Review
Cell & Tissue Engineering
Hoda Elkhenany, Azza El-Derby, Mohamed Abd Elkodous, Radwa A. Salah, Ahmed Lotfy, Nagwa El-Badri
Summary: The amniotic membrane (Amnio-M) has multiple applications in regenerative medicine, serving as a biocompatible scaffold, a source of stem cells and growth factors, and a nanoreservoir for drug delivery. Its use has evolved from simple sheet applications to more advanced forms, and nanotechnology is playing a role in expanding its applications in tissue engineering and clinical settings.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Damien Brezulier, Louis Chaigneau, Sylvie Jeanne, Ronan Lebullenger
Summary: Cleft lip and palate is a common congenital malformation, with surgical repair being crucial for functional and aesthetic outcomes. Research on substitute biomaterials, such as bioactive glasses, is gaining attention due to complications associated with traditional autogenous bone grafts. Advances in materials and technologies, like 3D printing of scaffolds combining bioglass with a biocompatible matrix, offer new possibilities for reconstructive surgery in cleft palates.
Review
Biochemistry & Molecular Biology
Agustin Aibar-Almazan, Ana Voltes-Martinez, Yolanda Castellote-Caballero, Diego Fernando Afanador-Restrepo, Maria del Carmen Carcelen-Fraile, Elena Lopez-Ruiz
Summary: Osteoporosis, a silent disease of the 21st century, poses a public health risk and mainly affects postmenopausal women and older adults. The disease is characterized by an imbalance between bone resorption and production. Treatments include pharmacological approaches using anti-resorptive drugs as well as non-pharmacological approaches focusing on lifestyle habits such as physical activity and diet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Hong Fan, Zhe Chen, Hai-Bin Tang, Le-Qun Shan, Zi-Yi Chen, Xiao-Hui Wang, Da-Geng Huang, Shi-Chang Liu, Xun Chen, Hao Yang, Dingjun Hao
Summary: Transplantation of olfactory ensheathing cells (OECs) and their exosomes have shown therapeutic effects for spinal cord injury (SCI) by modulating neuroinflammation, supporting neuronal survival, and promoting angiogenesis. OECs-derived exosomes (OECs-Exo) can be engulfed by microglia, inhibit pro-inflammatory polarization, and promote the numbers of anti-inflammatory cells after SCI. In vitro studies also demonstrate that OECs-Exo can alleviate neuronal death induced by pro-inflammatory microglia, promote neuronal survival and axon preservation, and facilitate functional recovery after SCI.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2022)
Article
Engineering, Biomedical
Talia Feijao, Mariana Neves, Aureliana Sousa, Ana L. Torres, Silvia J. Bidarra, Iasmim D. Orge, Daniel T. O. Carvalho, Cristina C. Barrias
Summary: Modular tissue engineering using spheroids as building blocks offers exciting possibilities for creating vascularized tissues from the bottom-up. A new injectable approach combining fibroblasts and endothelial progenitors has been developed to generate dense vascularized dermal tissue, showing promising results for clinical applications.
Review
Chemistry, Multidisciplinary
Yi Qin, Gaoran Ge, Peng Yang, Liangliang Wang, Yusen Qiao, Guoqing Pan, Huilin Yang, Jiaxiang Bai, Wenguo Cui, Dechun Geng
Summary: In the past decade, adipose-derived stem cells (ADSCs) have gained increasing attention in the field of regenerative medicine due to their accessibility, multipotency, and active paracrine activity. This review discusses the challenges in translating ADSC-based therapies to clinical settings and proposes novel strategies to overcome the limitations. It also provides an update on the advancements in ADSC-based therapies in various fields of regenerative medicine.
Review
Biochemistry & Molecular Biology
Yu Seon Kim, Farshid Guilak
Summary: Osteoarthritis is a degenerative joint disease with limited treatment options. Tissue engineering has focused on developing strategies using hyaluronic acid-based hydrogels to alleviate symptoms and regenerate damaged tissue in osteoarthritis patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Soudeh Ghafouri-Fard, Vahid Niazi, Bashdar Mahmud Hussen, Mir Davood Omrani, Mohammad Taheri, Abbas Basiri
Summary: Extracellular vesicles play important roles in cell-cell communication, inflammation modulation, cell proliferation, and tissue regeneration, with advantages such as lower risk and easier production and storage compared to cell therapy. Particularly, exosomes derived from mesenchymal stem cells are introduced as a therapeutic option for various human diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Saeed Abbasalizadeh, Sahab Babaee, Reza Kowsari-Esfahan, Zahra Mazidi, Yichao Shi, Jake Wainer, Joaquim M. S. Cabral, Robert Langer, Giovanni Traverso, Hossein Baharvand
Summary: Organoid medicine has made significant progress in the past decade as a novel therapeutic approach for addressing unmet medical needs, such as chronic liver disease. Through the use of scalable and xeno-free differentiation platforms, hepatic progenitors, mesenchymal stromal cells, and endothelial cells are generated from human pluripotent stem cell lines to produce vascularized liver organoids. A scalable microfluidic system is developed to generate cells-loaded microcapsules, which support cell proliferation and the self-organization of liver organoids using a self-biodegradable peptide hydrogel. These vascularized hepatobiliary organoids exhibit key functional features similar to fetal and adult liver tissue, making them promising for liver organoid medicine and drug development.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Cell Biology
Elahe Tahmasebi, Mehdi Mohammadi, Mostafa Alam, Kamyar Abbasi, Saeed Gharibian Bajestani, Rojin Khanmohammad, Mohsen Haseli, Mohsen Yazdanian, Peyman Esmaeili Fard Barzegar, Hamid Tebyaniyan
Summary: Craniofacial deformities (CFDs) can occur as a result of oncological resection, trauma, or congenital disorders. Trauma, which varies in rates across countries, is a leading cause of death globally. CFDs lead to non-healing composite tissue wounds as they deteriorate in soft or hard tissues. Gum disease is responsible for approximately one-third of oral diseases. The complex anatomical structures and tissue-specific requirements in the craniofacial region pose numerous challenges for CFD treatments. Various treatment methods, including drugs, regenerative medicine, surgery, and tissue engineering, are available for CFDs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Editorial Material
Cell & Tissue Engineering
G-I. Im
Summary: Currently, there is little evidence to prove the efficacy of regenerative medicine for OA treatment. Clinical applications of regenerative medicine need to ensure both symptomatic relief and structural improvement to delay or avoid the need for joint arthroplasty.
BONE & JOINT RESEARCH
(2021)
Article
Engineering, Biomedical
Zhi Wu, Dan He, Haiyan Li
Summary: The study demonstrates that BG ion products can significantly enhance the production of exosomes from MSCs and modulate their biological function by influencing relevant pathways, thereby providing a feasible approach to improve the practical application of exosomes in regenerative medicine.
BIOACTIVE MATERIALS
(2021)
Article
Cardiac & Cardiovascular Systems
Eva Querdel, Marina Reinsch, Liesa Castro, Deniz Kose, Andrea Bahr, Svenja Reich, Birgit Geertz, Barbel Ulmer, Mirja Schulze, Marc D. Lemoine, Tobias Krause, Marta Lemme, Jascha Sani, Aya Shibamiya, Tim Stuedemann, Maria Koehne, Constantin von Bibra, Nadja Hornaschewitz, Simon Pecha, Yusuf Nejahsie, Ingra Mannhardt, Torsten Christ, Hermann Reichenspurner, Arne Hansen, Nikolai Klymiuk, M. Krane, C. Kupatt, Thomas Eschenhagen, Florian Weinberger
Summary: The transplantation of engineered heart tissue (EHT) patches resulted in partial remuscularization of the injured heart and improved left ventricular function in a dose-dependent manner in guinea pig and pig models. Human-scale patches were successfully transplanted onto pigs in a proof-of-principle study.
Review
Cell Biology
Thamil Selvee Ramasamy, Yong Mei Yee, Ilyas M. Khan
Summary: Osteoarthritis is a common degenerative joint disease associated with aging, where damage to articular chondrocytes plays a key role. Understanding the complexity of cellular aging is crucial for developing new therapies targeting the specific causes of age-related functional decline in OA.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Physical
Ramon Rial, Natalia Hassan, Zhen Liu, Juan M. Ruso
Summary: The study successfully produced hydrogel microparticles with different morphologies and compositions by combining experimental and computational methods, incorporating drug-doped Hydroxyapatite in their inner matrix. The use of a microfluidic system to obtain crosslinked HMPs with homogeneous sizes and morphologies, as well as the adsorption kinetics and desorption profiles of the chosen drug models, were key aspects of the research. The development of these hydrogel microparticles with improved functionalities is crucial for innovative and sustainable solutions in regenerative medicine.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
