Article
Multidisciplinary Sciences
Jihoon Shin, Shinichiro Toyoda, Yosuke Okuno, Reiko Hayashi, Shigeki Nishitani, Toshiharu Onodera, Haruyo Sakamoto, Shinya Ito, Sachiko Kobayashi, Hirofumi Nagao, Shunbun Kita, Michio Otsuki, Atsunori Fukuhara, Kazuhiro Nagata, Iichiro Shimomura
Summary: HSP47 is identified as a key determinant of body adiposity, with abundant expression in adipose tissue. It is influenced by factors such as diet, exercise, hormones, and genetics. HSP47 affects body fat levels through its role in collagen dynamics, FAK signaling, and protection of PPAR gamma protein.
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Reem S. Shawar, Maurice Puyau, Roman Shypailo, Salma Musaad, Nancy F. Butte, Fida Bacha
Summary: This study investigates the relationship between adiposity, insulin resistance, cardiorespiratory fitness, and bone mass in Hispanic youth. The findings suggest that adiposity is negatively related to bone mass, and this relationship is partially mediated by insulin resistance, while cardiorespiratory fitness may attenuate it.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Ramy H. Bishay, Katherine T. Tonks, Jacob George, Dorit Samocha-Bonet, Gideon Meyerowitz-Katz, Donald J. Chisholm, David E. James, Jerry R. Greenfield
Summary: In obese individuals with insulin resistance, there was a significant decrease in glucose infusion rate/fat-free mass (GIR/FFM), and higher levels of visceral and liver fat, despite similar overall adiposity compared to insulin-sensitive individuals. Total bile acid (BA) concentrations were higher in the obese insulin-resistant group and individuals with type 2 diabetes compared to the insulin-sensitive obese group. Total BAs were positively associated with waist circumference, visceral fat, and fibroblast growth factor 21, and negatively associated with insulin sensitivity, abdominal subcutaneous fat, adiponectin, and liver fat. Conjugated BAs were also elevated in individuals with type 2 diabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Martina Chiriaco, Lorenzo Nesti, Allan Flyvbjerg, Alain Golay, Julie-Anne Nazare, Christian-Heinz Anderwald, Asimina Mitrakou, Roberto Bizzotto, Andrea Mari, Andrea Natali
Summary: The impact of obesity on glucose homeostasis varies greatly among individuals, which may be attributed to different concentrations of adipokines. Subjects with inappropriately elevated leptin levels for their fat mass show whole-body/adipose tissue insulin resistance and hyperinsulinemia, regardless of BMI.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cell Biology
Gwan-Jun Lee, Youn Ju Kim, Bongju Park, Sujin Yim, Chansang Park, Hyunsoo Roh, Yunwon Moon, Je Kyung Seong, Hyunsung Park
Summary: This study found that adipocytes are primarily responsible for the increase in Wnt5a levels in obesity. Adipocytes in subcutaneous white adipose tissues are more sensitive to high-fat diet and have a positive correlation between cell size and Wnt5a levels. YAP and TAZ activity responds to mechanical changes in hypertrophic adipocytes to promote Wnt5a expression.
CELL DEATH & DISEASE
(2022)
Article
Endocrinology & Metabolism
Gal Tsaban, Anat Yaskolka Meir, Hila Zelicha, Ehud Rinott, Alon Kaplan, Aryeh Shalev, Amos Katz, Dov Brikner, Matthias Bluher, Uta Ceglarek, Michael Stumvoll, Meir J. Stampfer, Iris Shai
Summary: This study found that lower fasting ghrelin levels were associated with unfavorable cardiometabolic parameters during weight loss. After 18 months of weight loss, the increase in fasting ghrelin levels differed between different diet groups, with the green-MED diet group showing the highest increase. In addition, the increase in fasting ghrelin levels among men was associated with improved insulin sensitivity and regression of visceral adipose tissue.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biology
Nicole Aaron, Michael J. Kraakman, Qiuzhong Zhou, Qiongming Liu, Samantha Costa, Jing Yang, Longhua Liu, Lexiang Yu, Liheng Wang, Ying He, Lihong Fan, Hiroyuki Hirakawa, Lei Ding, James Lo, Weidong Wang, Baohong Zhao, Edward Guo, Lei Sun, Cliff J. Rosen, Li Qiang
Summary: Adipsin is the most upregulated adipokine during MAT expansion in mice and humans in a PPAR gamma acetylation-dependent manner. Genetic ablation of Adipsin in mice specifically inhibited MAT expansion but not peripheral adipose depots, and improved bone mass during calorie restriction, thiazolidinedione treatment, and aging. The effects were mediated through its downstream effector, complement component C3, to prime common progenitor cells toward adipogenesis rather than osteoblastogenesis through inhibiting Wnt/beta-catenin signaling.
Article
Endocrinology & Metabolism
Xiangyan Ruan, Meng Li, Min Min, Rui Ju, Husheng Wang, Zhongting Xu, Suiyu Luo, Alfred Otto Mueck
Summary: This study investigated the levels of visfatin and apelin in adolescent girls with PCOS and explored their importance in glucose and lipid metabolism. The results showed that higher levels of visfatin were associated with insulin resistance and lipid levels, suggesting a possible protective role in certain stages of metabolic syndrome.
GYNECOLOGICAL ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Berta Portugal, Fanny Artaud, Cloe Domenighetti, Emmanuel Roze, Isabelle Degaey, Marianne Canonico, Alexis Elbaz
Summary: This study found an inverse association between obesity and Parkinson's disease in a cohort of French women. The occurrence of obesity was less frequent in patients with PD before diagnosis, indicating a potential protective effect of obesity in the development of PD.
Article
Endocrinology & Metabolism
Yaxin Guan, Fan Zuo, Juan Zhao, Xin Nian, Li Shi, Yushan Xu, Jingshan Huang, Tsutomu Kazumi, Bin Wu
Summary: This study aims to compare the differences in circulating adiponectin levels and their relationships to regional adiposity, insulin resistance, serum lipid, and inflammatory factors in young, healthy Japanese women with different physical activity statuses. The results suggest that regardless of insulin sensitivity and physical activity status, adiponectin is primarily associated with regional adiposity and HDL-C.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Tilda Herrgardh, Christian Simonsson, Mattias Ekstedt, Peter Lundberg, Karin G. Stenkula, Elin Nyman, Peter Gennemark, Gunnar Cedersund
Summary: By combining models for short-term glucose homeostasis and intracellular insulin signaling with long-term weight regulation models, a interconnected digital twin has been developed for the progression of insulin resistance in humans.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Article
Medicine, General & Internal
Jose Ignacio Ramirez-Manent, Angel Arturo Lopez-Gonzalez, Pilar Tomas-Gil, Pere Riutord-Sbert, Lucia Garrido-Sepulveda, Maria Teofila Vicente-Herrero
Summary: This study examines the relationship between two obesity assessment methods based on hip circumference and metabolic syndrome (MetS) and insulin resistance risk scales. The results show that AVI demonstrates higher predictive value for MetS, while AVI and BAI mainly show predictive value for high insulin resistance risk scales in the case of METS-IR, with higher predictive value in women.
Article
Medicine, General & Internal
Kui Deng, Menglei Shuai, Zheqing Zhang, Zengliang Jiang, Yuanqing Fu, Luqi Shen, Ju-Sheng Zheng, Yu-ming Chen
Summary: This study revealed the temporal relationship between adiposity and gut microbiota and identified Lachnospiraceae bacterium 3 1 57FAA CT1 as a potential mediator of the effect of adiposity on insulin resistance. The findings are helpful for the discovery of novel therapeutic targets.
Article
Endocrinology & Metabolism
Bertrand Cariou
Summary: Non-alcoholic fatty liver disease (NAFLD) is associated with visceral obesity, insulin resistance, and type 2 diabetes. Adipocyte dysfunction plays a key role in the molecular link between NAFLD, visceral adipose tissue, and metabolic syndrome. Strategies targeting metabolic dysfunction, such as weight loss and specific medications, are effective in treating NAFLD and related conditions.
DIABETES OBESITY & METABOLISM
(2022)
Article
Food Science & Technology
Thiago dos Reis Araujo, Mariana Roberta Rodrigues Muniz, Bruna Lourenconi Alves, Lohanna Monali Barreto dos Santos, Maressa Fernandes Bonfim, Joel Alves da Silva Junior, Jean Franciesco Vettorazzi, Claudio Cesar Zoppi, Everardo Magalhaes Carneiro
Summary: Early childhood malnutrition may lead to the onset of obesity and diabetes mellitus in adulthood. The study found that tauroursodeoxycholic acid (TUDCA) has beneficial effects on glucose homeostasis and body fat accumulation in protein-restricted mice. TUDCA reduces obesity, improves metabolic flexibility, and restores glucose tolerance and insulin sensitivity through multiple pathways, serving as a potential strategy to reverse metabolic disorders.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Sun Ok Song, Jae-Seung Yun, Seung-Hyun Ko, Yu-Bae Ahn, Bo-Yeon Kim, Chul-Hee Kim, Ja Young Jeon, Dae Jung Kim, Da Hae Seo, So Hun Kim, Jung Hyun Noh, Da Young Lee, Kyung-Soo Kim, Soo-Kyung Kim
Summary: The prevalence of type 1 diabetes mellitus was 1.2% among all patients with diabetes, and that of fulminant type 1 diabetes mellitus was 3.2% among those newly diagnosed with type 1 diabetes mellitus. Patients with fulminant type 1 diabetes mellitus had significant differences in age, BMI, glycated hemoglobin levels, etc., compared to non-fulminant type 1 diabetes mellitus at diagnosis.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Editorial Material
Endocrinology & Metabolism
Ja Young Jeon, Dae Jung Kim
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Kyoung Hwa Ha, Dae Jung Kim, Yong Jun Choi
Summary: In individuals with type 2 diabetes, the use of SGLT2 inhibitors does not increase the risk of fracture in a real-world clinical setting.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Medicine, General & Internal
Seung-Hwa Lee, Jungchan Park, Rae Woong Park, Seo Jeong Shin, Jinseob Kim, Ji Dong Sung, Dae Jung Kim, Kwangmo Yang
Summary: Studies have shown conflicting results on the association between the use of RAAS inhibitors and cancer development. This study compared the incidence of cancer between patients using RAAS inhibitors and other antihypertensive drugs. The findings suggest that the use of RAAS inhibitors may be associated with a lower incidence of cancer.
Article
Endocrinology & Metabolism
Nami Lee, So Jeong Park, Dongwoo Kang, Ja Young Jeon, Hae Jin Kim, Dae Jung Kim, Kwan-Woo Lee, Edward J. Boyko, Seung Jin Han
Summary: DEP is more likely to require insulin therapy than type 2 diabetes. Hypoglycemia, micro- and macrovascular complications, and all-cause mortality events are higher in DEP compared with type 2 diabetes.
Article
Environmental Sciences
Yun Jung Jung, Eun Jin Kim, Jung Yeon Heo, Young Hwa Choi, Dae Jung Kim, Kyoung Hwa Ha
Summary: We investigated the association between short-term exposure to air pollution and the risk of acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) in seven metropolitan cities in Korea. The results showed that short-term exposure, particularly to PM10, increases the risk of hospital visits for AE-COPD. This association is more pronounced in male patients aged 40-64, with low household income, and with a history of asthma.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Da Hea Seo, Yongin Cho, Seongha Seo, Seong Hee Ahn, Seongbin Hong, Kyung Hwa Ha, Jee-Seon Shim, Hyeon Chang Kim, Dae Jung Kim, So Hun Kim
Summary: We found no significant association between metabolically healthy obesity and subclinical atherosclerosis in patients without previous cardiovascular disease, suggesting that metabolic health may not play a role in the development of early stage atherosclerosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Endocrinology & Metabolism
Dae Jung Kim
DIABETES & METABOLISM JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Yu-Jung Heo, Nami Lee, Sung-E Choi, Ja-Young Jeon, Seung-Jin Han, Dae-Jung Kim, Yup Kang, Kwan-Woo Lee, Hae-Jin Kim
Summary: This study found that Empagliflozin improves liver fibrosis by activating the Hippo signaling pathway, reducing liver fibrosis in a mouse model, and reducing the expression of genes related to fibrosis.
Article
Endocrinology & Metabolism
Duhoe Kim, Jaehun Seo, Kyoung Hwa Ha, Dae Jung Kim
Summary: This study investigated the association between changes in physical activity and the risk of major adverse cardiovascular events (MACE) in individuals with newly diagnosed diabetes. The results showed that maintaining active physical activity after a diabetes diagnosis significantly reduced the risk of MACE. This association was particularly beneficial for individuals with a history of cardiovascular disease and obesity.
JOURNAL OF OBESITY & METABOLIC SYNDROME
(2022)
Article
Medicine, General & Internal
Hyun Uk Moon, Seung Jin Han, Hae Jin Kim, Yoon-Sok Chung, Dae Jung Kim, Yong Jun Choi
Summary: This study found that the positive correlation between muscle mass and bone status was largely conserved in men with diabetes, and this association may be stronger in diabetic individuals.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Hyun Ho Choi, Giwoong Choi, Hojun Yoon, Kyoung Hwa Ha, Dae Jung Kim
Summary: The overall incidence rate of diagnosed diabetes in South Korean adults has been decreasing, but there has been a slight increase in the 20-39 age group. The proportion of obese young adults with diabetes has significantly increased.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Endocrinology & Metabolism
Dae Jung Kim, Wayne H-H Sheu, Wook-Jin Chung, Daisuke Yabe, Kyoung Hwa Ha, Masaomi Nangaku, Elise Chia-Hui Tan, Koichi Node, Atsutaka Yasui, Weiyu Lei, Sunwoo Lee, Laura Saarelainen, Anouk Deruaz-Luyet, Moe H. Kyaw, Yutaka Seino, EMPRISE East Asia Study Grp
Summary: The EMPA-REG OUTCOME trial showed that empagliflozin, an SGLT2 inhibitor, provides cardiovascular and renal benefits as well as reduces all-cause mortality in patients with type 2 diabetes and established cardiovascular disease. The EMPRISE study program evaluates the translation of these effects in routine clinical care of type 2 diabetes patients in East Asia.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Medicine, General & Internal
Kyoung Hwa Ha, Kyung Ae Lee, Kyung-Do Han, Min Kyong Moon, Dae Jung Kim
Summary: This study aimed to determine the age threshold for diabetes screening in Korean adults. The study found that universal screening for adults aged >= 35 and selective screening for adults aged 20 to 34, considering diabetes risk factors, may be appropriate for detecting prediabetes and diabetes in South Korea.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Jee-Seon Shim, Kyoung Hwa Ha, Dae Jung Kim, Hyeon Chang Kim
Summary: This study examined the relationship between ultraprocessed food (UPF) consumption and adiposity indicators among Korean adults. The results showed that UPF intake was positively associated with higher adiposity indicators, and this association was partially mediated by overall diet quality.