Synthesis of antimicrobial polymers with mannose residues as binders for the FimH adhesin of Escherichia coli

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作者

Atsushi Miyagawa¹

1. Nagoya Institute of Technology

会议/活动

The 37th annual meeting of the Japanese Society of Carbohydrate Research, August 2018 (Sendai, Japan)

海报摘要

Recently, antimicrobial polymers have been developed as new antibiotics, and they are beneficial for human health. An advantage of the polymers is that they can be easily functionalized by the addition of monomers. In this study, to enhance the bacterial selectivity and antimicrobial activity of polymers, hexyl mannose monomer was co-polymerized with aminopropyl monomer and isoalkyl monomer. The assembly of mannose residues was found to mimic the mannan and N-glycan moieties on mammalian cells interacting with the FimH adhesin of Escherichia coli. The mannose unit with hexyl linker enhanced the antimicrobial activity against E. coli selectivity (not observed against Staphylococcus aureus). Consequently, polymers with mannose units, which have a high affinity for the FimH adhesin, can serve as effective and selective antimicrobial agents against E. coli.

关键词

Antimicrobial polymer, FimH adhesin, E. coli, Mannose

研究领域

Chemistry, Material Sciences

参考文献

1. Journal of Biomaterials Science, Polymer Edition, 33(3) (2022) 299-312
2. Journal of Polymer Science, 61(4) (2023) 277-288

基金

暂无数据

补充材料

暂无数据

附加信息

利益冲突

No competing interests were disclosed.

数据可用性声明

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

知识共享许可协议

Copyright © 2023 Miyagawa. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.