Multi-regulator of EZH2-PPARs therapeutic targets: A hallmark for prospective restoration of pancreatic insulin production and cancer dysregulation

发表日期 June 21, 2023 (DOI: https://doi.org/10.54985/peeref.2306p3331152)

未经同行评议

2^nd Place Peeref Competition

作者

Christopher Olowosoke¹ , Otitoola Gbemisola² , Adebola Alaba¹ , Oluwadamilola Adepoju³ , Benson Okorie¹ , Peace Odjegba¹ , Ayomide Ogunsanmi⁴ , Grace Oke¹ , Oluwatoyin Akinlolu¹ , Tomiwa Olubena¹ , Ridwan Bello¹ , Benjamin Adegboyega¹

1. Federal University of Technology, Akure
2. University of Ibadan
3. Federal University of Agriculture, Abeokuta
4. Kwara State University

会议/活动

Institute of Bioinformatics and Molecular Therapeutics (IBMT) Workshop Training (Virtual), April 2023 (虚拟会议)

海报摘要

Cancer and diabetes pose significant global challenges, and research is focused on identifying biomarkers for innovative therapeutic targets. The regulatory role of EZH2-PPARs in these diseases has been discovered, with GSK-126 and bezafibrate as effective inhibitors. This study identified gene-disease associations, protein interactions, and potential natural products for drug development. Obesity and hypertension were linked to the investigated biomarkers, validating their connection to cancer and diabetes. Nine natural products showed strong binding capacity, particularly phytocassane A, surpassing standard drugs. Experimental screening is recommended to further explore their potential in diabetes and cancer therapy targeting EZH2-PPARs.

关键词

EZH2-PPARs, Diabetes mellitus, Natural products, Pancreatic cancer, Protein-protein network, In silico profiling

研究领域

Biological Sciences, Bioinformatics and Genomics, Molecular and Cellular Biosciences, Pharmacy and Pharmacology

参考文献

1. Olowosoke CB, Gbemisola O, Alaba AA, Adepoju OH, Okorie B, Odjegba PI, Ogunsanmi AO, Oke GA, Akinlolu O, Olubena TL, Bello RO. Multi-regulator of EZH2-PPARs Therapeutic Targets: A Hallmark for Prospective Restoration of Pancreatic Insulin Production and Cancer Dysregulation. Applied Biochemistry and Biotechnology. 2023 Apr 3:1-33.

基金

暂无数据

补充材料

1. PEEREF INTERNATIONAL POSTER CHALLENGER PRESENTATION (Christopher et al., 2023)   Download

附加信息

利益冲突

No competing interests were disclosed.

数据可用性声明

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

知识共享许可协议

Copyright © 2023 Olowosoke et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.