Synthesis of antimicrobial polymers with mannose residues as binders for the FimH adhesin of Escherichia coli

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Authors

Atsushi Miyagawa¹

1. Nagoya Institute of Technology

Conference / event

The 37th annual meeting of the Japanese Society of Carbohydrate Research, August 2018 (Sendai, Japan)

Poster summary

Recently, antimicrobial polymers have been developed as new antibiotics, and they are beneficial for human health. An advantage of the polymers is that they can be easily functionalized by the addition of monomers. In this study, to enhance the bacterial selectivity and antimicrobial activity of polymers, hexyl mannose monomer was co-polymerized with aminopropyl monomer and isoalkyl monomer. The assembly of mannose residues was found to mimic the mannan and N-glycan moieties on mammalian cells interacting with the FimH adhesin of Escherichia coli. The mannose unit with hexyl linker enhanced the antimicrobial activity against E. coli selectivity (not observed against Staphylococcus aureus). Consequently, polymers with mannose units, which have a high affinity for the FimH adhesin, can serve as effective and selective antimicrobial agents against E. coli.

Keywords

Antimicrobial polymer, FimH adhesin, E. coli, Mannose

Research areas

Chemistry, Material Sciences

References

1. Journal of Biomaterials Science, Polymer Edition, 33(3) (2022) 299-312
2. Journal of Polymer Science, 61(4) (2023) 277-288

Funding

No data provided

Supplemental files

No data provided

Additional information

Competing interests

No competing interests were disclosed.

Data availability statement

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

Creative Commons license

Copyright © 2023 Miyagawa. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.