Review
Medicine, General & Internal
Andrea Bonnin Marquez, Emiel P. C. van der Vorst, Sanne L. Maas
Summary: Atherosclerosis is a major cause of cardiovascular diseases, and chemokines and their receptors play a crucial role in its pathophysiological development. Targeting these factors through various methods shows promise in ameliorating atherosclerosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Bing Jiang, Xuan Zhou, Tao Yang, Linlin Wang, Longfei Feng, Zheng Wang, Jin Xu, Weiyao Jing, Tao Wang, Haixiang Su, GuoWei Yang, Zheng Zhang
Summary: Autophagy is a conserved pathway that degrades cytoplasmic proteins and organelles, meeting the metabolic needs and renewal of cells. Autophagy-related genes (ATGs) are the main mechanisms controlling autophagy, coordinating the entire process. Autophagy can impact cardiovascular disease through various signaling pathways, such as PI3K/Akt/mTOR, IGF/EGF, AMPK/mTOR, MAPKs, p53, Nrf2/p62, Wnt/beta-catenin, and NF-kappa B pathways.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cell Biology
Heng Li, Jin Zou, Xiao-Hua Yu, Xiang Ou, Chao-Ke Tang
Summary: Zinc finger E-box binding homeobox 1 (ZEB1) plays a crucial role in regulating gene expression for both normal physiological and pathological processes, and recent studies have shown its involvement in atherosclerotic cardiovascular disease initiation and progression.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Shuxian Chen, Yuanming Zou, Chunyu Song, Kexin Cao, Kexin Cai, Yanjiao Wu, Zhaobo Zhang, Danxi Geng, Wei Sun, Nanxiang Ouyang, Naijin Zhang, Zhao Li, Guozhe Sun, Yixiao Zhang, Yingxian Sun, Ying Zhang
Summary: Cardiovascular disease is a significant threat to human health, and the glycolytic pathway and its enzymes play important roles in its development.
BASIC RESEARCH IN CARDIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Valentina A. Rossi, Martin Gruebler, Luca Monzo, Alessandro Galluzzo, Matteo Beltrami
Summary: Epicardial adipose tissue (EAT) is an endocrine and paracrine organ that can exert both protective and harmful effects in heart failure. Its role may differ depending on the type of heart failure, but it has the potential to be a therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Immunology
Raul Y. Sanchez-David, Pierre V. Maillard
Summary: The study highlights the significance of RNA interference in antiviral immunity in mammals and demonstrates the potential of designer peptides as a promising approach for antiviral therapy.
Review
Biotechnology & Applied Microbiology
Eduarde Rohner, Ran Yang, Kylie S. Foo, Alexander Goedel, Kenneth R. Chien
Summary: mRNA therapeutics face challenges, but with the help of solutions, they have the potential to become a widely applicable treatment modality for both rare and common diseases.
NATURE BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nikolas Dovrolis, Maria Nikou, Alexandra Gkrouzoudi, Nikolaos Dimitriadis, Ioanna Maroulakou
Summary: Alzheimer's Disease (AD) is a neurodegenerative disorder characterized by memory loss and cognitive decline. Recent research has shown that the mechanisms involved in AD are complex and diverse. This study presents a computational approach to analyze genes and biological processes specific to brain regions in AD. The identified genes participate in various biological processes and provide new insights into the molecular background of AD.
Review
Pharmacology & Pharmacy
Yan Wang, Jianliang Wei, Peng Zhang, Xin Zhang, Yifei Wang, Wenjing Chen, Yanan Zhao, Xiangning Cui
Summary: This article provides a summary of the role and mechanisms of NRG1 in cardiovascular diseases, discusses therapeutic approaches for cardiovascular diseases, and highlights future research directions.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Hongyu Chen, Junmin Wang, Caiyun Zhang, Peilun Ding, Shuxia Tian, Junming Chen, Guang Ji, Tao Wu
Summary: Sphingosine 1-phosphate receptor (S1PR), a G protein-coupled receptor, regulates the migration of various cells through the modulation of signals, pathways, and enzymes, making it a potential target for the treatment of autoimmune diseases, pulmonary disease, liver disease, and cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Oncology
Vishakha Anand Pawar, Anuradha Tyagi, Chaitenya Verma, Kanti Prakash Sharma, Sekhu Ansari, Indra Mani, Shailesh Kumar Srivastva, Pradeep Kumar Shukla, Antresh Kumar, Vinay Kumar
Summary: Drug repurposing refers to the use of drugs that have been approved or assessed for different diseases than their original indications. Recent research focuses on patient-centered approaches and explores the mechanisms of pathological abnormalities, and the availability of information on repurposed drugs increases the chances of approval in clinical trials. Repurposed drug immunotherapy has been successful in treating various diseases.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Hao Li, Sumit Agrawal, Seyed Alireza Rohani, Ning Zhu, Daniela Cacciabue, Marcelo N. Rivolta, Douglas E. H. Hartley, Dan Jiang, Hanif M. Ladak, Gerard M. O'Donoghue, Helge Rask-Andersen
Summary: This study provides a detailed characterization of the functional architecture of the inner ear, making it safely accessible for therapeutic intervention for the first time. The findings will facilitate future clinical trials for restoring hearing.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Karen Bayne, Anita Wreford, Peter Edwards, Alan Renwick
Summary: There has been significant national interest and movement towards bioeconomic policy in New Zealand over the past decade. While the country has strengths in primary production and green growth with low carbon policies, there are barriers to overcome in developing a cohesive bioeconomy that integrates new niche industries and attracts finance.
Review
Pharmacology & Pharmacy
Yuanyuan Guo, Rongzhen Zhang, Wenlan Li
Summary: Emodin, a natural anthraquinone derivative extracted from Chinese herbs, has shown significant effects in treating cardiovascular diseases through various mechanisms and has great potential in clinical applications.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Savelii R. Kuvarzin, Ilya Sukhanov, Kirill Onokhin, Konstantin Zakharov, Raul R. Gainetdinov
Summary: SEP-363856 (Ulotaront) is a novel antipsychotic drug that acts on trace amine-associated receptor 1 and serotonin 5-HT1A receptors instead of dopamine D2 receptors. Clinical studies have shown that Ulotaront can effectively reduce both positive and negative symptoms of schizophrenia without causing typical side effects associated with other antipsychotic medications.
Editorial Material
Medicine, General & Internal
Chris Piech, Ali Malik, Eric J. Topol
Review
Medicine, General & Internal
Daniel P. Oran, Eric J. Topol
Summary: Available data suggests that at least one third of SARS-CoV-2 infections are asymptomatic. Longitudinal studies indicate that nearly three quarters of individuals who test positive via PCR but show no symptoms at the time of testing will remain asymptomatic. Control strategies for COVID-19 need to be adjusted considering the prevalence and transmission risk of asymptomatic SARS-CoV-2 infections.
ANNALS OF INTERNAL MEDICINE
(2021)
Editorial Material
Biochemistry & Molecular Biology
Eric J. Topol
Review
Biochemistry & Molecular Biology
Pranav Rajpurkar, Emma Chen, Oishi Banerjee, Eric J. Topol
Summary: This Review discusses the potential of AI to reshape medicine and make healthcare more accurate, efficient, and accessible. It covers recent progress in medical AI, including advances in medical image analysis, non-image data sources, and human-AI collaboration. The article also addresses technical and ethical challenges, such as data scarcity and racial bias.
Editorial Material
Multidisciplinary Sciences
Eric Topol
Article
Health Care Sciences & Services
Matteo Gadaleta, Jennifer M. Radin, Katie Baca-Motes, Edward Ramos, Vik Kheterpal, Eric J. Topol, Steven R. Steinhubl, Giorgio Quer
Summary: Individual smartwatch or fitness band sensor data have shown promise in identifying COVID-19 infection, and a explainable gradient boosting prediction model based on decision trees was proposed for detection. The model demonstrated good performance in symptomatic individuals and also performed well in all individuals, including asymptomatic and pre-symptomatic cases.
NPJ DIGITAL MEDICINE
(2021)
Article
Medicine, General & Internal
Siegfried Karl Wagner, Fintan Hughes, Mario Cortina-Borja, Nikolas Pontikos, Robbert Struyven, Xiaoxuan Liu, Hugh Montgomery, Daniel C. Alexander, Eric Topol, Steffen Erhard Petersen, Konstantinos Balaskas, Jack Hindley, Axel Petzold, Jugnoo S. Rahi, Alastair K. Denniston, Pearse A. Keane
Summary: Retinal signatures of systemic disease are being revealed through high-resolution ophthalmic imaging and advanced modelling. However, progress is limited due to the lack of large labelled datasets. This study aims to link longitudinal multimodal retinal imaging with systemic disease data to identify hidden retinal signatures for earlier detection and risk management of life-threatening conditions.
Article
Health Care Sciences & Services
Giorgio Quer, Matteo Gadaleta, Jennifer M. Radin, Kristian G. Andersen, Katie Baca-Motes, Edward Ramos, Eric J. Topol, Steven R. Steinhubl
Summary: The ability to track physiological changes in individuals after vaccination using wearable devices can provide objective evidence of vaccine-induced immune response. Preliminary findings show that resting heart rate increases after vaccination in most individuals and returns to normal within days. Vaccine dosage, gender, and age may also affect the physiological response.
NPJ DIGITAL MEDICINE
(2022)
Letter
Biotechnology & Applied Microbiology
Giorgio Quer, Eric J. Topol, Steven R. Steinhubl
NATURE BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Jay A. Pandit, Jennifer M. Radin, Giorgio Quer, Eric J. Topol
Summary: During the COVID-19 pandemic, smartphone apps played a crucial role in tracking outbreaks, individual screening, and contact tracing. Despite limitations and concerns, there is ample evidence that these apps have been beneficial in understanding and controlling the spread of the virus.
NATURE BIOTECHNOLOGY
(2022)
Review
Engineering, Biomedical
Rayan Krishnan, Pranav Rajpurkar, Eric J. Topol
Summary: This Review examines the advantages and limitations of self-supervised methods and models in medicine and healthcare, as well as the challenges in collecting unbiased data for their training. The utilization of self-supervised learning has the potential to accelerate the development of medical artificial intelligence, particularly in tasks involving multimodal datasets and the analysis of electronic health records, medical images, bioelectrical signals, and genetic and protein sequences and structures.
NATURE BIOMEDICAL ENGINEERING
(2022)
Review
Biochemistry & Molecular Biology
Julian N. Acosta, Guido J. Falcone, Pranav Rajpurkar, Eric J. Topol
Summary: This Review discusses the potential applications, technical pitfalls, and challenges of multimodal artificial intelligence models in the field of health and medicine. By utilizing data from large biobanks, electronic health records, medical imaging, and genomics, multimodal AI solutions have the ability to capture the complexity of human health and disease. Key areas such as personalized medicine, digital clinical trials, remote monitoring and care, pandemic surveillance, and virtual health assistants offer opportunities, but data, modeling, and privacy challenges need to be addressed for the full potential of multimodal AI in health to be realized.
Review
Microbiology
Hannah E. Davis, Lisa McCorkell, Julia Moore Vogel, Eric J. Topol
Summary: Long COVID is a common and debilitating illness that affects at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, with a wide range of symptoms and impacts on multiple organ systems. There are an estimated 65 million individuals worldwide with long COVID, and the number of cases is increasing daily. Current diagnostic and treatment options are insufficient, and there is a need for clinical trials to address leading hypotheses. Future research should account for biases and testing issues, build on viral-onset research, include marginalized populations, and meaningfully engage patients.
NATURE REVIEWS MICROBIOLOGY
(2023)
Correction
Microbiology
Hannah E. Davis, Lisa McCorkell, Julia Moore Vogel, Eric J. Topol
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Health Care Sciences & Services
Bertalan Mesko, Eric J. J. Topol
Summary: The rapid advancements in AI have led to the development of sophisticated large language models (LLMs) such as GPT-4 and Bard. The potential implementation of LLMs in healthcare settings has gained attention due to their diverse applications, but caution is necessary as these models are trained differently and require regulatory oversight to ensure safety and protect patient privacy. This paper provides practical recommendations for regulators to bring this vision to reality.
NPJ DIGITAL MEDICINE
(2023)