Sciences
Hannah D. Fulenwider, Yangmiao Zhang, Andrey E. Ryabinin
Summary: Social hierarchies have significant effects on overall health of individuals in animal groups, particularly the lowest-ranking individuals. Tube test can be used to determine social rank in male and female mice, and the complex interactions between social rank, sex, environment, and testing length influence peptide levels.
HORMONES AND BEHAVIOR
(2024)