Article
Biochemistry & Molecular Biology
Xueshan Huang, Jingyi Tan, Mei Chen, Weirang Zheng, Shanyang Zou, Xiaoxia Ye, Yutong Li, Minhua Wu
Summary: This study investigated the potential role of MTA2 and found that it is highly expressed in many cancers and associated with prognosis in different cancer types. It also showed that MTA2 is associated with tumor mutation burden and microsatellite instability in certain cancers. The study further revealed the correlation between MTA2 expression and immune cell infiltration in hepatocellular carcinoma, and identified a potential therapeutic drug, MK-886, for HCC. Overall, MTA2 is demonstrated to play critical roles in tumor progression and immunity, and could serve as a prognostic marker for various malignancies. The study is rated 8 out of 10 for its importance.
Article
Multidisciplinary Sciences
Caroline Ngetsa, Victor Osoti, Dorcas Okanda, Faith Marura, Krupali Shah, Henry Karanja, Daisy Mugo, John Gitonga, Martin Mutunga, Clement Lewa, Benedict Orindi, Philip Bejon, Lynette Isabella Ochola-Oyier
Summary: Normal saline, PBS, and REVITAL Viral Transport Media can be used for COVID-19 sample collection and testing, expanding the range of SARS-CoV-2 viral collection media.
Article
Pathology
Maria Cristina Pacheco, Michael S. Torbenson, Tsung-Teh Wu, Sanjay Kakar, Dhanpat Jain, Matthew M. Yeh
Summary: Hepatocellular adenomas are rare in children, and often associated with syndromes, especially in prepubescent patients. A greater percentage of adenomas in patients with syndromes were beta-catenin activated. In patients without known syndromes, the distribution of hepatocellular adenoma subtypes appears similar to adults.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Chemistry, Analytical
Chenyan Hu, Linlin Zhang, Zhongzhu Yang, Zhen Song, Qin Zhang, Yang He
Summary: The GO-based qRT-PCR assay shows promising results in improving sensitivity and specificity, distinguishing ovarian cancer from benign ovarian tumors, and can be considered as a potential method for the detection of miRNAs.
ANALYTICA CHIMICA ACTA
(2021)
Article
Plant Sciences
Jiajia Shen, Xiaohui Wang, Yuying Li, Lili Guo, Xiaogai Hou
Summary: This study aimed to screen the optimal reference miRNA in different tree peony varieties by evaluating the stability of 16 candidate reference miRNAs. The results provide a reference miRNA for studying expression changes of miRNA in different tree peony varieties and exploring the regulatory mechanism of miRNA in different peony varieties.
Article
Gastroenterology & Hepatology
Belle V. van Rosmalen, Alicia Furumaya, Anne J. Klompenhouwer, Maarten E. Tushuizen, Andries E. Braat, Roy J. Reinten, Marjolein A. P. Ligthart, Martijn P. D. Haring, Vincent E. de Meijer, Theo van Voorthuizen, R. Bart Takkenberg, Cornelis H. C. Dejong, Robert A. de Man, Jan N. M. IJzermans, Michail Doukas, Thomas M. van Gulik, Joanne Verheij
Summary: This nationwide retrospective cohort study of male patients with hepatocellular adenomas (HCA) found that expert revision and NGS testing played a crucial role in distinguishing between HCA and well-differentiated HCC in males, highlighting the importance of accurate diagnosis and prognosis in this rare condition.
LIVER INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Martijn P. D. Haring, Fabian Peeks, Maaike H. Oosterveer, Martijn C. G. J. Brouwers, Carla E. M. Hollak, Mirian C. H. Janssen, Janneke G. Langendonk, Alexander J. M. Rennings, Margreet A. E. M. Wagenmakers, Henkjan J. Verkade, Terry G. J. Derks, Vincent E. de Meijer
Summary: This study found that high serum triglyceride concentrations during childhood in patients with glycogen storage disease type Ia (GSDIa) were associated with an increased risk of hepatocellular adenoma (HCA) and earlier onset of HCA development, independent of sex-associated hypertriglyceridemia and G6PC1 genotype.
Article
Pharmacology & Pharmacy
A. A. El Leithy, A. A. Al-Karmalawy, O. M. Youssif, Y. A. Ebrahim, A. S. Khalifa, E. B. Elkaeed, F. S. Abo-Zeid
Summary: This study investigated the role of Spirulina (SP) in polycystic ovarian syndrome (PCOS). The results showed that SP had a significant effect on inhibiting the development of PCOS by regulating the expression of genes associated with PCOS. Therefore, SP may be a promising therapeutic drug for treating PCOS.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Matheus Vernet Machado Bressan Wilke, Bibiana Mello de Oliveira, Rodrigo Tzovenos Starosta, Marwan Shinawi, Liang Lu, Mai He, Yamin Ma, Janis Stoll, Carolina Fischinger Moura de Souza, Ana Cecilia Menezes de Siqueira, Sandra Maria Goncalves Vieira, Carlos Thadeu Cerski, Lilia Farret Refosco, Ida Vanessa Doederlein Schwartz
Summary: This study describes five cases of patients with GSD IV, with different ages of onset and outcomes, and identifies a novel GBE1 variant. The research findings indicate that GSD IV has different ages of onset and diverse cardiac phenotypes, and is associated with high levels of chitotriosidase. Dietary intervention did not show clear improvement in these cases.
Article
Agronomy
Ranran Xu, Yubei Wang, Zhilei Zhao, Guiqin Qu, Jiankang Cao
Summary: An integrative analysis of metabolomics and transcriptomics revealed the mechanism of flesh bleeding in plums during cold storage. Cyanidin derivatives were identified as the main components in red flesh, and some genes were associated with flesh bleeding. Additionally, the MAPK cascade signal system and ethylene signal transduction pathway played a role in the mechanism of flesh bleeding.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Abhirami Venugopal, Agnes Michalczyk, Mustafa Khasraw, M. Leigh Ackland
Summary: Neuroendocrine neoplasms (NENs) are relatively rare tumors that occur primarily in the gastrointestinal tract and pancreas. The heterogeneity of these tumors presents challenges for diagnosis and treatment. This study identified differential expression of epithelial-mesenchymal transition (EMT) molecules in different tumor grades, suggesting their potential use in tumor stratification, prognosis, and therapeutic targeting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pathology
Christine Sempoux, Annette S. H. Gouw, Vincent Dunet, Valerie Paradis, Charles Balabaud, Paulette Bioulac-Sage
Summary: This study demonstrates that different CTNNB1 mutations in hepatocellular adenoma lead to variable patterns of glutamine synthetase expression, which can predict the risk of malignant transformation. The identified GS patterns show sensitivity in predicting CTNNB1 mutations, particularly in exon 3 S45 mutations.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Substance Abuse
James W. Bogenpohl, Rory M. Weston, Taylor N. Foreman, Kaitlyn E. Kitchen, Michael F. Miles
Summary: Through immunohistochemical and stereological techniques, we found that CLIC4 protein is robustly expressed by oligodendrocytes (most abundant), microglia, and astrocytes, with minimal expression in neurons. Following acute EtOH exposure, we observed a rapid increase in Clic4 mRNA expression in female but not male mice, and an overall increase in the number of oligodendrocytes and astrocytes expressing the CLIC4 protein. These findings suggest that Clic4 functions as an early response gene for acute EtOH in brain, which likely underlies its ability to modulate EtOH behavior.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Abdourazak Alio Moussa, Ajmal Mandozai, Yukun Jin, Jing Qu, Qi Zhang, He Zhao, Gulaqa Anwari, Mohamed Abdelsamiaa Sayed Khalifa, Abraham Lamboro, Muhammad Noman, Yacoubou Bakasso, Mo Zhang, Shuyan Guan, Piwu Wang
Summary: This study identified QTLs and SNPs associated with root traits in maize, revealing the genetic mechanism of root development and providing a key reference for breeding high-yielding maize varieties with propitious root systems.
Article
Oncology
Natalia Mitiushkina, Alexandr A. Romanko, Elena Preobrazhenskaya, Vladislav Tiurin, Tatiana Ermachenkova, Alexandr S. Martianov, Rimma S. Mulkidjan, Tatiana N. Sokolova, Maksim M. Kholmatov, Ilya Bizin, Alexandr O. Ivantsov, Olga S. Yatsuk, Olga A. Zaitseva, Aglaya G. Iyevleva, Ekatherina Sh Kuligina, Evgeny N. Imyanitov
Summary: The study analyzed ALK/ROS1 fusions and 5'-/3'-end unbalanced expression in NSCLC samples. It demonstrated that variant-specific PCR tests can detect common ALK and ROS1 rearrangements, with additional rare ALK fusions identified by PCR or NGS. While unbalanced gene expression can comprehensively analyze ALK, it is more complicated for the detection of ROS1 fusions, suggesting that variant-specific PCR assays are preferable for ROS1 testing.