Article
Cardiac & Cardiovascular Systems
Jian Ye, Rongxue Xiao, Xu Wang, Ruiqing He, Zongjun Liu, Junqing Gao
Summary: This study confirmed that RDN can effectively reduce the occurrence of ventricular arrhythmia after AMI, and its main mechanism may be via the inhibition of central sympathetic nerve discharge.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Cardiac & Cardiovascular Systems
Kun Wang, Yu Qi, Rong Gu, Qing Dai, Anqi Shan, Zhu Li, Chenyi Gong, Lei Chang, Han Hao, Junfeng Duan, Jiamin Xu, Jiaxin Hu, Dan Mu, Ning Zhang, Jianrong Lu, Lian Wang, Han Wu, Lixin Li, Lina Kang, Biao Xu
Summary: RDN is an effective therapeutic strategy for counteracting postreperfusion myocardial injury and dysfunction, and the application of RDN holds promising prospects in clinical practice.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jun-Qing Gao, You-Long Xu, Jian Ye, Shu-Xin Hou, Wei Yang, Min Li, Jing-Jing Fa, Cheng-Hao Yang, Hui -Gen Jin, Rui-Qing He, Zong-Jun Liu
Summary: The objective of this study was to observe the effect of renal artery denervation (RDN) on cardiac function in patients with acute myocardial infarction after percutaneous coronary intervention (AMI-PCI). A total of 108 AMI-PCI patients were randomly assigned to the RDN group or the control group. After 6 months of follow-up, the RDN group showed significantly improved left ventricular ejection fraction, cardiopulmonary exercise test indicators, and heart rate variability compared to the control group. The findings suggest that RDN intervention after PCI in AMI patients can improve cardiac function and exercise tolerance, possibly by inhibiting sympathetic nerve activity and restoring sympathetic-vagal balance.
Article
Multidisciplinary Sciences
An Nu-Khanh Ton, Shin-Huei Liu, Li-Wei Lo, Thien Chuong-Nguyen Khac, Yu-Hui Chou, Wen-Han Cheng, Wei-Lun Lin, Tzu-Yen Peng, Pin-Yi Lin, Shih-Lin Chang, Shih-Ann Chen
Summary: Renal artery denervation (RDN) leads to electrical remodeling and reduces ventricular arrhythmia (VA) inducibility in LQTS models.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Ting-Chun Huang, Li-Wei Lo, Yu-Hui Chou, Wei-Lun Lin, Shih-Lin Chang, Yenn-Jiang Lin, Shin-Huei Liu, Wen-Han Cheng, Ping-Yen Liu, Shih-Ann Chen
Summary: Renal denervation (RDN) has been found to suppress the renin-angiotensin-aldosterone system and reduce inflammatory cytokines, leading to the prevention of cardiac remodeling. However, limited studies have investigated the effect of RDN on ventricular electrophysiology. This study used optical mapping to evaluate the impact of RDN on ventricular structural and electrical remodeling in a tachycardia-induced cardiomyopathy rabbit model. The results showed that RDN reversed the reduction of conduction velocity and prolongation of action potential duration, which are significant hallmarks of heart failure.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Wei-Lun Lin, Chun-Ting Lai, Shinya Yamada, Shin-Huei Liu, Wen-Han Cheng, Yu-Hui Chou, Cheryl C. H. Yang, Terry B. J. Kuo, Shih-Ann Chen, Li-Wei Lo
Summary: This study investigated the effects of renal denervation (RDN) on cardiac autonomic activity and sleep patterns in rats with myocardial infarction (MI). The results showed that sympathetic hyperactivity and sleep fragmentation were observed after MI, and RDN prevented autonomic dysfunction and sleep disorders. RDN may have the potential to reduce sleep apnea and sleep-related sudden cardiac death after MI.
Article
Peripheral Vascular Disease
Roland E. Schmieder, Felix Mahfoud, Giuseppe Mancia, Michael Azizi, Michael Boehm, Kyriakos Dimitriadis, Kazuomi Kario, Abraham A. Kroon, Melvin D. Lobo, Christian Ott, Atul Pathak, Alexandre Persu, Filippo Scalise, Markus Schlaich, Reinhold Kreutz, Costas Tsioufis
Summary: This paper presents updated recommendations based on new pivotal sham-controlled randomized clinical trials, demonstrating the efficacy and safety of endovascular device-based renal denervation for hypertension treatment. Meta-analyses show a significant reduction in blood pressure and a decreased incidence of cardiovascular events with this treatment option.
JOURNAL OF HYPERTENSION
(2021)
Review
Peripheral Vascular Disease
Kenichi Katsurada, Keisuke Shinohara, Jiro Aoki, Shinsuke Nanto, Kazuomi Kario
Summary: Renal nerves play a critical role in regulating blood pressure and fluid volume, with dysfunction implicated in cardiovascular diseases. Afferent renal sensory nerves project to the hypothalamus to modulate sympathetic outflow, while efferent renal sympathetic nerves affect renin secretion and vascular resistance. Studies on renal denervation show promise for treating hypertension and heart failure in both basic and clinical research settings.
HYPERTENSION RESEARCH
(2022)
Review
Peripheral Vascular Disease
Kazuomi Kario, Douglas A. Hettrick, Aleksander Prejbisz, Andrzej Januszewicz
Summary: There is a bidirectional, causal relationship between obstructive sleep apnea (OSA) and hypertension, with hypoxia/hypercapnia-related sympathetic activation being the key mechanism. While continuous positive airway pressure is the gold standard therapy for OSA, its effects on blood pressure are modest. Antihypertensive agents targeting sympathetic pathways or the renin-angiotensin-aldosterone system may have potential in patients with comorbid hypertension and OSA.
Article
Cardiac & Cardiovascular Systems
Zihan Liu, Zhihao Liu, Xiao Xu, Yuyang Zhou, Hu Chen, Huixin Zhou, Zeyan Li, Fuding Guo, Zhen Zhou, Yuhong Wang, Meng Wang, Yueyi Wang, Liping Zhou, Hong Jiang, Lilei Yu
Summary: Psychological stress is a contributing factor to worsened prognosis following myocardial infarction. This study identified the role of the VMHVL-PVN-SCG sympathetic pathway in the post-MI heart and proposed denervation as a promising strategy to mitigate cardiac prognosis in stressful rats. Understanding this mechanism is of great significance in improving cardiac outcomes in patients with psychological stress.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Ann-Kathrin Kahle, Niklas Klatt, Christiane Jungen, Aaron Dietenberger, Pawel Kuklik, Paula Muenkler, Stephan Willems, Viacheslav Nikolaev, Dainius H. Pauza, Katharina Scherschel, Christian Meyer
Summary: Selective intracardiac sympathetic denervation can modulate left ventricular control by transvenous catheter stimulation along the coronary sinus. Epicardial coronary sinus ablation prolongs ventricular refractory period in mice, while intracardiac axotomy via the coronary sinus attenuates the blood pressure increase in healthy sheep during sympathetic stimulation. Therefore, nerve fiber targeting along the coronary sinus enables acute modulation of left ventricular control by selective sympathetic denervation.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Review
Peripheral Vascular Disease
Revathy Carnagarin, Marcio G. Kiuchi, Gerard Goh, Leon Adams, Neale Cohen, Helen Kavnoudias, Seng K. Gan, Greg Van Schie, Murray D. Esler, Vance B. Matthews, Markus P. Schlaich
Summary: Sympathetic overdrive plays a crucial role in disrupting cardiometabolic homeostasis. Current pharmacological approaches may have limitations, leading to a clinical need for complementary therapies such as interventional sympathetic neuromodulation. Modulating multiorgan sympathetic activity could offer a holistic approach to managing cardiometabolic diseases.
JOURNAL OF HYPERTENSION
(2021)
Article
Peripheral Vascular Disease
Gianni Sesa-ashton, Janis M. Nolde, Ida Muente, Revathy Carnagarin, Rebecca Lee, Vaughan G. Macefield, Tye Dawood, Yusuke Sata, Elisabeth A. Lambert, Gavin W. Lambert, Antony Walton, Marcio G. Kiuchi, Murray D. Esler, Markus P. Schlaich
Summary: Long-term follow-up studies on catheter-based renal denervation in patients with resistant hypertension show that the method can still effectively reduce blood pressure and decrease medication usage after nearly 9 years of follow-up, without any adverse effects on renal function.
Article
Cardiac & Cardiovascular Systems
Zhen Zhou, Chengzhe Liu, Saiting Xu, Jun Wang, Fuding Guo, Shoupeng Duan, Qiang Deng, Ji Sun, Fu Yu, Yuyang Zhou, Meng Wang, Yueyi Wang, Liping Zhou, Hong Jiang, Lilei Yu
Summary: In this study, it was found that adiponectin can protect the heart by modulating the function and neural activity of the stellate ganglia, as well as reducing sympathetic nervous system activity. Adiponectin also improves heart rate variability, decreases cardiac sympathetic activity, serum noradrenaline and neuropeptide Y levels, and reduces the expression of nerve growth factors and growth associated proteins. These findings suggest that adiponectin may be a potential therapeutic strategy for the treatment of myocardial infarction.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Joseph Hadaya, Al-Hassan Dajani, Steven Cha, Peter Hanna, Ronald Challita, Donald B. Hoover, Olujimi A. Ajijola, Kalyanam Shivkumar, Jeffrey L. Ardell
Summary: This study evaluated the impact of chronic vagal nerve stimulation (cVNS) on cardiac and extracardiac neural structure/function after myocardial infarction (MI). The results showed that cVNS improved cardiac mechanical function and reduced the occurrence of ventricular tachycardia and fibrillation. Additionally, cVNS mitigated extracardiac neural remodeling, particularly glial activation.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Bao-Oanh Nguyen, Vanessa Weberndorfer, Harry J. G. M. Crijns, Bastiaan Geelhoed, Hugo Ten Cate, Henri Spronk, Abraham Kroon, Ruben De With, Meelad Al-Jazairi, Alexander H. Maass, Yuri Blaauw, Robert G. Tieleman, Martin E. W. Hemels, Justin Luermans, Joris de Groot, Cornelis P. Allaart, Arif Elvan, Mirko De Melis, Coert Scheerder, Anton Jan van Zonneveld, Ulrich Schotten, Dominik Linz, Isabelle Van Gelder, Michiel Rienstra
Summary: This study aims to develop a new atrial fibrillation (AF) progression risk prediction model in patients with paroxysmal AF (PAF) to determine the risk and treatment targets for AF progression. The study found that markers for atrial remodeling, sex, mitral valve regurgitation, waist circumference, and biomarkers associated with coagulation, inflammation, cardiomyocyte stretch, and atherosclerosis were all associated with AF progression.
Article
Critical Care Medicine
Sobhan Salari Shahrbabaki, Dominik Linz, Susan Redline, Katie Stone, Kristine Ensrud, Mathias Baumert
Summary: Arousal during sleep triggers ventricular repolarization lability, which may increase the risk of long-term cardiovascular mortality. The QT variability index during arousal is independently associated with all-cause and cardiovascular mortality, indicating maladaptation of ventricular repolarization to the arousal stimulus. Further study is needed to determine if arousal suppression can reduce ventricular repolarization lability and subsequent mortality, and if arousal-related QT variability index can be used for more accurate risk stratification.
Article
Cardiac & Cardiovascular Systems
Jean Jacques Noubiap, Dominic Millenaar, Dike Ojji, Q. Eileen Wafford, Christian Ukena, Michael Boehm, Karen Sliwa, Mark D. Huffman, Felix Mahfoud
Summary: This study analyzed the quantity and impact of cardiovascular research in Africa, as well as the determinants and patterns of research collaboration. It found that despite progress, the output of cardiovascular research from African authors remains low. Therefore, urgent measures are needed to improve the quantity and quality of cardiovascular research in Africa, including increased investments, human resource training, improved infrastructures, and expanded collaborative research networks, particularly within Africa.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Letter
Cardiac & Cardiovascular Systems
Peder E. Warming, Rodrigue Garcia, Carl J. Hansen, Sami O. Simons, Christian Torp-Pedersen, Dominik Linz, Jacob Tfelt-Hansen
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Roland Richard Tilz, Vanessa Schmidt, Helmut Puererfellner, Philippe Maury, K. R. Julian Chun, Martin Martinek, Christian Sohns, Boris Schmidt, Franck Mandel, Estelle Gandjbakhch, Mikael Laredo, Melanie Anuscha Gunawardene, Stephan Willems, Thomas Beiert, Martin Borlich, Leon Iden, Anna Fueting, Raphael Spittler, Thomas Gaspar, Sergio Richter, Anja Schade, Malte Kuniss, Thomas Neumann, Alexander Francke, Carsten Wunderlich, Dong-In Shin, Dirk Grosse Meininghaus, Mike Foresti, Marc Bonsels, David Reek, Uwe Wiegand, Alexander Bauer, Andreas Metzner, Lars Eckardt, Sorin Tefan Popescu, Olaf Krahnefeld, Christian Sticherling, Michael Kuehne, Dinh Quang Nguyen, Laurent Roten, Ardan M. Saguner, Dominik Linz, Pepijn van der Voort, Bart A. Mulder, Johan Vijgen, Alexandre Almorad, Charles Guenancia, Laurent Fauchier, Serge Boveda, Y. De Greef, Antoine Da Costa, Pierre Jais, Nicolas Derval, Antoine Milhem, Laurence Jesel, Rodrigue Garcia, Herve Poty, Ziad Khoueiry, Julien Seitz, Julien Laborderie, Alexis Mechulan, Francois Brigadeau, Alexandre Zhao, Yannick Saludas, Olivier Piot, Nikhil Ahluwalia, Claire Martin, Jian Chen, Bor Antolic, Georgios Leventopoulos, Emin Evren Ozcan, Hikmet Yorgun, Serkan Cay, Kivanc Yalin, Maichel Sobhy Botros, Ahmed Taher Mahmoud, Ewa Jedrzejczyk-Patej, Osamu Inaba, Ken Okumura, Koichiro Ejima, Houman Khakpour, Noel Boyle, John N. Catanzaro, Vivek Reddy, Sanghamitra Mohanty, Andrea Natale, Hermann Blessberger, Bing Yang, Irene Stevens, Philipp Sommer, Christian Veltmann, Daniel Steven, Julia Vogler, Karl-Heinz Kuck, Jose Luis Merino, Ahmad Keelani, Christian-H. Heeger
Summary: This international multicentre registry investigates the characteristics of oesophageal fistulae after treatment of atrial fibrillation by catheter ablation. The incidence of oesophageal fistula is low and mainly associated with the use of radiofrequency energy. Mortality rate is exceedingly high without surgical or endoscopic intervention.
EUROPEAN HEART JOURNAL
(2023)
Article
Peripheral Vascular Disease
Felix Goetzinger, Thomas Wilke, Faence Hardtstock, Julia Krieger, Ulf Maywald, Michael Kunz, Lucas Lauder, Martin Schulz, Felix Mahfoud, Michael Boehm
Summary: This study compared the cancer risk associated with hydrochlorothiazide (HCT) versus other diuretics. The results showed that HCT treatment was associated with a lower overall cancer risk but a slightly increased risk of skin cancer compared to non-HCT diuretics.
JOURNAL OF HYPERTENSION
(2023)
Review
Cardiac & Cardiovascular Systems
Felix Goetzinger, Lucas Lauder, Andrew S. P. Sharp, Irene M. Lang, Stephan Rosenkranz, Stavros Konstantinides, Elazer R. R. Edelman, Michael Boehm, Wissam Jaber, Felix Mahfoud
Summary: Pulmonary embolism (PE) is a major cause of in-hospital and cardiovascular death. The treatment of PE traditionally involved anticoagulation, thrombolysis, or surgery, but newer percutaneous interventional technologies have emerged for intermediate-high-risk or high-risk PE patients. This review discusses the pathophysiology of PE, assists with patient selection, and evaluates the clinical evidence for interventional, catheter-based approaches for PE treatment.
NATURE REVIEWS CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Julie Norup Hertel, Kezia Jerltorp, Malthe Emil Hotbjerg Hansen, Jonas L. L. Isaksen, Stefan Michael Sattler, Benedikt Linz, Sevasti-Maria Chaldoupi, Thomas Jespersen, Arnela Saljic, Uffe Gang, Martin Manninger, Dominik Linz
Summary: This study proposes a standardized workflow for 3D-electroanatomical mapping guided pulmonary vein isolation in pigs. The study conducted procedures such as femoral vein puncture, blood pressure measurement, intracardiac ultrasound-guided puncture, and 3D-electroanatomical mapping of the left atrium. The results show that reproducible and safe pulmonary vein isolation can be achieved in pigs using current technologies and a step-by-step approach.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Ann-Kathrin Rahm, Dominik Linz, Uffe Jakob Ortved Gang
Summary: This case series examines the imaging and ablation strategies used in patients who have undergone lobectomy or pneumonectomy for pulmonary vein isolation in atrial fibrillation. The study shows that both radiofrequency and cryocatheter ablation can be successful despite the anatomical alterations caused by surgery. Pre- and peri-procedural imaging by cardiac computed tomography and transoesophageal echocardiography enhance understanding of the complex anatomical substrate.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Silvia Leao, Justin Luermans, Kevin Vernooy, Rachel ter Bekke, Dennis den Uijl, Dominik Linz, Sevasti-Maria Chaldoupi
Summary: This article describes three cases of double fire (DF) atrioventricular (AV) nodal response, which is often misdiagnosed and can lead to unnecessary invasive procedures. The condition can be confirmed through electrophysiological study and effectively treated with radiofrequency ablation of the slow pathway.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Sobhan Salari Shahrbabaki, Dominik Linz, Mathias Baumert
Summary: This study aims to evaluate the association between nocturnal temporal pulse wave amplitude attenuations and cardiovascular events. The results show that nocturnal pulse wave amplitude attenuation is inversely associated with cardiovascular risk, particularly in men and African-Americans.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Manouk J. W. van Mourik, Dominik Linz, Harm J. A. Verwijs, Sebastiaan C. A. M. Bekkers, Jerremy Weerts, Ulrich Schotten, Hanspeter Brunner-La Rocca, Joost Lumens, Harry J. G. M. Crijns, Bob Weijs, Christian Knackstedt
Summary: The objective of this study was to evaluate subtle alterations in left ventricular (LV) function in patients with idiopathic atrial fibrillation (IAF) using speckle-tracking echocardiography (STE) based global longitudinal strain (GLS). The results showed that patients with IAF had more negative GLS compared to healthy controls, but the difference was not significant when indexed for ventricular cycle length. Patients with IAF did not show any overt LV or left atrial (LA) dysfunction compared to healthy controls.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
David E. Kandzari, Raymond R. Townsend, Kazuomi Kario, Felix Mahfoud, Michael A. Weber, Roland E. Schmieder, Stuart Pocock, Konstantinos Tsiou, Dimitrios Konstantinidis, James Choi, Cara East, Lucas Lauder, Debbie L. Cohen, Taisei Kobayashi, Axel Schmid, David P. Lee, Adrian Ma, Joachim Weil, Tolga Agdirlioglu, Markus P. Schlaich, Sharad Shetty, Chandan M. Devireddy, Janice Lea, Jiro Aoki, Andrew S. P. Sharp, Richard Anderson, Martin Fahy, Vanessa DeBruin, Sandeep Brar, Michael Boehm
Summary: This trial evaluated the safety and efficacy of renal denervation (RDN) in patients with uncontrolled hypertension who were also taking antihypertensive medications. The study found no significant difference between the RDN group and the sham control group in terms of the primary efficacy endpoint. However, multiple secondary endpoint analyses favored RDN over the sham control.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Amr Abdin, Christian Werner, Haran Burri, Jose L. Merino, Davor Vukadinovic, Noureddin Sawan, Jacek Gajek, Michael Boehm, Christian Ukena
Summary: This meta-analysis found that left bundle branch area pacing (LBBaP) was superior to His bundle pacing (HBP) regarding pacing metrics and implant success rate as an initial pacing strategy, although absence of head-to-head randomized comparison warrants caution in interpretation of the results.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Emanuele Barbato, Michel Azizi, Roland E. Schmieder, Lucas Lauder, Michael Boehm, Sofie Brouwers, Rosa Maria Bruno, Dariusz Dudek, Thomas Kahan, David E. Kandzari, Thomas F. Luescher, Gianfranco Parati, Atul Pathak, Flavio L. Ribichini, Markus P. Schlaich, Andrew S. P. Sharp, Isabella Sudano, Massimo Volpe, Costas Tsioufis, William Wijns, Felix Mahfoud
Summary: According to the 2018 ESC/ESH guidelines, radiofrequency and ultrasound renal denervation (RDN) have been proven effective and safe in lowering blood pressure in a broad range of patients with hypertension, including resistant hypertension. The expert group suggests that RDN can be used as an adjunct treatment option in uncontrolled resistant hypertension, especially in patients with high cardiovascular risk or hypertension-mediated organ damage. Multidisciplinary hypertension teams should evaluate the indication and perform the RDN procedure.
