Blockade of ATP-sensitive potassium channels impairs vascular control in exercising rats

Authors

Clark Holdsworth¹ , Steven Copp¹ , Daniel Hirai¹ , Scott Ferguson¹ , Gabrielle Sims¹ , Sue Hageman¹ , David Poole¹ , Timothy Musch¹

1. Kansas State University

Conference / event

American College of Sports Medicine Annual Meeting, May 2014 (Orlando, FL, United States)

Poster summary

The ATP-sensitive K+ (KATP) channel is a class of inward rectifier K+ channels that can link local O2 availability to vasomotor tone across exercise-induced metabolic transients. This investigation tested the hypothesis that, if KATP channels are crucial to exercise hyperemia, inhibition via glibenclamide (GLI) would lower hindlimb skeletal muscle blood flow (BF) and vascular conductance (VC) during treadmill exercise. In 27 adult male Sprague Dawley rats mean arterial pressure (MAP), blood [lactate], and hindlimb muscle BF (radiolabelled microspheres) were determined at rest (n=6) or during exercise (n=6-8; 20, 40 and 60 m min-1, 5% incline, i.e. ~60-100% maximal oxygen uptake) under control and GLI conditions (5 mg kg-1, i.a). That KATP channel inhibition reduces hindlimb muscle BF during exercise in rats supports the obligatory contribution of KATP channels in large muscle mass exercise-induced hyperemia.

Keywords

exercise hyperemia, vascular control, metabolic coupling

Research areas

Anatomy and Physiology

References

No data provided

Funding

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Supplemental files

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Additional information

Competing interests

No competing interests were disclosed.

Data availability statement

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Creative Commons license

Copyright © 2022 Holdsworth et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.