Article
Medicine, General & Internal
Robert Krysiak, Karolina Kowalcze, Witold Szkrobka, Boguslaw Okopien
Summary: The aim of this study was to determine if the androgen status modulates the impact of metformin on plasma prolactin levels in women. The results showed that the drug decreased total and monomeric prolactin and increased luteinizing hormone (LH) in control subjects. In women with polycystic ovary syndrome (PCOS), metformin reduced LH, LH/FSH ratio, testosterone, and free androgen index (FAI).
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Licy L. Yanes Cardozo, Damian G. Romero
Summary: PCOS is the most common endocrine disorder in reproductive-age women, with heterogeneous clinical presentations and involvement of multiple abnormal physiological pathways. Women with PCOS also have a high prevalence of cardiometabolic risk factors, but there is limited evidence-based therapeutic agents available to treat these complications. Recent studies suggest opportunities for timely effective medical care for women with PCOS, highlighting the unmet need for effective and safe management of the cardiometabolic complications in these patients.
Article
Endocrinology & Metabolism
Linyi Song, Jin Yu, Danying Zhang, Xi Li, Lu Chen, Zailong Cai, Chaoqin Yu
Summary: Excess androgen could damage the mitochondrial ultrastructure and function of ovarian granulosa cells in PCOS model rats by down-regulating the expression of NDUFB8 and ATP5j.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Zhenyan Pan, Fangfang Zhu, Kai Zhou
Summary: Anogenital distance (AGD) reflects androgen exposure during gestational weeks 8-14 and has been linked to endocrine-disrupting compounds. Studies show that PCOS patients tend to have longer AGD, while endometriosis patients tend to have shorter AGD. Further well-designed studies are needed to confirm these findings.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
T. Rajendra Kumar
Summary: Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) are synthesized in the same pituitary cell, and their secretion pathways differ. The carboxy terminus heptapeptide of human LH-b subunit is a determinant for sorting in gonadotropes. When genetically fused to human FSH-b subunit, the rerouted FSH enters the LH secretory pathway and shows similar effectiveness as wild-type FSH. Rerouted FSH suppresses follicle atresia, enhances ovulations, and prolongs female reproductive life span.
FERTILITY AND STERILITY
(2023)
Review
Cell Biology
Yi-Ru Tsai, Yen-Nung Liao, Hong-Yo Kang
Summary: Polycystic ovary syndrome (PCOS) is a common gynecological and endocrine disorder that affects the reproductive health of women. This article provides an overview of the latest cellular approaches used to study the pathophysiology of PCOS through in vitro cell models. It discusses abnormalities in folliculogenesis and explores potential treatments and underlying mechanisms, aiming to enhance our understanding of PCOS at a cellular level.
Article
Reproductive Biology
Ge Xu, Xuedan Zhao, Zhihao Li, Junwei Hu, Xu Li, Juanjuan Li, Yuelai Chen
Summary: This study found that electroacupuncture (EA) can improve the reproductive characteristics of PCOS rats by regulating the kisspeptin-GnRH/LH circuit. EA treatment can reduce androgen activity and increase estrogen levels, leading to increased ovulation frequency.
JOURNAL OF OVARIAN RESEARCH
(2023)
Review
Endocrinology & Metabolism
Haigang Ding, Juan Zhang, Feng Zhang, Songou Zhang, Xiaozhen Chen, Wenqing Liang, Qiong Xie
Summary: Polycystic ovary syndrome has a wide range of negative impacts on women's health and is one of the most frequent reproductive systemic endocrine disorders. It is mainly caused by increased levels of androgen (hyperandrogenemia) and insulin resistance. Understanding the effects of these two factors on the pathophysiology of symptoms related to PCOS is crucial for further research and potential treatments.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Medicine, General & Internal
Mert Yesiladali, Melis G. K. Yazici, Erkut Attar, Fahrettin Kelestimur
Summary: Polycystic ovary syndrome (PCOS) is a common hyperandrogenic disorder in women, and it shares clinical features with adrenal-related androgen excess disorders. A thorough endocrinological investigation and testing are necessary to differentiate between PCOS and other hyperandrogenic disorders for a certain diagnosis.
Article
Plant Sciences
Meng-fan Peng, Shuo Tian, Ya-gang Song, Cai-xia Li, Ming-san Miao, Zhen Ren, Ming Li
Summary: This study aimed to investigate the mechanism of TFEL intervention in a rat model of PCOS-IR, finding that TFEL can inhibit ovarian hyperplasia, regulate disorders of glucose and lipid metabolism, and improve the secretion of sex hormones by regulating the expression of signaling pathway-related proteins in the ovary and HPO axis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Cell Biology
Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, Kun Yu
Summary: Female infertility is mainly caused by ovulation disorders, with polycystic ovary syndrome (PCOS) being the most prevalent. PCOS is associated with abnormal function of estrogen and estrogen receptors (ERs), affecting cellular activities. Selective estrogen receptor modulators (SERMs) like tamoxifen and clomiphene have shown clinical applications for subfertility with PCOS, but further understanding of the role of ER in PCOS is needed.
Article
Endocrinology & Metabolism
Chuan Xing, Han Zhao, Jiaqi Zhang, Bing He
Summary: The study aimed to observe the effects of MET monotherapy and MET plus LIRA combination therapy on gonadal and metabolic profiles in overweight patients with PCOS. The results showed that both MET monotherapy and MET plus LIRA combination therapy improved glucose metabolism and relieved insulin resistance in overweight patients with PCOS. Furthermore, MET plus LIRA combination therapy was more effective in improving reproductive abnormalities and hyperandrogenemia compared to MET monotherapy.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Xueqi Yan, Aiqing Zhu, Yexing Li, Ziyi Yang, Yuteng Wang, Li Liu, Wei Liu, Dan Liu, Fenghua Li, Juan Du, Fang Cheng, Xueying Gao, Junli Zhao
Summary: In recent years, the right 2D:4D digit ratio has been considered as a marker for prenatal testosterone exposure. There is an ongoing debate whether the ratio is reduced in the right hand of Polycystic Ovary Syndrome (PCOS) women compared to non-PCOS women. This study systematically measured various digit ratios and found significant differences, particularly in the left hand 2D ratios, suggesting that digit ratios can serve as anatomical markers of prenatal testosterone exposure and potentially of PCOS diagnosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Dong Liu, Yuexin Gan, Yue Zhang, Linlin Cui, Tao Tao, Jun Zhang, Jian Zhao
Summary: Previous studies have reported an association between lower birth weight and higher risk of polycystic ovary syndrome (PCOS), but the causal relationship is still unclear. This study conducted a Mendelian randomization analysis using a large-scale genome-wide association study to investigate the potential causal relationship between fetal genome predicted birth weight and PCOS risk. The results showed little evidence to support a causal effect of fetal genome determined birth weight on the risk of developing PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Sang Il Kim, Joo Hee Yoon, Dong Choon Park, Seung Ho Yang, Young Il Kim
Summary: This study investigated the prevalence of pituitary adenomas (PAs) in polycystic ovary syndrome (PCOS) patients, the cutoff prolactin (PRL) level to detect PAs, and the treatment strategy. The relationship between these diseases was assessed through a literature review.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Obstetrics & Gynecology
Monica Recabarren, Albert Carrasco, Daniel Sandoval, Felipe Diaz, Teresa Sir-Petermann, Sergio E. Recabarren
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2019)
Article
Endocrinology & Metabolism
Pedro P. Rojas-Garcia, Monica P. Recabarren, Luis Sarabia, Jennifer Schoen, Christoph Gabler, Ralf Einspanier, Manuel Maliqueo, Teresa Sir-Petermann, Rodolfo Rey, Sergio E. Recabarren
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2010)
Article
Endocrinology & Metabolism
Sergio E. Recabarren, Pedro P. Rojas-Garcia, Monica P. Recabarren, Victor H. Alfaro, Rosita Smith, Vasantha Padmanabhan, Teresa Sir-Petermann
Article
Endocrinology & Metabolism
Sergio E. Recabarren, Teresa Sir-Petermann, Rafael Rios, Manuel Maliqueo, Barbara Echiburu, Rosita Smith, Pedro Rojas-Garcia, Monica Recabarren, Rodolfo A. Rey
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2008)
Article
Multidisciplinary Sciences
Maria Seron-Ferre, Maria Luisa Forcelledo, Claudia Torres-Farfan, Francisco J. Valenzuela, Auristela Rojas, Marcela Vergara, Pedro P. Rojas-Garcia, Monica P. Recabarren, Guillermo J. Valenzuela
Article
Developmental Biology
Monica P. Recabarren, Pedro P. Rojas-Garcia, Ralf Einspanier, Vasantha Padmanabhan, Teresa Sir-Petermann, Sergio E. Recabarren
Article
Reproductive Biology
M. E. Silva, M. P. Recabarren, S. E. Recabarren, G. P. Adams, M. H. Ratto
Article
Multidisciplinary Sciences
Albert Carrasco, Monica P. Recabarren, Pedro P. Rojas-Garcia, Mario Gutierrez, Karina Morales, Teresa Sir-Petermann, Sergio E. Recabarren
SCIENTIFIC REPORTS
(2020)
Article
Public, Environmental & Occupational Health
Albert Carrasco, Monica P. Recabarren, Pedro P. Rojas-Garcia, Nelson Silva, Jonathan Fuenzalida, Teresa Sir-Petermann, Sergio E. Recabarren
Summary: Prenatal exposure to excess testosterone may affect pancreatic beta-cells insulin release in ovine males, with effects more evident in castrated males versus intact males.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2021)
Article
Agriculture, Dairy & Animal Science
S. E. Recabarren, M. Recabarren, D. Sandoval, A. Carrasco, V. Padmanabhan, R. Rey, H. G. Richter, C. C. Perez-Marin, T. Sir-Petermann, P. P. Rojas-Garcia
DOMESTIC ANIMAL ENDOCRINOLOGY
(2017)
Article
Endocrinology & Metabolism
Pedro P. Rojas-Garcia, Monica P. Recabarren, Teresa Sir-Petermann, Rodolfo Rey, Sergio Palma, Albert Carrasco, Carlos C. Perez-Marin, Vasantha Padmanabhan, Sergio E. Recabarren
Article
Neurosciences
JL Valdés, P Maldonado, M Recabarren, R Fuentes, F Torrealba
EUROPEAN JOURNAL OF NEUROSCIENCE
(2006)
Article
Behavioral Sciences
MM Meynard, JL Valdés, M Recabarren, M Serón-Ferré, F Torrealba
BEHAVIOURAL BRAIN RESEARCH
(2005)
Article
Veterinary Sciences
MP Recabarren, M Vergara, MC Martínez, K Gordon, M Serón-Ferré
JOURNAL OF MEDICAL PRIMATOLOGY
(2000)