Article
Cardiac & Cardiovascular Systems
Jian Ye, Rongxue Xiao, Xu Wang, Ruiqing He, Zongjun Liu, Junqing Gao
Summary: This study confirmed that RDN can effectively reduce the occurrence of ventricular arrhythmia after AMI, and its main mechanism may be via the inhibition of central sympathetic nerve discharge.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Cardiac & Cardiovascular Systems
Kun Wang, Yu Qi, Rong Gu, Qing Dai, Anqi Shan, Zhu Li, Chenyi Gong, Lei Chang, Han Hao, Junfeng Duan, Jiamin Xu, Jiaxin Hu, Dan Mu, Ning Zhang, Jianrong Lu, Lian Wang, Han Wu, Lixin Li, Lina Kang, Biao Xu
Summary: RDN is an effective therapeutic strategy for counteracting postreperfusion myocardial injury and dysfunction, and the application of RDN holds promising prospects in clinical practice.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jun-Qing Gao, You-Long Xu, Jian Ye, Shu-Xin Hou, Wei Yang, Min Li, Jing-Jing Fa, Cheng-Hao Yang, Hui -Gen Jin, Rui-Qing He, Zong-Jun Liu
Summary: The objective of this study was to observe the effect of renal artery denervation (RDN) on cardiac function in patients with acute myocardial infarction after percutaneous coronary intervention (AMI-PCI). A total of 108 AMI-PCI patients were randomly assigned to the RDN group or the control group. After 6 months of follow-up, the RDN group showed significantly improved left ventricular ejection fraction, cardiopulmonary exercise test indicators, and heart rate variability compared to the control group. The findings suggest that RDN intervention after PCI in AMI patients can improve cardiac function and exercise tolerance, possibly by inhibiting sympathetic nerve activity and restoring sympathetic-vagal balance.
Article
Multidisciplinary Sciences
An Nu-Khanh Ton, Shin-Huei Liu, Li-Wei Lo, Thien Chuong-Nguyen Khac, Yu-Hui Chou, Wen-Han Cheng, Wei-Lun Lin, Tzu-Yen Peng, Pin-Yi Lin, Shih-Lin Chang, Shih-Ann Chen
Summary: Renal artery denervation (RDN) leads to electrical remodeling and reduces ventricular arrhythmia (VA) inducibility in LQTS models.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Ting-Chun Huang, Li-Wei Lo, Yu-Hui Chou, Wei-Lun Lin, Shih-Lin Chang, Yenn-Jiang Lin, Shin-Huei Liu, Wen-Han Cheng, Ping-Yen Liu, Shih-Ann Chen
Summary: Renal denervation (RDN) has been found to suppress the renin-angiotensin-aldosterone system and reduce inflammatory cytokines, leading to the prevention of cardiac remodeling. However, limited studies have investigated the effect of RDN on ventricular electrophysiology. This study used optical mapping to evaluate the impact of RDN on ventricular structural and electrical remodeling in a tachycardia-induced cardiomyopathy rabbit model. The results showed that RDN reversed the reduction of conduction velocity and prolongation of action potential duration, which are significant hallmarks of heart failure.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Wei-Lun Lin, Chun-Ting Lai, Shinya Yamada, Shin-Huei Liu, Wen-Han Cheng, Yu-Hui Chou, Cheryl C. H. Yang, Terry B. J. Kuo, Shih-Ann Chen, Li-Wei Lo
Summary: This study investigated the effects of renal denervation (RDN) on cardiac autonomic activity and sleep patterns in rats with myocardial infarction (MI). The results showed that sympathetic hyperactivity and sleep fragmentation were observed after MI, and RDN prevented autonomic dysfunction and sleep disorders. RDN may have the potential to reduce sleep apnea and sleep-related sudden cardiac death after MI.
Article
Peripheral Vascular Disease
Roland E. Schmieder, Felix Mahfoud, Giuseppe Mancia, Michael Azizi, Michael Boehm, Kyriakos Dimitriadis, Kazuomi Kario, Abraham A. Kroon, Melvin D. Lobo, Christian Ott, Atul Pathak, Alexandre Persu, Filippo Scalise, Markus Schlaich, Reinhold Kreutz, Costas Tsioufis
Summary: This paper presents updated recommendations based on new pivotal sham-controlled randomized clinical trials, demonstrating the efficacy and safety of endovascular device-based renal denervation for hypertension treatment. Meta-analyses show a significant reduction in blood pressure and a decreased incidence of cardiovascular events with this treatment option.
JOURNAL OF HYPERTENSION
(2021)
Review
Peripheral Vascular Disease
Kenichi Katsurada, Keisuke Shinohara, Jiro Aoki, Shinsuke Nanto, Kazuomi Kario
Summary: Renal nerves play a critical role in regulating blood pressure and fluid volume, with dysfunction implicated in cardiovascular diseases. Afferent renal sensory nerves project to the hypothalamus to modulate sympathetic outflow, while efferent renal sympathetic nerves affect renin secretion and vascular resistance. Studies on renal denervation show promise for treating hypertension and heart failure in both basic and clinical research settings.
HYPERTENSION RESEARCH
(2022)
Review
Peripheral Vascular Disease
Kazuomi Kario, Douglas A. Hettrick, Aleksander Prejbisz, Andrzej Januszewicz
Summary: There is a bidirectional, causal relationship between obstructive sleep apnea (OSA) and hypertension, with hypoxia/hypercapnia-related sympathetic activation being the key mechanism. While continuous positive airway pressure is the gold standard therapy for OSA, its effects on blood pressure are modest. Antihypertensive agents targeting sympathetic pathways or the renin-angiotensin-aldosterone system may have potential in patients with comorbid hypertension and OSA.
Article
Cardiac & Cardiovascular Systems
Zihan Liu, Zhihao Liu, Xiao Xu, Yuyang Zhou, Hu Chen, Huixin Zhou, Zeyan Li, Fuding Guo, Zhen Zhou, Yuhong Wang, Meng Wang, Yueyi Wang, Liping Zhou, Hong Jiang, Lilei Yu
Summary: Psychological stress is a contributing factor to worsened prognosis following myocardial infarction. This study identified the role of the VMHVL-PVN-SCG sympathetic pathway in the post-MI heart and proposed denervation as a promising strategy to mitigate cardiac prognosis in stressful rats. Understanding this mechanism is of great significance in improving cardiac outcomes in patients with psychological stress.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ann-Kathrin Kahle, Niklas Klatt, Christiane Jungen, Aaron Dietenberger, Pawel Kuklik, Paula Muenkler, Stephan Willems, Viacheslav Nikolaev, Dainius H. Pauza, Katharina Scherschel, Christian Meyer
Summary: Selective intracardiac sympathetic denervation can modulate left ventricular control by transvenous catheter stimulation along the coronary sinus. Epicardial coronary sinus ablation prolongs ventricular refractory period in mice, while intracardiac axotomy via the coronary sinus attenuates the blood pressure increase in healthy sheep during sympathetic stimulation. Therefore, nerve fiber targeting along the coronary sinus enables acute modulation of left ventricular control by selective sympathetic denervation.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Review
Peripheral Vascular Disease
Revathy Carnagarin, Marcio G. Kiuchi, Gerard Goh, Leon Adams, Neale Cohen, Helen Kavnoudias, Seng K. Gan, Greg Van Schie, Murray D. Esler, Vance B. Matthews, Markus P. Schlaich
Summary: Sympathetic overdrive plays a crucial role in disrupting cardiometabolic homeostasis. Current pharmacological approaches may have limitations, leading to a clinical need for complementary therapies such as interventional sympathetic neuromodulation. Modulating multiorgan sympathetic activity could offer a holistic approach to managing cardiometabolic diseases.
JOURNAL OF HYPERTENSION
(2021)
Article
Peripheral Vascular Disease
Gianni Sesa-ashton, Janis M. Nolde, Ida Muente, Revathy Carnagarin, Rebecca Lee, Vaughan G. Macefield, Tye Dawood, Yusuke Sata, Elisabeth A. Lambert, Gavin W. Lambert, Antony Walton, Marcio G. Kiuchi, Murray D. Esler, Markus P. Schlaich
Summary: Long-term follow-up studies on catheter-based renal denervation in patients with resistant hypertension show that the method can still effectively reduce blood pressure and decrease medication usage after nearly 9 years of follow-up, without any adverse effects on renal function.
Article
Cardiac & Cardiovascular Systems
Zhen Zhou, Chengzhe Liu, Saiting Xu, Jun Wang, Fuding Guo, Shoupeng Duan, Qiang Deng, Ji Sun, Fu Yu, Yuyang Zhou, Meng Wang, Yueyi Wang, Liping Zhou, Hong Jiang, Lilei Yu
Summary: In this study, it was found that adiponectin can protect the heart by modulating the function and neural activity of the stellate ganglia, as well as reducing sympathetic nervous system activity. Adiponectin also improves heart rate variability, decreases cardiac sympathetic activity, serum noradrenaline and neuropeptide Y levels, and reduces the expression of nerve growth factors and growth associated proteins. These findings suggest that adiponectin may be a potential therapeutic strategy for the treatment of myocardial infarction.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Joseph Hadaya, Al-Hassan Dajani, Steven Cha, Peter Hanna, Ronald Challita, Donald B. Hoover, Olujimi A. Ajijola, Kalyanam Shivkumar, Jeffrey L. Ardell
Summary: This study evaluated the impact of chronic vagal nerve stimulation (cVNS) on cardiac and extracardiac neural structure/function after myocardial infarction (MI). The results showed that cVNS improved cardiac mechanical function and reduced the occurrence of ventricular tachycardia and fibrillation. Additionally, cVNS mitigated extracardiac neural remodeling, particularly glial activation.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Review
Cardiac & Cardiovascular Systems
Monika Gawalko, Arnela Saljic, Na Li, Issam Abu-Taha, Thomas Jespersen, Dominik Linz, Stanley Nattel, Jordi Heijman, Anke Fender, Dobromir Dobrev
Summary: Obesity is a significant contributing factor to atrial fibrillation (AF) by causing systemic changes and affecting different adipose tissue depots. Adipose tissue secretes various mediators that promote AF and cardiac remodeling. This review discusses the role of obesity-related factors, specific adipose tissue depots, and molecular mechanisms in AF, highlighting gaps in current knowledge and implications for clinical management.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Renate B. Schnabel, Elena Andreassi Marinelli, Elena Arbelo, Giuseppe Boriani, Serge Boveda, Claire M. Buckley, A. John Camm, Barbara Casadei, Winnie Chua, Nikolaos Dagres, Mirko de Melis, Lien Desteghe, Soren Zoga Diederichsen, David Duncker, Lars Eckardt, Christoph Eisert, Daniel Engler, Larissa Fabritz, Ben Freedman, Ludovic Gillet, Andreas Goette, Eduard Guasch, Jesper Hastrup Svendsen, Stephane N. Hatem, Karl Georg Haeusler, Jeff S. Healey, Hein Heidbuchel, Gerhard Hindricks, F. D. Richard Hobbs, Thomas Huebner, Dipak Kotecha, Michael Krekler, Christophe Leclercq, Thorsten Lewalter, Honghuang Lin, Dominik Linz, Gregory Y. H. Lip, Maja Lisa Lochen, Wim Lucassen, Katarzyna Malaczynska-Rajpold, Steffen Massberg, Jose L. Merino, Ralf Meyer, Lluis Mont, Michael C. Myers, Lis Neubeck, Teemu Niiranen, Michael Oeff, Jonas Oldgren, Tatjana S. Potpara, George Psaroudakis, Helmut Purerfellner, Ursula Ravens, Michiel Rienstra, Lena Rivard, Daniel Scherr, Ulrich Schotten, Dipen Shah, Moritz F. Sinner, Rudiger Smolnik, Gerhard Steinbeck, Daniel Steven, Emma Svennberg, Dierk Thomas, Mellanie True Hills, Isabelle C. van Gelder, Burcu Vardar, Elena Pala, Reza Wakili, Karl Wegscheider, Mattias Wieloch, Stephan Willems, Henning Witt, Andre Ziegler, Matthias Daniel Zink, Paulus Kirchhof
Summary: This article summarizes the key outcomes of the 8th AFNET/EHRA Consensus Conference, which was held in Hamburg in October 2021 and attended by 83 international experts. The consensus paper highlights new evidence-based approaches to improve care for patients with atrial fibrillation (AF), including population-based screening, evolving management strategies, atrial cardiomyopathy characterization, cognitive function assessment, and the role of artificial intelligence (AI).
Article
Cardiac & Cardiovascular Systems
Monika Gawalko, Astrid Nl Hermans, Rachel Mj van Der Velden, Konstanze Betz, Dominique Vm Verhaert, Henrike Ak Hillmann, Daniel Scherr, Julia Meier, Arian Sultan, Daniel Steven, Elena Terentieva, Ron Pisters, Martin Hemels, Leonard Voorhout, Piotr Lodzinski, Bartosz Krzowski, Dhiraj Gupta, Nikola Kozhuharov, Laurent Pison, Henri Gruwez, Lien Desteghe, Hein Heidbuchel, Stijn Evens, Emma Svennberg, Tom de Potter, Kevin Vernooy, Nikki Aha Pluymaekers, Martin Manninger, David Duncker, Afzal Sohaib, Dominik Linz, Jeroen M. Hendriks
Summary: In the TeleCheck-AF project, more than one-fourth of patients with atrial fibrillation had optimal motivation and adherence to app-based heart rate/rhythm monitoring. Older age and absence of diabetes were predictors of optimal motivation/adherence.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Cardiac & Cardiovascular Systems
Roland E. Schmieder, Felix Mahfoud, Giuseppe Mancia, Krzysztof Narkiewicz, Luis Ruilope, David Hutton, Khoa Cao, Douglas A. Hettrick, Martin Fahy, Markus P. Schlaich, Michael Bohm, Jan B. Pietzsch
Summary: Renal denervation using radiofrequency has been found to lower blood pressure and reduce cardiovascular events in patients with uncontrolled hypertension. The magnitude of blood pressure reduction and associated risks of cardiovascular events vary among different high-risk subgroups. Model-based projections suggest that radiofrequency renal denervation provides significant clinical benefits for patients with uncontrolled hypertension.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Sport Sciences
Christian V. Verdicchio, Celine Gallagher, Rajiv Mahajan, Melissa E. Middeldorp, Dominik Linz, Dennis H. Lau, Prashanthan Sanders, Adrian D. Elliott
Summary: The study aimed to assess the validity of heart rate reserve (HRR) as a surrogate for oxygen uptake reserve (VO2R) to guide exercise intensity in patients with atrial fibrillation (AF). The results showed a significant difference between HRR and VO2R, suggesting that an individualized HRR-VO2R relationship should be considered when prescribing exercise intensity for AF patients.
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2023)
Article
Cardiac & Cardiovascular Systems
Martijn E. van de Lande, Rajiv S. Rama, Tim Koldenhof, Vicente Artola Arita, Bao-Oanh Nguyen, Colinda van Deutekom, Vanessa Weberndorfer, Harry J. G. M. Crijns, Martin E. W. Hemels, Robert G. Tieleman, Mirko de Melis, Ulrich Schotten, Dominik Linz, Isabelle C. Van Gelder, Michiel Rienstra
Summary: This study aims to assess the association between the time of onset of atrial fibrillation (AF) episodes with the clinical phenotype and AF progression. The results suggest that patients with either predominant nocturnal or daytime onset of AF episodes have less associated comorbidities and less AF progression compared to patients with mixed onset of AF.
Article
Cardiac & Cardiovascular Systems
Astrid N. L. Hermans, Jonas L. Isaksen, Monika Gawalko, Nikki A. H. A. Pluymaekers, Rachel M. J. van der Velden, Hilco Snippe, Stijn Evens, Glenn De Witte, Justin G. L. M. Luermans, Martin Manninger, Joost Lumens, Jorgen K. Kanters, Dominik Linz
Summary: This study aimed to evaluate the accuracy of continuous PPG-based 1 min mean heart rate assessment during persistent AF. By comparing PPG-based smartwatch and Holter ECG monitoring in 50 AF patients, it was found that PPG technology showed high accuracy and small estimation error in 1 min mean heart rate compared with Holter ECG. Only chronic heart failure was associated with a lower agreement between ECG-derived and PPG-derived heart rates.
Article
Cardiac & Cardiovascular Systems
Vicente Artola Arita, Martijn E. Van de Lande, Neda Khalilian Ekrami, Bao-Oanh Nguyen, Joost M. Van Melle, Bastiaan Geelhoed, Ruben R. De With, Vanessa Weberndorfer, Omer Erkuner, Hans Hillege, Dominik Linz, Hugo Ten Cate, Henri M. H. Spronk, Tim Koldenhof, Robert G. Tieleman, Ulrich Schotten, Harry J. G. M. Crijns, Isabelle C. Van Gelder, Michiel Rienstra
Summary: This study aimed to assess whether the 4S-AF scheme predicts AF progression in patients with self-terminating AF. The study found that the 4S-AF scheme does not predict AF progression, but the 3S-AF scheme can predict progression. Therefore, the 3S-AF scheme may be more appropriate for predicting AF progression.
Article
Peripheral Vascular Disease
Mathias Hohl, Lucas Lauder, Oezlem Sevimli, Mert Tokcan, Lea Wagmann, Felix Goetzinger, Clara Schneider, Ulrich Huebner, Ulrike Lehnert, Markus R. Meyer, Michael Boehm, Felix Mahfoud
Summary: This study investigated the effect of different antihypertensive medications following renal denervation (RDN) on blood pressure and cardiac phenotypes in spontaneously hypertensive rats. The results showed that treatment with amlodipine and olmesartan after RDN resulted in the largest reduction in blood pressure. The antihypertensive medications also had heterogeneous effects on the renin-angiotensin-aldosterone system activity and cardiac remodeling.
Article
Peripheral Vascular Disease
Felix Mahfoud, Giuseppe Mancia, Roland E. Schmieder, Luis Ruilope, Krzysztof Narkiewicz, Markus Schlaich, Bryan Williams, Flavio Ribichini, Joachim Weil, Khaled Almerri, Faisal Sharif, Lucas Lauder, Marianne Wanten, Martin Fahy, Michael Boehm
Summary: This study investigated whether the number or type of antihypertensive medications were associated with increased long-term blood pressure reductions and cardiovascular outcomes following radiofrequency renal denervation (RDN) in hypertensive patients. The results showed that radiofrequency RDN reduced blood pressure safely through 36 months, regardless of the number and type of baseline antihypertensive medication classes.
Article
Medicine, General & Internal
Joonatan Palmu, Christin S. Boerschel, Alfredo Ortega-Alonso, Lajos Marko, Michael Inouye, Pekka Jousilahti, Rodolfo A. Salido, Karenina Sanders, Caitriona Brennan, Gregory C. Humphrey, Jon G. Sanders, Friederike Gutmann, Dominik Linz, Veikko Salomaa, Aki S. Havulinna, Sofia K. Forslund, Rob Knight, Leo Lahti, Teemu Niiranen, Renate B. Schnabel
Summary: This study found that the gut microbiome composition is associated with the risk of atrial fibrillation (AF). Certain microbial genera were found to be related to the occurrence and prediction of AF. These findings establish the basis for using microbiome profiling in predicting AF risk, but further research is needed before microbiome sequencing can be used in prevention and targeted treatment of AF.
Article
Medicine, General & Internal
Jesse H. J. Rijks, Theo Lankveld, Randolph Manusama, Bernard Broers, Antonius M. W. van Stipdonk, Sevasti Maria Chaldoupi, Rachel M. A. ter Bekke, Ulrich Schotten, Dominik Linz, Justin G. L. M. Luermans, Kevin Vernooy
Summary: This study investigated the feasibility and safety of performing left bundle branch area pacing (LBBAP) and atrioventricular (AV) node ablation in a single procedure in elderly patients with symptomatic atrial fibrillation (AF). The results showed that LBBAP combined with AV node ablation was successfully performed in 22 out of 25 patients, demonstrating that this approach is feasible and safe in elderly patients with symptomatic AF.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Samuel J. Tu, Celine Gallagher, Adrian D. Elliott, Kathryn E. Bradbury, Gregory M. Marcus, Dominik Linz, Bradley M. Pitman, Melissa E. Middeldorp, Jeroen M. Hendriks, Dennis H. Lau, Prashanthan Sanders, Christopher X. Wong
Summary: This study aimed to examine the associations between specific dietary patterns and incident atrial fibrillation (AF). Data from the UK Biobank were used to calculate dietary intakes and assess adherence to Mediterranean-style, Dietary Approaches to Stop Hypertension (DASH), and plant-based diets. Results showed that adherence to Mediterranean-style or DASH diets was initially associated with a lower incidence of AF, but the associations became non-significant after adjusting for lifestyle factors. Plant-based diets were not associated with AF risk. However, high ultra-processed food consumption was consistently linked to an increased risk of AF even after adjusting for confounding factors.
Article
Cardiac & Cardiovascular Systems
Felix Goetzinger, Michael Kunz, Lucas Lauder, Felix Mahfoud, Michael Boehm
Summary: Radiofrequency-based renal denervation is a safe and effective method for lowering blood pressure by modulating sympathetic renal activity. Clinical trials have demonstrated its feasibility, safety, and efficacy in hypertensive patients, both with and without concomitant antihypertensive medication.
Article
Cardiac & Cardiovascular Systems
Hedwig M. J. M. Nies, Geertruida P. Bijvoet, Jouke Smink, Sevasti-Maria Chaldoupi, Casper Mihl, Dominik Linz, Robert J. Holtackers
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
