期刊
HEPATOLOGY RESEARCH
卷 45, 期 4, 页码 441-447出版社
WILEY
DOI: 10.1111/hepr.12372
关键词
cryptogenic liver disease; diabetes mellitus; hepatocellular carcinoma; liver cirrhosis; old age
资金
- Ministry of Health, Labor and Welfare of Japan
AimTo clarify the clinical features of patients with hepatocellular carcinoma (HCC) with cryptogenic liver diseases, we analyzed the data from a nationwide survey in Japan. MethodsThe survey was conducted in 2009. The factors examined included age and underlying liver diseases: alcoholic liver disease (ALD; n=991), non-alcoholic fatty liver disease (n=292), modest alcohol intake (intake between 20 and 70g/day, n=214) and cryptogenic liver diseases (n=316). We compared the clinical features of cryptogenic HCC among patient-age subgroups. ResultsHCC with ALD etiology was most common among the non-viral HCC patients under 80 years old; for those aged 80 years or older, cryptogenic HCC was the most common etiology. Among the cryptogenic HCC patients, the body mass index values and the prevalences of liver cirrhosis (LC) and diabetes mellitus (DM) were significantly lower in the 80 years or older group versus the 50-79 years group. In the 80 years or older group, 28% of the patients developed HCC without cirrhosis, obesity and DM. ConclusionIn the HCC patients aged 80 years and over, the etiology of most of the non-viral HCC cases was classified as cryptogenic. In light of our finding that the prevalences of obesity, DM and LC in the 80 years or older group of cryptogenic HCC patients were significantly lower those in the younger patients, it is apparent that analyses of HCC cases must take age differences into account.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据