Article
Pediatrics
Daniel Bowen, Martijn Kauling, Bernardo Loff Barreto, Jackie McGhie, Judith Cuypers, Tamas Szili-Torok, Jolien Roos-Hesselink, Annemien van den Bosch
Summary: This study aimed to evaluate the synchronicity of multiple RV walls using 2D-MPE in ToF patients. The results showed that ToF patients had electromechanical delays between the lateral, anterior, and septal RV walls, with anterior wall dysfunction likely associated with surgical repair. 2D-MPE may have an emerging role in evaluating RV mechanical response to electrical resynchronisation therapy.
FRONTIERS IN PEDIATRICS
(2023)
Article
Cardiac & Cardiovascular Systems
Eike M. Wuelfers, Joachim Greiner, Max Giese, Josef Madl, Johannes Kroll, Brigitte Stiller, Peter Kohl, Eva A. Rog-Zielinska, Hannah E. Fuerniss
Summary: This study aimed to evaluate fibrosis distribution in right ventricular outflow tract (RVOT) myocardium of TOF patients and explore fibrosis quantification using SHGI as an alternative method. The research found high heterogeneity in fibrosis distribution and the need for extended volume analyses for accurate quantification. SHGI provided faster data and enabled collagen anisotropy quantification.
Review
Pediatrics
Rahi Alipour S. Symakani, Wouter J. van Genuchten, Lotte M. Zandbergen, Surya Henry, Yannick J. H. J. Taverne, Daphne Merkus, Willem A. Helbing, Beatrijs Bartelds
Summary: Right ventricular dysfunction is a crucial factor in determining the outcome of patients with complex congenital heart disease, particularly tetralogy of Fallot. The dysfunction arises from initial pressure overload and hypoxemia, followed by chronic volume overload due to pulmonary regurgitation after corrective surgery. The adaptation of the myocardium and the transition to right ventricular failure are not well understood.
FRONTIERS IN PEDIATRICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Li Jiang, Yuan Li, Shan Huang, Pei-Lun Han, Wei-Feng Yan, Han Fang, Zhi-Gang Yang
Summary: In patients with repaired Tetralogy of Fallot, cardiac MRI showed that there was a gradual decrease in right ventricular, left ventricular, and septal strain. The correlation between left ventricular deformation and right ventricular function was strongest in patients with right ventricular heart failure.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Nienke J. Verzaal, Stephane Masse, Eugene Downar, Kumaraswamy Nanthakumar, Tammo Delhaas, Frits W. Prinzen
Summary: The delayed activation in the right ventricle of rToF patients is predominantly due to block(s) in the Purkinje system, while conduction in RV tissue is fairly normal. It is noteworthy that RV pacing increases dispersion of septal activation compared to sinus rhythm.
Editorial Material
Cardiac & Cardiovascular Systems
Julian Rodriguez-Garcia, Antonia Pijuan-Domenech, Jaume Francisco-Pascual, Laura Dos-Subira, Berta Miranda-Barrio, Alba Santos-Ortega, Nuria Rivas-Gandara
Summary: Right ventricular resynchronization therapy guided by high-density electroanatomic activation mapping can improve clinical condition and intraventricular synchrony in patients with repaired tetralogy of Fallot and right ventricular dysfunction. Identifying the optimal stimulation site through electroanatomic activation mapping is crucial for achieving maximum clinical benefit.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Ming Wu, Chengming Fan, Jian Liu, Chukwuemeka Daniel Iroegbu, Wangping Chen, Peng Huang, Mi Tang, Xun Wu, Chunle Wang, Kun Xiang, Wenwu Zhou, Jinfu Yang
Summary: The study aimed to establish a new method for reconstructing the right ventricular outflow tract in Tetralogy of Fallot by using the pulmonary valve bi-orifice method. Results showed that there were no significant differences in outcomes between the observation group where individualized reconstruction was done and the control group.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Christopher DeZorzi, Anais Marenco, Anne Marie Valente
Summary: Tricuspid regurgitation is a significant finding in patients who have undergone repair for tetralogy of Fallot, and it can have primary or secondary causes. Moderate or severe tricuspid regurgitation is associated with a higher occurrence of atrial tachyarrhythmias in these patients. The optimal timing for tricuspid valve intervention during pulmonary valve replacement in repaired tetralogy of Fallot patients remains uncertain.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Omonigho Ekhomu, Jennifer A. Faerber, Yan Wang, Jing Huang, Anh Duc Mai, Michael P. DiLorenzo, Shivani M. Bhatt, Catherine M. Avitabile, Laura Mercer-Rosa
Summary: Diastolic dysfunction is commonly observed after Tetralogy of Fallot (TOF) repair, and this study investigates the right atrial (RA) mechanics as a proxy of right ventricular (RV) diastolic function in the early post-operative period. Machine learning methods were utilized to identify important patient factors associated with strain. The study finds that there is significant worsening in RA and RV strain early after TOF repair, indicating early alteration in diastolic and systolic function after surgery.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2022)
Article
Acoustics
Greggory R. DeVore, Yalda Afshar, Danielle Harake, Gary Satou, Mark Sklansky
Summary: This study examines fetuses with TOF and evaluates the ventricular contractility and function using speckle-tracking analysis. The results show that LV contractility and function are significantly abnormal in fetuses with TOF, while RV contractility is mostly normal.
JOURNAL OF ULTRASOUND IN MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
S. Buddhe, V Jani, S. Sarikouch, L. Gaur, A. Schuster, P. Beerbaum, M. Lewin, S. Kutty
Summary: This study aimed to compare VVCR between patients with repaired standard TOF and TOF-PA, finding a significantly higher VVCR in the TOF-PA group. VVCR showed association with NYHA class and may serve as an indicator of cardiovascular function in this cohort.
DIAGNOSTIC AND INTERVENTIONAL IMAGING
(2021)
Article
Neurosciences
Sarah U. Morton, Lara Maleyeff, David Wypij, Hyuk Jin Yun, Caitlin K. Rollins, Christopher G. Watson, Jane W. Newburger, David C. Bellinger, Amy E. Roberts, Michael J. Rivkin, P. Ellen Grant, Kiho Im
Summary: The study found that in patients with tetralogy of Fallot, the similarity of right-hemispheric sulcal patterns to the control group was decreased, and was positively correlated with neuropsychological testing values including executive function. This suggests that sulcal pattern analysis may be a useful marker of neurodevelopmental risk in patients with congenital heart disease. Further research may help elucidate the mechanisms leading to different alterations in sulcal patterning.
Article
Cardiac & Cardiovascular Systems
Bryan H. Goldstein, Christopher J. Petit, Athar M. Qureshi, Courtney E. McCracken, Michael S. Kelleman, George T. Nicholson, Mark A. Law, Jeffery J. Meadows, Jeffrey D. Zampi, Shabana Shahanavaz, Christopher E. Mascio, Paul J. Chai, Jennifer C. Romano, Sarosh P. Batlivala, Shiraz A. Maskatia, Ivor B. Asztalos, Alicia M. Kamsheh, Steven J. Healan, Justin D. Smith, R. Allen Ligon, Joelle A. Pettus, Sarina Juma, James E. B. Raulston, Krissie M. Hock, Amy L. Pajk, Lindsay F. Eilers, Hala Q. Khan, Taylor C. Merritt, Matthew Canter, Stephan Juergensen, Fatuma-Ayaan Rinderknecht, Holly Bauser-Heaton, Andrew C. Glatz
Summary: In this multicenter comparison of staged repair (SR) and primary repair (PR) for neonates with symptomatic tetralogy of Fallot (sTOF), early mortality and neonatal morbidity were lower in the SR group, while cumulative morbidity and reinterventions favored the PR group, suggesting potential benefits to each strategy.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Biology
Chun-Ho Chan, Yin-Yu Lam, Nicodemus Wong, Lin Geng, Jilin Zhang, Virpi Ahola, Aman Zare, Ronald Adolphus Li, Fredrik Lanner, Wendy Keung, Yiu-Fai Cheung
Summary: This study reveals functional abnormalities in cardiomyocytes derived from Tetralogy of Fallot patients with DiGeorge syndrome, including impaired ventricular specification, altered cardiac gene expression, upregulated neural gene expression, and increased arrhythmogenicity. These findings are specific to patients with DiGeorge syndrome and have implications for their clinical outcomes.
COMMUNICATIONS BIOLOGY
(2023)
Article
Medical Laboratory Technology
Wei Wang, Hao Cui, Gao Ran, Chuhao Du, Xiao Chen, Shuo Dong, Siyuan Huang, Jun Yan, Junmin Chu, Jiangping Song
Summary: This study investigated the plasma metabolic profiles to identify key metabolites for early diagnosis of Tetralogy of Fallot (TOF), a common congenital heart disease. The researchers found significant metabolic differences between TOF patients and normal controls, specifically in nicotinamide and purine metabolism pathways. The study suggests that plasma FAD could serve as a highly valuable biomarker for differentiating TOF from normal. These findings contribute to the development of reliable biomarkers and improving early screening for TOF.
CLINICA CHIMICA ACTA
(2023)
Article
Critical Care Medicine
Pierre-Olivier Girodet, Gael Dournes, Matthieu Thumerel, Hugues Begueret, Pierre Dos Santos, Annaig Ozier, Isabelle Dupin, Thomas Trian, Michel Montaudon, Francois Laurent, Roger Marthan, Patrick Berger
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2015)
Letter
Cardiac & Cardiovascular Systems
Lionel Leroux, Nathalie Peragallo, Marina Dijos, Magdalena Murman, Frederic Casassus, Pierre Coste, Pierre Dos Santos
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
Fanny Vaillant, Julie Magat, Pierre Bour, Jerome Naulin, David Benoist, Virginie Loyer, Delphine Vieillot, Louis Labrousse, Philippe Ritter, Olivier Bernus, Pierre Dos Santos, Bruno Quesson
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2016)
Editorial Material
Cardiac & Cardiovascular Systems
Lionel Leroux, Marina Dijos, Julien Peltan, Frederic Casassus, Benjamin Seguy, Makoto Natsumeda, Stephane Lafitte, Louis Labrousse, Pierre Dos Santos
CANADIAN JOURNAL OF CARDIOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Martine Gilard, Helene Eltchaninoff, Patrick Donzeau-Gouge, Karine Chevreul, Jean Fajadet, Pascal Leprince, Alain Leguerrier, Michel Lievre, Alain Prat, Emmanuel Teiger, Thierry Lefevre, Didier Tchetche, Didier Carrie, Dominique Himbert, Bernard Albat, Alain Cribier, Arnaud Sudre, Didier Blanchard, Gilles Rioufol, Frederic Collet, Remi Houel, Pierre Dos Santos, Nicolas Meneveau, Said Ghostine, Thibaut Manigold, Philippe Guyon, Dominique Grisoli, Herve Le Breton, Stephane Delpine, Romain Didier, Xavier Favereau, Geraud Souteyrand, Patrick Ohlmann, Vincent Doisy, Gilles Grollier, Antoine Gommeaux, Jean-Philippe Claudel, Francois Bourlon, Bernard Bertrand, Marc Laskar, Bernard Iung
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Patricia Reant, Alexandre Metras, Dominique Detaille, Annabel Reynaud, Philippe Diolez, Beatrice Jaspard-Vinassa, Raymond Roudaut, Alexandre Ouattara, Laurent Barandon, Pierre Dos Santos, Stephane Lafitte
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2016)
Article
Cardiac & Cardiovascular Systems
Francois Roubertie, Romain Eschalier, Adlane Zemmoura, Jean-Benoit Thambo, Caroline Rooryck, Louis Labrousse, Sylvain Ploux, Philippe Ritter, Michel Haissaguerre, Pierre Dos Santos, Pierre Bordachar
PEDIATRIC CARDIOLOGY
(2016)
Article
Multidisciplinary Sciences
Veronique Deschodt-Arsac, Laurent Arsac, Julie Magat, Jerome Naulin, Bruno Quesson, Pierre Dos Santos
Article
Cardiac & Cardiovascular Systems
Jerome Corre, Francois Picard, Rodrigue Garcia, Adlane Zemmoura, Nicolas Derval, Arnaud Denis, Antoine Romen, Karine Nubret, Pierre Jais, Michel Haissaguerre, Pierre Dos Santos, Laurent Barandon, Frederic Sacher
ARCHIVES OF CARDIOVASCULAR DISEASES
(2018)
Article
Cardiac & Cardiovascular Systems
Frederic Sacher, Matthew Wright, Nicolas Derval, Arnaud Denis, Khaled Ramoul, Laurent Roten, Patrizzio Pascale, Pierre Bordachar, Philippe Ritter, Meleze Hocini, Pierre Dos Santos, Michel Haissaguerre, Pierre Jais
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Veronique Deschodt-Arsac, Guillaume Calmettes, Gilles Gouspillou, Mathilde Chapolard, Gerard Raffard, Richard Rouland, Pierre Jais, Michel Haissaguerre, Pierre Dos Santos, Philippe Diolez
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2013)
Article
Cardiac & Cardiovascular Systems
Romain Didier, Helene Eltchaninoff, Patrick Donzeau-Gouge, Karine Chevreul, Jean Fajadet, Pascal Leprince, Alain Leguerrier, Michel Lievre, Alain Prat, Emmanuel Teiger, Thierry Lefevre, Didier Tchetche, Didier Carrie, Dominique Himbert, Bernard Albat, Alain Cribier, Arnaud Sudre, Didier Blanchard, Gilles Rioufol, Frederic Collet, Remi Houel, Pierre Dos Santos, Nicolas Meneveau, Said Ghostine, Thibaut Manigold, Philippe Guyon, Thomas Cuisset, Herve Le Breton, Stephane Delepine, Xavier Favereau, Geraud Souteyrand, Patrick Ohlmann, Vincent Doisy, Therese Lognone, Antoine Gommeaux, Jean-Philippe Claudel, Francois Bourlon, Bernard Bertrand, Bernard Iung, Martine Gilard
Article
Public, Environmental & Occupational Health
Pauline Bosco-Levy, Stephanie Duret, Francois Picard, Pierre Dos Santos, Etienne Puymirat, Veronique Gilleron, Patrick Blin, Gilles Chatellier, Vincent Looten, Nicholas Moore
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2019)
Article
Multidisciplinary Sciences
Dominique Detaille, Philippe Pasdois, Audrey Semont, Pierre Dos Santos, Philippe Diolez
Article
Cardiac & Cardiovascular Systems
Marina Dijos, Amelie Reynaud, Lionel Leroux, Patricia Reant, Claire Cornolle, Raymond Roudaut, Pierre Dos Santos, Stephane Lafitte
