Article
Biochemistry & Molecular Biology
Olayiwola O. Oduwole, Ariel Poliandri, Anthony Okolo, Phil Rawson, Milena Doroszko, Marcin Chrusciel, Nafis A. Rahman, Gilberto Serrano de Almeida, Charlotte L. Bevan, Wolfgang Koechling, Ilpo T. Huhtaniemi
Summary: The study suggests that FSH, rather than LH, may directly stimulate the growth of androgen-independent prostate cancer. Continuous suppression of FSH during GnRH antagonist treatment may offer a therapeutic advantage over agonist in inhibiting tumor growth.
Article
Endocrinology & Metabolism
Gillian P. Johnson, Caitlan G. A. Onabanjo, Kate Hardy, Viktor Y. Butnev, George R. Bousfield, Kim C. Jonas
Summary: The glycosylation variants of follicle-stimulating hormone (FSH) have differential effects on ovarian follicle growth and survival, with partially glycosylated FSH promoting follicle function and fully glycosylated FSH causing follicle damage and apoptosis.
Article
Endocrinology & Metabolism
Teresa Zarinan, Julio Mayorga, Eduardo Jardon-Valadez, Ruben Gutierrez-Sagal, Jose Luis Maravillas-Montero, Nancy R. Mejia-Dominguez, Ivan Martinez-Luis, Omar G. Yacini-Torres, Ma del-Carmen Cravioto, Eric Reiter, Alfredo Ulloa-Aguirre
Summary: A novel missense mutation (I423T) in the FSHR second transmembrane domain was identified in a woman with primary ovarian failure, leading to impaired receptor expression and signaling. Meanwhile, the D408Y mutation severely affected membrane expression and signal transduction. Molecular dynamics simulations showed important disruptions in both mutant FSHRs, explaining the differences in expression levels, signaling, and phenotypic expression between I423T and D408Y mutant FSHRs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Agriculture, Dairy & Animal Science
Victor E. Gomez-Leon, Adam D. Beard, O. J. Ginther, Milo C. Wiltbank
Summary: This study aimed to investigate the impact of low-dose hCG on multiple ovulations in lactating dairy cows. The results showed that increased hCG led to larger follicle sizes and higher FSH concentrations, resulting in an increased frequency of double ovulation.
JOURNAL OF DAIRY SCIENCE
(2022)
Review
Oncology
Chao Xu, Zhao He, Yongfeng Song, Shanshan Shao, Guang Yang, Jiajun Zhao
Summary: It has been traditionally believed that pituitary hormones act on their cognate receptors in classical target glands to carry out their various functions. However, recent studies have revealed that multiple types of pituitary hormone receptors are widely expressed in non-classical target organs. This article summarizes the additional biological functions of pituitary hormones (thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, adrenocorticotrophic hormone, and prolactin) when they act on non-classical organs, defining them as part of an atypical pituitary hormone-target tissue axis. This novel concept provides insight into the mechanisms behind metabolic diseases and offers potential novel therapeutic targets.
FRONTIERS OF MEDICINE
(2023)
Article
Biology
Vitaly Ryu, Anisa Gumerova, Funda Korkmaz, Seong Su Kang, Pavel Katsel, Sari Miyashita, Hasni Kannangara, Liam Cullen, Pokman Chan, TanChun Kuo, Ashley Padilla, Farhath Sultana, Soleil A. Wizman, Natan Kramskiy, Samir Zaidi, Se-Min Kim, Maria New, Clifford J. Rosen, Ki A. Goosens, Tal Frolinger, Vahram Haroutunian, Keqiang Ye, Daria Lizneva, Terry F. Davies, Tony Yuen, Mone Zaidi
Summary: There is increasing evidence that anterior pituitary hormones have multiple functions in regulating somatic tissues and brain receptors. A comprehensive neuroanatomical atlas on the expression of TSHR, LHCGR, and FSHR has been created using single-transcript detection technology. This atlas provides a vital resource for studying the impact of glycoprotein hormone receptors on somatic function and may uncover new pathways for human disease.
Article
Biochemistry & Molecular Biology
Yuichi Shima, Kanako Miyabayashi, Takami Mori, Koji Ono, Mizuki Kajimoto, Hae Lim Cho, Hitomi Tsuchida, Yoshihisa Uenoyama, Hiroko Tsukamura, Kentaro Suzuki, Man Ho Choi, Kazunori Toida
Summary: This study discovered that deletion of the pituitary enhancer located in the 6th intron of the Nr5a1 gene in mice leads to the disappearance of NR5A1 in the pituitary gland and severely affects the development of reproductive organs. Transcriptomic analysis further identified genes that are specifically dependent on NR5A1 expression in pituitary gonadotropes, which play important roles in reproductive organ development through regulation of pituitary gonadotrope functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Multidisciplinary Sciences
Teresa K. Woodruff
Summary: Identification of a novel pituitary protein could offer new therapeutic possibilities for regulating female fertility.
Article
Endocrinology & Metabolism
Uchechukwu T. Agwuegbo, Emily Colley, Anthony P. Albert, Viktor Y. Butnev, George R. Bousfield, Kim C. Jonas
Summary: Recent studies have shown that the hypo-glycosylated FSH glycoform FSH21/18 is more bioactive than the fully-glycosylated FSH24. FSH21/18 predominates in women of reproductive prime while FSH24 is more common in peri-post-menopausal women. Differential FSH glycosylation modulates FSHR oligomerization, with high concentrations of FSH21/18 and FSH24 leading to dissociation of FSHR oligomers into monomers, and low concentrations promoting FSHR association into oligomers.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Anissa Lambertino, Victoria Persky, Sally Freels, Henry Anderson, Terry Unterman, Saria Awadalla, Mary Turyk
Summary: The study aimed to evaluate the associations of POPs with hormone levels in postmenopausal women, finding that exposure to dioxin-like POPs was negatively associated with LH, but not with FSH. These negative associations were influenced by potential effect modifiers such as obesity and inflammation.
Article
Reproductive Biology
Hirofumi Ohga, Michiya Matsuyama
Summary: The chub mackerel LPXRFamide gene produces three mature peptides and does not have the ability to suppress gonadotropin secretion but may promote gonadotropin secretion.
BIOLOGY OF REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Amanda de Moraes Narcizo, Tiago Gabriel Correia, Adalto Bianchini, Mario Gustavo Mayer, Ricardo Andrade Zampieri, Lucile Maria Floeter-Winter, Renata Guimaraes Moreira
Summary: This study revealed that aluminum and acidic pH can influence the bioconcentration of aluminum in Oreochromis niloticus females, with aluminum potentially acting as an endocrine disruptor directly affecting ovarian steroidogenesis.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Xue Yu, Zan Li, Xinzhe Zhao, Liping Hua, Shuanghang Liu, Changjiu He, Liguo Yang, John S. Davis, Aixin Liang
Summary: This study found that anti-Mullerian hormone has no effect on oocyte maturation, but inhibits the maturation and expansion of cumulus oocyte complexes stimulated by follicle-stimulating hormone. These findings expand our understanding of the functional role of anti-Mullerian hormone in regulating folliculogenesis.
Review
Endocrinology & Metabolism
Xiaojun Kuang, Yongzhe Tang, Hong Xu, Min Ji, Dongmei Lai
Summary: This review assesses the effectiveness of various therapies in recovering ovarian function in patients with primary ovarian insufficiency (POI) and explores a comprehensive evaluation method. The results indicate a lack of scientific evidence supporting any therapy in effectively restoring ovarian function in patients with POI.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Jingyi Wen, Kecheng Huang, Xiaofang Du, Hanwang Zhang, Ting Ding, Cuilian Zhang, Wenmin Ma, Ying Zhong, Wenyu Qu, Yi Liu, Zhiying Li, Song Deng, Aiyue Luo, Yan Jin, Jinjin Zhang, Shixuan Wang
Summary: The study found that inhibin B levels rapidly decrease with age in healthy reproductive age women. Inhibin B is positively correlated with AMH, AFC, and other ovarian reserve markers, and has a slightly higher predictive value for AFC compared to FSH.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Editorial Material
Endocrinology & Metabolism
Rodolfo A. Rey
Article
Endocrinology & Metabolism
Angela K. Lucas-Herald, Jillian Bryce, Andreas Kyriakou, Marie Lindhardt Ljubicic, Wiebke Arlt, Laura Audi, Antonio Balsamo, Federico Baronio, Silvano Bertelloni, Markus Bettendorf, Antonia Brooke, Hedi L. Claahsen van der Grinten, Justin H. Davies, Gloria Hermann, Liat de Vries, Ieuan A. Hughes, Rieko Tadokoro-Cuccaro, Feyza Darendeliler, Sukran Poyrazoglu, Mona Ellaithi, Olcay Evliyaoglu, Simone Fica, Lavinia Nedelea, Aneta Gawlik, Evgenia Globa, Nataliya Zelinska, Tulay Guran, Ayla Guven, Sabine E. Hannema, Olaf Hiort, Paul-Martin Holterhus, Violeta Iotova, Vilhelm Mladenov, Vandana Jain, Rajni Sharma, Farida Jennane, Colin Johnston, Gil Guerra Junior, Daniel Konrad, Odile Gaisl, Nils Krone, Ruth Krone, Katherine Lachlan, Dejun Li, Corina Lichiardopol, Lidka Lisa, Renata Markosyan, Inas Mazen, Klaus Mohnike, Marek Niedziela, Anna Nordenstrom, Rodolfo Rey, Mars Skaeil, Lloyd J. W. Tack, Jeremy Tomlinson, Naomi Weintrob, Martine Cools, S. Faisal Ahmed
Summary: This study examined trends in clinical practice for individuals with DSD requiring gonadectomy and found that the likelihood of gonadectomy depends on the underlying diagnosis, sex of rearing, and geographical setting. Variations in the practice of gonadectomy were observed among different countries.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Review
Developmental Biology
Franco G. Brunello, Rodolfo A. Rey
Summary: Anti-mullerian hormone (AMH) is crucial for male fetal genital development, with its deficiency potentially leading to abnormalities. Defects in the AMH pathway, resulting in Persistent Mullerian Duct Syndrome, cause a rare condition where patients have male external genitalia but also internal female reproductive organs.
SEXUAL DEVELOPMENT
(2022)
Editorial Material
Endocrinology & Metabolism
Rodolfo A. Rey
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Lloyd J. W. Tack, Saskia van der Straaten, Stefan Riedl, Alexander Springer, Paul-Martin Holterhus, Nadine C. Hornig, Zofia Kolesinska, Marek Niedziela, Federico Baronio, Antonio Balsamo, Sabine E. Hannema, Anna Nordenstrom, Sukran Poyrazoglu, Fatma F. Darendeliler, Romina Grinspon, Rodolfo Rey, Fahad Aljuraibah, Jillian Bryce, Faisal Ahmed, Rieko Tadokoro-Cuccaro, Ieuan Hughes, Guilherme Guaragna-Filho, Andrea T. Maciel-Guerra, Gil Guerra-Junior, Martine Cools
Summary: The study found that almost one out of three SGA boys experience insufficient catch-up growth by the age of 2. Additionally, SGA boys had higher LH levels during minipuberty and lower testosterone levels in stimulation tests.
CLINICAL ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Romina P. Grinspon, Sebastian Castro, Rodolfo A. Rey
Summary: In this review, we present a practical and updated approach to clinical and hormonal laboratory workup for newborns, children, and adolescents with suspected DSD. We emphasize the importance of tailoring the diagnostic approach based on age and presentation.
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Review
Endocrinology & Metabolism
Rodolfo A. Rey
Summary: Clinical manifestations and treatment needs of hypogonadism in males vary according to age. Early onset hypogonadism may result in disorders of sex development, while hypogonadism established later in fetal life presents with micropenis, cryptorchidism, and/or micro-orchidism. Diagnosis of hypogonadism becomes challenging after neonatal activation of the gonadal axis diminishes. Treatment usually focuses on micropenis and/or cryptorchidism in infancy and childhood, and on lack of pubertal development and relative short stature in teenagers.
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2022)
Editorial Material
Endocrinology & Metabolism
Rodolfo A. Rey
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Pediatrics
Sebastian Castro, Franco G. Brunello, Gabriela Sanso, Paula Scaglia, Maria Esnaola Azcoiti, Agustin Izquierdo, Florencia Villegas, Ignacio Bergada, Maria Gabriela Ropelato, Marcelo A. Marti, Rodolfo A. Rey, Romina P. Grinspon
Summary: Pubertal delay in males can be caused by constitutional delay of growth and puberty or pathologic hypogonadism. Central (or hypogonadotropic) hypogonadism, resulting from a defective function of the GnRH/gonadotropin axis, is the main differential diagnosis after ruling out general illnesses and primary testicular failure. Ciliopathies arising from defects in non-motile cilia can cause developmental disorders affecting the sense organs and reproductive system.
FRONTIERS IN PEDIATRICS
(2022)
Review
Endocrinology & Metabolism
Nadia Y. Edelsztein, Clara Valeri, Maria M. Lovaisa, Helena F. Schteingart, Rodolfo A. Rey
Summary: Anti-Mullerian hormone (AMH) is a biomarker of immature Sertoli cells, which is regulated by specific transcription factors and plays a role in the regression of Mullerian ducts in males. AMH is highly expressed before puberty and then downregulated. FSH increases AMH output, while intratesticular levels of androgens and estrogens also regulate AMH secretion.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Rodolfo A. Rey
Summary: This review discusses the etiologies and specific pharmacological therapies for delayed puberty in males. There is limited high-quality evidence available for the best pharmacological therapy approach, with most current practice based on small case series or unpublished experience. Medical treatment is likely beneficial for male teenagers seeking attention for pubertal delay to prevent psychosocial distress. While watchful waiting is appropriate for boys aged 12-14 with suspected constitutional delay of growth and puberty, hormone replacement should not be delayed beyond the age of 14. Hormone replacement should be proposed by the age of 12 when hypogonadism is diagnosed. Testosterone replacement is the standard treatment, but aromatase inhibitors have emerged as an interesting alternative. Gonadotrophin therapy appears more physiological for patients with central hypogonadism, but its efficacy and timing still need further research.
EXPERT OPINION ON PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Nathalie di Clemente, Chrystele Racine, Rodolfo A. Rey
Summary: This article reviews the main findings on anti-Mullerian hormone (AMH) and its involvement in the pathogenesis of polycystic ovary syndrome (PCOS) and its male equivalent. AMH has important roles in ovarian reserve, follicular development, and the differentiation of the genital tract. It is also used to assess Sertoli cell function in children and has potential implications for male fertility.
Editorial Material
Endocrinology & Metabolism
Lourdes Correa Brito, Rodolfo A. Rey
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Health Care Sciences & Services
Lourdes Correa Brito, Romina P. Grinspon, Jimena Lopez Dacal, Paula Scaglia, Maria Esnaola Azcoiti, Agustin Izquierdo, Maria Gabriela Ropelato, Rodolfo A. Rey
Summary: This study reported a case of a patient with 46,XY disorders of sex development (DSDs) in whom a novel variant in MYRF gene was identified, leading to the detection of a clinically inapparent congenital heart defect.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Meeting Abstract
Endocrinology & Metabolism
Jimena C. Lopez Dacal, Silvina Prada, Marcela E. Gutierrez, Patricia Bedecarras, M. Gabriela Ropelato, Andrea Arcari, M. Gabriela Ballerini, Mirta Gryngarten, Marcela Soria, Lorena Moran, Cristina Ferraro, Analia Freire, Ignacio Bergada, Guillermo Drelichman, Luis Aversa, Rodolfo A. Rey, Romina P. Grinspon
HORMONE RESEARCH IN PAEDIATRICS
(2021)