4.8 Letter

Early Determination of Hepatitis C Virus RNA May Help to Decide the Duration of Therapy for Chronic Hepatitis C Virus Genotype 2/3 Infection

Journal

HEPATOLOGY
Volume 53, Issue 3, Pages 1067-1068

Publisher

WILEY-BLACKWELL
DOI: 10.1002/hep.23962

Keywords

-

Ask authors/readers for more resources

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Article Surgery

Laryngeal and Pharyngeal Squamous Cell Carcinoma After Antireflux Surgery in the 5 Nordic Countries

Manar Yanes, Giola Santoni, John Maret-Ouda, Eivind Ness-Jensen, Martti Farkkila, Elsebeth Lynge, Eero Pukkala, Pal Romundstad, Laufey Tryggvadottir, My von Euler-Chelpin, Jesper Lagergren

Summary: This study found that antireflux surgery may decrease the risk of laryngeal and possibly pharyngeal squamous cell carcinoma.

ANNALS OF SURGERY (2022)

Article Gastroenterology & Hepatology

Early and accurate detection of cholangiocarcinoma in patients with primary sclerosing cholangitis by methylation markers in bile

Hege Marie Vedeld, Marit M. Grimsrud, Kim Andresen, Heidi D. Pharo, Erik von Seth, Tom H. Karlsen, Hilde Honne, Vemund Paulsen, Martti A. Farkkila, Annika Bergquist, Marine Jeanmougin, Lars Aabakken, Kirsten M. Boberg, Trine Folseraas, Guro E. Lind

Summary: The study aimed to establish robust DNA methylation biomarkers in bile for early and accurate diagnosis of CCA in PSC. Using ddPCR analysis, high accuracy was achieved in detecting CCA in PSC patients, even up to 12 months before official diagnosis, indicating the potential of these biomarkers to complement current detection methods.

HEPATOLOGY (2022)

Article Gastroenterology & Hepatology

Incidence and Mortality in Upper Gastrointestinal Cancer After Negative Endoscopy for Gastroesophageal Reflux Disease

Dag Holmberg, Giola Santoni, My Catarina von Euler-Chelpin, Martti Farkkila, Joonas H. Kauppila, John Maret-Ouda, Eivind Ness-Jensen, Jesper Lagergren

Summary: This population-based cohort study conducted in Denmark, Finland, Norway, and Sweden from 1979 to 2018 found that negative upper endoscopy in patients with GERD is associated with a significant and long-lasting decrease in both incidence and mortality of upper gastrointestinal cancer. The risk reduction persisted for at least 5 years in incidence and 10 years in mortality after a negative upper endoscopy.

GASTROENTEROLOGY (2022)

Article Gastroenterology & Hepatology

Impact on follow-up strategies in patients with primary sclerosing cholangitis

Annika Bergquist, Tobias J. Weismueller, Cynthia Levy, Christian Rupp, Deepak Joshi, Jeremy Shanika Nayagam, Aldo J. Montano-Loza, Ellina Lytvyak, Ewa Wunsch, Piotr Milkiewicz, Roman Zenouzi, Christoph Schramm, Nora Cazzagon, Annarosa Floreani, Ingalill Friis Liby, Miriam Wiestler, Heiner Wedemeyer, Taotao Zhou, Christian P. Strassburg, Eirini Rigopoulou, George Dalekos, Manasa Narasimman, Xavier Verhelst, Helena Degroote, Mette Vesterhus, Andreas E. Kremer, Bennet Buendgens, Fredrik Rorsman, Emma Nilsson, Kristin Kaasen Jorgensen, Erik von Seth, Martin Cornillet Jeannin, Nils Nyhlin, Harry Martin, Stergios Kechagias, Kristine Wiencke, Marten Werner, Benedetta Terziroli Beretta-Piccoli, Marco Marzioni, Helena Isoniemi, Johanna Arola, Agnes Wefer, Jonas Soderling, Martti Farkkila, Henrike Lenzen

Summary: This study compares different follow-up strategies in patients with PSC and finds that scheduled imaging can improve survival. There are considerable variations in follow-up strategies across centers, but multiple factors may contribute to this result.

LIVER INTERNATIONAL (2023)

Article Gastroenterology & Hepatology

Automated image analysis of keratin 7 staining can predict disease outcome in primary sclerosing cholangitis

Nelli Sjoblom, Sonja Boyd, Anniina Manninen, Sami Blom, Anna Knuuttila, Martti Farkkila, Johanna Arola

Summary: A study found that measuring the cytokeratin 7 (K7) load in liver samples using an artificial intelligence (AI) model can serve as an efficient surrogate marker to evaluate disease progression in primary sclerosing cholangitis (PSC). The K7-AI model 2.0 was more accurate in predicting the compound endpoint compared to other serum markers and pathological evaluations, and it also provided additional variables that cannot be measured by human pathologists.

HEPATOLOGY RESEARCH (2023)

Article Multidisciplinary Sciences

PNPLA3 allele frequency has no impact on biliary bile acid composition or disease course in patients with primary sclerosing cholangitis

Martti Farkkila, Hannu Kautiainen, Andrea Tenca, Kalle Jokelainen, Johanna Arola

Summary: The study aimed to evaluate the PNPLA3 allele frequency effect on the clinical outcomes, progression, and prognosis of PSC. The results showed that the PNPLA3 I148M variant had no significant impact on bile composition, including UDCA content, clinical outcomes, progression of liver fibrosis, hepatobiliary cancer risk, liver transplantation, or overall survival.

PLOS ONE (2022)

Article Gastroenterology & Hepatology

PRIMIS: design of a pivotal, randomized, phase 3 study evaluating the safety and efficacy of the nonsteroidal farnesoid X receptor agonist cilofexor in noncirrhotic patients with primary sclerosing cholangitis

Michael Trauner, Chuhan Chung, Kate Sterling, Xiangyu Liu, Xiaomin Lu, Jun Xu, Clare Tempany-Afdhal, Zachary D. Goodman, Martti Faerkkilae, Atsushi Tanaka, Palak Trivedi, Kris V. Kowdley, Christopher L. Bowlus, Cynthia Levy, Robert P. Myers

Summary: This article presents the background of PSC and the design and implementation of the phase 3 PRIMIS trial, which aims to evaluate the efficacy and safety of cilofexor in noncirrhotic patients with large-duct PSC. The primary objective is to assess whether cilofexor reduces the risk of fibrosis progression compared with placebo.

BMC GASTROENTEROLOGY (2023)

Article Gastroenterology & Hepatology

Magnitude and Time-Trends of Post-Endoscopy Esophageal Adenocarcinoma and Post-Endoscopy Esophageal Neoplasia in a Population-Based Cohort Study: The Nordic Barrett's Esophagus Study

Sachin Wani, Dag Holmberg, Giola Santoni, Joonas H. Kauppila, Martti Farkkila, My von Euler-Chelpin, Nicholas J. Shaheen, Jesper Lagergren

Summary: A significant number of esophageal adenocarcinoma cases are diagnosed within a year after an ostensibly negative upper endoscopy in patients with newly diagnosed Barrett's esophagus. Interventions to improve detection rates and reduce post-endoscopy esophageal adenocarcinoma and neoplasia are needed.

GASTROENTEROLOGY (2023)

Article Gastroenterology & Hepatology

Abdominal obesity and alcohol use modify the impact of genetic risk for incident advanced liver disease in the general population

Panu K. Luukkonen, Martti Farkkila, Antti Jula, Veikko Salomaa, Satu Mannisto, Annamari Lundqvist, Markus Perola, Fredrik Aberg

Summary: This study investigates the association between genetic variants, abdominal obesity, alcohol use and incident liver disease (ILD). Variants in genes such as PNPLA3, IFNL4, and TM6SF2 are found to be associated with ILD. Genetic risk scores (GRSs) calculated from these variants are exponentially associated with ILD, while not associated with waist-hip ratio (WHR) or alcohol use. The risk of ILD in individuals with high GRS and high WHR or alcohol use is increased by up to 90-fold.

LIVER INTERNATIONAL (2023)

Article Gastroenterology & Hepatology

Combined use of the ELF test and CLivD score improves prediction of liver-related outcomes in the general population

Fredrik Aberg, Kustaa Saarinen, Antti Jula, Annamari Lundqvist, Terhi Vihervaara, Iris Erlund, Martti Farkkila

Summary: This study evaluated the predictive performance of a combination of liver fibrosis assessment, phenotype profile, and genetic risk in predicting liver-related outcomes. The combination of the chronic liver disease risk score and the enhanced liver fibrosis test significantly improved the predictive performance compared to the enhanced liver fibrosis test alone. The addition of the polygenic risk score did not significantly increase the predictive performance.

LIVER INTERNATIONAL (2023)

Article Medicine, General & Internal

Non-erosive gastro-oesophageal reflux disease and incidence of oesophageal adenocarcinoma in three Nordic countries: population based cohort study

Dag Holmberg, Giola Santoni, My von Euler-Chelpin, Martti Farkkila, Joonas H. Kauppila, John Maret-Ouda, Eivind Ness-Jensen, Jesper Lagergren

Summary: Patients with non-erosive gastro-oesophageal reflux disease have a similar incidence of oesophageal adenocarcinoma as the general population.

BMJ-BRITISH MEDICAL JOURNAL (2023)

Article Infectious Diseases

Catch-up antibody responses and hybrid immunity in mRNA vaccinated patients at risk of severe COVID-19

Samer Al-Dury, Jesper Waldenstrom, Johan Ringlander, Sigrun Einarsdottir, Markus Andersson, Hevar Hamah Saed, Johan Waern, Anna Martner, Kristoffer Hellstrand, Martin Lagging

Summary: This study investigated the impact of repeated vaccination and hybrid immunity on antibody levels in immunosuppressed patients. The results showed that immunosuppressed patients achieved antibody levels comparable to controls after receiving three doses of the vaccine. Hybrid immunity resulted in approximately 10-fold higher antibody levels than vaccine-induced immunity alone in all study cohorts.

INFECTIOUS DISEASES (2023)

Correction Gastroenterology & Hepatology

Enhanced Liver Fibrosis® test predicts liver-related outcomes in the general population ( vol 5 , 100765 , 2023)

Kustaa Saarinen, Martti Faerkkilae, Antti Jula, Iris Erlund, Terhi Vihervaara, Annamari Lundqvist, Fredrik Aberg

JHEP REPORTS (2023)

Article Medicine, Research & Experimental

Waist-hip ratio is superior to BMI in predicting liver-related outcomes and synergizes with harmful alcohol use

Fredrik Aberg, Martti Farkkila, Veikko Salomaa, Antti Jula, Satu Mannisto, Markus Perola, Annamari Lundqvist, Ville Mannisto

Summary: Öberg et al. evaluated the predictive performance of obesity measures, including waist-hip ratio, waist circumference, and BMI, for liver-related outcomes in participants of Finnish health surveys. They found that waist-hip ratio is a better predictor for liver-related outcomes than other measures and synergizes with harmful alcohol use.

COMMUNICATIONS MEDICINE (2023)

No Data Available