Bacterial inhibition and osteogenic potentials of Sr/Zn co-doped nano-hydroxyapatite-PLGA composite scaffold for bone tissue engineering applications

Authors

Mozan Hassan¹ , Abbas Khaleel² , Sherif Karam¹ , Ali Al-Marzouqi³ , Ihtesham Ur Rehman⁴ , Sahar Mohsin¹

1. Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University
2. Department of Chemistry, College of Science, United Arab Emirates University
3. College of Engineering, United Arab Emirates University
4. School of Medicine, University of Central Lancashire

Conference / event

College of Medicine and Health Sciences Research Day 2023, UAE University, February 2023 (Abu Dhabi, United Arab Emirates)

Poster summary

Bacterial infection associated with bone grafts can lead to implant failure and their treatment is a costly endeavor; therefore, an ideal bone scaffold should merge both biocompatibility and antibacterial activity. In our study, a unique strontium/zinc (Sr/Zn) co-doped nano-hydroxyapatite (nHAp) and Poly (lactic-co-glycolic acid) -(PLGA) composite scaffold was fabricated using a chemical precipitation method with different ratios of Sr/Zn ions (1%, 2.5%, and 4%). The scaffolds’ antibacterial activity and cytocompatibility were evaluated. The results showed a dose-dependent reduction in bacterial numbers as the Zn concentration increased, with 4% Zn showing the best antibacterial properties. PLGA incorporation in Sr/Zn-nHAp did not affect the Zn antibacterial activity and the 4% Sr/Zn-nHAp-PLGA scaffold showed a 99.7% bacterial growth inhibition. MTT cell viability assay showed no apparent cytotoxicity and the highest doping percentage in the 4% Sr/Zn-nHAp-PLGA was found to be ideal for cell growth.

Keywords

Bone scaffold, Doped nano-hydroxyapatite, Antibacterial, MTT, PLGA

Research areas

Biological Sciences, Material Sciences

References

No data provided

Funding

1. UAEU Program for Advanced Research (UPAR) (No. G00003460)

Supplemental files

1. published manuscript   Download

Additional information

Competing interests

No competing interests were disclosed.

Data availability statement

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

Creative Commons license

Copyright © 2023 Hassan et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.