Multi-regulator of EZH2-PPARs therapeutic targets: A hallmark for prospective restoration of pancreatic insulin production and cancer dysregulation

PUBLISHED June 21, 2023 (DOI: https://doi.org/10.54985/peeref.2306p3331152)

NOT PEER REVIEWED

2^nd Place Peeref Competition

Authors

Christopher Olowosoke¹ , Otitoola Gbemisola² , Adebola Alaba¹ , Oluwadamilola Adepoju³ , Benson Okorie¹ , Peace Odjegba¹ , Ayomide Ogunsanmi⁴ , Grace Oke¹ , Oluwatoyin Akinlolu¹ , Tomiwa Olubena¹ , Ridwan Bello¹ , Benjamin Adegboyega¹

1. Federal University of Technology, Akure
2. University of Ibadan
3. Federal University of Agriculture, Abeokuta
4. Kwara State University

Conference / event

Institute of Bioinformatics and Molecular Therapeutics (IBMT) Workshop Training (Virtual), April 2023 (Virtual)

Poster summary

Cancer and diabetes pose significant global challenges, and research is focused on identifying biomarkers for innovative therapeutic targets. The regulatory role of EZH2-PPARs in these diseases has been discovered, with GSK-126 and bezafibrate as effective inhibitors. This study identified gene-disease associations, protein interactions, and potential natural products for drug development. Obesity and hypertension were linked to the investigated biomarkers, validating their connection to cancer and diabetes. Nine natural products showed strong binding capacity, particularly phytocassane A, surpassing standard drugs. Experimental screening is recommended to further explore their potential in diabetes and cancer therapy targeting EZH2-PPARs.

Keywords

EZH2-PPARs, Diabetes mellitus, Natural products, Pancreatic cancer, Protein-protein network, In silico profiling

Research areas

Biological Sciences, Bioinformatics and Genomics, Molecular and Cellular Biosciences, Pharmacy and Pharmacology

References

1. Olowosoke CB, Gbemisola O, Alaba AA, Adepoju OH, Okorie B, Odjegba PI, Ogunsanmi AO, Oke GA, Akinlolu O, Olubena TL, Bello RO. Multi-regulator of EZH2-PPARs Therapeutic Targets: A Hallmark for Prospective Restoration of Pancreatic Insulin Production and Cancer Dysregulation. Applied Biochemistry and Biotechnology. 2023 Apr 3:1-33.

Funding

No data provided

Supplemental files

1. PEEREF INTERNATIONAL POSTER CHALLENGER PRESENTATION (Christopher et al., 2023)   Download

Additional information

Competing interests

No competing interests were disclosed.

Data availability statement

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

Creative Commons license

Copyright © 2023 Olowosoke et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.