Article
Nanoscience & Nanotechnology
Lingwei Liu, Jialang Zhuang, Jizhou Tan, Ting Liu, Wenzhe Fan, Yuanqing Zhang, Jiaping Li
Summary: Transcatheter arterial chemoembolization (TACE) is the preferred treatment for intermediate hepatocellular carcinoma (HCC). However, there are still challenges in effectively targeting cancer cells without damage to normal liver cells. Researchers have developed multifunctional nanoparticles using a simple solvothermal method, which can achieve both photothermal effects and low pH-triggered drug release. The results demonstrate that these nanoparticles have high efficacy and biocompatibility for HCC treatment.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Health Care Sciences & Services
Evgenia Kotsifa, Chrysovalantis Vergadis, Michael Vailas, Nikolaos Machairas, Stylianos Kykalos, Christos Damaskos, Nikolaos Garmpis, Georgios D. Lianos, Dimitrios Schizas
Summary: HCC is the most common primary liver malignancy associated with liver cirrhosis and chronic liver disease. Key risk factors for HCC development include viral infections, alcoholic liver disease, and nonalcoholic fatty liver disease. Treatment options for HCC depend on tumor burden, liver function, and patient's health status, with surgical resection, transplantation, ablation, TACE, and systemic therapy being potential strategies.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cell Biology
Maria Carmen Ochoa, Sandra Sanchez-Gregorio, Carlos E. de Andrea, Saray Garasa, Maite Alvarez, Irene Olivera, Javier Glez-Vaz, Carlos Luri-Rey, Inaki Etxeberria, Assunta Cirella, Arantza Azpilikueta, Pedro Berraondo, Josepmaria Argemi, Bruno Sangro, Alvaro Teijeira, Ignacio Melero
Summary: Immune checkpoint-inhibitor combinations are the best therapeutic option for advanced hepatocellular carcinoma (HCC) patients, and the efficacy can be further improved by combining recombinant IL-2 or anti-CD137 mAb with anti-CTLA-4 + anti-PD1 mAbs treatment. A multifocal HCC model was developed to test immunotherapies, and the combination of tumor-specific adoptive T cell therapy with aCTLA-4/aPD1/rIL2 or aCTLA-4/aPD1/aCD137 regimens showed synergistic efficacy. The combined immunotherapy treatments enhanced T cell infiltration and the intratumoral performance of T lymphocytes.
CELL REPORTS MEDICINE
(2023)
Article
Oncology
Yusheng Guo, Yanqiao Ren, Lei Chen, Tao Sun, Weihua Zhang, Bo Sun, Licheng Zhu, Fu Xiong, Chuansheng Zheng
Summary: This study evaluated the efficacy and safety of transarterial chemoembolization (TACE) combined with camrelizumab in treating recurrent hepatocellular carcinoma (R-HCC). The results showed that TACE-camrelizumab had similar efficacy to TACE-alone in terms of objective response rate, disease control rate, progression-free survival, and survival rates. Neutrophil-to-lymphocyte ratio was significantly associated with progression-free survival. Adverse events related to camrelizumab were observed in a majority of patients, but none were severe.
Review
Oncology
Alexander Lawson, Sivesh K. Kamarajah, Alessandro Parente, Kamil Pufal, Ramanivas Sundareyan, Timothy M. Pawlik, Yuk Ting Ma, Tahir Shah, Salil Kharkhanis, Bobby V. M. Dasari
Summary: Non-surgical management options for hepatocellular carcinoma (HCC) include transarterial embolisation (TAE) and transarterial chemoembolisation (TACE), both of which have comparable long-term survival and complications profile. However, the current low-to-moderate quality of randomized controlled trials (RCTs) highlights the need for high-quality RCTs to provide definitive evidence for future treatment plans.
Review
Biochemistry & Molecular Biology
Antoni Sureda, Miguel Martorell, Xavier Capo, Margalida Monserrat-Mesquida, Maria Magdalena Quetglas-Llabres, Mahsa Rasekhian, Seyed M. Nabavi, Silvia Tejada
Summary: Triterpenes, derived from plants, have potential antitumor effects and can exhibit cytotoxic and anti-proliferative effects on hepatocellular carcinoma. Research suggests that triterpenes may serve as chemosensitizing agents when used in combination with chemotherapeutic drugs for improved efficacy.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Engineering, Biomedical
Yingliang Wang, Xuelian He, Chen Zhou, Yaowei Bai, Tongqiang Li, Jiacheng Liu, Shuguang Ju, Chaoyang Wang, Guangya Xiang, Bin Xiong
Summary: Transcatheter arterial chemoembolization (TACE) is commonly used for hepatocellular carcinoma (HCC) treatment, but its efficacy is limited by tumor hypoxia and the abnormal tumor microenvironment (TME). In this study, CaO2 nanoparticles were synthesized and combined with TACE to enhance the antitumor effect. CaO2 NPs relieved tumor hypoxia, neutralized the acidic TME, and induced Ca2+ overloading, resulting in improved efficacy of TACE in the rabbit liver cancer model.
ACTA BIOMATERIALIA
(2022)
Review
Medicine, General & Internal
Qiong Gao, Zhaolin Sun, Deyu Fang
Summary: Integrins, transmembrane receptors linking the extracellular matrix and actin skeleton, play key roles in tumorigenesis by regulating cell adhesion, migration, signal transduction, and gene transcription. This review focuses on the abnormal expression, activation, and signaling of integrins in human hepatocellular carcinoma (HCC), as well as their roles in the tumor microenvironment and regulation in hepatitis B virus-related HCC. Additionally, the clinical and preclinical studies of integrin-related drugs in HCC treatment are discussed.
CHINESE MEDICAL JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hee Ho Chu, Dong I. L. Gwon, Gun Ha Kim, Jin Hyoung Kim, Gi-Young Ko, Ji Hoon Shin, Heung-Kyu Ko, Hyun-Ki Yoon
Summary: This retrospective study compared the safety and efficacy of balloon-occluded transarterial chemoembolization (B-TACE) and conventional TACE (C-TACE) in treating single hepatocellular carcinoma (HCC). The results showed that B-TACE had a higher initial complete response rate and longer time to local tumor progression for medium- to large-sized HCCs (> 3 cm) compared to C-TACE.
EUROPEAN RADIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jizhou Tan, Wenzhe Fan, Ting Liu, Bowen Zhu, Yafang Liu, Shutong Wang, Jian Wu, Jun Liu, Fan Zou, Jialiang Wei, Lingwei Liu, Xiaokai Zhang, Jialang Zhuang, Yi Wang, Haibiao Lin, Xianzhang Huang, Songling Chen, Ming Kuang, Jiaping Li
Summary: This study characterizes the immune landscape following transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) and investigates the underlying mechanism of HCC progression. The results show that TACE leads to a reduced number of CD8+ T cells and an increased number of tumor-associated macrophages (TAMs). TREM2+ TAMs with high expression after TACE were associated with poor prognosis and their secretion of galectin-1 promoted PD-L1 overexpression in vessel endothelial cells, inhibiting CD8+ T cell recruitment. TREM2 deficiency increased CD8+ T cell infiltration and enhanced the therapeutic effect of anti-PD-L1 blockade. These findings provide insights into the immunotherapy of HCC after TACE.
JOURNAL OF HEPATOLOGY
(2023)
Article
Oncology
Sonia Simon Serrano, Michele Tavecchio, Josef Mallik, Alvar Gronberg, Eskil Elmer, Chamseddine Kifagi, Philippe Gallay, Magnus Joakim Hansson, Ramin Massoumi
Summary: Cyclophilins, which are overexpressed in hepatocellular carcinoma (HCC), play a key role in cancer progression and mediating chemoresistance. The novel cyclophilin inhibitor NV651 can reduce cell division and DNA repair in HCC cells. Combination treatment of NV651 and cisplatin significantly increases cancer cell death compared to cisplatin alone.
Article
Engineering, Biomedical
Yiming Liu, Chuan Tian, Chengzhi Zhang, Zaoqu Liu, Jing Li, Yahua Li, Quanhui Zhang, Shengnan Ma, Dechao Jiao, Xinwei Han, Yanan Zhao
Summary: In this study, a multifunctional cryogel (SQAP) was successfully developed using a biomaterial strategy, which effectively controlled the postoperative recurrence of hepatocellular carcinoma (HCC) in patients. Clinical and in vivo experiments showed that SQAP achieved significant inhibitory effects on cell growth and HCC recurrence through combined photothermal therapy and molecular targeted therapy. This study demonstrated the great potential of SQAP for clinical application.
MATERIALS TODAY BIO
(2023)
Review
Gastroenterology & Hepatology
Bin-Yan Zhong, Zhi-Cheng Jin, Jian-Jian Chen, Hai-Dong Zhu, Xiao-Li Zhu
Summary: This review article by experts from the Chinese Liver Cancer Clinical Study Alliance (CHANCE) summarizes the clinical evidence on the current application of TACE in patients with early-, intermediate-, and advanced-stage HCC. It also evaluates the combination of TACE with other treatment modalities, especially immunotherapy.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)
Article
Cell Biology
Jian Gao, Zuojing Yin, Zhuanbin Wu, Zhen Sheng, Chao Ma, Rui Chen, Xiongwen Zhang, Kailin Tang, Jian Fei, Zhiwei Cao
Summary: This study explored the synergistic effects of Berberine and Evodiamine in hepatocellular carcinoma by co-inhibiting NF-kappa B and c-JUN, which showed significant anticancer activity. The in vivo experiments in zebrafish and analysis of HCC individuals revealed promising results, suggesting the potential of natural compounds for developing combination therapies in combating malignant cancers.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Charlotte Ebeling Barbier, Femke Heindryckx, Hans Lennernaes
Summary: Clinical data review highlights the limitations of transarterial chemoembolization (TACE) as a treatment for hepatocellular carcinoma (HCC) and the complex interactions between drug delivery, tumor targeting mechanisms, liver pathophysiology, patient and tumor heterogeneity, and resistance mechanisms. Understanding and addressing these factors are essential to improving the effectiveness of TACE and developing novel drug delivery systems for locoregional treatment of HCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Katja Peschke, Hannah Jakubowsky, Arlett Schaefer, Carlo Maurer, Sebastian Lange, Felix Orben, Raquel Bernad, Felix N. Harder, Matthias Eiber, Rupert Oellinger, Katja Steiger, Melissa Schlitter, Wilko Weichert, Ulrich Mayr, Veit Phillip, Christoph Schlag, Roland M. Schmid, Rickmer F. Braren, Bo Kong, Ihsan Ekin Demir, Helmut Friess, Roland Rad, Dieter Saur, Gunter Schneider, Maximilian Reichert
Summary: This article introduces a longitudinal precision oncology platform based on functional model systems to identify chemotherapy-induced vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). It is found that treatment-induced tumor cell plasticity distinctly changes responsiveness to targeted therapies.
EMBO MOLECULAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhen Liu, Tao Cheng, Stephan Duwel, Ziying Jian, Geoffrey J. Topping, Katja Steiger, Qian Wang, Rickmer Braren, Sybille Reder, Markus Mittelhauser, Christian Hundshammer, Benedikt Feuerecker, Sung-Cheng Huang, Markus Schwaiger, Franz Schilling, Sibylle I. Ziegler, Kuangyu Shi
Summary: This study successfully developed a multimodal intravital imaging system that provided a co-registered in vivo platform for transparent investigation of the underlying pathology behind imaging. The system integrates visible tumor anatomy, vascular structures, and in vivo tumor microenvironment metabolism, potentially enhancing the translation of molecular imaging.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sebastian Ruehling, Fernando Navarro, Anjany Sekuboyina, Malek El Husseini, Thomas Baum, Bjoern Menze, Rickmer Braren, Claus Zimmer, Jan S. Kirschke
Summary: This study evaluated the accuracy of an artificial neural network for automated detection of iodinated contrast agent in MDCT scans and the effect of contrast correction for osteoporosis screening. The results showed that the 2D DenseNet model with anatomy-guided slice selection outperformed others and successfully reduced the bias in bone mineral density measurements after contrast application.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sean McTavish, Anh T. Van, Johannes M. Peeters, Kilian Weiss, Marcus R. Makowski, Rickmer F. Braren, Dimitrios C. Karampinos
Summary: The experimental results demonstrate that the gradient nonlinearity correction method effectively reduces ADC bias in various diffusion encoding waveforms and may further increase ADC overestimation in in vivo experiments due to motion and residual vessel signal.
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Felix N. Harder, Eva Jung, Sean McTavish, Anh Tu Van, Kilian Weiss, Sebastian Ziegelmayer, Joshua Gawlitza, Philip Gouder, Omar Kamal, Marcus R. Makowski, Fabian K. Lohoefer, Dimitrios C. Karampinos, Rickmer F. Braren
Summary: This study investigated the potential of high-resolution, high b-value computed DWI in the detection of PDAC. The results showed that high-resolution, high b-value computed DWI significantly improved lesion detection and had a higher incidence of strong lesion-to-pancreas intensity relation compared to conventional high b-value computed and high-resolution high b-value acquired DWI. However, the image quality was rated lower in the high-resolution, high b-value computed DWI datasets.
Article
Medicine, Research & Experimental
Ninelia Minaskan Karabid, Tobias Wiedemann, Sebastian Gulde, Hermine Mohr, Renu Chandra Segaran, Julia Geppert, Maria Rohm, Giovanni Vitale, Germano Gaudenzi, Alessandra Dicitore, Donna Pauler Ankerst, Yiyao Chen, Rickmer Braren, Georg Kaissis, Franz Schilling, Mathias Schillmaier, Graeme Eisenhofer, Stephan Herzig, Federico Roncaroli, Juergen B. Honegger, Natalia S. Pellegata
Summary: Invasive nonfunctioning pituitary neuroendocrine tumors (PitNETs) are difficult to remove and current therapies often fail. This study investigated the ANGPT2/TIE2 axis in NF-PitNETs and found that PitNET cells express functional TIE2 receptors and secrete bioactive ANGPT2, which promotes tumor cell growth. Inhibition of this signaling pathway showed promise in inhibiting PitNET growth in various models. Therefore, the ANGPT2/TIE2 axis could be a potential therapeutic target for NF-PitNETs.
EMBO MOLECULAR MEDICINE
(2022)
Article
Physics, Multidisciplinary
Alexander Ziller, Tamara T. Mueller, Rickmer Braren, Daniel Rueckert, Georgios Kaissis
Summary: This work presents an axiomatic definition of privacy based on quantifiable and irreducible information flows, synthesizing prior research from social science with contemporary understanding of privacy-enhancing technologies. It highlights the information-theoretic difficulties in protecting privacy and enables objective policy discourse regarding the implementation of privacy-enhancing technologies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Omar Kamal, Sean McTavish, Felix N. Harder, Anh T. Van, Johannes M. Peeters, Kilian Weiss, Marcus R. Makowski, Dimitrios C. Karampinos, Rickmer F. Braren
Summary: The study evaluated the use of L1 regularized iterative SENSE reconstruction (L1-R SENSE) to improve image quality and robustness of ADC estimation in high resolution diffusion-weighted magnetic resonance imaging of the pancreas. Compared to traditional SENSE reconstruction, L1-R SENSE resulted in higher image quality, reduced noise artifacts, and improved ADC measurements for both PDAC and normal pancreas. Although one reader found SENSE to be superior in anatomical details, overall L1-R SENSE performed better in terms of noise reduction and robustness in ADC estimation.
MAGNETIC RESONANCE IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Irina Heid, Marija Trajkovic-Arsic, Fabian Lohoefer, Georgios Kaissis, Felix N. Harder, Moritz Mayer, Geoffrey J. Topping, Friderike Jungmann, Barbara Crone, Moritz Wildgruber, Uwe Karst, Lucia Liotta, Hana Alguel, Hsi-Yu Yen, Katja Steiger, Wilko Weichert, Jens T. Siveke, Marcus R. Makowski, Rickmer F. Braren
Summary: This study found that in PDAC patients, regions with low tumor cellularity and high stromal content accumulated more contrast agent, while after treatment with gemcitabine, there was a significant reduction in contrast agent accumulation in vivo, affecting drug delivery.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sean McTavish, Anh T. Van, Johannes M. Peeters, Kilian Weiss, Marcus R. Makowski, Rickmer F. Braren, Dimitrios C. Karampinos
Summary: The study aimed to assess the impact of respiratory motion and cardiac driven pulsation on renal DWI and investigate the use of asymmetrical velocity-compensated diffusion encoding waveforms for robust ADC mapping in the kidneys. The results showed that short trigger delays in respiratory-triggered scans could cause higher ADC values, especially in the right kidney. The asym-vc waveform was found to reduce ADC variation due to respiratory motion, although at the cost of reduced SNR compared to the pgse waveform.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Computer Science, Artificial Intelligence
Patrick Bilic, Patrick Christ, Hongwei Bran Li, Eugene Vorontsov, Avi Ben-Cohen, Georgios Kaissis, Adi Szeskin, Colin Jacobs, Gabriel Efrain Humpire Mamani, Gabriel Chartrand, Fabian Lohoefer, Julian Walter Holch, Wieland Sommer, Felix Hofmann, Alexandre Hostettler, Naama Lev-Cohain, Michal Drozdzal, Michal Marianne Amitai, Refael Vivanti, Jacob Sosna, Ivan Ezhov, Anjany Sekuboyina, Fernando Navarro, Florian Kofler, Johannes C. Paetzold, Suprosanna Shit, Xiaobin Hu, Jana Lipkova, Markus Rempfler, Marie Piraud, Jan Kirschke, Benedikt Wiestler, Zhiheng Zhang, Christian Huelsemeyer, Marcel Beetz, Florian Ettlinger, Michela Antonelli, Woong Bae, Miriam Bellver, Lei Bi, Hao Chen, Grzegorz Chlebus, Erik B. Dam, Qi Dou, Chi-Wing Fu, Bogdan Georgescu, Xavier Giro-I-Nieto, Felix Gruen, Xu Han, Pheng-Ann Heng, Jurgen Hesser, Jan Hendrik Moltz, Christian Igel, Fabian Isensee, Paul Jaeger, Fucang Jia, Krishna Chaitanya Kaluva, Mahendra Khened, Ildoo Kim, Jae-Hun Kim, Sungwoong Kim, Simon Kohl, Tomasz Konopczynski, Avinash Kori, Ganapathy Krishnamurthi, Fan Li, Hongchao Li, Junbo Li, Xiaomeng Li, John Lowengrub, Jun Ma, Klaus Maier-Hein, Kevis-Kokitsi Maninis, Hans Meine, Dorit Merhof, Akshay Pai, Mathias Perslev, Jens Petersen, Jordi Pont-Tuset, Jin Qi, Xiaojuan Qi, Oliver Rippel, Karsten Roth, Ignacio Sarasua, Andrea Schenk, Zengming Shen, Jordi Torres, Christian Wachinger, Chunliang Wang, Leon Weninger, Jianrong Wu, Daguang Xu, Xiaoping Yang, Simon Chun-Ho Yu, Yading Yuan, Miao Yue, Liping Zhang, Jorge Cardoso, Spyridon Bakas, Rickmer Braren, Volker Heinemann, Christopher Pal, An Tang, Samuel Kadoury, Luc Soler, Bram van Ginneken, Hayit Greenspan, Leo Joskowicz, Bjoern Menze
Summary: This study reports the setup and results of the Liver Tumor Segmentation Benchmark (LiTS), which involved diverse image datasets and evaluated multiple segmentation algorithms. The best algorithms achieved high scores for liver segmentation, but varied performance for tumor segmentation. Further research is needed for tumor detection. LiTS remains an active benchmark and resource for liver-related segmentation tasks.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Acoustics
Anna Barner, Egon Burian, Alexander Simon, Katty Castillo, Birgit Waschulzik, Rickmer Braren, Uwe Heemann, Joseph Osterwalder, Alexander Spiel, Markus Heim, Konrad Friedrich Stock
Summary: This study investigated the localisation-dependent lesion patterns in COVID-19 using lung ultrasonography (LUS) and their correlation with thoracic computed tomography (CT) and clinical parameters. The LUS score showed an association with respiratory status and C-reactive protein, but weak correlation with the CT score. LUS could reflect the clinical condition of patients, although its prognostic value remains uncertain.
ULTRASCHALL IN DER MEDIZIN
(2023)
Article
Public, Environmental & Occupational Health
Daniel Maier, Joerg Janne Vehreschild, Barbara Uhl, Sandra Meyer, Karin Berger-Thuermel, Melanie Boerries, Rickmer Braren, Viktor Gruenwald, Boris Hadaschik, Stefan Palm, Susanne Singer, Martin Stuschke, David Juarez, Pierre Delpy, Mohamed Lambarki, Michael Hummel, Caecilia Engels, Stefanie Andreas, Nicola Goekbuget, Kristina Ihrig, Susen Burock, Dietmar Keune, Angelika Eggert, Ulrich Keilholz, Hagen Schulz, Daniel Buettner, Steffen Loeck, Mechthild Krause, Mirko Esins, Frank Ressing, Martin Schuler, Christian Brandts, Daniel P. Brucker, Gabriele Husmann, Thomas Oellerich, Patrick Metzger, Frederik Voigt, Anna L. Illert, Matthias Theobald, Thomas Kindler, Ursula Sudhof, Achim Reckmann, Felix Schwinghammer, Daniel Nasseh, Wilko Weichert, Michael von Bergwelt-Baildon, Michael Bitzer, Nisar Malek, Oeznur Oener, Klaus Schulze-Osthoff, Stefan Bartels, Joerg Haier, Raimund Ammann, Anja Franziska Schmidt, Bernd Guenther, Melanie Janning, Bernd Kasper, Sonja Loges, Stephan Stilgenbauer, Peter Kuhn, Eugen Tausch, Silvana Runow, Alexander Kerscher, Michael Neumann, Martin Breu, Martin Lablans, Hubert Serve
Summary: The Clinical Communication Platform of the German Cancer Consortium is a potential catalyst for translational cancer research, providing comprehensive patient groups and improving understanding of the clinical course of various malignancies. It serves as a decision-making tool for clinical trial design and contributes to the evaluation of scientific findings in real-world conditions.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Friederike Jungmann, Sebastian Ziegelmayer, Fabian K. Lohoefer, Stephan Metz, Christina Mueller-Leisse, Maximilian Englmaier, Marcus R. Makowski, Georgios A. Kaissis, Rickmer F. Braren
Summary: This study evaluated the perception of different types of AI-based assistance and the interaction of radiologists with the algorithm's predictions and certainty measures. Four radiologists classified Breast Imaging-Reporting and Data System 4 (BI-RADS4) lesions and the effect of different AI-based assistance on their performance was measured. The results showed that trust in the algorithm's performance was mostly dependent on the certainty of the predictions in combination with a plausible heatmap, and the human-AI interaction varied widely and was influenced by personality traits.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sebastian Ruehling, Andreas Scharr, Nico Sollmann, Maria Wostrack, Maximilian T. Loeffler, Bjoern Menze, Anjany Sekuboyina, Malek El Husseini, Rickmer Braren, Claus Zimmer, Jan S. Kirschke
Summary: There is a strong correlation between trabecular vBMD values in the cervicothoracic and lumbar regions, with vBMD values decreasing with age in both women and men. The proposed cut-off values for osteoporosis peaked at C4 and decreased towards T12, allowing for the determination of low bone mass in clinical cases where only parts of the spine are imaged.
EUROPEAN RADIOLOGY
(2022)
