Article
Gastroenterology & Hepatology
Hardik Ahuja, Barjesh Chander Sharma, Sanjeev Sachdeva, Bhawna Mahajan, Ashok Sharma, Sushma Bara, Siddharth Srivastava, Ajay Kumar, Ashok Dalal, Ujjwal Sonika
Summary: This study aimed to investigate the efficacy of nutrition therapy in preventing the recurrence of hepatic encephalopathy in patients with liver cirrhosis. The results showed that patients who received nutrition therapy had significantly fewer breakthrough episodes of hepatic encephalopathy and longer hospitalization time related to hepatic encephalopathy. Compared to patients who did not receive nutrition therapy, those who received nutrition therapy showed significant improvements in inflammatory parameters and anthropometric measurements at the end of 6 months.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Medicine, General & Internal
Piero Amodio, Sara Montagnese
Summary: Hepatic encephalopathy is a form of brain dysfunction caused by liver insufficiency and/or portal-systemic shunting, with inconsistencies in its detection and management. Diagnosis of HE involves consideration of its phenotypes, risk factors, and differential diagnosis from other similar conditions.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Jinyu Li, Duiping Feng, Ningdong Pang, Chao Zhao, Long Gao, Shuai Liu, Lei Li
Summary: This study aimed to investigate the association and predictive value of the Controlling Nutritional Status (CONUT) score for overt hepatic encephalopathy (OHE) in cirrhotic patients following transjugular intrahepatic portosystemic shunt (TIPS). The results showed that the CONUT score was directly correlated with OHE risk and could serve as a reliable prognostic marker for OHE risk in cirrhotic patients following TIPS, which could be beneficial in the evaluation and management of OHE.
CLINICAL NUTRITION
(2022)
Article
Biochemical Research Methods
Juliette Pelle, Florence A. Castelli, Marika Rudler, Imen Alioua, Benoit Colsch, Francois Fenaille, Christophe Junot, Dominique Thabut, Nicolas Weiss
Summary: Metabolomics is a technique used to study biological components involved in metabolic pathways below 1000 Daltons, which has shown potential in revealing pathophysiological insights, identifying new biomarkers, and predicting treatment response or outcome prognosis in hepatic encephalopathy.
ANALYTICAL BIOCHEMISTRY
(2022)
Article
Gastroenterology & Hepatology
Marika Rudler, Virginia Hernandez-Gea, Bogdan Dumitru Procopet, Alvaro Giraldez, Lucio Amitrano, Candid Villanueva, Luis Ibanez, Gilberto Silva-Junior, Joan Genesca, Christophe Bureau, Jonel Trebicka, Rafael Banares, Aleksander Krag, Elba Llop, Wim Laleman, Jose Maria Palazon, Jose Castellote, Susana Rodrigues, Lise Lotte Gluud, Carlos Noronha Ferreira, Nouria Canete, Manuel Rodriguez, Arnulf Ferlitsch, Jose Luis Mundi, Henning Gronbaek, Manuel Hernandez-Guerra, Romano Sassatelli, Alessandra Dell'era, Marco Senzolo, Juan G. Abraldes, Manuel Romero-Gomez, Alexander Zipprich, Meritxell Casas, Helena Masnou, Helene Larrue, Massimo Primignani, Frederik Nevens, Jose Luis Calleja, Remy Schwarzer, Christian Jansen, Marie-Angele Robic, Irene Conejo, Javier Martinez Gonzalez, Maria Vega Catalina, Agustin Albillos, Edilmar Alvarado, Maria Anna Guardascione, Maxime Mallet, Simona Tripon, Georgina Casanovas, Jaume Bosch, Juan-Carlos Garcia-Pagan, Dominique Thabut
Summary: pTIPS is more effective in improving survival compared to endoscopic treatment for high-risk patients with cirrhosis and variceal bleeding. HE at admission does not affect the efficacy of pTIPS.
Article
Gastroenterology & Hepatology
Barjesh Chander Sharma, Sudhir Maharshi, Sanjeev Sachdeva, Bhawna Mahajan, Ashok Sharma, Sushma Bara, Siddharth Srivastava, Ajay Kumar, Ashok Dalal, Ujjwal Sonika
Summary: This study examined the effects of nutritional therapy on patients with liver cirrhosis and associated minimal hepatic encephalopathy (MHE). The results showed that nutritional therapy effectively improved cognitive functions, health-related quality of life, anthropometry, endotoxins, and inflammatory markers in these patients.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Medicine, General & Internal
Simone Di Cola, Silvia Nardelli, Lorenzo Ridola, Stefania Gioia, Oliviero Riggio, Manuela Merli
Summary: The link between muscular alterations and hepatic encephalopathy (HE) has been extensively studied. The imbalance in ammonia metabolism and removal between muscles and the liver leads to the development of HE in patients with liver failure or porto-systemic shunts. This review focuses on the clinical burden, pathophysiological mechanisms, and management principles of muscular alterations in cirrhosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pediatrics
Johanna Ascher Bartlett, Rohit Kohli
Summary: Hepatic encephalopathy is a condition associated with both chronic and acute liver disease, characterized by mental status changes and neuropsychiatric impairment. It can be challenging to identify in children, but careful assessment is crucial as symptom progression may indicate cerebral edema and systemic deterioration. Hyperammonemia may be present, but its degree does not correlate with clinical severity. Current treatment options include addressing the underlying cause and reducing high ammonia levels with medications or extracorporeal liver support.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Medicine, General & Internal
Simon Johannes Gairing, Chiara Mangini, Lisa Zarantonello, Stefania Gioia, Elise Jonasson Nielsen, Sven Danneberg, Anna S. Lok, Philippe Sultanik, Peter Robert Galle, Joachim Labenz, Dominique Thabut, Jens Uwe Marquardt, Patricia P. Bloom, Mette Munk Lauridsen, Sara Montagnese, Silvia Nardelli, Christian Labenz
Summary: This large multicenter study demonstrates that screening for minimal hepatic encephalopathy (MHE) is a useful tool for predicting the development of overt hepatic encephalopathy (OHE) and poorer survival.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Medicine, General & Internal
Kessarin Thanapirom, Monton Wongwandee, Sirinporn Suksawatamnuay, Panarat Thaimai, Napaporn Siripon, Wanwisar Makhasen, Sombat Treeprasertsuk, Piyawat Komolmit
Summary: The study aimed to establish the normative data of PHES in healthy Thai individuals, assess the prevalence of MHE, and validate the use of S-ANT1 in detecting MHE in cirrhotic patients. The results showed that MHE was present in 26.6% of cirrhotic patients. S-ANT1 had a moderate positive correlation with PHES.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Dominique Thabut, Charlotte Bouzbib, Lucy Meunier, Manon Haas, Nicolas Weiss, Alexandre Louvet, Francois Imbert-Bismut, Fanny Mochel, Yann Nadjar, Antoine Santiago, Thierry Thevenot, Veronique Duhalde, Frederic Oberti, Claire Francoz, Audrey Coilly, Marie-Noelle Hilleret, Pascal Lebray, Amelie Liou-Schischmanoff, Louise Barbier, Christophe Duvoux, Georges-Philippe Pageaux, Michael Bismuth, Damien Galanaud, Thomas De Broucker, Jean-Francois Cadranel, Vincent Leroy, Vincent Di Martino, Dominique Larrey, Christophe Camus, Olivier Scatton, Victor De Ledinghen, Ariane Mallat, Marika Rudler, Christophe Bureau
Summary: Hepatic encephalopathy (HE) is a frequent and severe complication of liver disease that often goes undiagnosed due to a lack of understanding and consensus on diagnosis. Non-specific symptoms and comorbidities in cirrhotic patients make differential diagnosis challenging. Guidelines are provided to assist clinicians in diagnosing and treating HE. Liver transplantation may be indicated for HE, but its reversibility post-transplantation and the consequences in patients with other neurological disorders remain controversial.
LIVER INTERNATIONAL
(2023)
Article
Gastroenterology & Hepatology
Chiara Formentin, Lisa Zarantonello, Chiara Mangini, Anna C. Frigo, Sara Montagnese, Carlo Merkel
Summary: The study found that in patients without a history of overt hepatic encephalopathy, neuropsychological and neurophysiological tests can predict the occurrence of hepatic encephalopathy, while in patients with a history of overt hepatic encephalopathy, the severity of liver dysfunction plays a larger role in the development of hepatic encephalopathy.
LIVER INTERNATIONAL
(2021)
Editorial Material
Gastroenterology & Hepatology
Jasmohan S. Bajaj
Summary: Hepatic encephalopathy (HE) affects stakeholders from clinical, psychosocial, and financial perspectives, with three different groups involved in its development, consequences, and management. Understanding and integrating these three groups can encourage individualized care for patients and families affected by HE.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Leen Z. Hasan, George Y. Wu
Summary: Hepatic encephalopathy is a devastating complication of chronic liver disease with high mortality rates, and current treatment modalities, while promising, are limited by study design and lack of safety data.Various treatment options targeting gut microbiota, oxidative stress, and neurotransmitter modulation have shown promise but more research is needed to address their limitations.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Takao Miwa, Tatsunori Hanai, Maeda Toshihide, Yui Ogiso, Kenji Imai, Atsushi Suetsugu, Koji Takai, Makoto Shiraki, Naoki Katsumura, Masahito Shimizu
Summary: Zinc deficiency may predict the development of OHE and mortality in LC patients with MHE.
HEPATOLOGY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Carlos Perez-Monter, Alejandro Alvarez-Arce, Natalia Nuno-Lambarri, Ivonne Escalona-Nandez, Eva Juarez-Hernandez, Norberto C. Chavez-Tapia, Misael Uribe, Varenka J. Barbero-Becerra
Summary: Supplementing inulin in a classic obesity and fatty liver model mice can effectively prevent hepatic steatosis and reshape the composition of intestinal microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Itzayana Rodriguez-Antonio, Guillermo N. Lopez-Sanchez, Victor A. Reyes-Gomez, Ericka H. Contreras-Flores, Fernanda Farias-Garcia, Mariana Espejel-Deloiza, Marco A. Duran-Padilla, Fredy Chable-Montero, Misael Uribe, Norberto C. Chavez-Tapia, Eduardo E. Montalvo-Jave, Natalia Nuno-Lambarri
Summary: The study aimed to determine the severity of MAFLD and associated risk factors in patients with cholelithiasis. Among the 80 patients studied, 58.8% had MAFLD, but no substantial correlation was found between biochemical parameters and the histopathological analysis of MAFLD and fibrosis.
ANNALS OF HEPATOLOGY
(2022)
Article
Biology
Alberto Biscontin, Lisa Zarantonello, Antonella Russo, Rodolfo Costa, Sara Montagnese
Summary: The study aimed to develop a Polygenic Score-based model for molecular chronotype assessment and identified 83 variants predictive of chronotype with an estimated validity of approximately 80%.
JOURNAL OF BIOLOGICAL RHYTHMS
(2022)
Article
Multidisciplinary Sciences
Norberto C. Chavez-Tapia, Tonatiuh Barrientos-Gutierrez, Leticia Torres-Ibarra, Beatriz Sanchez-Jimenez, Eva Juarez-Hernandez, Martha Ramos-Ostos, Luis F. Alva-Lopez, Misael Uribe
Summary: This study aims to evaluate the effect of providing different levels of diagnostic information on medical care-seeking in adults newly diagnosed with NAFLD. The results showed that patients who received more information sought specialized medical care more frequently, which may help to increase patients' health-seeking behavior.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Gastroenterology & Hepatology
Misael Uribe, Arturo Panduro, Gisela DuPont, Nora A. Fierro
ANNALS OF HEPATOLOGY
(2022)
Letter
Gastroenterology & Hepatology
Sahaj Rati, Piero Amodio
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Medicine, General & Internal
Dieter Haeussinger, Radha K. Dhiman, Vicente Felipo, Boris Gorg, Rajiv Jalan, Gerald Kircheis, Manuela Merli, Sara Montagnese, Manuel Romero-Gomez, Alfons Schnitzler, Simon D. Taylor-Robinson, Hendrik Vilstrup
Summary: Hepatic encephalopathy is a neuropsychiatric syndrome that occurs in patients with liver disease. It affects the quality of life of patients and is the most serious complication of decompensated liver cirrhosis. Ammonia and inflammation play key roles in the development of hepatic encephalopathy, leading to cerebral edema, oxidative/nitrosative stress, inflammation, and disturbances in brain networks. Lactulose and rifaximin are currently the main medical treatments.
NATURE REVIEWS DISEASE PRIMERS
(2022)
Article
Gastroenterology & Hepatology
Daniel Granados-Fuentes, Kevin Cho, Gary J. Patti, Rodolfo Costa, Erik D. Herzog, Sara Montagnese
Summary: Hyperammonaemia affects circadian regulation of rest-activity behavior by increasing extracellular glutamate levels in the suprachiasmatic nuclei.
LIVER INTERNATIONAL
(2023)
Review
Oncology
Elizabeth B. Klerman, Allison Brager, Mary A. Carskadon, Christopher M. Depner, Russell Foster, Namni Goel, Mary Harrington, Paul M. Holloway, Melissa P. Knauert, Monique K. LeBourgeois, Jonathan Lipton, Martha Merrow, Sara Montagnese, Mingming Ning, David Ray, Frank A. J. L. Scheer, Steven A. Shea, Debra J. Skene, Claudia Spies, Bart Staels, Marie-Pierre St-Onge, Steffen Tiedt, Phyllis C. Zee, Helen J. Burgess
Summary: The manuscript provides guidance on measuring metrics of endogenous circadian rhythms in humans and advocates for the inclusion of circadian rhythms assessments in health and disease studies. It describes protocols and analyses commonly used for studying human daily rhythms and recommends definitions and examples of circadian terminology.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Editorial Material
Gastroenterology & Hepatology
Debbie L. Shawcross, Dominique Thabut, Piero Amodio
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Simon Johannes Gairing, Chiara Mangini, Lisa Zarantonello, Stefania Gioia, Elise Jonasson Nielsen, Sven Danneberg, Anna S. Lok, Philippe Sultanik, Peter Robert Galle, Joachim Labenz, Dominique Thabut, Jens Uwe Marquardt, Patricia P. Bloom, Mette Munk Lauridsen, Sara Montagnese, Silvia Nardelli, Christian Labenz
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Lisa Zarantonello, Chiara Mangini, Davide Erminelli, Silvano Fasolato, Paolo Angeli, Piero Amodio, Sara Montagnese
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Medicine, General & Internal
Chien-Hao Huang, Tung-Yang Yu, Wei-En Johnny Tseng, Yu-Tung Huang, Shang-Hung Chang, Sen-Yung Hsieh, Rong-Nan Chien, Piero Amodio
Summary: This study aimed to investigate the potential of the animal naming test (ANT(1) and simplified ANT(1) (s-ANT(1))) for assessing covert hepatic encephalopathy (CHE) in Chinese-speaking regions, specifically Taiwan. The study found that ANT(1) and s-ANT(1) showed diagnostic and prognostic value for CHE.
ANNALS OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Lisa Zarantonello, Chiara Mangini, Davide Erminelli, Silvano Fasolato, Paolo Angeli, Piero Amodio, Sara Montagnese
Summary: It is known that patients with covert hepatic encephalopathy (CHE) exhibit working memory abnormalities, but there is no study comparing patients with cirrhosis with/without CHE and controls with both electrophysiological and hemodynamic data collected at the same time. This study showed that the presence of cirrhosis had more effects on working memory than CHE at baseline. Treatment with rifaximin was more beneficial to patients without CHE, suggesting greater room for improvement in this complex task.
NEUROCHEMICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Simon Johannes Gairing, Chiara Mangini, Lisa Zarantonello, Stefania Gioia, Elise Jonasson Nielsen, Sven Danneberg, Anna S. Lok, Philippe Sultanik, Peter Robert Galle, Joachim Labenz, Dominique Thabut, Jens Uwe Marquardt, Patricia P. Bloom, Mette Munk Lauridsen, Sara Montagnese, Silvia Nardelli, Christian Labenz
Summary: This large multicenter study demonstrates that screening for minimal hepatic encephalopathy (MHE) is a useful tool for predicting the development of overt hepatic encephalopathy (OHE) and poorer survival.
JOURNAL OF INTERNAL MEDICINE
(2023)