Review
Medicine, General & Internal
Esmee J. Grobbee, Pieter Ha Wisse, Eline H. Schreuders, Aafke van Roon, Leonie van Dam, Ann G. Zauber, Iris Lansdorp-Vogelaar, Wichor Bramer, Sarah Berhane, Jonathan J. Deeks, Ewout W. Steyerberg, Monique E. van Leerdam, Manon Cw Spaander, Ernst J. Kuipers
Summary: FIT is superior to gFOBT in detecting advanced colorectal neoplasia and colorectal cancer in average-risk individuals. The specificity of both tests was similar, while the sensitivity of FIT was significantly higher than gFOBT at pre-specified specificities.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Gastroenterology & Hepatology
Reinier G. S. Meester, Hilliene J. van de Schootbrugge-vandermeer, Emilie C. H. Breekveldt, Lucie de Jonge, Esther Toes-Zoutendijk, Arthur Kooyker, Daan Nieboer, Christian R. Ramakers, Manon C. W. Spaander, Anneke J. van Vuuren, Ernst J. Kuipers, Folkert J. van Kemenade, Iris D. Nagtegaal, Evelien Dekker, Monique E. van Leerdam, Iris Lansdorp-Vogelaar
Summary: The prognostic potential of repeated faecal haemoglobin (F-Hb) concentration measurements in faecal immunochemical test (FIT)-based screening for colorectal cancer (CRC) was examined. The study found that F-Hb concentrations in rounds 1 and 2 were the strongest predictors. In external validation, the model retained similar discrimination accuracy. This suggests that individuals can be accurately identified as low or high risk based on age, sex, and prior F-Hb concentrations, and risk stratification should be considered based on this information.
Review
Gastroenterology & Hepatology
Noel Pin-Vieito, Manuel Puga, Daniel Fernandez-de-Castro, Joaquin Cubiella
Summary: FIT is widely used as a biomarker for colorectal cancer diagnosis and plays a crucial role in screening and surveillance. This review summarizes the diagnostic efficacy of FIT in symptomatic patients and post-adenoma resection, as well as discusses the potential impact of FIT strategies on healthcare resources and CRC prognosis.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Aasma Shaukat, Theodore R. Levin
Summary: This Review provides an overview of current CRC screening options worldwide, including colonoscopy and stool-based tests. It also highlights the key features of each modality and describes new screening tests under development.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Oncology
Sara G. Ribe, Edoardo Botteri, Magnus Loberg, Kristin R. Randel, Mette Kalager, Jens Aksel Nilsen, Elisabeth H. Gulichsen, Oyvind Holme
Summary: This study investigated the impact of time interval between faecal immunochemical testing (FIT) cycles on the detection rate of colorectal cancer (CRC) and advanced neoplasia (AN). The results showed that although the detection rates of CRC and AN increased with increasing time interval between FITs, individuals who had undetectable faecal haemoglobin (f-Hb) at the first screening round had a substantially lower risk of CRC at the next screening round compared to individuals with detectable f-Hb.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Business
Pranjal Pachpore, Prashant Kumar, D. Israel, Sanjay Patro, Sumit Kumar Maji
Summary: This study aims to examine the relationship between new ecological paradigm (NEP), consideration of future consequences (CFC), intention to buy, and intention to pay a premium in the context of electric car purchase in India. The study collected data from 491 Indian consumers using a structured questionnaire and analyzed the variables using structural equation modeling. The findings suggest that the values of NEP and CFC have a significant impact on the intention to buy and pay a premium for electric cars.
ASIA PACIFIC JOURNAL OF MARKETING AND LOGISTICS
(2023)
Review
Public, Environmental & Occupational Health
B. R. Chand, L. Phillipson, T. Ha
Summary: This comprehensive review examines the factors influencing participation in organised faecal occult blood test (FOBT) screening programmes among culturally and linguistically diverse populations. The review identifies barriers such as faecal aversion, fear of cancer, language barriers, and low knowledge and awareness of colorectal screening. Facilitators include positive attitudes towards screening, general practitioner recommendations, and social support. The review suggests multicomponent interventions to address low screening uptake and highlights the importance of successful community-level interventions and leveraging the general practitioner relationship.
Article
Medicine, General & Internal
Paulina Wieszczy, Michal F. Kaminski, Magnus Loberg, Marek Bugajski, Michael Bretthauer, Mette Kalager
Summary: Estimates of overdiagnosis of colorectal cancer through screening methods such as sigmoidoscopy and FOBT varied significantly depending on model assumptions. Microsimulation models showed a wide range of overdiagnosis percentages for both screening methods, indicating caution should be exercised when using these models to inform guidelines.
Review
Oncology
Gemma Ibanez-Sanz, Rebeca Sanz-Pamplona, Montse Garcia
Summary: Interval colorectal cancer serves as a measure of screening programme effectiveness, with further study into its epidemiological, clinical, and molecular characteristics providing insights for disease prevention.
Article
Multidisciplinary Sciences
Miriam P. van der Meulen, Esther Toes-Zoutendijk, Manon C. W. Spaander, Evelien Dekker, Johannes M. G. Bonfrer, Anneke J. van Vuuren, Ernst J. Kuipers, Folkert J. van Kemenade, M. F. van Velthuysen, Maarten G. J. Thomeer, Harriet van Veldhuizen, Harry J. de Koning, Iris Lansdorp-Vogelaar, Monique E. van Leerdam
Summary: The participation rate in FIT screening is lower for individuals with a lower socioeconomic status (SES), but they have a higher detection rate for advanced neoplasia. Screening has the potential to reduce health inequalities in CRC mortality.
Article
Public, Environmental & Occupational Health
Matthew T. Keys, Miquel Serra-Burriel, Natalia Martinez-Lizaga, Maria Pellise, Francesc Balaguer, Ariadna Sanchez, Enrique Bernal-Delgado, Antoni Castells
Summary: The study found that FIT-based organized colorectal cancer screening in Spain was associated with a reduction in population colorectal cancer mortality. No differences in outcome trends were observed between exposed and control provinces in the 7 years prior to screening implementation. Two years after implementation, exposed provinces experienced an increase in colorectal cancer incidence, followed by a decrease in mortality rates after 7 years.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Medicine, General & Internal
Lasse Kaalby, Ulrik Deding, Issam Al-Najami, Gabriele Berg-Beckhoff, Thomas Bjorsum-Meyer, Tinne Laurberg, Aasma Shaukat, Robert J. C. Steele, Anastasios Koulaouzidis, Morten Rasmussen, Morten Kobaek-Larsen, Gunnar Baatrup
Summary: New research suggests that faecal haemoglobin concentration (f-Hb) can indicate the presence of serious diseases not related to colorectal cancer (CRC). This study found an association between increasing f-Hb and the risk of mortality, as well as an increased risk of dying from respiratory disease, cardiovascular disease, and other cancers. f-Hb may be a potential biomarker for non-CRC diseases.
Article
Gastroenterology & Hepatology
Anna Pellat, Jacques Deyra, Marie Husson, Robert Benamouzig, Romain Coriat, Stanislas Chaussade
Summary: The study questioned the relevance of the current positivity threshold for colorectal cancer screening in the French population, suggesting it could be lowered to avoid delays in diagnosis. The high mean positivity value for normal colonoscopies raised concerns about upper gastrointestinal bleeding.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Review
Medical Laboratory Technology
Gavin R. C. Clark, Robert J. C. Steele, Callum G. Fraser
Summary: Women are at a disadvantage in colorectal cancer screening due to lower faecal haemoglobin concentrations, leading to poorer outcomes. Risk scoring strategies that consider sex have not been extensively tested or introduced. Governments and agencies should prioritize allocating resources to implement simple strategies, such as using different haemoglobin thresholds, to achieve equal positivity in both sexes.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Johanna Wangmar, Yvonne Wengstrom, Anna Jervaeus, Kaisa Fritzell
Summary: The acceptability of colorectal cancer screening procedures is crucial for the success of screening programs. This study explored how individuals experience CRC screening, finding that experiences vary from having no worries to experiencing bothersome emotions, logistical concerns, inconsistent information, and unmet expectations. Improving patient experiences may involve using one-sample FITs, optimizing bowel preparation for colonoscopies, and delivering clear information and emotional support at the right time.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Gastroenterology & Hepatology
Matthew D. Rutter, Rachel Evans, Zoe Hoare, Christian Von Wagner, Jill Deane, Shiran Esmaily, Tony Larkin, Rhiannon Edwards, Seow Tien Yeo, Llinos Haf Spencer, Emily Holmes, Brian P. Saunders, Colin J. Rees, Zacharias P. Tsiamoulos, Iosif Beintaris
Summary: In the context of unsedated sigmoidoscopies with enema preparation performed by accredited endoscopists, there was no significant difference in patient-reported pain between CO2 and WAS techniques. The adenoma detection rate was slightly different between the two techniques, but both remained above the national performance standard. Cost difference between CO2 and WAS was negligible.
Article
Behavioral Sciences
Sandro T. Stoffel, Mariella Bombagi, Robert S. Kerrison, Christian von Wagner, Benedikt Herrmann
Summary: The study tested an alternative screening strategy called enhanced active choice, which was found to increase screening participation among men. However, there were no statistically significant differences in overall acceptance and participation rates between the two conditions.
BEHAVIORAL MEDICINE
(2022)
Article
Medicine, General & Internal
Georgia Woodfield, Ilaria Belluomo, Piers R. Boshier, Annabelle Waller, Maya Fayyad, Christian von Wagner, Amanda J. Cross, George B. Hanna
Summary: The study examined the feasibility and acceptability of breath research in primary care settings. The recruitment methods and testing process were evaluated, showing high acceptability among both patients and general practitioners. The study provides a practical framework for designing Phase III trials on breath testing performance in primary care.
Article
Oncology
Juliet Usher-Smith, Christian von Wagner, Alex Ghanouni
Summary: Cancer screening programmes play a significant role in reducing cancer incidence and mortality. Personalised risk estimates can improve effectiveness and cost-effectiveness, as well as reduce harms of screening programmes. Risk-adapted colorectal cancer screening raises important questions that require further research and testing. Conducting behavioural science research alongside clinical research will help ensure that risk-adapted screening is understood and accepted by the population it aims to serve.
Article
Psychology, Social
Louise Hazel Hall, Jane Clark, Samuel George Smith, Christopher D. Graham
Summary: The study co-developed an ACT intervention to support medication adherence and quality of life for breast cancer survivors. Using patient and HCP co-design, the research found that BCSs preferred exercises focusing on values and self-compassion, and recommended face-to-face intervention delivery by a clinical psychologist.
JOURNAL OF PSYCHOSOCIAL ONCOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Sandro T. Stoffel, Lesley McGregor, Yasemin Hirst, Sahida Hanif, Lorraine Morris, Christian von Wagner
Summary: This study evaluated the effectiveness of the 'Call for a Kit' health promotion intervention in improving bowel cancer screening uptake. The results showed that both in-person consultations and phone consultations were effective in encouraging individuals to return test kits. Sociodemographic characteristics such as gender and socioeconomic status were found to impact the test kit return rate.
JOURNAL OF MEDICAL SCREENING
(2022)
Article
Public, Environmental & Occupational Health
Robert Stephen Kerrison, Andrew Prentice, Sarah Marshall, Christian von Wagner
Summary: Despite efforts to increase participation in colorectal cancer screening in England, most cases are diagnosed outside of the screening program. This study found that the main reason for this is suboptimal uptake of screening, with nearly two-thirds of eligible patients never participating. It highlights the need to encourage greater participation in order to improve outcomes.
JOURNAL OF MEDICAL SCREENING
(2022)
Article
Health Care Sciences & Services
Aradhna Kaushal, Caroline Bravo, Stephen Duffy, Douglas Lewins, Ralph Moehler, Rosalind Raine, Ivo Vlaev, Jo Waller, Christian von Wagner
Summary: The aim of this project is to develop, publish, and promote a list of items for the Reporting Guidelines for Social Media Research (RESOME) checklist. RESOME will be developed using a modified Delphi approach, and experts and stakeholders will be invited to participate in two rounds of questionnaires to reach a consensus. The guidelines will be published in a paper, and before publication, they will be piloted and refined to ensure clarity and understanding.
JMIR RESEARCH PROTOCOLS
(2022)
Article
Medicine, General & Internal
Sandro T. Stoffel, Aradhna Kaushal, Aikaterini Grimani, Christian von Wagner, Falko F. Sniehotta, Ivo Vlaev
Summary: This study examined whether communicating the social benefit through community protection for friends and family members versus overall society affects vaccination intention and perception. The findings suggest that although highlighting the social benefits of COVID-19 vaccinations can increase intentions among vaccine non-intenders, they are unlikely to address barriers among ethnically diverse communities.
Article
Primary Health Care
Kelly E. Lloyd, Louise H. Hall, Lucy Ziegler, Robbie Foy, Gillian M. Borthwick, Mairead MacKenzie, David G. Taylor, Samuel G. Smith
Summary: The study investigated the optimal type and level of information to communicate with GPs in order to increase their willingness to prescribe aspirin for Lynch syndrome. The results showed that providing different combinations of information on clinical guidance, trial results, and benefits and harms did not increase GPs' willingness to prescribe aspirin.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Medicine, General & Internal
Samuel G. Smith, Sophie M. C. Green, Rachel Ellison, Robbie Foy, Christopher D. Graham, Ellen Mason, David P. French, Louise H. Hall, Hollie Wilkes, Emma McNaught, Erin Raine, Rebecca Walwyn, Daniel Howdon, Jane Clark, Nikki Rousseau, Jacqueline Buxton, Sally J. L. Moore, Catherine Parbutt, Galina Velikova, Amanda Farrin, Michelle Collinson
Summary: Women with breast cancer who do not adhere to adjuvant endocrine therapy (AET) have increased risks of mortality and recurrence. Multiple barriers to AET adherence include medication side-effects, beliefs about medication, memory, and psychological distress. This pilot trial aims to establish key trial parameters, intervention component adherence, availability and feasibility of outcome and process data, and cost estimation.
Article
Health Care Sciences & Services
Sophie M. C. Green, David P. French, Louise H. Hall, Yvonne Kiera Bartlett, Nikki Rousseau, Erin Raine, Catherine Parbutt, Benjamin Gardner, Samuel G. Smith
Summary: This study aimed to develop a pool of brief SMS text messages targeting habit formation to support adherence to adjuvant endocrine therapy (AET) in women with breast cancer. The messages were developed using a transparent approach based on behavior change techniques (BCTs) and user input. After expert and user evaluations, a pool of 66 messages with fidelity to the intended BCTs and acceptability to the target population was created.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Review
Medicine, General & Internal
Ghalia Kayal, Robert Kerrison, Yasemin Hirst, Christian von Wagner
Summary: Colonoscopy is a commonly used screening and diagnostic test for colorectal cancer (CRC). This review examined patient experiences with colonoscopy following a positive screening result, and identified areas for improvement in patient experience, including making bowel preparation more acceptable, reducing pain and discomfort during the test, and alleviating post-colonoscopy symptoms.
Article
Public, Environmental & Occupational Health
Sophie M. C. Green, Kelly E. Lloyd, Samuel G. Smith
Summary: Women with a family history of breast cancer have an increased lifetime risk of the disease. Delay in symptom presentation can lead to poorer outcomes. Low awareness and help-seeking barriers are observed among women at increased risk of breast cancer, with education and socioeconomic status playing a role.
PREVENTIVE MEDICINE REPORTS
(2023)
Article
Medicine, Research & Experimental
Samuel G. Smith, Rachel Ellison, Louise Hall, Jane Clark, Suzanne Hartley, Ellen Mason, Jamie Metherell, Catherine Olivier, Vicky Napp, Jay Naik, Sarah Buckley, Charlotte Hirst, Sue Hartup, Richard D. Neal, Galina Velikova, Amanda Farrin, Michelle Collinson, Christopher D. Graham
Summary: This study aims to evaluate the impact of Acceptance and Commitment Therapy (ACT) intervention on medication adherence and quality of life in early stage breast cancer patients receiving adjuvant endocrine therapy. The intervention includes individual and group sessions, as well as access to self-management methods. Key trial parameters will be established through an exploratory pilot trial.
PILOT AND FEASIBILITY STUDIES
(2022)
Article
Health Care Sciences & Services
Louise Annemoon Jonker, Madelon T. Heijltjes, Judith A. C. Rietjens, Agnes van der Heide, Geeske Hendriksen, Johannes J. M. van Delden, Ghislaine J. M. W. van Thiel
Summary: This study explores the perceptions and experiences of patients and relatives regarding Continuous Deep Sedation (CDS). The findings suggest that patients and relatives consider CDS as a regular palliative care option and prioritize avoiding suffering at the end of life. They also claim a substantial say in the decision-making process.
HEALTH EXPECTATIONS
(2024)