Article
Biochemistry & Molecular Biology
Xingren Chen, Xiaobo Zhu, Jian Dong, Fang Chen, Qi Gao, Lijun Zhang, Dawei Cai, Hui Dong, Binjia Ruan, Yongxiang Wang, Qing Jiang, Wangsen Cao
Summary: The study demonstrates that diacerein has a significant protective effect on cartilage damage in OA mice, by inhibiting the upregulation of DNMT1/3a, promoter hypermethylation of PPAR gamma, and reversing the expression of antioxidant enzymes and inflammatory cytokines.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Plant Sciences
Haoyang Zou, Yiyao Gong, Haiqing Ye, Cuiping Yuan, Tiezhu Li, Jie Zhang, Li Ren
Summary: This study summarizes the physiological importance and clinical significance of PPARs and reviews the experimental evidence that natural products mediate metabolic syndrome via PPARs. The majority of currently described natural compounds are mild PPAR-selective agonists with therapeutic effects that are equivalent to synthetic medicines but less harmful adverse effects. Conclusion: PPAR agonists can be combined with natural products to treat and prevent metabolic syndrome.
Review
Gastroenterology & Hepatology
Swati Katoch, Vinesh Sharma, Vikram Patial
Summary: Hepatocellular carcinoma (HCC) is the most common type of liver cancer, with viral hepatitis being a significant risk factor. Peroxisome-proliferator-activated receptor gamma (PPAR gamma) plays a crucial role in the pathogenesis of HCC. Synthetic agonists of PPAR gamma have shown potential in suppressing HCC, but they may also have severe side effects. Natural PPAR gamma agonists can be an alternative option for HCC treatment.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shan Zhang, Yanru You, Yachong Li, Hairui Yuan, Jie Zhou, Lijie Tian, Ying Liu, Baoli Wang, Endong Zhu
Summary: Foxk1 promotes adipocyte differentiation by facilitating nuclear translocation and upregulating the transcriptional activity of the Ppar gamma 2 promoter.
Review
Cell Biology
Yaqin Zhao, Huabing Tan, Xiaoyu Zhang, Jing Zhu
Summary: This article summarizes the role of PPARs in the occurrence and development of HCC, as well as their value in the diagnosis, treatment, and prognosis of HCC.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Weibei Sheng, Qichang Wang, Haotian Qin, Siyang Cao, Yihao Wei, Jian Weng, Fei Yu, Hui Zeng
Summary: Osteoarthritis (OA) is a common degenerative joint disease that is exacerbated by population aging, resulting in a significant economic burden. Current therapies are inadequate, but research on peroxisome proliferator-activated receptors (PPARs) shows promise in slowing OA progression. PPARs have emerged as potential targets for effective OA treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pathology
Shinji Kaba, Yoshitaka Kawai, Yuki Tanigami, Hiroe Ohnishi, Tomoko Kita, Masayoshi Yoshimatsu, Koichi Omori, Yo Kishimoto
Summary: This study aimed to evaluate the effects of pioglitazone on macrophage phenotype and fibrosis following vocal fold injury. The results showed that pioglitazone reduced the expression of Ccl2, inhibited the accumulation of inflammatory macrophages, and improved tissue repair in a PPARy-dependent manner, resulting in decreased fibrosis.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yanhao Qiu, Mailin Gan, Xingyu Wang, Tianci Liao, Qiuyang Chen, Yuhang Lei, Lei Chen, Jinyong Wang, Ye Zhao, Lili Niu, Yan Wang, Shunhua Zhang, Li Zhu, Linyuan Shen
Summary: Excessive expansion of adipocytes can lead to ectopic fat deposition, increasing the risk of metabolic diseases. Peroxisome proliferator-activated receptor gamma (PPARγ) plays a crucial role in fat cell differentiation and adipogenesis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Neurosciences
Riham M. Mansour, Nesrine S. El Sayed, Maha A. E. Ahmed, Ayman E. El-Sahar
Summary: This study aimed to explore the neuroprotective effect of telmisartan in 3-nitropropionic acid-induced neurotoxicity. The results showed that telmisartan improved motor and cognitive functioning, reduced neuronal inflammation and apoptosis, and promoted mitochondrial biogenesis through PPAR gamma activation.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Environmental Sciences
Lydia Lichtiger, Jacqueline Jezioro, Janelle Rivera, Jacob D. McDonald, Mary Beth Terry, Debashish Sahay, Rachel L. Miller
Summary: Environmental exposure to polycyclic aromatic hydrocarbons (PAH) has been shown to be associated with altered regulation of the transcription factor peroxisome proliferator-activated receptor gamma (Ppar gamma) and increased risk of chronic diseases. In this study, pregnant mice were exposed to PAH and the effects were examined in mammary tissue of offspring and grandoffspring mice. The results suggested that prenatal PAH exposure led to lower Ppar gamma methylation in grandoffspring mice, while associations with gene expression or biomarkers of epithelial to mesenchymal transition (EMT) were not consistent. Additionally, lower Ppar gamma methylation was associated with higher body weight in the mice.
ENVIRONMENTAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Shi Fang, M. Christine Livergood, Pablo Nakagawa, Jing Wu, Curt D. Sigmund
Summary: This review focuses on the mechanisms by which nuclear receptors mediate transcriptional responses, with a specific emphasis on the role of PPARγ in regulating blood pressure. Genetic and clinical trial data demonstrate the importance of PPARγ in hypertension, and the tissue- and cell-specific molecular mechanisms by which PPARs modulate blood pressure and related phenotypes are detailed. The role of placental PPARs in preeclampsia is also discussed, along with future research directions and implications for novel therapies.
CIRCULATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mahesha Gangadhariah, Triveni Pardhi, Jahnavi Ravilla, Subhash Chandra, Sridevi Annapurna Singh
Summary: PPAR gamma agonists are effective in treating type 2 diabetes but have severe side effects. Lemon contains eriocitrin, which may have potential as a PPAR gamma agonist.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Immunology
Bingqiang Hua, Jin Qiu, Xiaoping Ye, Yiwen Kuang, Xianwen Liu
Summary: This study reveals the significant role of epigenetic PPAR gamma dysregulation in the pathogenesis of TMJOA. The suppression of PPAR gamma can be alleviated by DNA demethylation intervention, leading to cartilage restoration and stabilizing cartilage homeostasis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hiroyuki Miyachi
Summary: Recent progress in understanding the structure and pharmacology of hPPAR gamma has allowed for investigation of various ligands and their effects on biological responses. These ligands serve as valuable tools for studying hPPAR gamma function and potential drugs for hPPAR gamma-related diseases. This review summarizes the medicinal chemistry research on the design, synthesis, and evaluation of hPPAR gamma antagonists based on the induction/inhibition concept of helix 12 (H12) and presents X-ray crystallographic analyses of their unique binding modes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
S. Yuvaraj, B. R. Prashantha Kumar
Summary: Peroxisome proliferator activated receptors (PPARs) are nuclear receptors that play a key role in physiological processes such as cell metabolism, proliferation, and inflammation. Among them, PPAR gamma has been found to act as a tumor suppressor by regulating inflammatory pathways and inhibiting tumor cell growth and multiplication.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)