Neuprotective activity of a sulfated agaran isolated from red seaweed Gracilaria cornea in Parkinson’s disease model induced by 6-hydroxydopamine in rats: Behavioral and nitrite levels analyses

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作者

Ricardo Basto Souza¹

1. Universidade Federaldo Ceará

会议/活动

11th World Congress on Inflammation, September 2013 (Natal, Brazil)

海报摘要

The aim of this work is to evaluate the neuroprotective effects of SA in the modulation of behavioral and motor alterations and cerebral nitrite levels induced by 6-OHDA intrastriatal injection in rats. Male Wistar rats (250-300 g) were randomically divided in five groups. Rats were anesthetized and treated with SA (15, 30 or 60 µg) + 6-OHDA (20 µg); 6-OHDA (20 µg) only; or saline (sham group). All treatments were realized through stereotaxic injection into right striatum and solutions were prepared in saline (0.9%; with 0.01% ascorbic acid). Fourteen days later, rats were submitted to behavioural evaluation by open-field test and rotational test induced by apomorphine (3 mg/Kg). After, animals were euthanized and hippocampus, cortex and striatum were removed to measure nitrite levels. SA presented neuroprotective effects against motor alterations induced by 6-OHDA injection into striatum and recovered the nitrite levels in the rat cerebral tissues.

关键词

Sulfated polysaccharide, Gracilaria cornea, Parkinson's disease

研究领域

Biological Sciences, Biochemistry, Pharmacy and Pharmacology, Neuroscience, Toxicology

参考文献

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基金

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补充材料

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附加信息

利益冲突

No competing interests were disclosed.

数据可用性声明

The datasets generated during and / or analyzed during the current study are available from the corresponding author on reasonable request.

知识共享许可协议

Copyright © 2023 Basto Souza. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.