Article
Polymer Science
Lauren E. E. Ball, Gabriela Garbonova, Rueben Pfukwa, Bert Klumperman
Summary: Responsive triblock copolymers were synthesized and studied for their potential use in drug delivery systems in biomedical research.
Article
Chemistry, Multidisciplinary
Dana Kamzabek, Brieuc Le De, Liliane Coche-Guerente, Fabien Miomandre, Galina Dubacheva
Summary: In this study, reversible fluorescence switching is achieved by coupling metal nanoparticles with fluorophores through stimuli-responsive organic linkers. This system presents a general strategy for designing nanointerfaces with reversible fluorescence switching capabilities.
Article
Chemistry, Multidisciplinary
Kamila Zygadlo, Chung-Hao Liu, Emmanuel Reynoso Bernardo, Huayue Ai, Mu-Ping Nieh, Lindsey A. Hanson
Summary: Stimuli-responsive microgels, composed of small beads with soft, deformable polymer networks, are a versatile platform for development of multifunctional and biocompatible sensors. This study uses the plasmonic response of a gold nanorod embedded in a thermoresponsive microgel to monitor structural changes in the hydrogel near the nanorod surface. The findings provide valuable insight for the design of plasmonic sensors based on stimuli-responsive hydrogels.
NANOSCALE ADVANCES
(2023)
Article
Polymer Science
Parvaneh Gheysoori, Azin Paydayesh, Maryam Jafari, Hamed Peidayesh
Summary: This study focuses on the development of thermoresponsive nanocomposite hydrogels for minimally invasive drug delivery. Gelatin-based hydrogels with poly (N-isopropylacrylamide) (PNIPAM) were prepared using response surface methodology. The PNIPAM nanoparticles showed successful polymerization and a reversible sol-gel transition close to body temperature. These nanocomposite hydrogels demonstrated antibacterial activity and good potential for targeted drug delivery.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Materials Science, Multidisciplinary
Mahsa Rezaiyan, Frances Yau, Darius A. Shariaty, Mark E. Thompson
Summary: It is found that the gel-sol transition of biocompatible thermoresponsive sealants (TRS) can be enhanced with the presence of high surface area foams. Polyurethane foam demonstrates the greatest increase in TRS recovery (10-fold) while not significantly affecting its viscosity and storage modulus. This work provides important guidance for other injectable in situ forming hydrogels with suitable mechanical strength but less ideal phase transition times.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
A. A. Amirov, D. M. Yusupov, E. K. Murliev, C. A. Gritsenko, A. M. Aliev, A. M. Tishin
Summary: The state of a thermoresponsive polymer can be controlled through the magnetocaloric effect in a magnetic field, as demonstrated in in situ experiments. Composites made of PNIPAM polymer coated with magnetocaloric Gd showed a reversible phase transition induced by switching on/off a magnetic field at -32 degrees C. This smart effect may be useful for the development of new smart materials for biomedical applications.
Article
Polymer Science
Joanna M. White, Adelyn A. Crabtree, Frank S. Bates, Michelle A. Calabrese
Summary: Poloxamers, ABA triblock polymers, have been extensively studied for biomedical applications. Reverse P407, a polymer with an inverted architecture, exhibits higher gelation and micellization temperatures compared to P407, and displays interesting rheological behavior. Blending P407 and RP407 alters the micelle size and packing, which could have implications for drug delivery and protein stabilization applications.
Article
Chemistry, Physical
Runmei Li, Cong Cheng, Zhuorui Wang, Xuefan Gu, Caixia Zhang, Chen Wang, Xinyue Liang, Daodao Hu
Summary: The temperature sensitive failure of PNIPAM anchored on the surface of AuNPs was verified in the experiment, with a proposed mechanism involving strong interactions among PNIPAM molecules on the surface of AuNPs. The temperature sensitivity of Au-PNIPAM/PNIPAM originates from free PNIPAM molecules rather than anchored PNIPAM, and changing electrostatic interaction can effectively regulate the aggregation behavior of AuNPs-PNIPAM.
Article
Chemistry, Physical
Franky Curry, Taehwan Lim, Nicholas S. Fontaine, Michael D. Adkins, Huanan Zhang
Summary: Highly conductive nanocomposite hydrogels with switchable electronic performance are successfully produced by introducing ultralong silver nanowires into a thermoresponsive, volume changing PNIPAM gel. With its interconnected microporous structure and high swellability, this nanocomposite exhibits high electrical conductivity and excellent elastic behavior, expanding the prospects for conductive hydrogel applications.
Article
Polymer Science
Batuhan Unver, Onder Pekcan, Gulsen Akin Evingur
Summary: The aim of this study was to investigate the effects of drying, swelling, elastic properties, and optical band gap energies on the performance of PNIPAm-MWCNTs and PNIPAm-GO composites. The composites were prepared through free radical crosslinking copolymerization. Drying and swelling were analyzed using steady state fluorescence technique, while elastic properties and optical band gap energies were calculated using various models and spectroscopy. The findings showed that the composites with different contents of MWCNTs and GO exhibited different desorption coefficients, diffusion coefficients, modulus, and band gap values.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Chemistry, Applied
Yong Ho Yeo, Kiramage Chathuranga, Jong Soo Lee, Jaseung Koo, Won Ho Park
Summary: Multifunctional and thermoresponsive hydrogels containing methylcellulose, tannic acid, and Fe3+ were prepared in this study with reversible thermogelation properties. The gelation rates and mechanical properties of the MC composite hydrogel were controlled by varying its TA and Fe3+ contents. The hydrogel with a TA-Fe chelating complex showed excellent photothermal effect and multifunctional properties.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Alexander Rajakanthan, Paul Wilson, Kristian Kempe
Summary: We successfully synthesized three methylamide acrylate monomers that have different spacer lengths between the polymerizable acrylate and pendant amide functionalities: methylamide ethyl acrylate (MAmEA), methylamide propyl acrylate (MAmPA), and methylamide butyl acrylate (MAmBA). Through redox-initiated reversible addition-fragmentation chain transfer (RRAFT), we polymerized these monomers to obtain well-defined homopolymers with varying physicochemical properties. The study demonstrated that P(MAmEA) and P(MAmPA) were soluble in aqueous solution within a certain temperature range, while P(MAmBA) exhibited lower critical solution temperature (LCST) behavior. Further investigation on P(MAmBA) showed that the cloud point temperature (T-cp) could be adjusted based on the degree of polymerization, concentration, and nature of the aqueous media, indicating its potential as a water-soluble thermoresponsive polymer for various applications.
Article
Polymer Science
Mengwei Jia, Jie Zhang
Summary: This study presents a sustainable method for preparing PEDOT:PSS/PNIPAM conductive hydrogels and investigates its characteristics in temperature response and wearable sensor applications.
Article
Chemistry, Multidisciplinary
Yiyi Liu, Tharaka Perera, Qianqian Shi, Zijun Yong, Sudaraka Mallawaarachchi, Bo Fan, Julia Ann-Therese Walker, Christopher J. Lupton, San H. Thang, Malin Premaratne, Wenlong Cheng
Summary: This study investigates the thermoresponsive chiral plasmonic responses of PNIPAM-modified gold nanorods. The modified nanorods exhibit red shifts and enhanced intensities of plasmonic circular dichroism (PCD) peaks at 50 degrees C, while the unmodified ones show no peak shifts and reduced intensities. The enhanced PCD is attributed to the collapse of PNIPAM chains, resulting in the expulsion of water molecules surrounding the chiral plasmonic nanorods and an increase in refractive index. These thermoresponsive chiral plasmonic responses are reversible, general, and applicable to other types of chiral plasmonic nanoparticles.
Article
Chemistry, Physical
Jingcong Xu, Volker Abetz
Summary: Graft copolymers with POEGMA backbones and PNIPAM side chains were synthesized using photoiniferter RAFT polymerization, showing unique temperature-dependent behaviors in aqueous solutions. The thermoresponsive properties were affected by the introduced end-groups, and post-polymerization modification further expanded the potential applications.
Article
Chemistry, Physical
E. Read, B. Lonetti, S. Gineste, A. T. Sutton, E. Di Cola, P. Castignolles, M. Gaborieau, A. -F. Mingotaud, M. Destarac, J. -D. Marty
Summary: The study focuses on investigating the structural changes of polyion complexes (PICs) composed of thermoresponsive polymers with temperature variations, and suggests that the polymer structure and PICs composition play a crucial role in the observed modifications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Chemistry, Physical
Fang Yin, Hong Hanh Nguyen, Olivier Coutelier, Mathias Destarac, Nancy Lauth-de Viguerie, Jean-Daniel Marty
Summary: By increasing the amount of N-vinylpyrrolidone (VP) in statistical copolymers, the properties of hybrid materials can be modulated, affecting both the growth of gold nanoparticles and the catalytic performance. The choice of an appropriate molar fraction of VP can enhance the transition temperature of the hybrid material, achieving the best compromise between hydration level and interaction strength for a chosen application.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Chemistry, Physical
Faniry Andriamiseza, Delphine Bordignon, Bruno Payre, Laurence Vaysse, Juliette Fitremann
Summary: It has been shown that low molecular weight gels based on N-heptyl-D-galactonamide hydrogels can be 3D printed by solvent exchange, but they tend to dissolve in the printing bath. This study explores the printing of less soluble N-alkyl-D-galactonamides with longer alkyl chains. The solubilization and stability of the gels, as well as their suitability for cell culture scaffolds, are investigated.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Izabela Kurowska, Baptiste Amouroux, Marvin Langlais, Olivier Coutelier, Christophe Coudret, Mathias Destarac, Jean-Daniel Marty
Summary: A new methodology for synthesizing phosphonic acid-terminated polymers was described, utilizing phosphonated thiolactones and amine-thiol-ene or amine-thiol-thiosulfonate conjugation strategies. These polymers were used to prepare stable, water-dispersible multifunctional upconverting luminescent nanohybrids.
Article
Chemistry, Multidisciplinary
Carmen C. Piras, Alasdair G. Kay, Paul G. Genever, Juliette Fitremann, David K. Smith
Summary: This study reports simple strategies to fabricate self-assembled artificial tubular and filamentous systems using a low molecular weight gelator (LMWG). The LMWG can be used in combination with a polymer gelator or alone to create stable gel structures with the ability to generate gold nanoparticles. The results show potential for tissue engineering applications.
Article
Chemistry, Physical
Clemence Nadal, Stephane Gineste, Olivier Coutelier, Audrey Tourrette, Jean-Daniel Marty, Mathias Destarac
Summary: Block copolymers based on poly(vinylamine) and poly(N-isopropylacrylamide) were synthesized and their thermoresponsive and aggregation behavior in aqueous solution were studied. The copolymers showed self-assembling properties at room temperature and tended to form larger aggregates upon heating.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Polymer Science
Clemence Nadal, Olivier Coutelier, Sandrine Cavalie, Valerie Flaud, Jeremy Soulie, Jean-Daniel Marty, Mathias Destarac, Audrey Tourrette
Summary: This study successfully synthesized hydrogel-based composite core/shell nanoparticles and modified their surface with thermoresponsive copolymers. The smart system showed promising prospects in controlled drug delivery.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Chemistry, Physical
Stephane Gineste, Barbara Lonetti, Marjorie Yon, Joanna Giermanska, Emanuela Di Cola, Michael Sztucki, Yannick Coppel, Anne-Francoise Mingotaud, Jean-Paul Chapel, Jean-Daniel Marty, Christophe Mingotaud
Summary: The addition of gallium ions to a polymer solution leads to the formation of highly monodisperse micelles with a rigid core structure formed by the co localization of the poly(acrylic acid) blocks and gallium ions. This study provides a comprehensive structural characterization of the Gallium Hybrid PolyIon Complexes (HPICs) and demonstrates their potential in the development of new contrast agents for medical imaging.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Polymer Science
Guillaume Palaprat, Anne-Francoise Mingotaud, Dominique Langevin, Monique Mauzac, Jean-Daniel Marty
Summary: The study investigated a cholesteric network with two levels of chirality in gas phase towards the sorption properties of two enantiomers of a chiral amine, finding that both levels of chirality improved separation, with the presence of chiral-specific molecular cavities having a greater effect than the chiral environment.
Review
Clinical Neurology
Sirine Hacene, Alice Le Friec, Franck Desmoulin, Lorenne Robert, Nina Colitti, Juliette Fitremann, Isabelle Loubinoux, Carla Cirillo
Summary: Cell therapy is a promising strategy in regenerative medicine, but the lack of valid cell sources is a limiting factor. The gastrointestinal tract, specifically the enteric nervous system (ENS), has been identified as a valuable source of nerve cells for therapy. Enteric glial cells, with their neurotrophic and neurogenic potential, have shown promise in treating intestinal neuropathies. Additionally, the ENS has therapeutic potential for brain repair, particularly in cases of stroke. The urgency for alternative treatments to rehabilitation in chronic stroke patients is evident. This review explores the pathophysiology of stroke and discusses current therapeutic strategies, with a focus on cell- and biomaterial-based approaches. The anatomical and functional characteristics of the ENS, particularly glial cells, are also presented, highlighting their neurotrophic and neurogenic properties. Preliminary data on a possible therapeutic approach combining ENS-derived cells and a biomaterial are discussed.
Article
Chemistry, Physical
Stephanie Sistach, Elodie Marinoni, Christophe Mingotaud, Nancy Lauth-de Viguerie, Jean-Daniel Marty
Summary: Bolaamphiphilic-type structures can substitute conventional surfactants for the interaction and stabilization of colloidal interfaces in water. Various families of Bolaamphiphiles were used as growth control and stabilizing agents for gold nanoparticles formation, where the nature of polar heads and length of hydrophobic chains play key roles in modulating the interactions with gold surfaces. Moreover, the interactions between hydrophobic chains also affect the growth mechanism, stabilization properties, and catalytic properties of the modified gold nanoparticles.
JOURNAL OF PHYSICAL CHEMISTRY C
(2022)
Article
Chemistry, Physical
Camille Courtine, Ines Hamouda, Samuel Pearson, Laurent Billon, Pierre Lavedan, Sonia Ladeira, Jean-Claude Micheau, Veronique Pimienta, Erwan Nicol, Nancy Lauth de Viguerie, Anne-Francoise Mingotaud
Summary: This study found that switchable assemblies relevant for bio-applications can be accessed from water-soluble tetra-ortho-substituted azobenzenes that reversibly self-assemble and form complexes with beta-cyclodextrin under visible light.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Emma N. Drew, Carmen C. Piras, Juliette Fitremann, David K. Smith
Summary: Two different low-molecular-weight gelators were 3D-printed as filaments by wet-spinning, and the hybrid gel filaments, which combined the individual properties of the two gelators in synergistic ways, created gel objects with new properties.
CHEMICAL COMMUNICATIONS
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Keziban Korkmaz Bayram, Juliette Fitremann, Arslan Bayram, Zeynep Yilmaz, Ecmel Mehmetbeyoglu, Yusuf Ozkul, Minoo Rassoulzadegan
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Chemistry, Multidisciplinary
Zhihua Zhao, Yinping Wang, Celine Delmas, Christophe Mingotaud, Jean-Daniel Marty, Myrtil L. Kahn
Summary: The control and understanding of the nucleation and growth of nano-objects are crucial for improving and exploring new applications of materials at the nanoscale. Analyzing the formation of anisotropic ZnO nanoparticles under different experimental conditions revealed a growth process by oriented attachment, allowing for easy tuning of the size and aspect ratio of the nanostructures. By using statistical tools, the relative importance of experimental parameters governing the growth of nano-objects was highlighted, providing valuable insights for further research in this field.
NANOSCALE ADVANCES
(2021)
