Bacterial inhibition and osteogenic potentials of Sr/Zn co-doped nano-hydroxyapatite-PLGA composite scaffold for bone tissue engineering applications

作者

Mozan Hassan¹ , Abbas Khaleel² , Sherif Karam¹ , Ali Al-Marzouqi³ , Ihtesham Ur Rehman⁴ , Sahar Mohsin¹

1. Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University
2. Department of Chemistry, College of Science, United Arab Emirates University
3. College of Engineering, United Arab Emirates University
4. School of Medicine, University of Central Lancashire

会议/活动

College of Medicine and Health Sciences Research Day 2023, UAE University, February 2023 (Abu Dhabi, United Arab Emirates)

海报摘要

Bacterial infection associated with bone grafts can lead to implant failure and their treatment is a costly endeavor; therefore, an ideal bone scaffold should merge both biocompatibility and antibacterial activity. In our study, a unique strontium/zinc (Sr/Zn) co-doped nano-hydroxyapatite (nHAp) and Poly (lactic-co-glycolic acid) -(PLGA) composite scaffold was fabricated using a chemical precipitation method with different ratios of Sr/Zn ions (1%, 2.5%, and 4%). The scaffolds’ antibacterial activity and cytocompatibility were evaluated. The results showed a dose-dependent reduction in bacterial numbers as the Zn concentration increased, with 4% Zn showing the best antibacterial properties. PLGA incorporation in Sr/Zn-nHAp did not affect the Zn antibacterial activity and the 4% Sr/Zn-nHAp-PLGA scaffold showed a 99.7% bacterial growth inhibition. MTT cell viability assay showed no apparent cytotoxicity and the highest doping percentage in the 4% Sr/Zn-nHAp-PLGA was found to be ideal for cell growth.

关键词

Bone scaffold, Doped nano-hydroxyapatite, Antibacterial, MTT, PLGA

研究领域

Biological Sciences, Material Sciences

参考文献

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基金

1. UAEU Program for Advanced Research (UPAR) (No. G00003460)

补充材料

1. published manuscript   Download

附加信息

利益冲突

No competing interests were disclosed.

数据可用性声明

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

知识共享许可协议

Copyright © 2023 Hassan et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.