Article
Pathology
Brittni M. Foster, Kendall L. Langsten, Ammar Mansour, Lihong Shi, Bethany A. Kerr
Summary: Stem cell factor (SCF) plays a crucial role in development, with continued expression in many cell types and tissues in adult humans and mice. High SCF expression in certain organs may be linked to an increased risk of SCF/CD117-related diseases.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Pathology
Lulu Rong, Hongying Zhao, Yunlong Li, Mulan Jin, Jun Lu
Summary: In recent years, immunotherapy has benefitted patients with PD-L1-positive oesophageal squamous cell carcinoma (OSCC). However, improving the treatment efficacy for PD-L1-positive patients remains an issue. The relationship between PD-L1 and HER2 expression in OSCC is still unclear, although studies on this have been reported in other cancers.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Microbiology
Wenqing Rao, Zheng Lin, Shuang Liu, Zhihui Zhang, Qianwen Xie, Huilin Chen, Xi Lin, Yuanmei Chen, Huimin Yang, Kaili Yu, Zhijian Hu
Summary: Alcohol consumption is associated with alterations in both the diversity and composition of the oesophageal microbiota in ESCC patients. Specific bacteria related to alcohol consumption in ESCC patients were identified, with differences observed in the diversity and abundance of microbiota. The relative abundance of certain bacterial genera was found to be affected by the frequency and years of alcohol consumption in ESCC patients.
Article
Cell Biology
Xueke Shi, Jingjing Luo, Kelsey J. Weigel, Spencer C. Hall, Danfeng Du, Fanglong Wu, Michael C. Rudolph, Hongmei Zhou, Christian D. Young, Xiao-Jing Wang
Summary: The study demonstrates that TGF beta-enriched CAFs play a critical role in promoting SCC lung metastasis by facilitating tumor cell seeding and growth in the lung. Experimental results show that CAFs enhance tumor volume, inhibit apoptosis, and stimulate cell proliferation and angiogenesis in the lung. The findings suggest that CAFs could serve as a prognostic marker and therapeutic target for SCC lung metastasis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Chanchan Hu, Zheng Lin, Zhiqiang Liu, Xuwei Tang, Jianyu Song, Jianbo Lin, Yuanmei Chen, Zhijian Hu
Summary: This study investigates the associations between dietary fatty acid intake patterns and the risk of oesophageal squamous cell carcinoma (ESCC). It found that the intake of even-chain unsaturated fatty acids (EC-UFA) and n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) were associated with a decreased risk of ESCC, while other fatty acid patterns showed no association. The results suggest that modifying dietary intake of EC-UFA and n-3 LC-PUFA may be a potential intervention for preventing ESCC.
Article
Pathology
Kochli Channappa Niranjan, Monica Raj, Kaveri Hallikeri
Summary: Tumor budding and CD44 expression are of prognostic significance in OSCC.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Brittni M. Foster, Lihong Shi, Koran S. Harris, Chirayu Patel, Victoria E. Surratt, Kendall L. Langsten, Bethany A. Kerr
Summary: Skeletal metastasis is a major cause of morbidity and mortality in prostate cancer, and stem cell factor (SCF) plays an important role in this process. Platelet-derived SCF is necessary for primary tumor growth, while osteoblast-derived SCF has no effect on tumor size. The effects of SCF are determined by its source and the genetic profile of prostate cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pathology
Guorui Sun, Yanru Yang, Jin Liu, Zizhao Gao, Tianqi Xu, Jia Chai, Junpeng Xu, Zhenge Fan, Tian Xiao, Qingge Jia, Mingyang Li
Summary: This review discusses the importance of cancer stem cells (CSCs) in the diagnosis and treatment of esophageal squamous cell carcinoma (ESCC). It outlines the known methods for isolation and verification of CSCs, as well as the significance of CSCs' biomarkers and signaling pathways.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Oncology
Chengqiang Li, Shengguang Zhao, Yuyan Zheng, Yichao Han, Xiaoyan Chen, Zenghui Cheng, Yuquan Wu, Xijia Feng, Weixiang Qi, Kai Chen, Jie Xiang, Jian Li, Toni Lerut, Hecheng Li
Summary: This study investigated the safety and efficacy of preoperative pembrolizumab combined with chemoradiotherapy in resectable oesophageal squamous cell carcinoma patients. The results showed that this treatment was safe and induced a pathological complete response in 55.6% of the tumors.
EUROPEAN JOURNAL OF CANCER
(2021)
Article
Gastroenterology & Hepatology
Wen Wang, Dazhou Li, Linfu Zheng, Hongli Zhan
Summary: This case report describes a rare case of esophageal squamous cell carcinoma presenting as a submucosal tumour. It highlights the importance for clinicians to be alert to the possibility of malignancy in esophageal submucosal tumours with smooth overlying mucosa.
BMC GASTROENTEROLOGY
(2021)
Article
Anatomy & Morphology
Ozlem Ucer, Nevin Kocaman
Summary: In this study, the researchers found that Suprabasin protein is increased in expression in squamous cell carcinoma (SCC) and decreases with increasing grade. They also observed no expression of Suprabasin in basal cell carcinoma (BCC). Therefore, Suprabasin can be used as a biomarker to differentiate SCC from BCC.
Article
Oncology
Kang Tang, Takeshi Toyozumi, Kentaro Murakami, Haruhito Sakata, Masayuki Kano, Satoshi Endo, Yasunori Matsumoto, Hiroshi Suito, Masahiko Takahashi, Nobufumi Sekino, Ryota Otsuka, Kazuya Kinoshita, Soichiro Hirasawa, Jie Hu, Masaya Uesato, Koichi Hayano, Hisahiro Matsubara
Summary: This study elucidates the significance of the crosstalk between HIF-1α and the Wnt/β-catenin pathway in ESCC. HIF-1α serves as an oncogenic transcription factor by directly targeting TCF4/TCF7L2 and activating the Wnt/β-catenin pathway, promoting the development of ESCC.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Hannah Simba, Diana Menya, Blandina T. T. Mmbaga, Charles Dzamalala, Peter Finch, Yohannie Mlombe, Alex Mremi, Clement T. T. Narh, Joachim Schuz, Valerie McCormack
Summary: Tobacco use, including smoking and smokeless tobacco, is associated with an increased risk of esophageal squamous cell carcinoma (ESCC) in Tanzania, Malawi, and Kenya. The study highlights the importance of tobacco control and cessation in reducing the burden of ESCC in these countries.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Diana Marzic, Blazen Marijic, Tamara Braut, Stefan Janik, Manuela Avirovic, Ita Hadzisejdic, Filip Tudor, Katarina Radobuljac, Miran Coklo, Boban M. Erovic
Summary: IMP3 expression is higher in malignant laryngeal lesions compared to dysplasia and benign lesions, serving as a useful marker to differentiate between invasive and noninvasive lesions. Higher IMP3 expression is associated with worse clinical outcomes in patients with squamous cell carcinoma of the larynx.
Article
Pathology
Zhikai Chi, Jyoti Balani, Purva Gopal, Suntrea Hammer, Jing Xu, Lan Peng
Summary: This study is the first to investigate the incidence of GATA3 positivity in oesophageal squamous cell carcinoma (SCC) and demonstrates that GATA3 positivity is associated with poor prognosis in oesophageal SCC.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Oncology
Wenting Song, Zhan Chen, Cunzhen Shi, Yuyang Gao, Xiaoyan Feng, Hongwen Li, Zhaoming Li, Mingzhi Zhang
Summary: This study provides evidence that the combination of histone deacetylases (HDACs) inhibitor chidamide and DNA-damaging agent etoposide exerts a synergistic anticancer effect in natural killer/T cell lymphoma (NKTCL), possibly through increased histone acetylation, cell cycle arrest, and loss of mitochondrial membrane potential.
HEMATOLOGICAL ONCOLOGY
(2023)
Article
Plant Sciences
Li-Jun Huang, Xin-Ai Li, Meng-Ying Jin, Wen-Xiu Guo, Li-Rong Lei, Ran Liu, Ming-Zhi Zhang, Da-Le Guo, Dong Wang, Yan Zhou, Yun Deng, Jian-Guang Zhang
Summary: Amestolkins A and B, two previously undescribed phthalides, were isolated from Talaromyces amestolkiae. They exhibited anti-neuroinflammatory activity by inhibiting the gene expressions of proinflammatory factors and attenuating the excretion of inducible nitric oxide synthase in BV-2 microglial cells.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Oncology
Yuankai Shi, Qingyuan Zhang, Xiaonan Hong, Zhen Wang, Yuhuan Gao, Liqun Zou, Hong Cen, Lin Gui, Yufu Li, Jifeng Feng, Zhao Wang, Mingzhi Zhang, Chuan Jin, Weihua Zhang, Jianda Hu, Chengyun Zheng, Zhendong Zheng, Liling Zhang, Shaoshui Chen, Yunhong Huang, Yun Tang, Yajie Gao, Miaowang Hao, Xiaoling Li, Chunkang Chang, Haiyan Yang, Hui Wu, Lida Shen, Xiaoyan Ke, Liangming Zhang, Yaming Xi, Linhua Yang, Liangzhi Xie, Wenlin Gai, Yanan Ji
Summary: This study compared the efficacy, safety and immunogenicity of ripertamab and rituximab combined with CHOP as the first-line treatment for Chinese patients with CD20-positive DLBCL. The results showed that S-CHOP was not inferior to R-CHOP in terms of treatment outcomes, making it a viable alternative first-line standard treatment regimen for this patient population.
HEMATOLOGICAL ONCOLOGY
(2022)
Article
Chemistry, Organic
Yao Shi, Tongyan Yu, Longxiao Chi, Wei Shen, Jiangyan Xu, Mingzhi Zhang, Siliang You, Chao Deng
Summary: This study successfully developed an efficient method for the synthesis of sulfur-substituted 4-enyl-2-pyrrolidones through catalytic radical cascade cyclization, achieving green synthesis of 4-enyl-2-pyrrolidones with a broad substrate scope and high selectivity.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Oncology
Qing Wen, Jingjing Ge, Yaxin Lei, Yue Zhang, Xiaoshuang Kong, Wenhua Wang, Huting Hou, Zeyuan Wang, Siyu Qian, Mengjie Ding, Meng Dong, Linan Zhu, Mingzhi Zhang, Xudong Zhang, Qingjiang Chen
Summary: ABVD is superior to ABVD-like regimens in achieving PFS in young patients or patients with poor prognosis including high IPS score and beta 2-MG level. ABVD-like regimens are as effective as ABVD in elderly or low-risk patients including low IPS score and beta 2-MG level; elderly patients treated with bleomycin-free regimens exhibit a better survival trend compared with ABVD.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Chunyan Li, Linlin Zhang, Xiaohua Hu, Guohong Jin, Huiran Dong, Yu Su, Wenhua Ren, Mingzhi Zhang, Jun Wu
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Letter
Gastroenterology & Hepatology
Zhuangzhuang Shi, Guoru Hu, Min W. Li, Lei Zhang, Xin Li, Ling Li, Xinhua Wang, Xiaorui Fu, Zhenchang Sun, Xudong Zhang, Li Tian, Zhaoming Li, Wei-Hua Chen, Mingzhi Zhang
Article
Chemistry, Medicinal
Jing-Rui Liu, Ya Gao, Bing Jin, Dale Guo, Fang Deng, Qiang Bian, Hai-Feng Zhang, Xin-Ya Han, Abdallah S. Ali, Ming-Zhi Zhang, Wei-Hua Zhang, Yu-Cheng Gu
Summary: Based on natural products streptochlorin and pimprinine, a series of streptochlorin derivatives with nitrile group were synthesized. The most promising candidate, compound 3a, demonstrated over 85% growth inhibition against several fungi and displayed a broad antifungal spectrum. Structure-activity relationship analysis revealed that non-substituted or alkyl-substituted oxazole ring at the 2-position favored antifungal activity, while aryl and monosubstituted aryl were detrimental. Molecular docking models indicated that 3a formed interactions with Leucyl-tRNA Synthetase, providing insight into its mechanism of action.
Article
Agriculture, Multidisciplinary
Dai-Chuan Huang, Zhuo He, Dale Guo, Fang Deng, Qiang Bian, Haifeng Zhang, Abdallah S. Ali, Ming-Zhi Zhang, Wei-Hua Zhang, Yu-Cheng Gu
Summary: Streptochlorin, an indole alkaloid derived from marine microorganisms, showed potent bioactivity against phytopathogenic fungi. A series of benzoxaborole-containing streptochlorin derivatives were synthesized and exhibited significant antifungal activities, especially compounds 4i and 5f, which showed impressive effects against Gibberella zeae and Rhizoctorzia solani.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Analytical
Xin-Ai Li, Si-Ning Li, Yu Jiang, Zhen-Xing Zheng, Wen-Xiu Guo, Ran Liu, Guang-Zhi Wang, Xu Zhang, Qiang Bian, Ming-Zhi Zhang, Yu-Cheng Gu, Sheng Yin, Da-Le Guo, Yun Deng
Summary: The Panxi area in Sichuan Province is the main production area for truffles in China, with several species existing in this region. However, the differences in chemical composition between these truffle species are unclear. This study used advanced technology to analyze the chemical components of three truffles from Panxi, and identified similarities and differences in their composition. The findings can be used for quality control and differentiation of truffles from Panxi.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Agronomy
Lan Cheng, Jing-Rui Liu, Jia-Mu Liu, Dale Guo, Fang Deng, Qiang Bian, Haifeng Zhang, Xinya Han, Abdallah S. Ali, Wei-Hua Zhang, Ming-Zhi Zhang, Yu-Cheng Gu
Summary: In this study, we developed and synthesized ring-opening derivatives of pimprinine containing amide/thioamide, and evaluated their antifungal activity against six common plant pathogenic fungi. Our results showed that compound 3o exhibited pronounced antifungal effects, with high inhibition rates and low effective concentrations. Furthermore, docking studies revealed the potential antifungal mechanism of compound 3o. Overall, the optimized derivative 3o of ring-opening pimprinine is a promising candidate for further research as a new antifungal drug.
PEST MANAGEMENT SCIENCE
(2023)
Review
Immunology
Zhuangzhuang Shi, Hongwen Li, Wenting Song, Zhiyuan Zhou, Zhaoming Li, Mingzhi Zhang
Summary: The gut microbiota, residing in the intestinal epithelial barrier, plays a profound role in maintaining physiological functions, particularly immune modulation. The configuration of microbial communities differs significantly between cancer patients and healthy individuals. The plasticity of gut microbiota offers opportunities for individualized cancer treatment, as it interacts closely with various cancer immunotherapy protocols. Microbiota-based prognostic prediction and microbiotherapy targeting the gut microbiota can enhance anticancer efficacy while reducing toxicity, contributing to personalized cancer treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Linan Chen, Jun Jiang, Jialing Yao, Ying Lu, Xiaolong Zhang, Mingzhi Zhang, Qiu Zhang, Hao Peng
Summary: This study investigated the association between methylation levels of the CORIN gene promoter and the risk of stroke. The results showed that lower methylation levels were associated with stroke patients and predicted a higher risk of incident stroke in Chinese adults.
FRONTIERS IN NEUROLOGY
(2023)
Review
Chemistry, Multidisciplinary
Mingzhi Zhang, Yang Sun
Summary: Information on the temporal and spatial scale of cellular molecules in biological systems is crucial, but often difficult to obtain. DNA-based functional modules provide an opportunity to monitor a range of information and have been designed to gather different information about molecules. This paper summarizes the available designs and applications of these modules and discusses current challenges and prospects in biomolecular signal sensing and transformation.
FRONTIERS IN CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Xu Yang, Mingzhi Zhang, Yuqing Zhang, Hongcheng Wei, Quanquan Guan, Chao Dong, Siting Deng, Hein Min Tun, Yankai Xia
Summary: This study investigates the dynamic changes of the gut microbiome during pregnancy and its association with dyslipidemia in pregnant women. The results show that specific genera, including Bacteroides and Alistipes, are negatively associated with lipid profiles and dyslipidemia. Metagenomic analysis reveals the involvement of these genera in inflammatory pathways related to dyslipidemia. Combining gut microbiota and blood biochemical data can predict the risk of dyslipidemia in late pregnancy, suggesting a potential noninvasive diagnostic and therapeutic strategy for preventing dyslipidemia in pregnancy.
NPJ BIOFILMS AND MICROBIOMES
(2023)