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Multi-regulator of EZH2-PPARs therapeutic targets: A hallmark for prospective restoration of pancreatic insulin production and cancer dysregulation

PUBLISHED June 21, 2023 (DOI: https://doi.org/10.54985/peeref.2306p3331152)

2nd Place Peeref Competition


Christopher Olowosoke1 , Otitoola Gbemisola2 , Adebola Alaba1 , Oluwadamilola Adepoju3 , Benson Okorie1 , Peace Odjegba1 , Ayomide Ogunsanmi4 , Grace Oke1 , Oluwatoyin Akinlolu1 , Tomiwa Olubena1 , Ridwan Bello1 , Benjamin Adegboyega1
  1. Federal University of Technology, Akure
  2. University of Ibadan
  3. Federal University of Agriculture, Abeokuta
  4. Kwara State University

Conference / event

Institute of Bioinformatics and Molecular Therapeutics (IBMT) Workshop Training (Virtual), April 2023 (Virtual)

Poster summary

Cancer and diabetes pose significant global challenges, and research is focused on identifying biomarkers for innovative therapeutic targets. The regulatory role of EZH2-PPARs in these diseases has been discovered, with GSK-126 and bezafibrate as effective inhibitors. This study identified gene-disease associations, protein interactions, and potential natural products for drug development. Obesity and hypertension were linked to the investigated biomarkers, validating their connection to cancer and diabetes. Nine natural products showed strong binding capacity, particularly phytocassane A, surpassing standard drugs. Experimental screening is recommended to further explore their potential in diabetes and cancer therapy targeting EZH2-PPARs.


EZH2-PPARs, Diabetes mellitus, Natural products, Pancreatic cancer, Protein-protein network, In silico profiling

Research areas

Biological Sciences, Bioinformatics and Genomics, Molecular and Cellular Biosciences, Pharmacy and Pharmacology


  1. Olowosoke CB, Gbemisola O, Alaba AA, Adepoju OH, Okorie B, Odjegba PI, Ogunsanmi AO, Oke GA, Akinlolu O, Olubena TL, Bello RO. Multi-regulator of EZH2-PPARs Therapeutic Targets: A Hallmark for Prospective Restoration of Pancreatic Insulin Production and Cancer Dysregulation. Applied Biochemistry and Biotechnology. 2023 Apr 3:1-33.


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Additional information

Competing interests
No competing interests were disclosed.
Data availability statement
The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.
Creative Commons license
Copyright © 2023 Olowosoke et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Olowosoke, C., Gbemisola, O., Alaba, A., Adepoju, O., Okorie, B., Odjegba, P., Ogunsanmi, A., Oke, G., Akinlolu, O., Olubena, T., Bello, R., Adegboyega, B. Multi-regulator of EZH2-PPARs therapeutic targets: A hallmark for prospective restoration of pancreatic insulin production and cancer dysregulation [not peer reviewed]. Peeref 2023 (poster).
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