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Blockade of ATP-sensitive potassium channels impairs vascular control in exercising rats

PUBLISHED June 3, 2022 (DOI: https://doi.org/10.54985/peeref.2206p8529370)



Clark Holdsworth1 , Steven Copp1 , Daniel Hirai1 , Scott Ferguson1 , Gabrielle Sims1 , Sue Hageman1 , David Poole1 , Timothy Musch1
  1. Kansas State University

Conference / event

American College of Sports Medicine Annual Meeting, May 2014 (Orlando, FL, United States)

Poster summary

The ATP-sensitive K+ (KATP) channel is a class of inward rectifier K+ channels that can link local O2 availability to vasomotor tone across exercise-induced metabolic transients. This investigation tested the hypothesis that, if KATP channels are crucial to exercise hyperemia, inhibition via glibenclamide (GLI) would lower hindlimb skeletal muscle blood flow (BF) and vascular conductance (VC) during treadmill exercise. In 27 adult male Sprague Dawley rats mean arterial pressure (MAP), blood [lactate], and hindlimb muscle BF (radiolabelled microspheres) were determined at rest (n=6) or during exercise (n=6-8; 20, 40 and 60 m min-1, 5% incline, i.e. ~60-100% maximal oxygen uptake) under control and GLI conditions (5 mg kg-1, i.a). That KATP channel inhibition reduces hindlimb muscle BF during exercise in rats supports the obligatory contribution of KATP channels in large muscle mass exercise-induced hyperemia.


exercise hyperemia, vascular control, metabolic coupling

Research areas

Anatomy and Physiology


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Supplemental files

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Additional information

Competing interests
No competing interests were disclosed.
Data availability statement
The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
Creative Commons license
Copyright © 2022 Holdsworth et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Holdsworth, C., Copp, S., Hirai, D., Ferguson, S., Sims, G., Hageman, S., Poole, D., Musch, T. Blockade of ATP-sensitive potassium channels impairs vascular control in exercising rats [not peer reviewed]. Peeref 2022 (poster).
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