Blockade of ATP-sensitive potassium channels impairs vascular control in exercising rats

作者

Clark Holdsworth¹ , Steven Copp¹ , Daniel Hirai¹ , Scott Ferguson¹ , Gabrielle Sims¹ , Sue Hageman¹ , David Poole¹ , Timothy Musch¹

1. Kansas State University

会议/活动

American College of Sports Medicine Annual Meeting, May 2014 (Orlando, FL, United States)

海报摘要

The ATP-sensitive K+ (KATP) channel is a class of inward rectifier K+ channels that can link local O2 availability to vasomotor tone across exercise-induced metabolic transients. This investigation tested the hypothesis that, if KATP channels are crucial to exercise hyperemia, inhibition via glibenclamide (GLI) would lower hindlimb skeletal muscle blood flow (BF) and vascular conductance (VC) during treadmill exercise. In 27 adult male Sprague Dawley rats mean arterial pressure (MAP), blood [lactate], and hindlimb muscle BF (radiolabelled microspheres) were determined at rest (n=6) or during exercise (n=6-8; 20, 40 and 60 m min-1, 5% incline, i.e. ~60-100% maximal oxygen uptake) under control and GLI conditions (5 mg kg-1, i.a). That KATP channel inhibition reduces hindlimb muscle BF during exercise in rats supports the obligatory contribution of KATP channels in large muscle mass exercise-induced hyperemia.

关键词

exercise hyperemia, vascular control, metabolic coupling

研究领域

Anatomy and Physiology

参考文献

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基金

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补充材料

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附加信息

利益冲突

No competing interests were disclosed.

数据可用性声明

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

知识共享许可协议

Copyright © 2022 Holdsworth et al. This is an open access work distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.