Sorafenib perpetuates cellular anticancer effector functions by modulating the crosstalk between macrophages and natural killer cells

Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice

(2012) Leonhard Stross et al.   HEPATOLOGY

Characterization of kinase inhibitors using different phosphorylation states of colony stimulating factor-1 receptor tyrosine kinase

(2011) D. Kitagawa et al.   JOURNAL OF BIOCHEMISTRY

Transgenic Expression of Entire Hepatitis B Virus in Mice Induces Hepatocarcinogenesis Independent of Chronic Liver Injury

(2011) Bing Na et al.   PLoS One

High-performance liquid chromatographic method for the determination of sorafenib in human serum and peritoneal fluid

(2010) Werner J. Heinz et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents

(2010) Le-Xing Yu et al.   HEPATOLOGY

The multikinase inhibitor Sorafenib reverses the suppression of IL-12 and enhancement of IL-10 by PGE2 in murine macrophages

(2010) Justin P. Edwards et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Regulation of Th1 Responses by the p38 MAPK

(2010) Z. Yang et al.   JOURNAL OF IMMUNOLOGY

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

(2010) Heehyoung Lee et al.   NATURE MEDICINE

The interaction of human natural killer cells with either unpolarized or polarized macrophages results in different functional outcomes

(2010) F. Bellora et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Revisiting human natural killer cell subset function revealed cytolytic CD56dimCD16+ NK cells as rapid producers of abundant IFN-  on activation

(2010) A. De Maria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

M-CSF elevates c-Fos and phospho-C/EBP (S21) via ERK whereas G-CSF stimulates SHP2 phosphorylation in marrow progenitors to contribute to myeloid lineage specification

(2009) G. D. Jack et al.   BLOOD

Regulation of the IL-23 and IL-12 Balance by Stat3 Signaling in the Tumor Microenvironment

(2009) Marcin Kortylewski et al.   CANCER CELL

A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma

(2009) Johannes Haybaeck et al.   CANCER CELL

Sorafenib inhibits signal transducer and activator of transcription-3 signaling in cholangiocarcinoma cells by activating the phosphatase shatterproof 2

(2009) Boris R. A. Blechacz et al.   HEPATOLOGY

Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients

(2009) Jia Zhou et al.   INTERNATIONAL JOURNAL OF CANCER

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1

(2009) Dong-Ming Kuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflammatory tumour microenvironment is associated with superior survival in hepatocellular carcinoma patients

(2009) Valerie Chew et al.   JOURNAL OF HEPATOLOGY

The Kinase Inhibitors Sunitinib and Sorafenib Differentially Affect NK Cell Antitumor Reactivity In Vitro

(2009) M. Krusch et al.   JOURNAL OF IMMUNOLOGY

Interactions between Human NK Cells and Macrophages in Response to Salmonella Infection

(2009) N. Lapaque et al.   JOURNAL OF IMMUNOLOGY

TRAIL-induced apoptosis of hepatocellular carcinoma cells isaugmented by targeted therapies

(2009) Bruno Christian Koehler et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses

(2008) M. M. Hipp et al.   BLOOD

High Expression of Macrophage Colony-Stimulating Factor in Peritumoral Liver Tissue Is Associated With Poor Survival After Curative Resection of Hepatocellular Carcinoma

(2008) Xiao-Dong Zhu et al.   JOURNAL OF CLINICAL ONCOLOGY

“Re-educating” tumor-associated macrophages by targeting NF-κB

(2008) Thorsten Hagemann et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR-dependent cross talk between human Kupffer cells and NK cells

(2008) Zhengkun Tu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE