Article
Surgery
Worapat Attawettayanon, Teeranop Choorit, Virote Chalieopanyarwong, Choosak Pripatnanont
Summary: NLR and PLR are useful in assessing survival outcomes of nonmetastatic RCC patients, with high PLR being an independent prognostic factor; Elevated NLR and anemia were significantly associated with cancer-specific survival.
ASIAN JOURNAL OF SURGERY
(2021)
Article
Oncology
Hee Ho Chu, Jin Hyoung Kim, Ju Hyun Shim, Dong Il Gwon, Heung-Kyu Ko, Ji Hoon Shin, Gi-Young Ko, Hyun-Ki Yoon, Nayoung Kim
Summary: Baseline neutrophil-to-lymphocyte ratio (NLR) ≥ 3 is a strong independent predictor of overall survival in patients with intermediate-stage hepatocellular carcinoma (HCC) treated with chemoembolization. The study suggests that NLR and other factors can be used to predict overall survival and disease progression risk in these patients.
Article
Biochemistry & Molecular Biology
Maurizio A. Leone, Jessica Mandrioli, Sergio Russo, Aliona Cucovici, Giulia Gianferrari, Vitalie Lisnic, Dafin Fior Muresanu, Francesco Giuliani, Massimiliano Copetti, Andrea Fontana
Summary: This study suggests that the neutrophil-to-lymphocyte ratio (NLR) could be a potential marker for disease progression and survival in ALS, possibly associated with low-grade inflammation. Further prospective studies are needed to validate these findings.
Article
Oncology
Jiyun Park, Jun Park, Jung Hee Shin, Young-Lyun Oh, Hyun-Ae Jung, Man-Ki Chung, Jun-Ho Choe, Yong-Chan Ahn, Sun-Wook Kim, Jae-Hoon Chung, Tae-Hyuk Kim, Jae-Myoung Noh
Summary: The study found that high NLR before and after radiotherapy was associated with poor survival in patients with anaplastic thyroid cancer (ATC), indicating the importance of host immunity in ATC patients. This suggests that this finding may provide important information for designing future investigations on the impact of immune system modulating therapy in ATC.
Article
Oncology
Taizo Uchimoto, Kazumasa Komura, Wataru Fukuokaya, Takahiro Kimura, Kazuhiro Takahashi, Yusuke Yano, Kazuki Nishimura, Keita Nakamori, Yuya Fujiwara, Tomohisa Matsunaga, Takeshi Tsutsumi, Takuya Tsujino, Ryoichi Maenosono, Yuki Yoshikawa, Kohei Taniguchi, Tomohito Tanaka, Hirofumi Uehara, Hajime Hirano, Hayahito Nomi, Kiyoshi Takahara, Teruo Inamoto, Shin Egawa, Haruhito Azuma
Summary: Pembrolizumab has shown to improve overall survival in patients with platinum-refractory metastatic urothelial carcinoma, but the optimal risk stratification to predict survival outcomes remains controversial. A risk model was developed in this study using two clinical factors to predict overall survival at the initiation of pembrolizumab treatment, showing clear discrimination of survival outcomes among different risk groups and providing guidance for daily practice.
Article
Endocrinology & Metabolism
Xinran Li, Lin Zhou, Yuxin Chen, Na Li, Jian Meng
Summary: This study retrospectively analyzed 71 patients with ACC and found that preoperative neutrophil-to-lymphocyte ratio (NLR) is an effective biomarker for the prognosis of ACC patients. High NLR is associated with lymph node metastasis and tumor stage, and it is correlated with overall survival but not disease-free survival in ACC patients.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Multidisciplinary Sciences
Taek Yoon Cheong, Sang Duk Hong, Keun-Woo Jung, Yoon Kyoung So
Summary: The study aimed to evaluate the association between systemic inflammatory markers and clinicopathological factors in thyroid cancers. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were significantly higher in cases with lateral lymph node metastasis (LNM). NLR was found to be a significant predictor of thyroid cancers in cases with nodules greater than 2 cm.
Article
Medicine, General & Internal
Yerim Cho, Su Bee Park, Jin Young Yoon, Min Seob Kwak, Jae Myung Cha
Summary: This study aimed to investigate the prognostic role of the neutrophil-to-lymphocyte ratio (NLR) in stage II to III colorectal cancer (CRC) patients who underwent surgery. The results showed that NLR was significantly associated with overall survival (OS) and could be used as a simple and useful parameter for predicting OS in these patients.
Article
Oncology
Xin Wang, Ming Yang, Yizhong Ge, Meng Tang, Benqiang Rao, Yongbing Chen, Hongxia Xu, Minghua Cong, Zengqing Guo, Hanping Shi
Summary: Our study demonstrates that the nutritional status and inflammatory level of patients with nasopharyngeal carcinoma have a significant impact on their overall survival during chemoradiotherapy. High PG-SGA score and high NLR value adversely affect the survival time of patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Elena Daveri, Luca Sorrentino, Luca Lalli, Marcello Guaglio, Luigi Battaglia, Laura Cattaneo, Giovanna Sabella, Massimo Milione, Licia Rivoltini, Maurizio Cosimelli, Filiberto Belli
Summary: This study evaluated the prognostic role of peripheral immune estimators (NLR and PLR) in survival outcomes of locally recurrent rectal cancer patients. The study found that NLR and PLR were associated with worse 5-year overall survival rate and could serve as prognostic markers. However, NLR and PLR were irrelevant in cases of R0 surgery.
DIGESTIVE AND LIVER DISEASE
(2022)
Review
Nutrition & Dietetics
Lei Peng, Chunyang Meng, Jinze Li, Chengyu You, Yuelin Du, Wei Xiong, Zhongyou Xia, Dehong Cao, Yunxiang Li
Summary: This meta-analysis revealed that the preoperative CONUT score is a potential independent predictor of the postoperative prognosis of RCC/UTUC patients. A high CONUT predicts worse overall survival, cancer-specific survival, disease-free survival, and recurrence-free survival in patients.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Surgery
Francesca Savioli, Elizabeth S. Morrow, Ross D. Dolan, Laszlo Romics, Alison Lannigan, Joanne Edwards, Donald C. McMillan
Summary: Through a systematic review and meta-analysis, it was found that preoperative circulating markers of the systemic inflammatory response, such as NLR, dNLR, LMR, PLR, and CRP, may serve as prognostic markers in primary operable breast cancer.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Oncology
Qiang Hu, Weipu Mao, Tiange Wu, Zhipeng Xu, Junjie Yu, Can Wang, Saisai Chen, Shuqiu Chen, Bin Xu, Yueshuang Xu, Ming Chen
Summary: In RCC patients undergoing laparoscopic partial or radical nephrectomy, NLR and PLR were identified as biomarkers of systemic inflammation associated with increased risk of sarcopenia. The best cutoff points for predicting sarcopenia risk were NLR >2.88 and PLR >135.63, with higher levels indicating a greater risk. Adjusting for various variables, patients with NLR >2.88 and PLR >135.63 had significantly higher risks of developing sarcopenia compared to those with lower NLR or PLR levels.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Tetsuya Akaishi, Tatsuro Misu, Kazuo Fujihara, Naoki Nakaya, Tomohiro Nakamura, Mana Kogure, Rieko Hatanaka, Fumi Itabashi, Ikumi Kanno, Toshiyuki Takahashi, Hiroshi Kuroda, Juichi Fujimori, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Tadashi Ishii, Masashi Aoki, Ichiro Nakashima, Atsushi Hozawa
Summary: Patients with multiple sclerosis showed elevated counts of total white blood cells, monocytes, basophils, and neutrophils at the time of diagnosis. However, the clinical relevance of these biomarkers in the context of the development and progression of MS remains unclear.
SCIENTIFIC REPORTS
(2021)
Article
Otorhinolaryngology
Pei Gao, Wei Peng, Yuan Hu
Summary: This study found that a low LMR in patients with NPC is associated with poor overall survival and reduced disease-free/progression-free survival. It also showed correlations between low LMR and male gender, T3-T4 stage, and tumor stage III-IV.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
