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Synthesis of antimicrobial polymers with mannose residues as binders for the FimH adhesin of Escherichia coli
PUBLISHED June 22, 2023 (DOI: https://doi.org/10.54985/peeref.2306p3746137)
NOT PEER REVIEWED
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Authors
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Atsushi Miyagawa1
- Nagoya Institute of Technology
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Conference / event
- The 37th annual meeting of the Japanese Society of Carbohydrate Research, August 2018 (Sendai, Japan)
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Poster summary
- Recently, antimicrobial polymers have been developed as new antibiotics, and they are beneficial for human health. An advantage of the polymers is that they can be easily functionalized by the addition of monomers. In this study, to enhance the bacterial selectivity and antimicrobial activity of polymers, hexyl mannose monomer was co-polymerized with aminopropyl monomer and isoalkyl monomer. The assembly of mannose residues was found to mimic the mannan and N-glycan moieties on mammalian cells interacting with the FimH adhesin of Escherichia coli. The mannose unit with hexyl linker enhanced the antimicrobial activity against E. coli selectivity (not observed against Staphylococcus aureus). Consequently, polymers with mannose units, which have a high affinity for the FimH adhesin, can serve as effective and selective antimicrobial agents against E. coli.
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Keywords
- Antimicrobial polymer, FimH adhesin, E. coli, Mannose
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Research areas
- Chemistry, Material Sciences
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References
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- Journal of Biomaterials Science, Polymer Edition, 33(3) (2022) 299-312
- Journal of Polymer Science, 61(4) (2023) 277-288
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Funding
- No data provided
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Supplemental files
- No data provided
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Additional information
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- Competing interests
- No competing interests were disclosed.
- Data availability statement
- The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.
- Creative Commons license
- Copyright © 2023 Miyagawa. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Miyagawa, A. Synthesis of antimicrobial polymers with mannose residues as binders for the FimH adhesin of Escherichia coli [not peer reviewed]. Peeref 2023 (poster).
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