Article
Gastroenterology & Hepatology
Xinrong Zhang, Grace Lai-Hung Wong, Terry Cheuk-Fung Yip, Johnny T. K. Cheung, Yee-Kit Tse, Vicki Wing-Ki Hui, Huapeng Lin, Jimmy Che-To Lai, Henry Lik-Yuen Chan, Alice Pik-Shan Kong, Vincent Wai-Sun Wong
Summary: The duration of T2D is not associated with the occurrence of liver-related events, while age is. Therefore, screening for liver disease in patients with NAFLD and T2D starting at the age of 50 is reasonable.
Review
Gastroenterology & Hepatology
Pai-Chi Teng, Daniel Q. Huang, Ting-Yi Lin, Mazen Noureddin, Ju Dong Yang
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease caused by insulin resistance. Diabetes increases the risk of liver disease progression and cirrhosis development in NAFLD patients, as well as the risk of hepatocellular carcinoma (HCC). Diabetes promotes hepatocarcinogenesis through inflammatory cascades, resulting in genomic instability, cellular proliferation, and apoptosis inhibition.
Article
Gastroenterology & Hepatology
Daniel Q. Huang, Nabil Noureddin, Veeral Ajmera, Maral Amangurbanova, Ricki Bettencourt, Emily Truong, Tolga Gidener, Harris Siddiqi, Abdul M. Majzoub, Tarek Nayfeh, Nobuharu Tamaki, Namiki Izumi, Masato Yoneda, Atsushi Nakajima, Ramazan Idilman, Mesut Gumussoy, Digdem Kuru Oz, Ayse Erden, Alina M. Allen, Mazen Noureddin, Rohit Loomba
Summary: The presence of type 2 diabetes in patients with NAFLD is associated with a significantly higher risk of hepatic decompensation and hepatocellular carcinoma.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Xuan-vinh Kevin Nguyen, Jason Zhang, Ken Lee Chin, Stephen Bloom, Amanda J. Nicoll
Summary: This study compared the characteristics and survival rates of NAFLD-HCC patients to non-NAFLD-HCC patients, finding that NAFLD-HCC patients were more likely to be diagnosed based on symptoms and at an older age, with lower survival rates.
Article
Oncology
Michelle Junyi He, Wenjun Pu, Xi Wang, Xiaoni Zhong, Dong Zhao, Zhipeng Zeng, Wanxia Cai, Jiayi Liu, Jianrong Huang, Donge Tang, Yong Dai
Summary: This study utilized mass spectrometry mediated spatial metabolomics technique to investigate the metabolic changes in hepatocellular carcinoma (HCC). The results revealed that amino acid metabolism and glycerophospholipid metabolism exhibited the most significant alterations during HCC progression, and these altered metabolites and pathways were interconnected through the urea cycle.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Jin Gu, Erlei Zhang, Binyong Liang, Zunyi Zhang, Xiaoping Chen, Min Xiong, Zhiyong Huang
Summary: In HCC patients with Child-Pugh grade A liver function, cirrhosis staging can be determined by measuring liver collagen contents using Collagen Proportional Area (CPA), which significantly affects the risk of Posthepatectomy Liver Failure (PHLF). The study also found a significant correlation between CPA and a non-invasive method called Cirrhotic Severity Scoring (CSS) proposed by the team, showing that higher CPA values and extent of hepatectomy are independent risk factors for PHLF, and there is a positive correlation between CPA and CSS.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Koya Yasukawa, Akira Shimizu, Koji Kubota, Tsuyoshi Notake, Kiyotaka Hosoda, Hikaru Hayashi, Yuji Soejima
Summary: This study aimed to investigate the impact of liver fibrosis on the prognosis of patients with hepatocellular carcinoma (HCC). The results showed that patients with more severe liver fibrosis had worse cancer-specific prognosis. Moreover, patients with liver fibrosis had a higher incidence of multiple recurrences.
Review
Gastroenterology & Hepatology
Hwang Sik Shin, Baek Gyu Jun, Sang-Wook Yi
Summary: This review comprehensively summarizes the relationship between metabolic factors such as diabetes mellitus, obesity, and blood lipids and the risk of hepatocellular carcinoma (HCC) in patients with chronic liver diseases. Diabetes consistently increases the risk of HCC in patients with chronic liver disease, while obesity may also increase the risk. In terms of blood lipids, total cholesterol, low-density lipoprotein cholesterol, and triglyceride have strong inverse associations with HCC in individuals with chronic liver diseases.
CLINICAL AND MOLECULAR HEPATOLOGY
(2022)
Review
Oncology
Samuel J. Martinez-Dominguez, Sandra Garcia-Mateo, Viviana Laredo, Carla J. Gargallo-Puyuelo, Beatriz Gallego Llera, Julia Lopez de la Cruz, Fernando Gomollon
Summary: The article discusses the prevalence and risk factors of liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) and inflammatory bowel disease (IBD), as well as the progression to hepatocellular carcinoma (HCC). It highlights the importance of diagnosing and managing NAFLD and advanced liver fibrosis in daily clinical practice.
Review
Medicine, General & Internal
Laura I. Coman, Oana A. Coman, Ioana A. Badarau, Horia Paunescu, Mihai Ciocirlan
Summary: Research indicates that patients with diabetes mellitus and liver cirrhosis are at higher risk for complications such as hepatic encephalopathy, variceal hemorrhage, infections, and hepatocellular carcinoma. Diabetes mellitus also negatively impacts liver transplant outcomes.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Daniel Q. Huang, Laura A. Wilson, Cynthia Behling, David E. Kleiner, Kris Kowdley, Srinivasan Dasarathy, Maral Amangurbanova, Norah A. Terrault, Anna Mae Diehl, Naga Chalasani, Brent A. Neuschwander-Tetri, Arun J. Sanyal, James Tonascia, NASH Clinical Res Network, Rohit Loomba
Summary: Limited data exist on fibrosis progression in biopsy-proven nonalcoholic fatty liver disease (NAFLD) in people with type 2 diabetes mellitus (T2DM). A multicenter study found that participants with T2DM had a significantly higher cumulative incidence of fibrosis progression compared to participants without T2DM. These findings have important implications for clinical practice and trial design.
Article
Oncology
Mizelle D'Silva, Jai Young Cho, Ho-Seong Han, Yoo-Seok Yoon, Hae Won Lee, Jun Suh Lee, Boram Lee, Moonhwan Kim
Summary: Overall survival is similar between NAFLD-associated HCC and HBV-associated HCC, but NAFLD-associated HCC shows lower systemic recurrence.
SURGICAL ONCOLOGY-OXFORD
(2022)
Article
Oncology
Guizhi Zhang, Yinghui Hou
Summary: This study aimed to identify potential aberrantly methylated and differentially expressed genes in nonalcoholic fatty liver disease (NAFLD) of HCC patients with cirrhosis. By analyzing data from the Cancer Genome Atlas (TCGA) database, the researchers identified several candidate genes that were significantly correlated with the overall survival time of NAFLD patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Genetics & Heredity
Zhaobin He, Cheng Peng, Tianen Li, Jie Li
Summary: This study used single cell differentiation trajectory analysis to investigate the relevance of liver cirrhosis and hepatocellular carcinoma (HCC). It was found that the cell differentiation trajectory of liver cirrhosis can predict the prognosis of HCC, providing new perspectives on the mechanisms of progression from liver cirrhosis to HCC.
FRONTIERS IN GENETICS
(2022)
Article
Gastroenterology & Hepatology
Ji H. Nahm, Hye S. Lee, Haeryoung Kim, Sun Y. Yim, Ji-hyun Shin, Jeong E. Yoo, Sang H. Ahn, Jin S. Choi, Ju-Seog Lee, Young N. Park
Summary: This study developed a nomogram for predicting late recurrence of hepatocellular carcinoma (HCC) based on clinicopathological and molecular factors. The combination of pSTAT3, pERK1/2 and SYK immunoexpression with high lobular inflammatory activity and cirrhosis was found to predict late HCC recurrence.
LIVER INTERNATIONAL
(2021)