Neuprotective activity of a sulfated agaran isolated from red seaweed Gracilaria cornea in Parkinson’s disease model induced by 6-hydroxydopamine in rats: Behavioral and nitrite levels analyses

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Authors

Ricardo Basto Souza¹

1. Universidade Federaldo Ceará

Conference / event

11th World Congress on Inflammation, September 2013 (Natal, Brazil)

Poster summary

The aim of this work is to evaluate the neuroprotective effects of SA in the modulation of behavioral and motor alterations and cerebral nitrite levels induced by 6-OHDA intrastriatal injection in rats. Male Wistar rats (250-300 g) were randomically divided in five groups. Rats were anesthetized and treated with SA (15, 30 or 60 µg) + 6-OHDA (20 µg); 6-OHDA (20 µg) only; or saline (sham group). All treatments were realized through stereotaxic injection into right striatum and solutions were prepared in saline (0.9%; with 0.01% ascorbic acid). Fourteen days later, rats were submitted to behavioural evaluation by open-field test and rotational test induced by apomorphine (3 mg/Kg). After, animals were euthanized and hippocampus, cortex and striatum were removed to measure nitrite levels. SA presented neuroprotective effects against motor alterations induced by 6-OHDA injection into striatum and recovered the nitrite levels in the rat cerebral tissues.

Keywords

Sulfated polysaccharide, Gracilaria cornea, Parkinson's disease

Research areas

Biological Sciences, Biochemistry, Pharmacy and Pharmacology, Neuroscience, Toxicology

References

No data provided

Funding

No data provided

Supplemental files

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Additional information

Competing interests

No competing interests were disclosed.

Data availability statement

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

Creative Commons license

Copyright © 2023 Basto Souza. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.