Article
Gastroenterology & Hepatology
Theodoros Michelakos, Filippos Kontos, Yurie Sekigami, Motaz Qadan, Lei Cai, Onofrio Catalano, Vikram Deshpande, Madhukar S. Patel, Teppei Yamada, Nahel Elias, Leigh Anne Dageforde, Shoko Kimura, Tatsuo Kawai, Kenneth K. Tanabe, James F. Markmann, Heidi Yeh, Cristina R. Ferrone
Summary: This study found that in patients with solitary hepatocellular carcinoma, different hepatic resection margin widths did not have a significant impact on overall survival, recurrence-free survival, and liver-specific recurrence-free survival.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Gastroenterology & Hepatology
Hisashi Nakayama, Yukiyasu Okamura, Tokio Higaki, Masamichi Moriguchi, Tadatoshi Takayama
Summary: This study examined the effect of blood product transfusion on the prognosis of patients who underwent hepatectomy for hepatocellular carcinoma. The results showed that transfusion groups had lower tumor recurrence rate and overall survival rate compared to non-transfusion groups. Red blood cell transfusion negatively impacts the recurrence and long-term survival of hepatocellular carcinoma.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Surgery
Fabrizio Di Benedetto, Paolo Magistri, Stefano Di Sandro, Carlo Sposito, Christian Oberkofler, Ellie Brandon, Benjamin Samstein, Cristiano Guidetti, Alexandros Papageorgiou, Samuele Frassoni, Vincenzo Bagnardi, Pierre-Alain Clavien, Davide Citterio, Tomoaki Kato, Henrik Petrowsky, Karim J. Halazun, Vincenzo Mazzaferro, Robotic HPB Study Grp
Summary: This study examined the short-term and long-term outcomes of robotic liver resection (RLR) for hepatocellular carcinoma (HCC) in Western high-volume centers. The study found that RLR had shorter hospital stays and lower incidence of postoperative liver failure compared to open liver resection (OLR). Furthermore, there were no significant differences in tumor recurrence and overall survival rates between the two groups.
Article
Oncology
Liuhua Long, Bo Chen, Hongzhi Wang, Yuting Zhao, Fan Wu, Liming Wang, Weiqi Rong, Jianxiong Wu, Yexiong Li, Weihu Wang
Summary: This study evaluated the effects of postoperative radiotherapy (PORT) on prognosis and recurrence in patients with hepatocellular carcinoma (HCC) who underwent narrow-margin hepatectomy (NH). The results showed that the PORT group had significantly higher 5-year overall survival and disease-free survival rates compared to the non-PORT group, and the tumor recurrence rate was lower in the PORT group. Therefore, postoperative radiotherapy may have significant benefits in the treatment of HCC.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Ryo Saito, Hidetake Amemiya, Naohiro Hosomura, Hiromichi Kawaida, Katsutoshi Shoda, Shinji Furuya, Hidenori Akaike, Yoshihiko Kawaguchi, Shingo Inoue, Hiroshi Kono, Daisuke Ichikawa
Summary: Intended preoperative trans-arterial embolization (TAE) may improve the prognosis of patients with large HCC and reduce the occurrence of adverse factors.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Hikaru Hayashi, Akira Shimizu, Hiroaki Motoyama, Koji Kubota, Tsuyoshi Notake, Hitoshi Masuo, Takahiro Yoshizawa, Kiyotaka Hosoda, Hiroki Sakai, Koya Yasukawa, Yuji Soejima
Summary: This retrospective study shows that hepatectomy is safe and effective for octogenarians with hepatocellular carcinoma (HCC), with similar postoperative outcomes compared to younger patients.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Oncology
Shi-Chuan Tang, Kong-Ying Lin, Ting-Feng Huang, Kai -Ling Zhang, Jie Kong, Xiao-Lu He, Cong Luo, Qing-Jing Chen, Peng-Fei Guo, Wei -Ping Zhou, Yong-Yi Zeng
Summary: The impact of primary tumor location on long-term prognosis after hepatectomy for HCC was investigated. It was found that patients with left-sided HCC had worse overall survival and recurrence-free survival compared to those with right-sided HCC. This suggests that careful surgical options selection and frequent follow-up may be justified for HCC patients with left-sided primary tumors.
Review
Surgery
Yeting Lin, Jiaxuan Xu, Jiaze Hong, Yuexiu Si, Yujing He, Jinhang Zhang
Summary: This study found that among HCC patients, a surgical margin wider than 1 cm can prolong the overall survival and disease-free survival, while a margin narrower than 1 cm leads to worse prognosis. Although most subgroup analyses showed consistent prognostic benefits of a wide surgical margin, studies from Western countries indicated that margin width does not impact prognosis.
FRONTIERS IN SURGERY
(2022)
Article
Oncology
Bart Vanderborght, Kevin De Muynck, Eva Gijbels, Sander Lefere, Charlotte L. Scott, Martin Guilliams, Alain Beschin, Mathieu Vinken, Xavier Verhelst, Anja Geerts, Hans Van Vlierberghe, Lindsey Devisscher
Summary: Due to the rapid progression of the disease and the lack of curative treatments, hepatocellular carcinoma (HCC) is one of the deadliest cancers worldwide. While monocyte-derived tumor-associated macrophages are known to contribute to HCC, the role of Kupffer cells (KCs) remains unclear. This study used a mouse model to investigate the effect of KC depletion on HCC initiation and progression, and found that the temporary ablation of resident KCs did not impact HCC pathogenesis.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Gastroenterology & Hepatology
Shohei Komatsu, Masahiro Kido, Kaori Kuramitsu, Daisuke Tsugawa, Hidetoshi Gon, Kenji Fukushima, Takeshi Urade, Hiroaki Yanagimoto, Hirochika Toyama, Takumi Fukumoto
Summary: This study evaluated the impact of hepatectomy on HCC with macroscopic PVTT in 100 patients. The presence of Vp3/4 PVTT had a significant impact on survival, with hepatectomy being considered an effective treatment option.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Oncology
Gordana Rasic, Susanna W. L. de Geus, Brendin Beaulieu-Jones, Gyulnara G. Kasumova, Tara S. Kent, Sing Chau Ng, David McAneny, Jennifer F. Tseng, Teviah E. Sachs
Summary: This study compared the outcomes of ablation and resection for early-stage hepatocellular carcinoma (HCC) and found that resection provides better long-term survival rates for tumors ≤ 50 mm. Ablation may serve as a feasible bridging strategy for patients awaiting transplantation.
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Rui Luo, Chongkai Fang, Chuyao Chen, Ying Zhang, Ruiwei Yao, Jinan Wang, Hanqian Shi, Kunliang Feng, Mingli Hu, Chong Zhong
Summary: This study retrospectively examined the efficacy and safety of Jianpi Huayu decoction (JPHYD) as adjuvant therapy for hepatocellular carcinoma (HCC) following hepatectomy. The results showed that JPHYD significantly improved recurrence-free survival (RFS) and overall survival (OS) without increasing adverse events.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Gastroenterology & Hepatology
Qiang Sun, Xiangda Zhang, Xueyi Gong, Zhipeng Hu, Qiao Zhang, Weiming He, Xiaojian Chang, Zemin Hu, Yajin Chen
Summary: This study compared the survival outcomes of LH and OH in the treatment of HCC based on reconstructed time-to-event data from high-quality propensity-score matching studies. The results indicated that LH can improve RFS in patients with HCC undergoing minor hepatectomy, and may benefit long-term RFS in overall patients.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kaiwen Liu, Hang Zheng, Xinzi Sui, Bo Liu, Min Meng, Yuemin Feng, Qiang Zhu, Xinya Zhao
Summary: There were no significant differences in long-term outcomes between microwave ablation and surgical resection for subcapsular hepatocellular carcinoma. Microwave ablation may be an alternative curative option for subcapsular hepatocellular carcinoma.
EUROPEAN RADIOLOGY
(2023)
Review
Oncology
Nikolaos Machairas, Dimitrios Papaconstantinou, Panagiotis Dorovinis, Diamantis I. Tsilimigras, Myrto D. Keramida, Stylianos Kykalos, Dimitrios Schizas, Timothy M. Pawlik
Summary: In patients with recurrent hepatocellular carcinoma (HCC), both repeat hepatectomy (RH) and radiofrequency ablation (RFA) are viable treatment options. This systematic review and meta-analysis aimed to compare the outcomes of patients undergoing RH versus RFA for recurrent HCC. The results showed that both treatments had comparable overall and disease-free survival rates, but patients undergoing RH were less likely to develop a second recurrence. However, RH was associated with higher overall and major morbidity rates. Despite this, repeat resection remains the preferred option due to its better disease control.