Differential expression of interferon inducible protein: guanylate binding protein (GBP1 & GBP2) in severe dengue

Authors

Sanchita Chakraborty¹ , Vignesh Mariappan¹ , Shalinda Adikari² , Lokesh Shanmugam³ , Joshy M Easow⁴ , Agieshkumar Balakrishna Pillai¹

1. Mahatma Gandhi Medical Advanced Research Institute
2. National University of Singapore
3. ICMR-Natinal Institute of Epidemiology
4. Mahatma Gandhi Medical College and Research Institute

Conference / event

Sri Balaji Vidyapeeth Research Week 2020, December 2020 (Puducherry, India)

Poster summary

Severe dengue infection is characterized with plasma leakage. Currently there are no means to monitor the disease manifestation. Present study discusses the expression dynamics of two interferon-inducible antiviral molecules called Guanylate Binding Proteins (GBP1 &2) and their efficacy in predicting disease severity. A decreased expression of GBP-1 and 2 accompanied with elevated levels of plasma leakage in severe dengue cases during the critical phase was recorded. Machine models found that GBP1 and 2 levels along with routine clinical symptoms could predict the dengue disease severity with higher accuracy. Thus, GBP1 and GBP2 are potential candidates as the prognostic markers for the early prediction of dengue severity.

Keywords

Guanylate binding proteins, Oxidative stress, Dengue, Biomarker, Plasma leakage, Machine learning model

Research areas

Microbiology, Medicine, Molecular and Cellular Biosciences

References

1. Mariappan V, Adikari S, Shanmugam L, Easow JM, Pillai AB. Differential expression of interferon inducible protein: Guanylate binding protein (GBP1 & GBP2) in severe dengue. Free Radical Biology and Medicine. 2023 Jan 1;194:131-46.
2. Kutsch M, Coers J. Human guanylate binding proteins: nanomachines orchestrating host defense. The FEBS Journal. 2021 Oct;288(20):5826-49.
3. Merabet O, Pietrosemoli N, Perthame E, Armengaud J, Gaillard JC, Borges-Cardoso V, Daniau M, Legras-Lachuer C, Carnec X, Baize S. Infection of Human Endothelial Cells with Lassa Virus Induces Early but Transient Activation and Low Type I IFN Response Compared to the Closely-Related Nonpathogenic Mopeia Virus. Viruses. 2022 Mar 21;14(3):652.

Funding

1. Nil

Supplemental files

No data provided

Additional information

Competing interests

No competing interests were disclosed.

Data availability statement

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

Creative Commons license

Copyright © 2023 Chakraborty et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.