Review
Polymer Science
Bo Pang, Yuewen Yu, Wangqing Zhang
Summary: In recent years, significant progress has been made in the research of thermoresponsive polymers based on tertiary amine moieties, which exhibit unique phase transition properties in aqueous solutions and can be modulated by the solution's pH value and CO2.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Review
Food Science & Technology
He Liu, Jiaxin Xu, Xinyue Xu, Zhiheng Yuan, Hong Song, Lina Yang, Danshi Zhu
Summary: This review provides a foundation for future research and development of bean polysaccharides. It summarizes the sources, structure, and functions of bioactive bean polysaccharides, focusing on their role in immunology, antioxidant, and anti-diabetic activities. The article offers useful guidance for optimizing polysaccharide structure and developing bean polysaccharides as novel functional materials.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Multidisciplinary
Dan Liu, Shanshan Dai, Li Wang, Ya Liu, Hongsheng Lu
Summary: In this study, an organogelator with pH-triggered recyclable property was developed, allowing the separation and recovery of organic solvents/oil and organogelator. This new approach provides a promising solution for the recovery of leaked organic solvents/oil by utilizing organogelators with pH responsiveness.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Qinping Yang, Yanliang Dong, Xuanyu Wang, Zhihao Lin, Mingyu Yan, Weiwei Wang, Anjie Dong, Jianhua Zhang, Pingsheng Huang, Changrong Wang
Summary: pH-sensitive polyelectrolytes with tertiary amine structures have been explored for siRNA delivery, showing potential for controlled gene release. The molecular structures, particularly asymmetric alkyl substituents, can affect the proton buffering capacity and siRNA delivery efficiency. Among the synthesized copolymers, PAMA-PMEMA-PEG exhibited the best luciferase knockdown efficiency and low cytotoxicity, indicating its potential for improving siRNA delivery efficiency in gene therapy applications.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Engineering, Environmental
Zeyu Geng, Qin Xie, Zhongjiao Fan, Weining Sun, Wei Zhao, Junhao Zhang, Jianqiu Chen, Yun Xu
Summary: Four tertiary amine-based protic ionic liquids have been designed and tested for SO2 uptake, showing a high capacity for SO2 and a high selectivity for SO2/CO2 separation. The kinetic study demonstrated their efficient and quick absorption of SO2 under ambient pressure. Due to their excellent recyclability and fast absorption process, these PILs are considered as a potential alternative to traditional absorbents in flue gas desulfurization (FGD).
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Chemistry, Inorganic & Nuclear
Sayontani Sinha Roy, Kallol Talukdar, Sha Tamanna Sahil, Jonah W. Jurss
Summary: Properly positioned second-coordination sphere functional groups play a crucial role in enhancing catalytic activity, altering product selectivity, and reducing the energy cost for desired chemical transformations. By investigating Re(bpy) catalysts with second-sphere tertiary amine groups, we found that the DMA-substituted tertiary amine complexes show the highest turnover frequency and turnover number, and the catalysis is predominantly governed by inductive electronic effects.
Article
Engineering, Chemical
Pengcheng Wang, Zhihong Liu, Tao Zhang, Zhiyong Liu, Deqing Zhu, Tao Jiang
Summary: With the increasing demand for germanium in high-technology fields, the study investigated the mechanism of Ge(IV) extraction from a sulfuric acid solution using the tertiary amines (N235) and trioctyl phosphate (TOP) system. The extraction process followed an anion exchange mechanism and Ge(IV) was extracted as a Ge(OH)(HL)3 anion complex. Tartaric acid coordinated to Ge(IV) via a C-O bond from the carboxylate group. The extracted complex species were identified as Ge(OH)(HL)(2)L center dot HN(R-1)(3) and Ge(OH)(HL)L-2 center dot[HN(R-1)(3)](2) (R=C8H17).
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Jia Tan, Binbin Ding, Bo Teng, Ping'an Ma, Jun Lin
Summary: This article reviews nanoadjuvants and their structure-function relationships, as well as their applications in cancer therapy. The article first introduces different types of adjuvants and then discusses their mechanisms. It summarizes the methods for evaluating immune effects of adjuvants. The authors particularly focus on the structure-function relationships of nanoadjuvants and explore their impact on immune activities. Finally, the safety of adjuvants is discussed, and representative advancements of nanoadjuvants in tumor immunotherapy and other therapies are presented.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Michael T. Kelly, Zhan Chen, Thomas P. Russell, Bin Zhao
Summary: By combining the characteristics of molecular bottlebrushes and stimuli-responsive polymers, researchers have developed efficient and robust pH-responsive emulsifiers. The emulsions formed at pH 4.0 and disrupted at pH 10.0, with reversible behavior over multiple cycles. The high stability of the emulsions is attributed to the large size and Janus architecture of the molecular bottlebrushes at the interface.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Luciana Esposito, Nicole Balasco, Giovanni Smaldone, Rita Berisio, Alessia Ruggiero, Luigi Vitagliano
Summary: One of the key features of KCTD proteins is their involvement in various physiological and pathological processes. Despite the lack of structural data, the use of predicted three-dimensional models by AlphaFold has enabled researchers to gain insights into the relationships within the KCTD family. A novel pseudo-phylogenetic tree based on a common structurally similar domain in the C-terminal region has revealed previously undetected similarities among the KCTD proteins, providing a solid foundation for understanding their diverse functions.
Article
Chemistry, Organic
Keshu Yin, Mingjie Wei, Zhenguo Wang, Wenjun Luo, Le Li
Summary: A safer and more sustainable method for recycling organophosphorus compounds is achieved by reducing phosphine oxides without the use of highly reactive reductants. This is accomplished through an unusual intermolecular hydride transfer mediated by N,N,N',N'-tetramethylethylenediamine (TMEDA). Mechanistic studies reveal the role of TMEDA as a hydride donor and the P(V) halophosphonium salt as the hydride acceptor. This methodology provides a scalable and efficient protocol for mild reduction of phosphine oxides.
Article
Engineering, Chemical
Kaavya Rathnakumar, Juan C. Osorio-Arias, Padmanaban Krishnan, Sergio Martinez-Monteagudo
Summary: This study fractionated spent coffee ground with a tertiary amine to obtain a carbohydrate fraction rich in dietary fiber, a phenolic fraction made of chlorogenic acids, and a lipid fraction mainly consisting of palmitic and linoleic acid. The extraction process was evaluated at different time and temperature conditions, resulting in high total dietary fiber content in the carbohydrate fraction and detection of seven major species of chlorogenic acids within the phenolic fraction. The lipid fraction obtained was overestimated due to incomplete conversion of the amine into its respective salt.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Thermodynamics
Rujie Wang, Huajun Zhao, Cairao Qi, Xiaotong Yang, Shihan Zhang, Ming Li, Lidong Wang
Summary: A tertiary amine-based biphasic solvent was proposed for energy-efficient CO2 capture. It achieved low regeneration energy consumption and superior desorption properties, as well as high CO2-rich loading and large desorption capacity.
Article
Chemistry, Multidisciplinary
Hirokazu Narita, Motoki Maeda, Chiharu Tokoro, Tomoya Suzuki, Mikiya Tanaka, Hideaki Shiwaku, Tsuyoshi Yaita
Summary: In this study, the mechanism of Se(iv) and Se(vi) extraction from aqueous HCl solutions by EHBAA was investigated. The extraction behavior and structural properties of the dominant Se species in solution were examined. It was found that Se(vi) was reduced to Se(iv) in 8 M HCl, and around 50% of Se(vi) was extracted from 0.5 M HCl using 0.5 M EHBAA. On the other hand, Se(iv) was hardly extracted from 0.5 to 5 M HCl, but the extraction efficiency increased drastically above 5 M, reaching approximately 85%. The apparent stoichiometries of Se(iv) or Se(vi) to EHBAA were 1:1 and 1:2, respectively.
Article
Polymer Science
Bjorn Erik Fristrup Ekbrant, Anne Ladegaard Skov, Anders E. Daugaard
Summary: The study demonstrates the catalytic effects of tertiary amines in amine-epoxy reactions and etherifications in epoxy systems. Experimental results show that different amines exhibit varying preferences in reactions, which can be confirmed through different analytical techniques.
Article
Engineering, Biomedical
Liwei Ni, Pawan Kc, Emily Mulvany, Ge Zhang, Jiang Zhe
BIOMEDICAL MICRODEVICES
(2019)
Article
Engineering, Electrical & Electronic
Liang-Liang Fan, Zhi Zhao, Xu Wu, Jiang Zhe, Liang Zhao
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2020)
Article
Biochemical Research Methods
Liang-Liang Fan, Zhi Zhao, Yi-Yi Tao, Xu Wu, Qing Yan, Jiang Zhe, Liang Zhao
Article
Chemistry, Multidisciplinary
Liwei Ni, Rubia Shaik, Ruiting Xu, Ge Zhang, Jiang Zhe
Article
Biochemical Research Methods
Liang-Liang Fan, Zhuang-Zhuang Tian, Jiang Zhe, Liang Zhao
Summary: This study successfully enriched and focused nano-/submicroparticles of 500 and 860 nm using a specially designed microchannel, achieving efficient enrichment by adjusting flow rate, particle size, solid concentration, and channel geometry. This simple, small footprint, easy-to-operate, and high-performance device shows promise as a platform for various lab-chip microvesicle-related biomedical research and disease diagnosis.
Article
Engineering, Electrical & Electronic
Dian Jiao, Liwei Ni, Xueyang Yu, Jiang Zhe
Summary: A new method using planar inductive sensors to measure gap from irregular and narrow targets without tedious calibration process was proposed in this paper. The numerical study and validation showed that the approach can accurately measure different targets' gaps, suitable for various applications.
IET SCIENCE MEASUREMENT & TECHNOLOGY
(2021)
Article
Engineering, Electrical & Electronic
Long-Run Huang, Liang-Liang Fan, Qi Liu, Zhi Zhao, Jiang Zhe, Liang Zhao
Summary: A novel microfluidic device utilizing sharp corner structures on the side wall of an arc microchannel was reported for efficient passive mixing, achieving a significant increase in interfacial contact area between different fluids and enhancing fluid mixing from approximately 87% to 92% at moderate Reynolds numbers. The device has great potential in various lab-chip applications, such as clinic diagnosis and analytic chemistry, due to its single-layer structure and high mixing efficiency.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2021)
Article
Engineering, Electrical & Electronic
Zhi Zhao, Zhen-Yu Xun, Liang-Liang Fan, Jiang Zhe, Liang Zhao
Summary: Generating small-volume satellite droplets in a microchannel is crucial for achieving a high volume ratio of cell to droplet, which is essential for fast detection of secreted molecules. Experimental results demonstrate that even at low cell concentrations, a high average volume ratio of cell to droplet can be achieved.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2021)
Article
Cell Biology
Leixin Ouyang, Rubia Shaik, Ruiting Xu, Ge Zhang, Jiang Zhe
Summary: This article presents a method of mapping cell surface charge distribution via electrostatic cell-nanoparticle interactions, using fluorescent nanoparticles as markers. By establishing a relationship between fluorescent light intensity and number of nanoparticles, cells' surface charge distribution can be quantified. This method can be used for rapid surface charge mapping of single particles or cells, and yields results in good agreement with standard electrophoretic light scattering measurements.
Article
Biophysics
Ruiting Xu, Lidya Abune, Brandon Davis, Leixin Ouyang, Ge Zhang, Yong Wang, Jiang Zhe
Summary: This article introduces a method for detecting small biomolecules based on molecular recognition and nanoparticle counting. By releasing nanoparticles and counting them using a micropore sensor, the concentration of target biomolecules can be measured with high sensitivity and high throughput. The experiments demonstrate that this method has a low detection limit and high reproducibility, showing great potential for the ultrasensitive detection of low abundance small biomolecules.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Engineering, Electrical & Electronic
Rui Huang, Aaron Urban, Dian Jiao, Jiang Zhe, Jae-Won Choi
Summary: This study successfully designed and manufactured an inductive proximity sensor with a 3D-printed ceramic housing and embedded sensing elements using a hybrid manufacturing process. By carefully selecting materials and designing internal structures, the sensing element can maintain functionality in high-temperature environments. The developed manufacturing method allows for precise control of the sensor housing's geometry, dimensions, and infill density, making it suitable for various types of sensors or smart components.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Engineering, Electrical & Electronic
Aaron Urban, Jiang Zhe
Summary: The interdigital sensor array based on an artificial neural network and stochastic global optimization method can accurately measure the critical properties concentrations in diesel powered machine's lubricant oil, addressing the issues of cross sensitivity and tedious calibrations associated with traditional sensors. This technology improves prediction accuracy and eliminates the need for calibrating for various operating temperatures, providing comprehensive information about the health status of diesel powered machines.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Cell Biology
Leixin Ouyang, Rubia Shaik, Ruiting Xu, Ge Zhang, Jiang Zhe
Summary: Cellular functions are regulated by cell surface charges and understanding these functions requires noninvasive measurement of surface charge distribution of a single cell. This study introduces a method for cell surface charge mapping via photoelectric interactions. The method involves placing a cell on a microelectrode array and analyzing the reflected light intensity to quantify the cell surface charge distribution. The method was validated using charged microparticles and different types of cells.
Review
Chemistry, Analytical
Ruiting Xu, Leixin Ouyang, Heyi Chen, Ge Zhang, Jiang Zhe
Summary: The fast and accurate detection of biomolecules plays an essential role in biomedical applications such as disease diagnostics, environmental monitoring, public health, and food safety. Aptamer recognition and biosensing with nanoparticles have gained extensive attention due to their high selectivity, affinity, reproducibility, and robustness. Biosensors combining aptamers and nanoparticles offer high sensitivity, reliability, specificity, and detection speed for a wide range of biomolecules.
Article
Biotechnology & Applied Microbiology
Ruiting Xu, Leixin Ouyang, Rubia Shaik, Ge Zhang, Jiang Zhe
Summary: This article reports a novel geometry modulation based resistive pulse sensor (RPS) that improves the throughput for characterizing nano/micro targets in biomedical research. The sensor consists of multiple parallel sensing channels with uniquely designed geometries based on 7-bit spreading sequences. The device accurately sizes and counts various microparticles with errors of 5.8% and 5.2% while improving the throughput by 300%.
SENSORS AND ACTUATORS REPORTS
(2023)