Article
Multidisciplinary Sciences
Yi-Fan Jiang, Pin-Huan Yu, Yovita Permata Budi, Chih-Hsien Chiu, Chi-Yu Fu
Summary: This study investigated the dynamics of mitochondria in mammalian ovaries during folliculogenesis and luteal formation. The results showed that mitochondrial networks shifted from branched structures in follicles to spherical and tubular mitochondria in large luteal cells. Additionally, mitochondrial diameter and volume increased from folliculogenesis to luteal formation, indicating mitochondrial enlargement as an event during these processes. Modulation of mitochondrial morphology and respiratory enzyme expressions may be related to tissue remodeling during luteal formation.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Dainan Yu, Xun Jiang, Wenjing Ge, Bo Qiao, Dalei Zhang, Hui Liu, Haibin Kuang
Summary: This study found that acrylamide exposure during early- and mid-pregnancy had negative effects on luteal function, including decreased levels of serum progesterone and estradiol, reduced numbers and relative areas of ovarian corpora lutea, dysregulation of ovarian angiogenesis, increased oxidative stress, and induced apoptosis of ovarian cells.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Agriculture, Dairy & Animal Science
Dody Houston Billhaq, Seunghyung Lee
Summary: This review discusses the role of the RAS protein in the formation and regression of the corpus luteum in the ovary, highlighting its regulation of cell survival, proliferation, and differentiation through various signaling pathways. The complex molecular events in the ovarian microenvironment, such as angiogenesis and apoptosis, are also emphasized. Further research is needed to better understand how the RAS family impacts the biological events of the corpus luteum in the ovary.
Review
Agriculture, Dairy & Animal Science
J. L. Pate, C. H. K. Hughes
Summary: The corpus luteum plays a critical role in pregnancy in all mammals. However, the fate of the corpus luteum in ruminants depends on the presence of a functional uterus or signals from a developing embryo. Prostaglandin F2alpha, secreted by the uterus, is a key molecule that needs to be modified. The sensitivity of the corpus luteum to prostaglandin F2alpha can be influenced by internal mechanisms. Understanding the molecular changes that occur during different stages of luteal development and pregnancy can provide insight into the regulation of luteolytic capacity in ruminants.
Article
Agriculture, Dairy & Animal Science
Sang-Hee Lee, Seunghyung Lee
Summary: The study found that PGF2 alpha affects cell adhesion in bovine luteal theca cells by disrupting cytokeratin, vimentin, and desmoplakin proteins, as well as increasing ROCK protein levels, leading to decreased cell-cell adhesion during corpus luteum regression.
Article
Obstetrics & Gynecology
Krutika Patil, Indira Hinduja, Srabani Mukherjee
Summary: In women with PCOS, both follicular fluid (FF) and granulosa-lutein cells (GLCs) exhibit reduced expression of pro-angiogenic factors compared to controls, leading to diminished capacity to induce angiogenesis and potentially contributing to corpus luteum (CL) defects.
HUMAN REPRODUCTION
(2021)
Article
Reproductive Biology
Mahesh Gupta, Jayant P. Korde, K. B. Bahiram, V. M. Sardar, Nitin V. Kurkure
Summary: This study investigated the expression of apelin and its receptor APJ in ovarian follicles and corpora lutea, as well as the effects of apelin on steroidogenesis and cell survival. The results showed that apelin and APJ were expressed in granulosa and theca cells of follicles, as well as small and large luteal cells of corpora lutea. Furthermore, apelin was found to stimulate the production of estrogen and progesterone, and promote the survival of granulosa cells and luteal cells.
Review
Agriculture, Dairy & Animal Science
Jamie M. Studer, Wesley P. Schweer, Nicholas K. Gabler, Jason W. Ross
Summary: Manganese, a widely distributed element, is essential for various metabolic functions in mammals, including skeletal development, energy metabolism, enzyme activation, nervous system function, immune system function, and reproductive hormone function. It acts as a cofactor for enzymes involved in cholesterol synthesis and can affect reproduction through actions at the hypothalamus.
ANIMAL REPRODUCTION SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Granit Thaqi, Bajram Berisha, Michael W. Pfaffl
Summary: Adipokines play a crucial role in various biological processes, and their expression levels show significant differences during the estrous cycle and pregnancy in cows. This study aimed to investigate the local production of adipokines and their receptors in the bovine corpus luteum and their potential involvement in ovarian physiology. The findings suggest that adipokines are expressed and regulated differently during different phases of the cycle and during pregnancy, indicating their importance in corpus luteum function.
Article
Agriculture, Dairy & Animal Science
Bartlomiej Maria Jaskowski, Hartwig Bostedt, Marek Gehrke, Jedrzej Maria Jaskowski
Summary: The study shows that recipients with a cavitary corpus luteum have higher progesterone levels and pregnancy rates during embryo transfer. Therefore, the presence of a cavity inside the corpus luteum should not be a reason to exclude recipients from embryo transfer.
Review
Physiology
Corrine F. Monaco, John S. Davis
Summary: The corpus luteum is a transient endocrine gland in the ovary that produces progesterone for pregnancy. The formation and function of this gland rely on angiogenesis, which establishes the necessary blood flow and microvasculature. During regression, the corpus luteum undergoes structural changes and the blood vessels regress, impacting progesterone production. Factors released during luteolysis play a role in these processes, but the exact mechanisms remain unknown.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Maria Camila Lopez-Duarte, Camila Londono, Sergio Lasso, Daniella Heredia, Morgan Brown, Nicolas DiLorenzo, Ky Pohler, Angela Gonella
Summary: During cell death, DNA is fragmented and enters the bloodstream as cell-free DNA (cfDNA). We hypothesized that cfDNA concentrations would increase when inducing luteolysis through the use of a prostaglandin F-2α (PGF2α) analog. The results showed a significant increase in cfDNA concentrations after luteolysis induction, indicating that cfDNA could be used as a biomarker for luteolysis in plasma.
REPRODUCTION IN DOMESTIC ANIMALS
(2023)
Article
Cell Biology
Zonghao Tang, Zhenghong Zhang, Qingqiang Lin, Renfeng Xu, Jiajie Chen, Yuhua Wang, Yan Zhang, Yedong Tang, Congjian Shi, Yiping Liu, Hongqin Yang, Zhengchao Wang
Summary: This study demonstrated that HIF-1 alpha/BNIP3-mediated autophagy plays a crucial role in the luteinization of granulosa cells during the early luteal formation, both in vivo and in vitro.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Adomar Laurindo Neto, Felipe Lopes Ruas, Bruno Silva Espirito Santo, Ana Clara Degan Mattos, Junior Borges Silva, Marcos Flavio Diniz Jr, Danilo Fonseca Cardoso Pereira, Izabelle Pereira Lacerda, Jose Oliveira Carvalho, Guilherme Pugliesi
Summary: This study tested the impact of supplementing long-acting P4 at different times during the initial dioestrus on the pregnancy rates of dairy and beef recipients undergoing fixed-time embryo transfer. The results showed that using iP4 during FTET can enhance the pregnancy rates of beef recipients, although the effectiveness of iP4 supplementation on pregnancy maintenance may vary under different experimental conditions.
REPRODUCTION IN DOMESTIC ANIMALS
(2023)
Review
Developmental Biology
Kayhan Yakin, Francesko Hela, Ozgur Oktem
Summary: The corpus luteum is the main source of progesterone, and understanding its signaling pathways is crucial for managing reproductive disorders. This review focuses on the complex mechanisms of progesterone-induced signaling in luteal granulosa cell activity and discusses future research priorities and limitations of the current data.
MOLECULAR HUMAN REPRODUCTION
(2023)
Article
Ophthalmology
Natalia Smorodinova, Herbert Kaltner, Katerina Jirsova, Enkela Hrdlickova-Cela, Sabine Andre, Tomas Kucera, Karel Smetana, Hans-Joachim Gabius
CURRENT EYE RESEARCH
(2016)
Article
Cell Biology
Sabine Andre, Herbert Kaltner, Klaus Kayser, Paul V. Murphy, Hans-Joachim Gabius
HISTOCHEMISTRY AND CELL BIOLOGY
(2016)
Article
Medicine, Research & Experimental
Vlasta Perzelova, Frantisek Sabol, Tomas Vasilenko, Martin Novotny, Ivan Kovac, Martin Slezak, Jan Durkac, Martin Holly, Martina Pilatova, Pavol Szabo, Lenka Varinska, Zuzana Criepokova, Tomas Kucera, Herbert Kaltner, Sabine Andre, Hans-Joachim Gabius, Pavel Mucaji, Karel Smetana, Peter Gal
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2016)
Article
Biochemistry & Molecular Biology
Gusheng Wu, Zi-Hua Lu, Sabine Andre, Hans-Joachim Gabius, Robert W. Ledeen
JOURNAL OF NEUROCHEMISTRY
(2016)
Review
Biochemistry & Molecular Biology
H. -J. Gabius, J. C. Manning, J. Kopitz, S. Andre, H. Kaltner
CELLULAR AND MOLECULAR LIFE SCIENCES
(2016)
Article
Immunology
Stefan Toegel, Daniela Weinmann, Sabine Andre, Sonja M. Walzer, Martin Bilban, Sebastian Schmidt, Catharina Chiari, Reinhard Windhager, Christoph Krall, Idriss M. Bennani-Baiti, Hans-Joachim Gabius
JOURNAL OF IMMUNOLOGY
(2016)
Article
Multidisciplinary Sciences
Qi Xiao, Shaodong Zhang, Zhichun Wang, Samuel E. Sherman, Ralph-Olivier Moussodia, Mihai Peterca, Adam Muncan, Dewight R. Williams, Daniel A. Hammer, Sabine Vertesy, Sabine Andre, Hans-Joachim Gabius, Michael L. Klein, Virgil Percec
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Multidisciplinary Sciences
Qi Xiao, Srujana S. Yadavalli, Shaodong Zhang, Samuel E. Sherman, Elodie Fiorin, Louise da Silva, Daniela A. Wilson, Daniel A. Hammer, Sabine Andre, Hans-Joachim Gabius, Michael L. Klein, Mark Goulian, Virgil Percec
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Biochemistry & Molecular Biology
Malwina Michalak, Viola Golde, Dominik Helm, Herbert Kaltner, Johannes Gebert, Jurgen Kopitz
Summary: In this study, the researchers explored the function of tumor suppressor protein Gal4 in colorectal cancer (CRC) and found that Gal4 can influence nucleic acid-binding proteins in the nucleus and regulate the expression and activity of proteins involved in transcriptional and translational control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)