Immune responses to human factor IX in haemophilia B mice of different genetic backgrounds are distinct and modified by TLR4

Immune Tolerance Induction to Factor IX through B Cell Gene Transfer: TLR9 Signaling Delineates between Tolerogenic and Immunogenic B Cells

(2014) Xiaomei Wang et al.   MOLECULAR THERAPY

Effective gene therapy for haemophilic mice with pathogenic factor IX antibodies

(2013) David M. Markusic et al.   EMBO Molecular Medicine

Toll-Like Receptor 4 Deficiency Accelerates the Development of Insulin-Deficient Diabetes in Non-Obese Diabetic Mice

(2013) Elke Gülden et al.   PLoS One

Cleavage of Fibrinogen by Proteinases Elicits Allergic Responses Through Toll-Like Receptor 4

(2013) V. O. Millien et al.   SCIENCE

Immune tolerance in haemophilia: the long journey to the fork in the road

(2012) Donna M. DiMichele   BRITISH JOURNAL OF HAEMATOLOGY

Pathogenic Long-Lived Plasma Cells and Their Survival Niches in Autoimmunity, Malignancy, and Allergy

(2012) O. Winter et al.   JOURNAL OF IMMUNOLOGY

Transient B Cell Depletion or Improved Transgene Expression by Codon Optimization Promote Tolerance to Factor VIII in Gene Therapy

(2012) Brandon K. Sack et al.   PLoS One

Coagulation Factor X Activates Innate Immunity to Human Species C Adenovirus

(2012) K. Doronin et al.   SCIENCE

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Induction of tolerance to factor VIII by transient co-administration with rapamycin

(2011) B. MOGHIMI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Prevention and Reversal of Antibody Responses Against Factor IX in Gene Therapy for Hemophilia B

(2011) Sushrusha Nayak et al.   Frontiers in Microbiology

Immunoglobulin isotypes and functional anti-FVIII antibodies in response to FVIII treatment in Balb/c and C57BL/6 haemophilia A mice

(2010) M. QADURA et al.   HAEMOPHILIA

TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice

(2010) José M. González-Navajas et al.   JOURNAL OF CLINICAL INVESTIGATION

High-efficiency Transduction and Correction of Murine Hemophilia B Using AAV2 Vectors Devoid of Multiple Surface-exposed Tyrosines

(2010) David M Markusic et al.   MOLECULAR THERAPY

Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice

(2010) D. Verma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prophylactic immune tolerance induced by changing the ratio of antigen-specific effector to regulatory T cells

(2009) S. NAYAK et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Impact of the Underlying Mutation and the Route of Vector Administration on Immune Responses to Factor IX in Gene Therapy for Hemophilia B

(2009) Ou Cao et al.   MOLECULAR THERAPY

Gram-negative pathogen Klebsiella oxytoca is associated with spontaneous chronic otitis media in Toll-like receptor 4-deficient C3H/HeJ mice

(2008) Carol J. Macarthur et al.   ACTA OTO-LARYNGOLOGICA

Klebsiella oxytoca: opportunistic infections in laboratory rodents

(2008) Andre Bleich et al.   LABORATORY ANIMALS