Review
Pharmacology & Pharmacy
Marta Bryk, Elzbieta Karnas, Jakub Mlost, Ewa Zuba-Surma, Katarzyna Starowicz
Summary: MSCs, as multipotent progenitor cells derived from mesoderm, have been extensively studied for their regenerative properties, including the release of EVs which play a role in their functions. They regulate various processes in target cells and show potential applications in pain treatment and other diseases.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Rui Alvites, Mariana Branquinho, Ana C. Sousa, Bruna Lopes, Patricia Sousa, Ana Colette Mauricio
Summary: Mesenchymal Stem/Stromal Cells (MSCs) have high clinical value and have been extensively studied. Their immunomodulatory influence occurs through both direct and paracrine routes, but the mechanisms are not fully understood. This review summarizes the immunoregulatory capacity of MSCs and their secretion products, with a focus on migration, homing, direct cell action, and paracrine activity, and explores related techniques.
Review
Biochemistry & Molecular Biology
Giuliana Minani Bertolino, Marie Maumus, Christian Jorgensen, Daniele Noel
Summary: Extracellular vesicles (EVs) isolated from induced pluripotent stem cells (iMSCs) show promise in regenerative medicine for the treatment of various diseases. However, the heterogeneity between MSC donors may lead to batch-to-batch variability in the use of EVs as cell-free therapeutic agents.
Article
Agriculture, Dairy & Animal Science
Michal Domaniza, Marian Hluchy, Dasa Cizkova, Filip Humenik, Lucia Slovinska, Nikola Hudakova, Lubica Hornakova, Juraj Vozar, Alexandra Trbolova
Summary: This study aimed to investigate the potential of cell-based regenerative therapy for elbow joints affected by osteoarthritis. The results showed that two injections of amnion-derived mesenchymal stem cells improved joint range of motion and had an impact on synovial fluid biomarkers. Concentrations of IFN-γ, IL-6, and TNF-α decreased while IL-10 increased between day 0 and day 28 after treatment.
Article
Cell Biology
Hugo Abreu, Elena Canciani, Davide Raineri, Giuseppe Cappellano, Lia Rimondini, Annalisa Chiocchetti
Summary: Tissue regeneration is a hot topic in health sciences. Studying the relationship between mesenchymal stem/stromal cells (MSCs), extracellular vesicles (EVs), and biomaterials is important for the treatment of musculoskeletal diseases.
Article
Biochemistry & Molecular Biology
Ruei-Hong Lin, Hsu-Tung Lee, Chun-An Yeh, Yi-Chin Yang, Chiung-Chyi Shen, Kai-Bo Chang, Bai-Shuan Liu, Hsien-Hsu Hsieh, Hui-Min David Wang, Huey-Shan Hung
Summary: The research shows that using AuNPs at concentrations of 1.25 and 2.5 ppm can enhance cell proliferation, reduce reactive oxygen species generation, and attenuate platelet/monocyte activation. AuNPs can also promote cell adhesion, increase the expression of matrix metalloproteinase (MMP-2/9), decrease cell apoptosis and the release of inflammatory cytokines. Animal model experiments demonstrate that treating with 1.25 and 2.5 ppm AuNPs exhibits better biocompatibility and endothelialization. This suggests that AuNPs can be used as a biocompatible nanomedicine for regeneration research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Riccardo Giorgino, Domenico Albano, Stefano Fusco, Giuseppe M. Peretti, Laura Mangiavini, Carmelo Messina
Summary: Osteoarthritis (OA) is a common chronic orthopedic disorder that primarily affects hips and knees. The variability in the prevalence of knee OA across studies highlights the heterogeneity of reported data worldwide. The pathogenetic mechanism of knee OA involves an inflammatory process in the synovial membrane, mediated by immune system activation and damage-associated molecular patterns (DAMPs). Mesenchymal stem cells (MSCs) offer promising therapeutic options, but unresolved issues remain regarding the optimal cell source and quantity. Further research is necessary to address these uncertainties. This review provides a comprehensive overview of the molecular mechanisms of cartilage damage in knee OA and discusses current regenerative medicine approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
P. Vatsa, R. Negi, U. A. Ansari, V. K. Khanna, A. B. Pant
Summary: Mesenchymal stem cells (MSCs) are multipotent adult stem cells found in various tissues, showing promise in treating neurodegenerative diseases. Extracellular vesicles (EVs) derived from MSCs carry biologically active molecules for intercellular communication, serving as potential cell-free therapies with therapeutic cargo and ethical advantages.
MOLECULAR NEUROBIOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Qian Wei, Xi Liu, Jian-Long Su, Ya-Xi Wang, Zi-Qiang Chu, Kui Ma, Qi-Lin Huang, Hai-Hong Li, Xiao-Bing Fu, Cui-Ping Zhang
Summary: Chronic non-healing wounds pose a significant threat to both the physical and mental health of patients, with abnormal behavior of remaining cells identified as the main obstacle to healing. Mesenchymal stem cells (MSCs) therapy has emerged as a promising option for chronic wound healing, primarily due to their exocrine functions. Small extracellular vesicles derived from MSCs (MSC-sEVs) have been reported to regulate cellular behavior and have a positive impact on various stages of wound healing. This review discusses the characteristics and therapeutic potential of MSC-sEVs in chronic wound treatment, as well as their application avenues and strategies for large-scale production and engineering.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Cell Biology
Yuxuan Zhong, Xiang Li, Fanglin Wang, Shoushuai Wang, Xiaohong Wang, Xiaohong Tian, Shuling Bai, Di Miao, Jun Fan
Summary: Recent studies have shown that various exosomes can influence the adipogenic differentiation of stem cells. Exosomes play an important role in promoting tissue regeneration and provide new ideas for adipose tissue engineering research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jeremy Boulestreau, Marie Maumus, Christian Jorgensen, Daniele Noel
Summary: Osteoarthritis is associated with a high number of senescent cells in joint tissues, which release senescence-associated secretory phenotype (SASP) factors contributing to the disease progression. Targeting senescent cells has shown improvement in OA features in mouse models. MSCs and MSC-EVs are promising treatments for OA, but their functions are affected by aging.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Veterinary Sciences
Hussein M. M. El-Husseiny, Eman A. A. Mady, Mahmoud A. Y. Helal, Ryou Tanaka
Summary: The use of stem cells in veterinary practice is rapidly evolving, with significant research efforts focused on both experimental animals and clinical cases. Stem cells, particularly mesenchymal stem cells (MSCs), are promising for therapeutic applications due to their immunomodulatory capabilities and ease of isolation. However, challenges remain in their clinical implementation for treating various animal diseases, driving further advancements in stem cell therapies.
VETERINARY SCIENCES
(2022)
Review
Neurosciences
Milena B. P. Soares, Renata G. J. Goncalves, Juliana F. Vasques, Almir J. Da Silva-Junior, Fernanda Gubert, Girlaine Cafe Santos, Thais Alves de Santana, Gabriela Louise Almeida Sampaio, Daniela Nascimento Silva, Massimo Dominici, Rosalia Mendez-Otero
Summary: Neurological disorders have limited treatment options, and there is a need for cell-based therapies. Mesenchymal stem/stromal cells (MSCs) have been widely studied but no cell-based treatment for neurological diseases currently exists. This review explores the therapeutic potential of MSC-based therapies for neurological disorders and discusses challenges in culture conditions, quality control, and the development of potency tests to improve cell therapy products for these conditions.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Biotechnology & Applied Microbiology
Forough Mahdavi-Jouibari, Benyamin Parseh, Ezatolah Kazeminejad, Ayyoob Khosravi
Summary: Cartilage lesions are common and challenging to regenerate. Stem cell-based therapies, especially using Mesenchymal stem cells (MSCs) and Stem cells from human exfoliated deciduous teeth (SHED), offer promising solutions for cartilage regeneration. MSCs can differentiate into mature chondrocytes and engraft into the host, while SHED-derived secretome contains biomolecules that promote tissue regeneration, including cartilage.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kotaro Tanaka, Ryohei Ogino, Sho Yamakawa, Shota Suda, Kenji Hayashida
Summary: Skin wounds usually heal on their own, but this is only true for healthy individuals. Mesenchymal stem cells (MSCs) have been found to play a significant role in wound healing and regeneration, with their ability to self-renew and differentiate, as well as their anti-inflammatory and immunomodulatory properties. This review aims to explain the functions and effects of MSCs in wound healing.
Article
Otorhinolaryngology
Yalda Jabbari Moghadam, Mohammad Reza Asadi, Vahdat Abbaszadeh, Jalal Gharesouran, Hossein Dehghani, Hani Sabaie, Bashdar Mahmud Hussen, Mohammad Taheri, Nader Akbari Dilmaghnai, Maryam Rezazadeh
Summary: Sudden Sensorineural Hearing Loss (SSNHL) is a common health problem with significant impact on quality of life. This study examined the expression levels of NFKB1 and NFKB2 in SSNHL patients and healthy individuals, and found that NFKB2 expression levels were higher in patients, while NFKB1 expression levels did not differ significantly. The study also revealed a strong positive correlation between the expression levels of NFKB1 and NFKB2, indicating an interconnected network. These findings suggest that NFKB2 is a significant inflammatory factor in the pathophysiology of SSNHL.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2023)
Article
Pathology
Lina Moallemi-Rad, Amin Ghorbani, Maryam Dadyar, Bashdar Mahmud Hussen, Mohammed Fatih Rasul, Solat Eslami, Mohammad Taheri, Elena Jamali, Soudeh Ghafouri-Fard
Summary: This study evaluated the expression of five Treg-related long non-coding RNAs in breast cancer tissues. The results showed significantly higher expression levels of RMRP, TH2-LCR, MAFTRR, and GATA3-AS1 in breast cancer samples compared to non-tumoral tissues. Positive associations were found between the expression levels of RMRP and MAFTRR genes in tumor tissues and certain tumor characteristics. Additionally, differences in FLICR expression were observed among tumors with different levels of the HER2/neu receptor. These findings suggest that Treg-associated lncRNAs may contribute to the pathogenesis of breast cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Mohammad Taheri, Bashdar Mahmud Hussen, Snur Rasool Abdullah, Soudeh Ghafouri-Fard, Elena Jamali, Seyedpouzhia Shojaei
Summary: Wilms tumor, the most common pediatric kidney tumor, is associated with dysregulation of non-coding RNAs. Dysregulated miRNAs such as miR-200c, miR-155-5p, miR-1180, miR-22-3p, miR-483-5p, miR-140-5p, miR-92a-3p, miR-483-3p, miR-572, miR-539, and miR-613, as well as dysregulated long non-coding RNAs including CRNDE, XIST, SNHG6, MEG3, LINC00667, MEG8, DLGAP1-AS2, and SOX21-AS1, have been identified in this tumor. Additionally, circCDYL is down-regulated, while circ0093740 and circSLC7A6 are up-regulated in Wilms tumor. These dysregulated transcripts offer new insights into understanding the pathogenesis and developing targeted therapies for this pediatric tumor.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Pathology
Soudeh Ghafouri-Fard, Yadollah Poornajaf, Bashdar Mahmud Hussen, Shiva Tavakkoli Avval, Mohammad Taheri, Majid Mokhtari
Summary: The Hippo pathway plays a crucial role in regulating organ size, homeostasis, and tumorigenesis. It is involved in lung carcinogenesis through various mechanisms, including the interaction between miRNAs and the Hippo pathway. Non-coding RNAs such as PVT1, SFTA1P, NSCLCAT1, and circ_0067741 are also implicated in this process. Furthermore, several anti-cancer agents can modulate the Hippo pathway to exert their anti-cancer effects in lung cancer. This article summarizes recent studies on the role of Hippo signaling in lung cancer progression, the impact of non-coding RNAs on this pathway, and the effects of anti-cancer agents.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Arian Askari, Kimia Behzad Moghadam, Bashdar Mahmud Hussen, Mohammad Taheri, Mohammad Samadian
Summary: ZEB1-AS1 is a long non-coding RNA that plays important regulatory roles on its related gene, ZEB1. It has been implicated in various malignancies and non-malignant conditions. This review highlights the diverse molecular mechanisms of ZEB1-AS1 in different disorders and emphasizes its significance in their pathogenesis.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Mohammad Taheri, Arian Askari, Bashdar Mahmud Hussen, Soudeh Ghafouri-Fard, Fariborz Rashnoo
Summary: MAGI2-AS3 is a long non-coding RNA that is abnormally expressed in various malignancies and is associated with multiple clinical characteristics. It may play a role in the pathogenesis of congenital diaphragmatic hernia, Alzheimer's disease, and intervertebral disc degeneration. Mechanistically, MAGI2-AS3 acts as a molecular sponge for multiple miRNAs to regulate the expression of their mRNA targets. This review highlights the importance of MAGI2-AS3 in different disorders.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Soudeh Ghafouri-Fard, Ashkan Pourtavakoli, Bashdar Mahmud Hussen, Mohammad Taheri, Arda Kiani
Summary: LINC-ROR is a long non-coding RNA that plays diverse roles in human disorders, including cancer and autoimmune and neurodegenerative disorders. It contributes to disease development by altering gene expression, affecting cancer-related signaling pathways, and sequestering tumor suppressor miRNAs. Understanding the functions of LINC-ROR holds potential for developing therapeutic strategies against cancer and related diseases.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Pathology
Soudeh Ghafouri-Fard, Hamed Shoorei, Leili Noferesti, Bashdar Mahmud Hussen, Mohammad Hossein Behzad Moghadam, Mohammad Taheri, Fariborz Rashnoo
Summary: miRNA-loaded nanoparticles have been used for the treatment of various disorders, particularly cancers, ischemic stroke, and pulmonary fibrosis. The wide range application of this type of therapy is based on the important roles of miRNAs in regulating cell behavior. The ability of miRNAs to inhibit or increase gene expression gives them an advantage over other therapies.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Pathology
Lina Moallemi Rad, Arash Safarzadeh, Mohammad Taheri, Soudeh Ghafouri-Fard, Ahmad Eghbali
Summary: In this study, an in-silico approach was developed to identify the RNA network in breast cancer, which revealed differentially expressed mRNAs, lncRNAs, and miRNAs. Pathway analysis indicated the involvement of various pathways in breast cancer. Furthermore, a ceRNA network consisting of lncRNAs, mRNAs, and miRNAs was constructed, suggesting its potential as a target for anti-cancer therapy and identification of novel markers for breast cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Multidisciplinary Sciences
Mohammad Taheri, Ashkan Pourtavakoli, Solat Eslami, Soudeh Ghafouri-Fard, Arezou Sayad
Summary: This study assessed the expression of calcium signaling-related genes and non-coding RNAs in patients with epilepsy. The results showed dysregulation of these genes in epileptic patients, suggesting their potential as biomarkers for epilepsy.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Soudeh Ghafouri-Fard, Hamed Shoorei, Shahram Dabiri Oskuei, Bashdar Mahmud Hussen, Snur Rasool Abdullah, Mohammad Taheri, Elena Jamali
Summary: Toxic agents exist widely in the environment, households, and workplaces. Their contamination in food and drinking water leads to their entry into the body, where they interact with microRNAs (miRNAs), influencing the etiology of various disorders. These agents can alter redox status, release inflammatory cytokines, and affect mitochondrial function. Dysregulation of miRNA expression is implicated in the development of pathological conditions and signaling pathways, while also playing a role in environmental adaptation. Therefore, the interactions between miRNAs and toxic materials contribute to the detrimental effects on human health.
NON-CODING RNA RESEARCH
(2023)
Review
Oncology
Soudeh Ghafouri-Fard, Arian Askari, Bashdar Mahmud Hussen, Mohammad Taheri, Nader Akbari Dilmaghani
Summary: miR-424 is a miRNA involved in the carcinogenic process, with its expression being found to be up-regulated or down-regulated in various cancers. Its expression is regulated by the methylation status of its promoter, and it is also regulated by several long non-coding RNAs. Additionally, miR-424 is involved in the regulation of E2F transcription factors. This review aims to summarize the role of miR-424 in cancer evolution and its impact on clinical outcomes, in order to identify potential markers for malignancies.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Endocrinology & Metabolism
Melina Ghamari, Mahdieh Mehrab Mohseni, Mohammad Taheri, Seyedeh Morvarid Neishabouri, Zeinab Shirvani-Farsani
Summary: This study investigated the expression of three lncRNAs in bipolar disorder patients and found significant upregulation of RMRP and CTC-487M23.5 in BD individuals, with upregulation of RMRP in females with BD. The study suggests a potential role for RMRP and CTC-487M23.5 as biomarkers for BD.
METABOLIC BRAIN DISEASE
(2023)
Article
Cell Biology
Mohammad Taheri, Amir Nicknam, Atena Bagan, Solat Eslami, Azadeh Rakhshan, Soudeh Ghafouri-Fard
Summary: In this study, a bioinformatics analysis was used to identify significant differences in genes and pathways between tumor tissues of NFPA patients and normal pituitary tissues. The study focused on investigating the expression of specific lncRNAs in NFPA samples compared to healthy tissues adjacent to the tumors. Results showed dysregulation of three lncRNAs in NFPA tissues, suggesting their potential role as important regulators of pathogenic events in these tumors.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Bashdar Mahmud Hussen, Khozga Hazhar Abdullah, Snur Rasool Abdullah, Nasik Mahmood Majeed, Sayran Mohamadtahr, Mohammed Fatih Rasul, Peixin Dong, Mohammad Taheri, Majid Samsami
Summary: miRNAs play critical roles in the development and metastasis of breast cancer brain metastases. Certain miRNAs are overexpressed and promote tumor growth and metastasis, while others are downregulated and act as tumor suppressors. Strategies to modulate miRNA expression hold promise for treating breast cancer brain metastases.
NON-CODING RNA RESEARCH
(2023)
