AI in health and medicine

High-performance brain-to-text communication via handwriting

(2021) Francis R. Willett et al.   NATURE

Deep learning in histopathology: the path to the clinic

(2021) Jeroen van der Laak et al.   NATURE MEDICINE

Development and Assessment of an Artificial Intelligence–Based Tool for Skin Condition Diagnosis by Primary Care Physicians and Nurse Practitioners in Teledermatology Practices

(2021) Ayush Jain et al.   JAMA Network Open

Challenges to the Reproducibility of Machine Learning Models in Health Care

(2020) Andrew L. Beam et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of a Machine Learning–Derived Early Warning System for Intraoperative Hypotension vs Standard Care on Depth and Duration of Intraoperative Hypotension During Elective Noncardiac Surgery

(2020) Marije Wijnberge et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Improved protein structure prediction using potentials from deep learning

(2020) Andrew W. Senior et al.   NATURE

The single-cell pathology landscape of breast cancer

(2020) Hartland W. Jackson et al.   NATURE

International evaluation of an AI system for breast cancer screening

(2020) Scott Mayer McKinney et al.   NATURE

Near real-time intraoperative brain tumor diagnosis using stimulated Raman histology and deep neural networks

(2020) Todd C. Hollon et al.   NATURE MEDICINE

Preparing Medical Imaging Data for Machine Learning

(2020) Martin J. Willemink et al.   RADIOLOGY

Circulating tumor DNA methylation profiles enable early diagnosis, prognosis prediction, and screening for colorectal cancer

(2020) Huiyan Luo et al.   Science Translational Medicine

Precision Medicine and Artificial Intelligence: A Pilot Study on Deep Learning for Hypoglycemic Events Detection based on ECG

(2020) Mihaela Porumb et al.   Scientific Reports

Detection of colorectal adenomas with a real-time computer-aided system (ENDOANGEL): a randomised controlled study

(2020) Dexin Gong et al.   Lancet Gastroenterology & Hepatology

Effect of a deep-learning computer-aided detection system on adenoma detection during colonoscopy (CADe-DB trial): a double-blind randomised study

(2020) Pu Wang et al.   Lancet Gastroenterology & Hepatology

A Deep Learning Approach to Antibiotic Discovery

(2020) Jonathan M. Stokes et al.   CELL

Extracting drug-drug interactions from texts with BioBERT and multiple entity-aware attentions

(2020) Yu Zhu et al.   JOURNAL OF BIOMEDICAL INFORMATICS

Video-based AI for beat-to-beat assessment of cardiac function

(2020) David Ouyang et al.   NATURE

Integrating genomic features for non-invasive early lung cancer detection

(2020) Jacob J. Chabon et al.   NATURE

Artificial Intelligence to Detect Papilledema from Ocular Fundus Photographs

(2020) Dan Milea et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gender imbalance in medical imaging datasets produces biased classifiers for computer-aided diagnosis

(2020) Agostina J. Larrazabal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human–computer collaboration for skin cancer recognition

(2020) Philipp Tschandl et al.   NATURE MEDICINE

Hidden in Plain Sight — Reconsidering the Use of Race Correction in Clinical Algorithms

(2020) Darshali A. Vyas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Deep Learning Single-Frame and Multiframe Super-Resolution for Cardiac MRI

(2020) Evan M. Masutani et al.   RADIOLOGY

Ethics of Using and Sharing Clinical Imaging Data for Artificial Intelligence: A Proposed Framework

(2020) David B. Larson et al.   RADIOLOGY

Machine-learning approach expands the repertoire of anti-CRISPR protein families

(2020) Ayal B. Gussow et al.   Nature Communications

Use of Deep Learning to Develop and Analyze Computational Hematoxylin and Eosin Staining of Prostate Core Biopsy Images for Tumor Diagnosis

(2020) Aman Rana et al.   JAMA Network Open

Guidelines for clinical trial protocols for interventions involving artificial intelligence: the SPIRIT-AI extension

(2020) Samantha Cruz Rivera et al.   NATURE MEDICINE

Insulin dose optimization using an automated artificial intelligence-based decision support system in youths with type 1 diabetes

(2020) Revital Nimri et al.   NATURE MEDICINE

MARS: discovering novel cell types across heterogeneous single-cell experiments

(2020) Maria Brbić et al.   NATURE METHODS

Artificial intelligence in radiation oncology

(2020) Elizabeth Huynh et al.   Nature Reviews Clinical Oncology

Reporting guidelines for clinical trial reports for interventions involving artificial intelligence: the CONSORT-AI Extension

(2020) Xiaoxuan Liu et al.   BMJ-British Medical Journal

Cost-effectiveness of Autonomous Point-of-Care Diabetic Retinopathy Screening for Pediatric Patients With Diabetes

(2020) Risa M. Wolf et al.   JAMA Ophthalmology

Magnitude, Risk Factors, and Factors Associated With Adenoma Miss Rate of Tandem Colonoscopy: A Systematic Review and Meta-analysis

(2019) Shengbing Zhao et al.   GASTROENTEROLOGY

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

(2019) Christopher W. Seymour et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genome-wide cell-free DNA fragmentation in patients with cancer

(2019) Stephen Cristiano et al.   NATURE

End-to-end lung cancer screening with three-dimensional deep learning on low-dose chest computed tomography

(2019) Diego Ardila et al.   NATURE MEDICINE

Detecting middle ear fluid using smartphones

(2019) Justin Chan et al.   Science Translational Medicine

A clinically applicable approach to continuous prediction of future acute kidney injury

(2019) Nenad Tomašev et al.   NATURE

Unsupervised word embeddings capture latent knowledge from materials science literature

(2019) Vahe Tshitoyan et al.   NATURE

Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer

(2019) Jakob Nikolas Kather et al.   NATURE MEDICINE

Clinical-grade computational pathology using weakly supervised deep learning on whole slide images

(2019) Gabriele Campanella et al.   NATURE MEDICINE

Detection of Brain Activation in Unresponsive Patients with Acute Brain Injury

(2019) Jan Claassen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Weakly supervised classification of aortic valve malformations using unlabeled cardiac MRI sequences

(2019) Jason A. Fries et al.   Nature Communications

Assessment of Deep Natural Language Processing in Ascertaining Oncologic Outcomes From Radiology Reports

(2019) Kenneth L. Kehl et al.   JAMA Oncology

An artificial intelligence-enabled ECG algorithm for the identification of patients with atrial fibrillation during sinus rhythm: a retrospective analysis of outcome prediction

(2019) Zachi I Attia et al.   LANCET

Deep learning enables rapid identification of potent DDR1 kinase inhibitors

(2019) Alex Zhavoronkov et al.   NATURE BIOTECHNOLOGY

Do no harm: a roadmap for responsible machine learning for health care

(2019) Jenna Wiens et al.   NATURE MEDICINE

An augmented reality microscope with real-time artificial intelligence integration for cancer diagnosis

(2019) Po-Hsuan Cameron Chen et al.   NATURE MEDICINE

Artificial intelligence in digital pathology — new tools for diagnosis and precision oncology

(2019) Kaustav Bera et al.   Nature Reviews Clinical Oncology

Development and Validation of a Deep Learning System to Detect Glaucomatous Optic Neuropathy Using Fundus Photographs

(2019) Hanruo Liu et al.   JAMA Ophthalmology

Key challenges for delivering clinical impact with artificial intelligence

(2019) Christopher J. Kelly et al.   BMC Medicine

Potential Liability for Physicians Using Artificial Intelligence

(2019) W. Nicholson Price et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Deep learning-based classification of mesothelioma improves prediction of patient outcome

(2019) Pierre Courtiol et al.   NATURE MEDICINE

Simultaneous detection of genotype and phenotype enables rapid and accurate antibiotic susceptibility determination

(2019) Roby P. Bhattacharyya et al.   NATURE MEDICINE

Exploring single-cell data with deep multitasking neural networks

(2019) Matthew Amodio et al.   NATURE METHODS

Unified rational protein engineering with sequence-based deep representation learning

(2019) Ethan C. Alley et al.   NATURE METHODS

Dissecting racial bias in an algorithm used to manage the health of populations

(2019) Ziad Obermeyer et al.   SCIENCE

Deep learning extends de novo protein modelling coverage of genomes using iteratively predicted structural constraints

(2019) Joe G. Greener et al.   Nature Communications

Deciphering interaction fingerprints from protein molecular surfaces using geometric deep learning

(2019) P. Gainza et al.   NATURE METHODS

Deep Convolutional Neural Network–based Software Improves Radiologist Detection of Malignant Lung Nodules on Chest Radiographs

(2019) Yongsik Sim et al.   RADIOLOGY

Deep Neural Networks Improve Radiologists’ Performance in Breast Cancer Screening

(2019) Nan Wu et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Impact of Deep Learning Assistance on the Histopathologic Review of Lymph Nodes for Metastatic Breast Cancer

(2018) David F. Steiner et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Cardiologist-level arrhythmia detection and classification in ambulatory electrocardiograms using a deep neural network

(2018) Awni Y. Hannun et al.   NATURE MEDICINE

Deep learning for chest radiograph diagnosis: A retrospective comparison of the CheXNeXt algorithm to practicing radiologists

(2018) Pranav Rajpurkar et al.   PLOS MEDICINE

Dermatologist-level classification of skin cancer with deep neural networks

(2017) Andre Esteva et al.   NATURE

Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs

(2016) Varun Gulshan et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION